312
Participants
Start Date
December 12, 2014
Primary Completion Date
March 31, 2021
Study Completion Date
September 17, 2026
Cyclophosphamide
Given IV
Doxorubicin
Given IV
Doxorubicin Hydrochloride
Given IV
Etoposide
Given IV
Etoposide Phosphate
Given IV
External Beam Radiation Therapy
Undergo EBRT
Ganitumab
Given IV
Ifosfamide
Given IV
Stereotactic Radiosurgery
Undergo SBRT
Therapeutic Surgical Procedure
Undergo surgery
Vincristine
Given IV
Vincristine Sulfate
Given IV
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
Mount Sinai Hospital, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York
Montefiore Medical Center-Einstein Campus, The Bronx
Montefiore Medical Center-Weiler Hospital, The Bronx
Children's Hospital at Montefiore, The Bronx
Montefiore Medical Center - Moses Campus, The Bronx
New York Medical College, Valhalla
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park
NYU Langone Hospital - Long Island, Mineola
Stony Brook University Medical Center, Stony Brook
Albany Medical Center, Albany
Glens Falls Hospital, Glens Falls
State University of New York Upstate Medical University, Syracuse
Roswell Park Cancer Institute, Buffalo
University of Rochester, Rochester
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
Penn State Children's Hospital, Hershey
Geisinger Medical Center, Danville
Lehigh Valley Hospital - Muhlenberg, Bethlehem
Lehigh Valley Hospital-Cedar Crest, Allentown
Drexel University School of Medicine, Philadelphia
Children's Hospital of Philadelphia, Philadelphia
Saint Christopher's Hospital for Children, Philadelphia
Alfred I duPont Hospital for Children, Wilmington
MedStar Georgetown University Hospital, Washington D.C.
Children's National Medical Center, Washington D.C.
University of Maryland/Greenebaum Cancer Center, Baltimore
Sinai Hospital of Baltimore, Baltimore
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
Inova Fairfax Hospital, Falls Church
VCU Massey Comprehensive Cancer Center, Richmond
Children's Hospital of The King's Daughters, Norfolk
Carilion Children's, Roanoke
West Virginia University Healthcare, Morgantown
Wake Forest University Health Sciences, Winston-Salem
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
Duke University Medical Center, Durham
Carolinas Medical Center/Levine Cancer Institute, Charlotte
Mission Hospital, Asheville
Prisma Health Richland Hospital, Columbia
Medical University of South Carolina, Charleston
Saint Francis Hospital, Greenville
BI-LO Charities Children's Cancer Center, Greenville
Saint Francis Cancer Center, Greenville
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta
Augusta University Medical Center, Augusta
Memorial Health University Medical Center, Savannah
Nemours Children's Clinic-Jacksonville, Jacksonville
Nemours Children's Clinic - Pensacola, Pensacola
University of Florida Health Science Center - Gainesville, Gainesville
AdventHealth Orlando, Orlando
Arnold Palmer Hospital for Children, Orlando
Nemours Children's Hospital, Orlando
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
Nicklaus Children's Hospital, Miami
Saint Mary's Medical Center, West Palm Beach
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
Johns Hopkins All Children's Hospital, St. Petersburg
Golisano Children's Hospital of Southwest Florida, Fort Myers
Children's Hospital of Alabama, Birmingham
USA Health Strada Patient Care Center, Mobile
The Children's Hospital at TriStar Centennial, Nashville
Vanderbilt University/Ingram Cancer Center, Nashville
Pulmonary Medicine Center of Chattanooga-Hixson, Hixson
Memorial GYN Plus, Ooltewah
T C Thompson Children's Hospital, Chattanooga
Memorial Hospital, Chattanooga
East Tennessee Childrens Hospital, Knoxville
