A Comparative Study Of PF-06439535 Plus Paclitaxel-Carboplatin And Bevacizumab Plus Paclitaxel-Carboplatin Patients With Advanced Non-Squamous NSCLC

PHASE3CompletedINTERVENTIONAL
Enrollment

719

Participants

Timeline

Start Date

April 30, 2015

Primary Completion Date

May 31, 2017

Study Completion Date

December 31, 2017

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Bevacizumab-Pfizer

Bevacizumab-Pfizer: 15 mg/kg IV on Day 1 of a 21-day cycle for each of at least 4 and no more than six (6) 21-day cycles, followed by the assigned blinded bevacizumab monotherapy.

DRUG

Bevacizumab-EU

bevacizumab-EU: 15 mg/kg IV on Day 1 of a 21-day cycle for each of at least 4 and no more than six (6) 21-day cycles followed by the assigned blinded bevacizumab monotherapy.

DRUG

Paclitaxel

Paclitaxel 200 mg/m2 via IV infusions on Day 1 of a 21-day cycle for each of at least 4 and no more than six (6) 21-day cycles.

DRUG

Carboplatin

carboplatin AUC =6.0 via IV infusions on Day 1 of a 21-day cyclefor each of at least 4 and no more than six (6) 21-day cycles.

Trial Locations (263)

500

Changhua Christian Hospital, Changhua

1125

Semmelweis Egyetem Klinikai Pulmonologiai Klinikai Gyogyszertar, Budapest

Semmelweis Egyetem, Pulmonologiai Klinika, Budapest

2045

Tudogyogyintezet Torokbalint, Törökbálint

2196

The Medical Oncology Centre of Rosebank, Johannesburg

2480

Epic Pharmacy, Lismore

2485

The Tweed Hospital, Tweed Heads

3021

Western Health, Sunshine Hospital, St Albans

3084

Austin Health - Olivia Newton - John Cancer & Wellness Centre, Heidelberg

3233

Matrai Gyogyintezet Pulmonologiai Osztaly, Mátraháza

4126

Amanzimtoti Oncology Centre, eManzimtoti

4224

Cardiac Services, John Flynn Private Hospital -, Tugun

South Coast Radiology, John Flynn Private Hospital, Tugun

5000

Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz - Rendelointezet, Megyei Onkologiai Kozpont, Szolnok

6000

Cebu Doctors' University Hospital, Cebu City

6772

Csongrad Megyei Mellkasi Betegsegek Szakkorhaza, Deszk

7500

Drs Schnetler, Corbett and Partners Inc, Cape Town

7560

Dr Lior Sareli Inc, Cape Town

7570

Cape Town Oncology Trials (Pty) Ltd, Kraaifontein

8000

Davao Doctors Hospital, Davao City

8582

Veszprem Megyei Tudogyogyintezet, Farkasgyepű

8900

Zala Megyei Korhaz, Zalaegerszeg

9023

Petz Aladar Megyei Oktato Korhaz, Pulmonologiai Osztaly, Győr

9700

Complex Oncological Center Shumen EOOD, Shumen

10000

"University Hospital Centre Sestre Milosrdnice", Zagreb

10330

Chulalongkorn University, Patumwan

Chula Clinical Research Center, Bangkok

10350

Penang Adventist Hospital, George Town

10400

Clinical Research Center, Phramongkutklao Hospital, Bangkok

Medical Oncology Unit, Department of Medicine, Phramongkutklao Hospital, Bangkok

10700

Division of Medical Oncology, Department of Medicine, Faculty of Medicine Siriraj Hospital,, Bangkok

