TIGER-3: Open Label, Multicenter Study of Rociletinib (CO-1686) Mono Therapy Versus Single-agent Cytotoxic Chemotherapy in Patients With Mutant EGFR NSCLC Who Have Failed at Least One Previous EGFR-Directed TKI and Platinum-doublet Chemotherapy

PHASE3TerminatedINTERVENTIONAL
Enrollment

149

Participants

Timeline

Start Date

February 28, 2015

Primary Completion Date

March 29, 2018

Study Completion Date

March 29, 2018

Conditions
Non-small Cell Lung Cancer
Interventions
DRUG

Rociletinib

DRUG

Pemetrexed or gemcitabine or paclitaxel or docetaxel

Trial Locations (80)

2065

Royal North Shore Hospital, Saint Leonards

2145

Westmead Hospital, Westmead

5042

Flinders Medical Centre, Bedford Park

10002

National Taiwan University Hospital, Taipei

10043

A.O.U. San Luigi Gonzaga di Orbassano, Orbassano

11217

Taipei Veterans General Hospital, Taipei

13009

L'Assistance Publique - Hopitaux de Marseille, Marseille

14076

Centre François Baclesse, Caen

14263

Roswell Park Cancer Institute, Buffalo

15232

University of Pittsburgh Cancer Institute (UPMC), Pittsburgh

16132

IRCCS Azienda Ospedaliera Universitaria San Martino - IST, Genova

20141

Istituto Europeo di Oncologia, Milan

20889

Walter Reed National Military Medical Center, Bethesda

22903

University of Virginia, Charlottesville

22927

LungenClinic Großhansdorf GmbH, Großhansdorf

23230

Virginia Cancer Institute, Richmond

26121

Pius Hospital Oldenburg, Oldenburg

28040

Fundacion Jimenez Diaz (Clinica de la Concepcion) (UAM -FJD), Madrid

29010

Hospital Regional Universitario Carlos Haya, Málaga

30341

Northside Hospital, Atlanta

32429

Johannes-Wesling-Klinikum Minden, Minden

32608

University of Florida Health Science Center, Gainesville

33028

Memorial Healthcare System, Pembroke Pines

33442

Sylvester Comprehensive Cancer Center (UMHC), Deerfield Beach

35033

Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, Rennes

40447

China Medical University Hospital, Taichung

40705

Taichung Veterans General Hospital, Taichung

41013

Hospital Universitario Virgen del Rocio, Seville

43210

The Ohio State University Comprehensive Cancer Center, Columbus

48106

Saint Joseph Mercy Hospital, Ann Arbor

48201

Barbara Ann Karmanos Cancer Institute, Detroit

50139

Azienda Ospedaliero-Universitaria Careggi, Florence

55407

Virginia Piper Cancer Institute, Minneapolis

57124

Ospedale Civile di Livorno, Livorno

59037

CHRU de Lille - Hôpital Calmette, Lille

60201

North Shore University Health System, Evanston

67091

Hopital Hautepierre (CHU) de Strasbourg, Strasbourg

69126

Thoraxklinik Heidelberg gGmbH, Heidelberg

69373

Centre Léon Bérard, Lyon

70403

National Cheng-Kung University Hospital, Tainan City

75018

Hôpital Bichat-Claude Bernard, Paris

75390

University of Texas Southwestern Medical Center, Dallas

80336

LMU - Klinikum der Universität München, München

82131

Asklepios Fachkliniken München-Gauting, Gauting

84112

Huntsman Cancer Institute, Salt Lake City

87042

CHRU de Limoges - Hôpital Dupuytren, Limoges

90277

Cancer Care Associates Medical Group, Inc., Redondo Beach

90404

University of California at Los Angeles, Santa Monica

90603

The Oncology Institute of Hope and Innovation, Whittier

91010

City of Hope Cancer Center, Duarte

92835

Saint Joseph Heritage Healthcare, Fullerton

93309

Comprehensive Blood and Cancer Center, Bakersfield

93454

Central Coast Medical Oncology Corporation, Santa Maria

94010

Centre Hospitalier Intercommunal Créteil, Créteil

94115

University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco

94305

Stanford University School of Medicine, Stanford

95816

Sutter Cancer Center, Sacramento

97223

Providence Health and Services, Portland

97239

Oregon Health & Science University (OHSU) - Knight Cancer Institute, Portland

92093-0698

University of California San Diego Moores Cancer Center, La Jolla

08816

Regional Cancer Care Associates, LLC, East Brunswick

07962

Regional Cancer Care Associates, Morristown

06132

Azienda Ospedaliera di Perugia, Perugia

6229 HX

Academisch Ziekenhuis Maastricht, Maastricht

1066 CX

Antoni van Leeuwenhoek Hospital, Amsterdam

9700 RB

Universitair Medisch Centrum Groningen, Groningen

361-712

Chungbuk National University Hospital, Cheongju-si

463-707

Seoul National University Bundang Hospital, Seongnam-si

442-723

The Catholic University of Korea Saint Vincent's Hospital, Suwon

519-809

Chonnam National University Hwasun Hospital, Hwasun-gun

135-710

Samsung Medical Center, Seoul

138-736

Asan Medical Center, Seoul

08916

Hospital Universitari Germans Trias i Pujol, Badalona

08034

Hospital de Mataró, Mataró

08028

Institut Universitari Dexeus, Barcelona

08035

Hospital Universitari Vall D'Hebron, Barcelona

NW1 2BU

University College London Hospitals, London

SE1 9RT

Guy's and Saint Thomas NHS Foundation Trust, London

SW3 6JJ

Royal Marsden NHS Trust, London

M20 4BX

The Christie NHS Foundation Trust, Manchester

Sponsors
All Listed Sponsors
lead

Clovis Oncology, Inc.

INDUSTRY