Saint Jude Children's Research Hospital, Memphis
University of Mississippi Medical Center, Jackson
Flaget Memorial Hospital, Bardstown
Jewish Hospital Medical Center South, Shepherdsville
Jewish Hospital, Louisville
Norton Children's Hospital, Louisville
Saints Mary and Elizabeth Hospital, Louisville
UofL Health Medical Center Northeast, Louisville
Saint Joseph Radiation Oncology Resource Center, Lexington
Saint Joseph Hospital East, Lexington
University of Kentucky/Markey Cancer Center, Lexington
Commonwealth Cancer Center-Corbin, Corbin
Saint Joseph London, London
Nationwide Children's Hospital, Columbus
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
Rainbow Babies and Childrens Hospital, Cleveland
Cleveland Clinic Foundation, Cleveland
Children's Hospital Medical Center of Akron, Akron
Good Samaritan Hospital - Cincinnati, Cincinnati
Cincinnati Children's Hospital Medical Center, Cincinnati
Bethesda North Hospital, Cincinnati
TriHealth Cancer Institute-Westside, Cincinnati
TriHealth Cancer Institute-Anderson, Cincinnati
Dayton Children's Hospital, Dayton
Riley Hospital for Children, Indianapolis
Ascension Saint Vincent Indianapolis Hospital, Indianapolis
Franciscan Saint Anthony Health-Michigan City, Michigan City
Woodland Cancer Care Center, Michigan City
Chancellor Center for Oncology, Newburgh
Deaconess Clinic Downtown, Evansville
Huron Medical Center PC, Port Huron
Lake Huron Medical Center, Port Huron
Corewell Health Children's, Royal Oak
C S Mott Children's Hospital, Ann Arbor
University of Michigan Comprehensive Cancer Center, Ann Arbor
Wayne State University/Karmanos Cancer Institute, Detroit
Henry Ford Health Saint John Hospital, Detroit
Hurley Medical Center, Flint
Bronson Methodist Hospital, Kalamazoo
West Michigan Cancer Center, Kalamazoo
Bronson Battle Creek, Battle Creek
Beacon Kalamazoo, Kalamazoo
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph
Corewell Health Lakeland Hospitals - Niles Hospital, Niles
Trinity Health Muskegon Hospital, Muskegon
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
Trinity Health Grand Rapids Hospital, Grand Rapids
Corewell Health Reed City Hospital, Reed City
Munson Medical Center, Traverse City
Mercy Medical Center-West Lakes, West Des Moines
Blank Children's Hospital, Des Moines
Mercy Medical Center - Des Moines, Des Moines
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines
Mercy Cancer Center-West Lakes, Clive
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive
Greater Regional Medical Center, Creston
Alegent Health Mercy Hospital, Council Bluffs
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
Children's Hospital of Wisconsin, Milwaukee
Saint Vincent Hospital Cancer Center at Marinette, Marinette
Saint Vincent Hospital Cancer Center Green Bay, Green Bay
Marshfield Medical Center-Marshfield, Marshfield
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
University of Minnesota/Masonic Cancer Center, Minneapolis
Essentia Health Cancer Center, Duluth
Mayo Clinic in Rochester, Rochester
Sanford Broadway Medical Center, Fargo
Advocate Children's Hospital-Park Ridge, Park Ridge
Loyola University Medical Center, Maywood
Advocate Children's Hospital-Oak Lawn, Oak Lawn
Rush-Copley Medical Center, Aurora
Rush-Copley Healthcare Center, Yorkville
Lurie Children's Hospital-Chicago, Chicago
University of Illinois, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
Saint Jude Midwest Affiliate, Peoria
Carle Cancer Center, Urbana
The Carle Foundation Hospital, Urbana
Carle at The Riverfront, Danville
Carle Physician Group-Mattoon/Charleston, Mattoon
Carle Physician Group-Effingham, Effingham
Saint John's Hospital, Springfield
