A Study of Atezolizumab in Combination With Carboplatin + Paclitaxel or Carboplatin + Nab-Paclitaxel Compared With Carboplatin + Nab-Paclitaxel in Participants With Stage IV Squamous Non-Small Cell Lung Cancer (NSCLC) [IMpower131]

PHASE3CompletedINTERVENTIONAL
Enrollment

1,021

Participants

Timeline

Start Date

June 11, 2015

Primary Completion Date

October 3, 2018

Study Completion Date

February 17, 2021

Conditions
Squamous Non-Small Cell Lung Cancer
Interventions
DRUG

Atezolizumab (MPDL3280A), an engineered anti-programmed death-ligand 1 (anti-PD-L1) antibody

Atezolizumab 1200 milligrams (mg) intravenous infusion (IV) on day 1 of each 21-day cycle.

DRUG

Carboplatin

Carboplatin area under the concentration curve (AUC) 6 milligrams per milliliter per minute (mg/mL/min) on Day 1 of each 21-day cycle for 4 or 6 cycles.

DRUG

Nab-Paclitaxel

Nab-paclitaxel 100 milligrams per meter squared (mg/m\^2) IV on Day 1, 8, and 15 of each 21-day cycle for 4 or 6 cycles.

DRUG

Paclitaxel

Paclitaxel 200 mg/m\^2 IV on Day 1 of each 21-day cycle for 4 or 6 cycles. Participants of Asian race/ethnicity will be administered paclitaxel 175 mg/m\^2 IV.

Trial Locations (242)

104

Mackay Memorial Hospital, Taipei

500

Changhua Christian Hospital; Hematology-Oncology, Changhua

613

Chang Gung Memorial Hospital Chiayi, Putzu

736

Chi Mei Medical Center Liou Ying Campus, Liuying Township

807

Kaohsiung Medical University Hospital; Department of Urology, Kaohsiung City

1200

Cliniques Universitaires St-Luc, Brussels

1303

Multiprofile Hospital for Active Treatment Serdika EOOD, Sofia

2050

Chris O'Brien Lifehouse, Camperdown

2100

CH de Saint Quentin, Saint-Quentin

2298

Calvary Mater Newcastle; Medical Oncology, Waratah

2610

GasthuisZusters Antwerpen, Wilrijk

3021

Sunshine Hospital, St Albans

3084

Austin Health, Heidelberg

3144

Cabrini Hospital Malvern, Malvern

4000

CHU Sart-Tilman, Liège

Multiprofile Hospital for Active Treatment Central Onco Hospital OOD, Plovdiv

4032

Prince Charles Hospital, Chermside

4102

Princess Alexandra Hospital, Woolloongabba

4200

Hospital de Sao Joao; Servico de Pneumologia, Porto

4810

Townsville Hospital, Townsville

5000

Royal Adelaide Hospital, Adelaide

Clinique Ste-Elisabeth, Namur

5020

Paracelsus Medizinische Privatuniversität, Salzburg

6009

Sir Charles Gairdner Hospital, Nedlands

8208

Corporacio Sanitaria Parc Tauli; Servicio de Oncologia, Sabadell

9600

Werken Glorieux VZW, Ronse

10041

National Taiwan Uni Hospital, Taipei

11590

Clinical Research Alliance, Westbury

12203

Charite - Universitätsmedizin Berlin, Berlin

12345

Instituto Regional de Enfermedades Neoplásicas Del Norte, Trujillo

14008

Hospital Universitario Reina Sofia, Córdoba

15006

Complejo Hospitalario Universitario A Coruña, A Coruña

15212

Allegheny Cancer Center, Pittsburgh

15232

Univ of Pittsburgh Medical Ctr, Pittsburgh

16147

ASL 3 Genovese; DSM, Genoa

17325

Maryland Oncology Hematology (Lanham) - USOR, Gettysburg

18015

St. Luke's Cancer Care Associates, Bethlehem

20246

Universitätsklinikum Hamburg-Eppendorf, Hamburg

21029

Communal Nonprofit Enterprise Podilsky Regional Center Of Oncology OfTheVinnytsia Regional Council, Vinnytsia

