518
Participants
Start Date
July 31, 2015
Primary Completion Date
April 30, 2018
Study Completion Date
August 26, 2019
Whole brain radiation therapy with hippocampal avoidance
Intensity modulated radiation therapy (IMRT) 30 Gy in 10 fractions once per day, 5 days per week for approximately two week; starting within 21 calendar days after randomization.
Memantine
Given PO daily during and after radiation therapy for a total of 24 weeks. Week 1: 5 mg in the AM, none in the PM; Week 2: 5 mg in the AM, 5 mg in the PM; Week 3: 10 mg in the AM, 5 mg in the PM; Weeks 4-24: 10 mg in the AM, 10 mg in the PM. Should start the same day as radiation therapy, at latest before the fourth radiation treatment.
Whole brain radiation therapy
Whole brain radiation therapy (WBRT) 30 Gy in 10 fractions once per day, 5 days per week for approximately 2 weeks
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York
Montefiore Medical Center - Moses Campus, The Bronx
New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn
University of Rochester, Rochester
Geisinger Medical Center, Danville
Northeast Radiation Oncology Center, Dunmore
Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre
Abington Memorial Hospital, Abington
Crozer-Keystone Regional Cancer Center at Broomall, Broomall
Bryn Mawr Hospital, Bryn Mawr
Riddle Memorial Hospital, Media
Lankenau Medical Center, Wynnewood
Thomas Jefferson University Hospital, Philadelphia
Fox Chase Cancer Center, Philadelphia
Aria Health-Torresdale Campus, Philadelphia
Temple University Hospital, Philadelphia
Christiana Care Health System-Concord Health Center, Chadds Ford
Crozer Regional Cancer Center at Brinton Lake, Glen Mills
Reading Hospital, West Reading
Helen F Graham Cancer Center, Newark
Christiana Care Health System-Christiana Hospital, Newark
UM Upper Chesapeake Medical Center, Bel Air
Central Maryland Radiation Oncology in Howard County, Columbia
UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie
University of Maryland/Greenebaum Cancer Center, Baltimore
UM Saint Joseph Medical Center, Towson
MedStar Union Memorial Hospital, Baltimore
Virginia Commonwealth University/Massey Cancer Center, Richmond
Wheeling Hospital/Schiffler Cancer Center, Wheeling
West Virginia University Healthcare, Morgantown
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
NHRMC Radiation Oncology - 16th Street, Wilmington
Greenville Health System Cancer Institute-Spartanburg, Spartanburg
Greenville Health System Cancer Institute-Faris, Greenville
Greenville Health System Cancer Institute-Eastside, Greenville
Self Regional Healthcare, Greenwood
The Radiation Oncology Center-Hilton Head/Bluffton, Hilton Head Island
Grady Health System, Atlanta
Emory University Hospital Midtown, Atlanta
Piedmont Hospital, Atlanta
Emory University Hospital/Winship Cancer Institute, Atlanta
Emory Saint Joseph's Hospital, Atlanta
Memorial Health University Medical Center, Savannah
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah
UF Cancer Center at Orlando Health, Orlando
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables
Cleveland Clinic-Weston, Weston
UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach
Boca Raton Regional Hospital, Boca Raton
Lewis and Faye Manderson Cancer Center, Tuscaloosa
Vanderbilt University/Ingram Cancer Center, Nashville
University of Kentucky/Markey Cancer Center, Lexington
Ohio State University Comprehensive Cancer Center, Columbus
Case Western Reserve University, Cleveland
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
University Hospitals Parma Medical Center, Parma
UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights
Cleveland Clinic Cancer Center Independence, Independence
Cleveland Clinic Cancer Center Strongsville, Strongsville