10900

Prachachuen Imaging Center Co., Ltd., Bangkok

11200

Mount Miriam Cancer Hospital, Tanjung Bungah

11527

Univ. of Athens Hosp. of Chest Diseases of Athens ''Sotiria'', Athens

13125

Evangelische Lungenklinik Berlin, Berlin

Viereck-Apotheke, Berlin

13509

Vivantes GmbH Apotheke des Humboldt-Klinikums, Berlin

13585

Vivantes Klinikum Spandau, Berlin

13620

Seoul National University Bundang Hospital, Seongnam-si

14564

"General Oncology Hospital of Kifissia Ag. Anargiroi", Athens

16499

Ajou University Hospital, Suwon

20902

Holy Cross Hospital Resource Center, Silver Spring

Maryland Oncology & Hematology, PA, Wheaton

20904

Maryland Oncology & Hematology, PA, Silver Spring

20910

Holy Cross Hospital, Hospital Pharmacy, Silver Spring

Holy Cross Hospital, Silver Spring

21029

Vinnytsia Regional Clinical Oncology Dispensary, Vinnytsia

21742

Meritus Center for Clinical Research, Hagerstown

22045

Zytoservice Deutschland GmbH, Hamburg

22087

Katholisches Marienkrankenhaus gGmbH, Hamburg

23100

S.C. Oncologia Medica-Presidio Ospedaliero Sondrio, Sondrio

24047

UOC Oncologia, Treviglio

24534

Friedrich-Ebert-Krankenhaus Neumuenster, Neumünster

25124

Oncologia Medica, Fondazione Poliambulanza Instituto Ospedaliero, Brescia

25200

Centre Hospitalier Montbeliard, Montbéliard

26126

Lekarna Oblastni nemocnice Pribram, Příbram

26504

University General Hospital Of Patras, Pátrai

26789

Hirsch-Apotheke, Leer

Onkologie UnterEms, Leer

28040

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28041

Hospital 12 de Octubre, Madrid

28046

Hospital Universitario La Paz, Servicio de Oncologia, Madrid

28644

Chungbuk National University Hospital, Cheongju-si

28922

Hospital Universitario Fundacion Alcorcon, Alcorcón

30625

Institut fuer Diagnostische und Interventionelle Radiologie, Hanover

Medizinische Hochschule Hannover Zentralapotheke, Hanover

Medizinische Hochschule Hannover, Hanover

31701

Phoebe Putney Memorial Hospital, Albany

34020

Yedikule Gogus Hastaliklari ve Gogus Cerrahisi, Istanbul

34093

Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi, Istanbul

Istanbul Universitesi Onkoloji Enstitusu, Istanbul

34096

Iyitem Goruntuleme ve Tani Merkezi, Istanbul

34098

Istanbul Universitesi Cerrahpasa Tip Fakultesi Ic Hastaliklari, Istanbul

34371

Prof Dr Nuri Tenekeci Tani Merkezi, Istanbul

34724

Euromed Goruntuleme ve Tani Merkezi, Istanbul

35040

Ege Universitesi Tip Fakultesi lc Hastaliklari Anabilim Dali, Izmir

36011

Poltava Reg. Clinical Oncology Dispensary of PRC, thoracic department, SHEI of Ukr., Poltava

36526

Southern Cancer Center, PC, Daphne

36607

Southern Cancer Center, PC, Mobile

36608

Southern Cancer Center, PC, Mobile

37045

UOC Oncologia Medica, Legnago

38114

Staedtisches Klinikum Braunschweig gGmbH Apotheke, Braunschweig

Staedtisches Klinikum Braunschweig gGmbH Institut fuer Roentgendiagnostik und Nuklearmedizin, Braunschweig

Staedtisches Klinikum Braunschweig gGmbH, Braunschweig

39338

Nemocnice Pelhrimov p.o, Radioterapeuticke oddeleni, Pelhřimov

40022

"RMI Sumy Reg. Clin. Oncology Dispensary. oncothoracic dep.-nt. Surny State Univ.,", Sumy

