Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)

PHASE2/PHASE3TerminatedINTERVENTIONAL
Enrollment

732

Participants

Timeline

Start Date

February 24, 2016

Primary Completion Date

July 1, 2019

Study Completion Date

July 1, 2019

Conditions
Non Arteritic Anterior Ischemic Optic Neuropathy
Interventions
DRUG

QPI-1007 Injection - 1.5 mg

DRUG

QPI-1007 Injection - 3.0 mg

OTHER

Sham Injection Procedure

Sham Procedure

Trial Locations (85)

2000

Sydney Eye Hospital/Save Sight Institute, Sydney

3002

The Royal Victorian Eye and Ear Hospital, Fitzroy

5267

Vision South Australia, Kent Town

6000

Royal Perth Hospital, Perth

10003

New York Eye and Ear Infirmary of Mount Sinai, New York

10583

Cornell University School of Medicine, New York

11794

State University of New York at Stony Brook, Stony Brook

13210

SUNY Upstate Medical University, Syracuse

14642

University of Rochester, Flaum Eye Institute, Rochester

19104

University of Pennsylvania, Scheie Eye Institute, Philadelphia

20852

Bethesda Neurology, LLC, Bethesda

21118

Boston Medical Center, Boston

21204

Greater Baltimore Medical Center, Baltimore

22908

University of Virginia Health Sciences Center, Charlottesville

27607

Raleigh Neurology Associates, Raleigh

27705

Duke University Eye Center, Durham

29414

Retina Consultants of Charleston, Charleston

31048

Bnai Zion Medical Center, Haifa

33136

University of Miami Miller School of Medicine/Bascom Palmer Eye Institute, Miami

33904

Cape Coral Eye Center, Cape Coral

34239

Sarasota Retina Institute, Sarasota

40139

AOU Policlinico S. Orsola-Malpighi, Bologna

40536

University of Kentucky, Department of Neurology, Lexington

43100

University Eye Clinic, Parma

44195

Cleveland Clinic, Cole Eye Institute, Cleveland

48105

University of Michigan, Ann Arbor

48149

Universitätsklinikum Münster, Münster

49100

Rabin Medical Center, Belinson Campus, Petah Tikva

50134

AOU Careggi, Florence

52074

Universitätsklinikum Aachen-Augenklinik, Aachen

52621

The Chaim Sheba Medical Center, Tel Litwinsky

55131

Universitätsmedizin d. Johannes Gutenberg-Universität Mainz, Mainz

55455

University of Minnesota, Minneapolis

55905

Mayo Clinic, Rochester

60026

NorthShore University Healthsystem, Glenview

60611

Northwestern University, Chicago

60612

University of Illinois at Chicago, Department of Ophthalmology (MC 648), Chicago

63110

Washington University in St. Louis, St Louis

64239

The Tel-Aviv Sourasky Medical Center, Tel Aviv

68198

University of Nebraska Medical Center and Truhlsen Eye Institute, Omaha

72076

Universitäts-Augenklinik Tübingen, Tübingen

72205

University of Arkansas Medical Center, Jones Eye Institute, Little Rock

73013

Dean McGee Eye Institute, Oklahoma City

76100

Kaplan Medical Center, Rehovot

77025

University of Houston, Neuro-Ophth of Texas, Houston

77030

Houston Methodist Hospital, Blanton Eye Institute, Houston

78240

Foresight Studies, San Antonio

80045

University of Colorado Denver, Department of Neurology, Aurora

80909

Retina Consultants of Southern Colorado, PC, Colorado Springs

84101

Soroka University Medical Center, Beersheba

84132

University of Utah John A. Moran Eye Center, Salt Lake City

90033

University of Southern California, Los Angeles

90048

NeuroEyeOrbit Institute, Los Angeles

91105

Unversity of California, Los Angeles (UCLA), Pasadena

92354

Loma Linda University Eye Institute, Loma Linda

93053

Universitätsklinikum Regensburg-Klinik und Poliklinik für Augenheilkunde, Regensburg

94303

Stanford University, Palo Alto

98104

Swedish Medical Center, CO/NOCNW, Seattle

University of Washington Department of Ophthalmology, Seattle

100191

Peking University Eye Center, The Third Hospital Peking University., Beijing

100730

Beijing Tongren Hospital, Capital Medical University, Beijing

Peking Union Medical College Hospital, Beijing

110029

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, A.I.I.M.S., New Delhi

168751

Singapore National Eye Centre, Singapore

201301

ICARE Research Centre and Post Graduate Institute, Noida

226014

Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow

300000

Tianjin Eye Hospital, Tianjin

308433

Tan Tock Seng Hospital, Department of Ophthalmology, Singapore

410013

The Second Xiangya Hospital of Central South University, Changsha

411060

PBMA'S H. V. Desai Eye Hospital, Pune

442005

Datta Meghe Institute of Medical Sciences, Wardha

500034

L V Prasad Eye Institute, Hyderabad

530040

L V Prasad Eye Institute, Visakhapatnam

560010

Narayana Nethralaya, Bangalore

600006

Sankara Nethralaya (Vision Research Foundation), Chennai

625020

Aravind Eye Hospital, Madurai

751024

L V Prasad Eye Institute, Bhubaneswar

781028

Sri Sankaradeva Nethralaya, Guwahati

9112001

Hadassah Medical Center, Jerusalem

06708

The Eye Care Group, Waterbury

02114

Massachusetts Eye and Ear Infirmary, Boston

07103

Rutgers, New Jersey Medical School, Newark

01307

Universitätsklinikum Carl Gustav Carus-Dresden-Klinik und Poliklinik für Augenheilkunde, Dresden

Unknown

Scientific Institute Auxologico Italiano, Milan

Scientific institute San Raffaele, Milan

Sponsors
All Listed Sponsors
lead

Quark Pharmaceuticals

INDUSTRY