Southern Illinois University School of Medicine, Springfield
Springfield Memorial Hospital, Springfield
SSM Health Good Samaritan, Mount Vernon
Cardinal Glennon Children's Medical Center, St Louis
Mercy Infusion Center - Chippewa, St Louis
Washington University School of Medicine, St Louis
Mercy Hospital Saint Louis, St Louis
Children's Mercy Hospitals and Clinics, Kansas City
Heartland Regional Medical Center, Saint Joseph
Freeman Health System, Joplin
Mercy Hospital Joplin, Joplin
University of Missouri Children's Hospital, Columbia
Mercy Clinic-Rolla-Cancer and Hematology, Rolla
Phelps Health Delbert Day Cancer Institute, Rolla
Central Care Cancer Center - Bolivar, Bolivar
Cox Cancer Center Branson, Branson
Mercy Hospital Springfield, Springfield
CoxHealth South Hospital, Springfield
Midlands Community Hospital, Papillion
Children's Hospital and Medical Center of Omaha, Omaha
Nebraska Medicine-Village Pointe, Omaha
Alegent Health Immanuel Medical Center, Omaha
Hematology and Oncology Consultants PC, Omaha
Nebraska Medicine-Bellevue, Bellevue
Alegent Health Bergan Mercy Medical Center, Omaha
Alegent Health Lakeside Hospital, Omaha
Creighton University Medical Center, Omaha
University of Nebraska Medical Center, Omaha
Saint Elizabeth Regional Medical Center, Lincoln
Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island
Fred and Pamela Buffett Cancer Center - Kearney, Kearney
CHI Health Good Samaritan, Kearney
Children's Hospital New Orleans, New Orleans
Ochsner Medical Center Jefferson, New Orleans
CHI Saint Vincent Cancer Center Hot Springs, Hot Springs
University of Oklahoma Health Sciences Center, Oklahoma City
Mercy Hospital Oklahoma City, Oklahoma City
Medical City Dallas Hospital, Dallas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Cook Children's Medical Center, Fort Worth
Scott and White Memorial Hospital, Temple
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
M D Anderson Cancer Center, Houston
Saint Joseph Regional Cancer Center, Bryan
Children's Hospital of San Antonio, San Antonio
Methodist Children's Hospital of South Texas, San Antonio
University of Texas Health Science Center at San Antonio, San Antonio
Driscoll Children's Hospital, Corpus Christi
Dell Children's Medical Center of Central Texas, Austin
Covenant Children's Hospital, Lubbock
UMC Cancer Center / UMC Health System, Lubbock
Texas Tech University Health Sciences Center-Lubbock, Lubbock
El Paso Children's Hospital, El Paso
Children's Hospital Colorado, Aurora
AdventHealth Littleton, Littleton
AdventHealth Parker, Parker
Rocky Mountain Cancer Centers-Parker, Parker
AdventHealth Porter, Denver
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver
Rocky Mountain Cancer Centers-Lakewood, Lakewood
Saint Anthony Hospital, Lakewood
Rocky Mountain Cancer Centers-Thornton, Thornton
Mountain Blue Cancer Care Center, Golden
Longmont United Hospital, Longmont
Rocky Mountain Cancer Centers-Longmont, Longmont
Penrose-Saint Francis Healthcare, Colorado Springs
Rocky Mountain Cancer Centers-Penrose, Colorado Springs
Saint Mary Corwin Medical Center, Pueblo
Rocky Mountain Cancer Centers - Pueblo, Pueblo
CommonSpirit Cancer Center Mercy, Durango
Mercy Medical Center, Durango
Saint Luke's Cancer Institute - Boise, Boise
Primary Children's Hospital, Salt Lake City
Phoenix Childrens Hospital, Phoenix
Banner Children's at Desert, Mesa
Onvida Health Yuma Medical Center, Yuma
Banner University Medical Center - Tucson, Tucson
Hope Cancer Care of Nevada-Pahrump, Pahrump
Comprehensive Cancer Centers of Nevada-Horizon Ridge, Henderson
University Medical Center of Southern Nevada, Las Vegas
Sunrise Hospital and Medical Center, Las Vegas
Ann M Wierman MD LTD, Las Vegas