21075

Asklepios Klinik Harburg, Hamburg

22031

Virginia Cancer Specialists, PC, Fairfax

22927

LungenClinic Großhansdorf GmbH, Großhansdorf

23502

Virginia Oncology Associates, Norfolk

24014

Blue Ridge Cancer Care, Roanoke

27003

Hospital Lucus Augusti; Servicio de Oncologia, Lugo

27100

Fondazione IRCCS Policlinico San Matteo, Pavia

28007

Hospital General Universitario Gregorio Marañon; Servicio de Oncologia, Madrid

28034

Hospital Ramon y Cajal; Servicio de Oncologia, Madrid

28040

Fundación Jimenez Díaz, Madrid

Hospital Clinico San Carlos; Servicio de Oncologia, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28050

HOSPITAL DE MADRID NORTE SANCHINARRO- CENTRO INTEGRAL ONCOLOGICO CLARA CAMPAL; Servicio de Oncologia, Madrid

30117

Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital, Carrollton

30265

Southeastern Regional Medical Center, Inc., Newnan

30607

University Cancer & Blood Center, LLC; Research, Athens

31201

Central Georgia Cancer Care PC, Macon

32429

Johannes Wesling Klinikum Minden; Hämatologie, Onkologie, Hämostaseologie und Palliativmedizin, Minden

33308

Holy Cross Hospital Inc, Fort Lauderdale

33410

Florida Cancer Specialists, Palm Beach Gardens

33611

Ev.Krankenhaus Bielefeld gGmbH; Klinik für Innere Medizin und Geriatrie, Bielefeld

33705

Florida Cancer Specialists (St. Petersburg - St. Anthony's Professional Building), St. Petersburg

33916

SCRI Florida Cancer Specialists South, Fort Myers

34070

Clinique Clémentville, Montpellier

34376

Fachklinik für Lungenerkrankungen, Immenhausen

34952

Hematology Oncology Associates of the Treasure Coast, Port Saint Lucie

35016

Complejo Hospitalario Universitario Insular-Materno Infantil, Las Palmas de Gran Canaria

35033

Hopital de Pontchaillou; Service de Pneumologie, Rennes

36011

Poltava Regional Clinical Oncology Dispensary of Poltava Regional Council; Thoracic department, Poltava

37404

SCRI Tennessee Oncology Chattanooga, Chattanooga

37920

Tennessee Cancer Specialists, Knoxville

38043

CHU de Grenoble, Grenoble

38320

Hospital Universitario de Canarias, S. Cristobal de La Laguna

38801

Hematology and Oncology Associates at Bridgepoint, Tupelo

39008

Hospital Universitario Marques de Valdecilla; Servicio de Oncologia, Santander

40005

Regional Municipal Institution Sumy Regional Clinical Oncology Dispensary, Sumy

40202

Norton Cancer Institute, Louisville

40447

China Medical University Hospital, Taichung

41014

Hospital Nuestra Senora de Valme, Seville

43219

Mark H. Zangmeister Center, Columbus

44791

Augusta Kranken-Anstalt gGmbH, Bochum

45067

Hopital de La Source, Orléans

45103

Oncology Hematology Care, Inc., Hamilton

46010

Hospital Clinico Universitario de Valencia, Valencia

46014

Hospital General Universitario de Valencia, Valencia

46845

Fort Wayne Med Oncology & Hematology Inc, Fort Wayne

48106

St. Joseph Mercy Health System, Ann Arbor

48201

Karmanos Cancer Institute, Detroit

48431

Stiftung Mathias-Spital Rheine, Rheine

49102

Municipal Institution City Clinical Hospital #4 of Dnipro City Council - PPDS; Dept of Chemotherapy, Dnipropetrovsk

50009

Hospital Universitario Miguel Servet, Zaragoza

50048

ME Kryviy Rih Oncology Dispensary of Dnipropetrovs'k Regional Council; Chemotherapy Department, Kryvyi Rih