UHHS-Westlake Medical Center, Westlake
Cleveland Clinic Foundation, Cleveland
Summa Akron City Hospital/Cooper Cancer Center, Akron
Cleveland Clinic Akron General, Akron
Community Cancer Center East, Indianapolis
Community Cancer Center South, Indianapolis
Community Cancer Center North, Indianapolis
Parkview Hospital Randallia, Fort Wayne
Henry Ford Macomb Hospital-Clinton Township, Clinton Township
McLaren Cancer Institute-Macomb, Mount Clemens
McLaren-Port Huron, Port Huron
21st Century Oncology MHP - Troy, Troy
Saint Joseph Mercy Hospital, Ann Arbor
Saint Joseph Mercy Chelsea, Chelsea
Saint Mary Mercy Hospital, Livonia
Henry Ford Cancer Institute-Downriver, Brownstown
Wayne State University/Karmanos Cancer Institute, Detroit
Henry Ford Hospital, Detroit
Henry Ford West Bloomfield Hospital, West Bloomfield
21st Century Oncology MHP - Farmington, Farmington Hills
Saint Joseph Mercy Oakland, Pontiac
21st Century Oncology MHP - Clarkston, Clarkston
McLaren Cancer Institute-Clarkston, Clarkston
McLaren Cancer Institute-Lapeer Region, Lapeer
Genesys Hurley Cancer Institute, Flint
McLaren Cancer Institute-Flint, Flint
McLaren Cancer Institute-Bay City, Bay City
McLaren Cancer Institute-Central Michigan, Mount Pleasant
McLaren Cancer Institute-Owosso, Owosso
West Michigan Cancer Center, Kalamazoo
Lakeland Medical Center Saint Joseph, Saint Joseph
Mercy Health Mercy Campus, Muskegon
Spectrum Health at Butterworth Campus, Grand Rapids
McLaren Cancer Institute-Northern Michigan, Petoskey
Saint Luke's Hospital, Cedar Rapids
Aurora Cancer Care-Grafton, Grafton
UW Cancer Center Johnson Creek, Johnson Creek
Community Memorial Hospital, Menomonee Falls
Aurora Medical Center in Summit, Summit
Aurora Cancer Care-Kenosha South, Kenosha
Ascension Columbia Saint Mary's Water Tower Medical Commons, Milwaukee
Aurora Saint Luke's Medical Center, Milwaukee
Medical College of Wisconsin, Milwaukee
Aurora West Allis Medical Center, West Allis
Aurora Sinai Medical Center, Milwaukee
Zablocki Veterans Administration Medical Center, Milwaukee
University of Wisconsin Hospital and Clinics, Madison
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers
Aurora BayCare Medical Center, Green Bay
Aspirus Regional Cancer Center, Wausau
Langlade Hospital and Cancer Center, Antigo
Diagnostic and Treatment Center, Weston
Marshfield Clinic Stevens Point Center, Stevens Point
Aspirus UW Cancer Center, Wisconsin Rapids
Gundersen Lutheran Medical Center, La Crosse
Mayo Clinic Health System-Franciscan Healthcare, La Crosse
Mayo Clinic Health System-Eau Claire Clinic, Eau Claire
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh
Mayo Clinic Radiation Therapy-Northfield, Northfield
Abbott-Northwestern Hospital, Minneapolis
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park
Unity Hospital, Fridley
Mayo Clinic, Rochester
Mayo Clinic Health Systems-Mankato, Mankato
Mayo Clinic Health System in Albert Lea, Albert Lea
Sanford Roger Maris Cancer Center, Fargo
Sanford Bismarck Medical Center, Bismarck
Billings Clinic Cancer Center, Billings
Benefis Healthcare- Sletten Cancer Institute, Great Falls
Community Medical Hospital, Missoula
Condell Memorial Hospital, Libertyville
Northwestern Medicine Cancer Center Delnor, Geneva
Edward Hines Jr VA Hospital, Hines
Loyola University Medical Center, Maywood
Northwestern Medicine Cancer Center Warrenville, Warrenville
Northwestern University, Chicago
John H Stroger Jr Hospital of Cook County, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
Methodist Medical Center of Illinois, Peoria
OSF Saint Francis Medical Center, Peoria
Carle Cancer Center, Urbana
Crossroads Cancer Center, Effingham
Decatur Memorial Hospital, Decatur
Memorial Medical Center, Springfield
SIH Cancer Institute, Carterville