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas
Summerlin Hospital Medical Center, Las Vegas
Renown Regional Medical Center, Reno
Saint Mary's Regional Medical Center, Reno
Radiation Oncology Associates, Reno
Carson Tahoe Regional Medical Center, Carson City
Children's Hospital Los Angeles, Los Angeles
Kaiser Permanente Downey Medical Center, Downey
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance
Miller Children's and Women's Hospital Long Beach, Long Beach
City of Hope Comprehensive Cancer Center, Duarte
Rady Children's Hospital - San Diego, San Diego
Loma Linda University Medical Center, Loma Linda
Children's Hospital of Orange County, Orange
Valley Children's Hospital, Madera
UCSF Medical Center-Parnassus, San Francisco
UCSF Medical Center-Mission Bay, San Francisco
Lucile Packard Children's Hospital Stanford University, Palo Alto
UCSF Benioff Children's Hospital Oakland, Oakland
Kaiser Permanente-Oakland, Oakland
Sutter Medical Center Sacramento, Sacramento
University of California Davis Comprehensive Cancer Center, Sacramento
Straub Clinic and Hospital, Honolulu
Kaiser Permanente Moanalua Medical Center, Honolulu
Kapiolani Medical Center for Women and Children, Honolulu
Legacy Emanuel Children's Hospital, Portland
Oregon Health and Science University, Portland
Saint Francis Hospital, Federal Way
Saint Elizabeth Hospital, Enumclaw
Seattle Children's Hospital, Seattle
Highline Medical Center-Main Campus, Burien
Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo
Saint Michael Cancer Center, Silverdale
Franciscan Research Center-Northwest Medical Plaza, Tacoma
Mary Bridge Children's Hospital and Health Center, Tacoma
Northwest Medical Specialties PLLC, Tacoma
Madigan Army Medical Center, Tacoma
Saint Clare Hospital, Lakewood
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
Providence Alaska Medical Center, Anchorage
Arkansas Children's Hospital, Little Rock
Connecticut Children's Medical Center, Hartford
Yale University, New Haven
Eastern Maine Medical Center, Bangor
Maine Children's Cancer Program, Scarborough
Walter Reed National Military Medical Center, Bethesda
Massachusetts General Hospital Cancer Center, Boston
Dana-Farber Cancer Institute, Boston
Baystate Medical Center, Springfield
UMass Memorial Medical Center - University Campus, Worcester
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
Hackensack University Medical Center, Hackensack
Morristown Medical Center, Morristown
Saint Peter's University Hospital, New Brunswick
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick
Newark Beth Israel Medical Center, Newark
Saint Joseph's Regional Medical Center, Paterson
Rhode Island Hospital, Providence
Sanford USD Medical Center - Sioux Falls, Sioux Falls
Central Vermont Medical Center/National Life Cancer Treatment, Berlin Corners
University of Vermont Medical Center, Burlington
University of Vermont and State Agricultural College, Burlington
Naval Medical Center - Portsmouth, Portsmouth
Alberta Children's Hospital, Calgary
University of Alberta Hospital, Edmonton
British Columbia Children's Hospital, Vancouver
CancerCare Manitoba, Winnipeg
Janeway Child Health Centre, St. John's
IWK Health Centre, Halifax
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton
Kingston Health Sciences Centre, Kingston
Children's Hospital, London
Children's Hospital of Eastern Ontario, Ottawa
Hospital for Sick Children, Toronto
The Montreal Children's Hospital of the MUHC, Montreal
Centre Hospitalier Universitaire Sainte-Justine, Montreal
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Québec
San Jorge Children's Hospital, San Juan
University Pediatric Hospital, San Juan
National Cancer Institute (NCI)
NIH