32
Participants
Start Date
July 28, 2015
Primary Completion Date
September 13, 2018
Study Completion Date
August 9, 2021
Hypofractionated Stereotactic Irradiation (HFSRT)
Radiation therapy treatment (FSRT) which will be given to participants over 5 days.
Pembrolizumab
"Dose Escalation: The dose of pembrolizumab will be escalated per schema in a 3+3 fashion. The starting dose (i.e., dose level 1) will be 100 mg.~Dose Expansion: The pembrolizumab dose used in the dose expansion cohort will be maximum tolerated dose (MTD) determined from the dose escalation phase."
Bevacizumab
Initial cycle of bevacizumab must start within 10 days of registering to the trial. It will be given concurrent with radiation therapy. Bevacizumab will be administered intravenously at a dose of 10 mg/kg every 2 weeks. Doses will be adjusted if there is a \> 10% change in weight.
H. Lee Moffitt Cancer Center and Research Institute, Tampa
Merck Sharp & Dohme LLC
INDUSTRY
H. Lee Moffitt Cancer Center and Research Institute
OTHER