Washington University School of Medicine, St Louis
Siteman Cancer Center-South County, St Louis
Missouri Baptist Medical Center, St Louis
Siteman Cancer Center at West County Hospital, Creve Coeur
Mercy Hospital Saint Louis, St Louis
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters
Saint Francis Medical Center, Cape Girardeau
North Kansas City Hospital, Kansas City
CoxHealth South Hospital, Springfield
Lawrence Memorial Hospital, Lawrence
University of Kansas Cancer Center, Kansas City
University of Kansas Cancer Center-Overland Park, Overland Park
Ascension Via Christi Hospitals Wichita, Wichita
Wesley Medical Center, Wichita
University of Nebraska Medical Center, Omaha
Tulane University Health Sciences Center, New Orleans
University of Oklahoma Health Sciences Center, Oklahoma City
M D Anderson Cancer Center, Houston
UTMB Cancer Center at Victory Lakes, League City
Swedish Medical Center, Englewood
Rocky Mountain Cancer Centers-Boulder, Boulder
Penrose-Saint Francis Healthcare, Colorado Springs
UCHealth Memorial Hospital Central, Colorado Springs
Saint Luke's Mountain States Tumor Institute-Twin Falls, Twin Falls
Saint Luke's Mountain States Tumor Institute - Meridian, Meridian
Saint Luke's Mountain States Tumor Institute - Nampa, Nampa
Saint Alphonsus Cancer Care Center-Boise, Boise
Saint Luke's Mountain States Tumor Institute, Boise
Huntsman Cancer Institute/University of Utah, Salt Lake City
Ogden Regional Medical Center, Ogden
Banner MD Anderson Cancer Center, Gilbert
Banner University Medical Center - Tucson, Tucson
Renown Regional Medical Center, Reno
Kaiser Permanente Los Angeles Medical Center, Los Angeles
Los Angeles County-USC Medical Center, Los Angeles
USC / Norris Comprehensive Cancer Center, Los Angeles
City of Hope Comprehensive Cancer Center, Duarte
Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank
UC San Diego Moores Cancer Center, La Jolla
University of California San Diego, San Diego
Kaiser Permanente Cancer Treatment Center, South San Francisco
California Pacific Medical Center-Pacific Campus, San Francisco
Stanford Cancer Institute Palo Alto, Palo Alto
Sutter Solano Medical Center/Cancer Center, Vallejo
Kaiser Permanente Oakland-Broadway, Oakland
Rohnert Park Cancer Center, Rohnert Park
Kaiser Permanente Medical Center - Santa Clara, Santa Clara
Stanford Cancer Center South Bay, San Jose
Mercy San Juan Medical Center, Carmichael
Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville
Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova
The Permanente Medical Group-Roseville Radiation Oncology, Roseville
Mercy Cancer Center - Sacramento, Sacramento
Sutter Medical Center Sacramento, Sacramento
Legacy Mount Hood Medical Center, Gresham
Legacy Good Samaritan Hospital and Medical Center, Portland
Virginia Mason Medical Center, Seattle
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima
Saint Vincent's Medical Center, Bridgeport
Tufts Medical Center, Boston
Lahey Hospital and Medical Center, Burlington
Lowell General Hospital, Lowell
Wentworth-Douglass Hospital, Dover
Dartmouth Hitchcock Medical Center, Lebanon
Sanford USD Medical Center - Sioux Falls, Sioux Falls
University of Texas Medical Branch, Galveston
Norris Cotton Cancer Center-North, Saint Johnsbury
CHUM - Hopital Notre-Dame, Montreal
McGill University Department of Oncology, Montreal
CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal
The Research Institute of the McGill University Health Centre (MUHC), Montreal
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Québec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke
Allan Blair Cancer Centre, Regina
Saskatoon Cancer Centre, Saskatoon
Lead Sponsor
National Cancer Institute (NCI)
NIH
NRG Oncology
OTHER