51101

Siouxland Hematology/Oncology, Sioux City

51109

Kliniken der Stadt Koln gGmbH, Cologne

52722

Hematology-Oncology; Associates of the Quad Cities, Bettendorf

55805

St. Luke's Regional Cancer Center, Duluth

56100

Azienda Ospedaliero Universitaria Pisana, Pisa

57124

Ospedale Civile - Livorno, Livorno

58013

Municipal Institution Chernivtsi Regional Clinical Oncology Dispensary; Surgery Department #1, Chernivtsi

58675

Lungenklinik Hemer, Hemer

59102

Billings Clinic, Billings

60435

Joliet Oncology-Hematology; Associates, Ltd., Joliet

60487

St. Elisabethen Krankenhaus, Frankfurt am Main

60637

University of Chicago, Chicago

61024

SI Institute of Medical Radiology n.a. S.P. Hryhoriev of NAMS of Ukraine, Kharkiv

61070

Communal Non profit Enterprise Regional Center of Oncology; Oncosurgical dept of thoracic organs, Kharkiv

62301

Quincy Medical Group, Quincy

64020

Centro Universitario Contra El Cancer, Monterrey

66421

Universität Des Saarlandes; Klinik für Innere Medizin V, Homburg

69008

Centre Léon Bérard Centre Régional de Lutte Contre Le Cancer Rhône Alpes, Lyon

69040

MNPE Zaporizhzhia Regional Antitumor Center ZRC, Zaporizhzhia

69495

Centre Hospitalier Lyon Sud, Pierre-Bénite

70121

Ochsner Clinic Foundation, New Orleans

70124

IRCCS Giovanni Paolo II Istituto Oncologico, Bari

70839

Robert Bosch Krankenhaus; Pneumologie und pneumologische Onkologie, Gerlingen

72000

Ctr Jean Bernard Clin V. Hugo; Service d'Oncologie Méd, Le Mans

72762

Highlands Oncology Group, Springdale

75601

Longview Cancer Center, Longview

76090

Cancerología, Querétaro

76210

SCRI The Center For Cancer and Blood Disorders, Denton

78052

Schwarzwald-Baar Klinikum/VS GmbH; Onkologie/Hämatologie/Infektologie, Villingen-Schwenningen

79031

MI of the Lviv Regional Council Lviv Oncology Regional Treatment and Diagnostic Centre; Chemotherapy, Lviv

80131

AORN A Cardarelli, Napoli

Azienda Ospedaliero Universitaria Seconda Università degli Studi di Napoli; Farmacia Centralizzata, Napoli

Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione G. Pascale, Napoli

80218

Rocky Mountain Cancer Center, Denver

81925

Klinikum Bogenhausen; Klinik für Pneumologie und Pneumologische Onkologie, München

83100

Azienda Ospedaliera di Rilievo Nazionale e di Alta Specialita San Giuseppe Moscati, Avellino

83800

Hôpital d'Instruction des Armées de Sainte Anne; Service Pharmacie Essais Cliniques, Toulon