40024

Centre Hospitalier General De Mont De Marsan, Mont-de-Marsan

44277

L'hopital prive du Confluent S.A.S., Nantes

46014

Consorcio Hospital Universitario General De Valencia, Valencia

46015

Hospital Arnau de Vilanova, Valencia

47014

Unita di Oncologia Toracica, Meldola

47441

Onkologie Moers GbR, Moers

49102

MI 'City Dnipropetrovsk Multi-field Clin. Hospital #4 of DRC', Dep.-nt of Chemotherapy;, Dnipropetrovsk

50048

MI 'Kryvyi Rih Oncology Dispensary of Dnipropetrovsk Regional Council', Kryvyi Rih

54645

Euromedica General Clinic of Thessaloniki, Thessaloniki

55041

UOC di Oncologia Medica, Lido di Camaiore

56068

Institut Fuer Versorgungsforschung In Der Onkologie, Koblenz

Radiologisches Institut Koblenz, Koblenz

Sonnenschein Apotheke, Koblenz

57000

Chiangrai Prachanukroh Hospital, Muang

57001

European Inter-Balkan Medical Centre, Thessaloniki

Thermi Clinic S.A, Thessaloniki

57010

"Gen.Hospital G. Papanikolaou", Thessaloniki

58013

"Municipal Institution Chernivtsi Regional Clinical Oncology Dispensary,", Chernivtsi

60322

Radiologie Nuklearmedizin Adickesallee, Frankfurt am Main

60487

St. Elisabethen - Krankenhaus, Frankfurt am Main

60596

Sued-Apotheke, Frankfurt am Main

60625

Swedish Covenant Hospital, Chicago

61070

"Communal Non-Profit Enterprise Regional Center of Oncology,", Kharkiv

65000

Oncology Unit, Department of Medicine, Faculty of Medicine, Naresuan University, Phitsanulok

66421

Universitaetsklinikum des Saarlandes - Klinik fuer Diagnostische und Interventionelle Radiologie, Homburg/Saar

Universitaetsklinikum des Saarlandes - Klinik fuer Innere Medizin V - Pneumologie, Allergologie,, Homburg/Saar

Universitaetsklinikum des Saarlandes, Apotheke, Homburg/Saar

71110

University Hospital of Heraklion, Heraklion

71800

Nilai Medical Centre, Kampung Baharu Nilai

73730

Klinikum Esslingen GmbH, Esslingen a.N.

74101

Lekarna Agel Novy Jicin, Nový Jičín

76137

Vincentius-Diakonissen-Kliniken gAG Karlsruhe, Karlsruhe

Vincentius-Diakonissen-Kliniken gAG Klinik fuer Diagnostische und Interventionelle Radiologie, Karlsruhe

Vincentius-Diakonissen-Kliniken gAG Zentralapotheke, Karlsruhe

77090

Millennium Oncology, Houston

77339

Millennium Oncology, Kingwood

77380

Millennium Oncology, The Woodlands

77384

Millennium Oncology, Shenandoah

79031

Lviv State Oncologic Regional Treatment and Diagnostic Center, Lviv

82131

Asklepios Fachkliniken Muenchen Gauting, Gauting

82194

Johannes-Apotheke, Gröbenzell

83800

Hopital d'instruction des armees Sainte Anne, Toulon

88017

"Central City Clinical Hospital, City Oncology Center, SHEI Uzhhorod National University", Uzhhorod

92346

Beaver Medical Group, L.P., Highland

95123

UO Oncologia Medica, Catania

95445

Klinikum Bayreuth GmbH, Bayreuth

115478

"FSBI N.N.Blokhin Russian Cancer Research Center RAMS", Moscow

125284

P.A.Hertsen Moscow Oncology Research Institute - Branch of the National Medical Radiological, Moscow

143423

"SAHI of Moscow Moscow City Oncology Hospital #62 of Health Department of Moscow", P/o Stepanovskoe

163045

State Budget Healthcare Institution of Arkhangelsk Region, Arkhangelsk

197758

FSBI 'Scientific-Research Oncology Institute n.a. N.N.Petrov' of MoH of RF, Saint Petersburg

