Early Salpingectomy (Tubectomy) With Delayed Oophorectomy in BRCA1/2 Gene Mutation Carriers

NAActive, not recruitingINTERVENTIONAL
Enrollment

510

Participants

Timeline

Start Date

January 31, 2015

Primary Completion Date

January 31, 2030

Study Completion Date

January 31, 2035

Conditions
BRCA1 Gene MutationBRCA2 Gene MutationOvarian Cancer
Interventions
PROCEDURE

Salpingectomy with delayed oophorectomy

Early salpingectomy upon completions of childbearing with postponement of oophorectomy until between 40 and 45 in BRCA1 mutation carriers and between age 45 and 50 in BRCA2 mutation carriers.

PROCEDURE

Risk-reducing salpingo-oophorectomy

This is the current guideline procedure, usually performed between age 35 and 40 in BRCA1 mutation carriers and between age 40 and 45 in BRCA2 mutation carriers.

Trial Locations (13)

6229 HX

Maastricht University Medical Center, Maastricht

5623 EJ

Catharina Hospital, Eindhoven

5042 AD

Elisabeth-TweeSteden Hospital, Tilburg

1066 CX

Netherlands Cancer Institute / Antoni van Leeuwenhoek Hospital, Amsterdam

2333 ZA

Leiden University Medical Center, Leiden

3015 CE

Erasmus Medical Center, Rotterdam

Unknown

Academic Medical Center, Amsterdam

VU University Medical center, Amsterdam

Medical Center, Leeuwarden

Radboudumc, Nijmegen

Maxima Medical Center, Veldhoven

9713 GZ

University Medical Center Groningen, Groningen

3584 CX

University Medical Center Utrecht, Utrecht

All Listed Sponsors
lead

University Medical Center Nijmegen

OTHER

NCT02321228 - Early Salpingectomy (Tubectomy) With Delayed Oophorectomy in BRCA1/2 Gene Mutation Carriers | Biotech Hunter | Biotech Hunter