85224

Ironwood Cancer & Research Centers, Chandler

88000

Uzhgorod Central City Clinical Hospital, Uzhhorod

93049

Krankenhaus Barmherzige Bruder Regensburg, Regensburg

93053

Klinikum der Universität Regensburg, Regensburg

94577

Kaiser Permanente - San Leandro Medical Center, San Leandro

94589

Kaiser Permanente; Oncology Clinical Trials, Vallejo

94596

Kaiser Permanente - Walnut Creek, Walnut Creek

94611

Kaiser Permanente Oakland Medical Center, Oakland

95051

Kaiser Permanente - Santa Clara, Santa Clara

95123

Policlinico Vittorio Emanuele, Catania

95825

Kaiser Permanente - Sacramento Medical Center and Medical Offices, Sacramento

97239

Oregon Health & Science Uni, Portland

97448

Centre Hospitalier Regional Sud Reunion; Service de Pneumologie, Saint-Pierre

98201

Providence Regional Cancer Partnership, Everett

99208

Medical Oncology Associates, Spokane

115478

Russian Oncology Research Center n.a. N.N. Blokhin, Moscow

119074

National University Hospital, Singapore

143423

Moscow City Oncology Hospital #62, Moscovskaya Oblast

169610

National Cancer Centre, Singapore

197022

City Clinical Oncology Dispensary, Saint Petersburg

280146

Hospital Universitario La Paz, Madrid

400138

Volgograd Regional Clinical Oncology Dispensary, Volgograd

644013

Clinical Oncology Dispensary, Omsk

3525408

Rambam Health Corporation; Oncology Institute, Rambam

4428164

Meir Medical Center; Oncology, Kfar Saba

4810469

Sociedad de Investigaciones Medicas Ltda (SIM), Temuco

4941492

Rabin Medical Center, Petach Tiqwa

5262100

Chaim Sheba Medical Center; Oncology Dept, Ramat Gan

6423906

Tel Aviv Sourasky Medical Ctr; Oncology, Tel Aviv

7500006

Health & Care SPA, Santiago

8410101

Soroka Medical Center, Beersheba

9112001

Hadassah University Hospital - Ein Kerem, Jerusalem

59040150

Liga Norte Riograndense Contra O Câncer, Natal

Unknown

Southern CA Permanente Med Grp, Bellflower

W.G. Bill Hefner VA Medical Center, Salisbury

06810

Danbury Hospital, Danbury

02421

Lahey Clinic Med Ctr, Lexington

04074

New England Cancer Specialists, Scarborough

02719

Southcoast Health System; Southcoast Centers For Cancer Care, Fairhaven

07652

Valley Hospital; Oncology Research, Paramus

08080

Regional Cancer Care Associates LLC, Sewell

45203-0542

University of Cincinnati, Cincinnati

C1125ABD

Fundación CENIT para la Investigación en Neurociencias, Buenos Aires

X5000JHQ

Sanatorio Allende, Córdoba

F5300COE

Centro Oncologico Riojano Integral (CORI), La Rioja

B2700CPM

Clínica Pergamino, Pergamino

L6304BOC

Fundacion Koriza, Santa Rosa

R8500ACE

Centro de Investigacion; Clinica - Clinica Viedma S.A., Viedma

30130-090

Cenantron - Centro Avancado de Tratamento Oncologico, Belo Horizonte

86 015 520

Instituto Do Cancer Delondrina_X; Unidade De Pesquisa Clinica, Londrina

95070-560

IPCEM; Instituto de Pesquisa de Estudos Multicêntricos, Caxias do Sul

95900-000

Hospital Bruno Born, Lajeado

90035-903

Hospital das Clinicas - UFRGS, Porto Alegre

90470-340

Hospital Mae de Deus, Porto Alegre

14784-400

*X*Fundação Pio XII Hospital de Câncer de Barretos, Barretos

15090-000

Hospital de Base de Sao Jose do Rio Preto, São José do Rio Preto

01525-001

Hospital Do Cancer A C Camargo, São Paulo

L4M 6M2

Royal Victoria Regional Health Centre, Barrie

M9V 1R8

William Osler Health Centre, Etobicoke

L1J 2J2

Lakeridge Health Center, Oshawa

H7M 3L9

Cite de La Sante de Laval; Hemato-Oncologie, Laval

H4J 1C5

Hôpital du Sacré-Coeur de Montreal, Montreal

J7Z 5T3

St. Jerome Medical Research, Saint-Jérôme

01307

"Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden", Dresden

06120

Krankenhaus Martha-Maria; Halle-Dolau gGmbH, Halle

00152

Azienda Ospedaliera San Camillo Forlanini, Rome

06122

Ospedale Silvestrini, Perugia

464-8681

Aichi Cancer Center Hospital; Respiratory Medicine, Aichi

466-8560

Nagoya University Hospital; Respiratory Medicine, Aichi

277-8577

National Cancer Center Hospital East; Thoracic Oncology, Chiba

791-0280

National Hospital Organization Shikoku Cancer Center; Internal Medicine, Ehime

810-8563

National Hospital Organization Kyushu Medical Center; Respiratory Internal Medicine, Fukuoka