198255

"SPb SBHI City Clinical Oncology Dispensary", Saint Petersburg

200347

S.C. Centrul de Oncologie Sf. Nectarie S.R.L., Oncologie Medicala, Craiova

200352

SPAD Imaging International S.R.L, Craiova

200382

SC Cardio-Center SRL, Craiova

200385

SC Oncolab SRL, Oncologie, Craiova

300158

Hiperdia Timisoara, Cardiologie, Timișoara

Hiperdia Timisoara, Radiologie si imagistica medicala, Timișoara

300166

S.C. Oncocenter Oncologie Clinica SRL, Timișoara

302016

Institute of Respiratory Diseases, SMS Medical College & Hospital, Jaipur

305524

"RBHI Kursk Regional Clinical Oncology Dispensary of Healthcare Committee of Kursk Region", Kislino Steading of Kursk Region

350012

"SBHI Regional clinical hospital #2 of MoH of Krasnodar Region", Krasnodar

354003

"Limited Liability Company Common health", Sochi

354010

Dr's Grineva Private Clinic, Sochi

354057

SHI Oncology Dispensary #2 of Health Department of Krasnodar Region, Sochi

355047

"Stavropol Krai State Budget Healthcare Institute Stavropol Regional Oncology Clinic", Stavropol

357340

"Federal State Budgetary Institution of Healthcare Clinical Hospital #", Lermontov

357502

"SBHI of Stavropol Region Pyatigorsk Oncology Dispensary", Pyatigorsk

357600

"SBHI of Stavropol Region Essentuki Central City Hospital", Yessentuki

390011

SBEI HPE RyazSMU of MoH of Russia based on SBI of Ryazan Region, Ryazan

400058

Medisprof, Cluj-Napoca

400139

Spitalul Clinic Municipal, Cluj-Napoca

400489

SC Hiperdia SA, Cluj-Napoca

407280

SC Radiotherapy Center Cluj SRL, Jud Cluj

410002

Saratov scientific research institute of traumatology and orthopedics, Saratov

410004

NHI Road clinical hospital at the st. Saratov II of OJSC Russian Railways, Saratov

410054

Clinical hospital n.a. S.R. Mirotvortseva of SSMU, Saratov

411004

Sahyadri Clinical Research and Development Center (A Unit of Sahayadri hospitals Limited), Pune

Sahyadri Speciality Hospital, Pune

422005

Shatabdi Super Speciality Hospital, Nashik

426067

S.G. Primushko Republican Clinical Oncology Dispensary, Izhevsk

454048

Evimed Llc, Chelyabinsk

454076

Chelyabinsk Regional Hospital, Chelyabinsk

"SBHI Chelyabinsk Regional Clinical Hospital", Chelyabinsk

454087

"SBHI Chelyabinsk Regional Clinical Oncology Dispensary", Chelyabinsk

Chelyabinsk Regional Clinical Oncology Dispensary, Chelyabinsk

MRT-Expert, LLC, Chelyabinsk

454092

"Road Clinical Hospital on the station Chelyabinsk of OJSC RZD", Chelyabinsk

540136

Spitalul Clinic Judetean de Urgenta Targu Mures, Cardiologie, Târgu Mureş

540141

Spitalul Clinic Judetean Mures, radiologie si imagistica medicala, Târgu Mureş

Spitalul Clinic Judetean Mures, sectia Clinica de Oncologie Medicala, Târgu Mureş

560027

HealthCare Global Enterprises Limited, Bangalore

600020

"SBHI of Vladimir Region Regional Clinical Oncology Dispensary", Vladimir

603001

Privolzhskiy District Medical Center of Federal Biomedical Agency, Nizhny Novgorod

603006

SBHI NR Clinical Diagnostic Center, Nizhny Novgorod

603081

SBHI of NNR Nizhniy Novgorod Regional Oncology Dispensary, Nizhny Novgorod

603163

SBHI of NNR Nizhniy Novgorod Regional Oncology Dispensary, Nizhny Novgorod

644013

"Budgetary Healthcare Institution of Omsk Region Clinical Oncology Dispensary", Omsk