812-8582

Kyushu University Hospital; Respiratory, Fukuoka

650-0047

Kobe City Medical Center General Hospital; Respiratory Medicine, Hyōgo

670-8520

National Hospital Organization Himeji Medical Center, Hyōgo

673-8558

Hyogo Cancer Center; Thoracic Oncology, Hyōgo

309-1793

Ibaraki Prefectural Central Hospital; Division of respiratory, Ibaraki

241-8515

Kanagawa Cancer Center;Thoracic Oncology, Kanagawa

606-8507

Kyoto University Hospital, Respiratory Medicine, Kyoto

980-0873

Sendai Kousei Hospital; Pulmonary Medicine, Miyagi

951-8520

Niigata University Medical & Dental Hospital; Respiratory Medicine and Infectious Disease, Niigata

700-8558

Okayama University Hospital; Respiratory and Allergy Medicine, Okayama

541-8567

Osaka International Cancer Institute; Thoracic Oncology, Osaka

545-8586

Osaka City Uni Hospital; Respiratory Medicine, Osaka

573-1191

Kansai Medical university Hospital; Thoracic Oncology, Osaka

583-8588

Osaka Habikino Medical Center, Osaka

591-8555

National Hospital Organization Kinki-Chuo Chest Medical Center, Sakaishi

362-0806

Saitama Cancer Center; Thoracic Oncology, Satima

411-8777

Shizuoka Cancer Center; Thoracic Oncology, Shizuoka

104-0045

National Cancer Center Hospital; Thoracic Medical Oncology, Tokyo

160-0023

Tokyo Medical University Hospital; Dept of Surgery, Tokyo

LV-1002

Pauls Stradins Clinical University Hospital, Riga

LV-1079

Riga East Clinical University Hospital Latvian Oncology Centre, Riga

08660

National Cancer Institute, Vilnius

1007 MB

VU Medisch Centrum; VU University Medical Center, Amsterdam

1066 CX

Het Nederlands Kanker Instituut Antoni Van Leeuwenhoek Ziekenhuis, Amsterdam

6716 RP

Ziekenhuis Gelderse Vallei, Ede

5623 EJ

Catharina Hospital; Afdeling Longgeneeskunde en Tuberculose, Eindhoven

3435 CM

St. Antonius Ziekenhuis; R&D Long, Nieuwegein

04001

Centro Medico Monte Carmelo, Arequipa

Lima 13

Hospital Nacional Guillermo Almenara Irigoyen ESSALUD, Lima

1099-023

IPO de Lisboa; Servico de Pneumologia, Lisbon

1796-001

Hospital Pulido Valente; Servico de Pneumologia, Lisbon

4099-001

Centro Hospitalar do Porto - Hospital de Santo António, Porto

4200-072

Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe, Porto

813 69

Univerzitna nemocnica Bratislava, Bratislava

833 10

Narodny onkologicky ustav, Bratislava

058 01

POKO Poprad s.r.o., Poprad

07014

Hospital Universitario Son Espases, Palma de Mallorca

08908

Instituto Catalan de Oncologia de Hospitalet (ICO); Servicio de Farmacia, L'Hospitalet de Llobregat

08003

Hospital del Mar, Barcelona

08035

Hospital Univ Vall d'Hebron; Servicio de Oncologia, Barcelona

08036

Hospital Clinic de Barcelona, Barcelona

08041

Hospital de la Santa Creu i Sant Pau; Servicio de Oncologia, Barcelona

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT02367794 - A Study of Atezolizumab in Combination With Carboplatin + Paclitaxel or Carboplatin + Nab-Paclitaxel Compared With Carboplatin + Nab-Paclitaxel in Participants With Stage IV Squamous Non-Small Cell Lung Cancer (NSCLC) [IMpower131] | Biotech Hunter | Biotech Hunter