900591

"Spitalul Clinic Judetean de Urgenta Sf Apostol Andrei Constanta Clinica Oncologie Medicala", Constanța

900663

Centrul Medical Pozimed, SC Pozitron Medical Investigation SRL, Constanța

2540364

Centro de Investigaciones Clinicas Vina del Mar Ltda., Viña del Mar

4810469

Instituto Clinico Oncologico del Sur (ICOS), Temuco

Instituto Clínico Oncológico del Sur (ICOS), Temuco

8420383

Bradford Hill Centro de Investigaciones Clinicas, Santiago

Centro Internacional de Estudios Clinicos (CIEC), Santiago

8940575

Fresenius Kabi Chile, Therapia i.v., Santiago

60160230

Oncoclinic (Clinica de Oncologia e Atendimento de Urgencia Ltda), Fortaleza

06052

Cancer Center of Central Connecticut, New Britain

06489

Cancer Center of Central Connecticut, Southington

07503

St. Joseph's Regional Medical Center, Paterson

40050-410

Hospital Santa Izabel / Santa Casa de Misericordia da Bahia, Salvador

38408-150

COT - Centro Oncologico do Triangulo Ltda, Uberlândia

81520-060

Liga Paranaense de Combate ao Cancer - Hospital Erasto Gaertner, Curitiba

95900-000

Hospital Bruno Born (Sociedade Beneficencia e Caridade de Lajeado), Lajeado

93510-250

Oncosinos (Lessa Ferreira Servicos Oncologicos Ltda), Novo Hamburgo

99010-260

Hospital da Cidade de Passo Fundo - HCPF, Passo Fundo

90020-090

Irmandade da Santa Casa de Misericordia de Porto Alegre - ISCMPA, Porto Alegre

90050-170

Irmandade da Santa Casa de Misericordia de Porto Alegre - Hospital Santa Rita, Porto Alegre

90610-000

Centro de Pesquisa em Oncologia - Uniao Brasileira de Educacao e Assistencia, Porto Alegre

89201-260

Instituto Joinvillense de Hematologia e Oncologia SS Ltda - Clinica de Hematologia e Oncologia, Joinville

15090-000

Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto -, São José do Rio Preto

18035-300

Instituto de Oncologia de Sorocaba - ONCO Clinicas Especializadas SC Ltda, Sorocaba

22793-080

Instituto COI de Pesquisa, Educacao e Gestao - COI Clinicas Barra Da Tijuca, Rio de Janeiro

01246-000

lnstituto do Cancer do Estado de Sao Paulo - Octavio Frias de -, São Paulo

04039-004

Instituto de Assistencia Medica ao Servidor Publico Estadual - IAMSPE/HSPE-FMO, São Paulo

262 04

Nemocnice na Plesi s.r.o, Nová Ves pod Pleší

741 01

Nemocnice Novy Jicin a.s, Nový Jičín

01640

Fachkrankenhaus Coswig GmbH, Coswig

01307

Apotheke Johannstadt Sven Ullrich e.K., Dresden

06120

Krankenhaus Martha-Maria Halle-Doelau gGmbH - Apotheke, Halle

Krankenhaus Martha-Maria Halle-Doelau gGmbH - Institut fuer Radiologie, Halle

Krankenhaus Martha-Maria Halle-Doelau gGmbH, Halle

04103

Zentrum fuer Radiologie und Nuklearmedizin am Johannisplatz (ZRN Leipzig), Leipzig

04315

Arkana Apotheke OHG, Leipzig

04357

POIS Leipzig GbR, Pneumologisch/onkologisch/internistisches Studienzentrum, Leipzig

530 017

Mahatma Gandhi Cancer Hospital And Research Institute, Visakhapatnam

00152

UOSD Pneumologia Oncologica - Padiglione Flaiani, Roma

036-8545

National Hospital Organization Hirosaki National Hospital, Hirosaki

070-8644

National Hospital Organization Asahikawa Medical Center, Asahikawa

670-8520

National Hospital Organization Himeji Medical Center, Himeji

311-3193

National Hospital Organization Mito Medical Center, Higashi-ibaraki-gun

920-8641

Kanazawa University Hospital, Kanazawa

236-0051

Kanagawa Cardiovascular and Respiratory Center, Yokohama

514-1101

National Hospital Organization Mie Chuo Medical Center, Tsu

983-8520

National Hospital Organization Sendai Medical Center, Sendai

204-8585

National Hospital Organization Tokyo National Hospital, Kiyose

152-8902

National Hospital Organization Tokyo Medical Center, Meguro-Ku

190-0014

National Hospital Organization Disaster Medical Center, Tachikawa

810-0001

Saiseikai Fukuoka General Hospital, Fukuoka

780-8077

National Hospital Organization Kochi National Hospital, Kochi

700-8607

Japanese Red Cross Okayama Hospital, Okayama

870-0263

National Hospital Organization Oita Medical Center, Ōita

6815 AD

Klinisch Chemisch en Hematologisch Laboratorium (KCHL), Arnhem

Rijnstate Ziekenhuis, Arnhem

6716 RP

Ziekenhuis De Gelderse Vallei, Ede

5707 HA

Elkerliek Ziekenhuis, Helmond

82-300

Wojewodzki Szpital Zespolony w Elblagu, Elblag

93-513

Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. Kopernika w Lodzi,, Lodz

10-357

Samodzielny Publiczny Zespol Gruzlicy i Chorob Pluc w Olsztynie, Olsztyn

60-569

Wielkopolskie Centrum Pulmonologii i Torakochirurgii im.Eugenii i Janusza Zeylandow, Poznan

35-021

MRUKMED. Lekarz Beata Madej Mruk i Partner. Sp. p. Oddzial nr 1 w Rzeszowie, Rzeszów

70-891

Samodzielny Publiczny Wojewodzki Szpital Zespolony w Szczecinie Szpital Wojewodzki w, Szczecin-Zdunowo

87-100

Wojewodzki Szpital Zespolony im. L. Rydygiera w Toruniu Szpital Obserwacyjno-Zakazny, Torun

02-781

Centrum Onkologii - Instytut im. Marii Sklodowskiej-Curie, Warsaw

04-141

Wojskowy Instytut Medyczny, Klinika Onkologii, Warsaw

44-300

Wojewodzki Szpital Chorob Pluc im. dr Alojzego Pawelca, Wodzisław Śląski

05368

VHS Medical Center, Seoul

06591

The Catholic University of Korea, Seoul St.Mary's Hospital, Seoul

07198

Hospital Son Llatzer, Palma de Mallorca

08208

Corporacio Sanitaria Parc Tauli, Sabadell

01120

Baskent Universitesi Tip Fakultesi Adana Hastanesi, Adana

01330

Cukurova Universitesi Tip Fakultesi Balcali Hastanesi, Adana

06230

Hacettepe Universitesi Tip Fakultesi, Ankara

06330

Diskapi Yildirim Beyazit Egitim ve Arastirma Hastanesi, Ankara

06590

Ankara Universitesi Tip Fakultesi Cebeci Hastanesi, Ankara

06800

Yildirim Beyazit Universitesi Tip Fakultesi Ataturk Egitim ve Arastirma Hastanesi, Ankara

07352

"LLC Medical clinic INNOVACIA, chemotherapy department", Liutizh

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT02364999 - A Comparative Study Of PF-06439535 Plus Paclitaxel-Carboplatin And Bevacizumab Plus Paclitaxel-Carboplatin Patients With Advanced Non-Squamous NSCLC | Biotech Hunter | Biotech Hunter