200
Participants
Start Date
May 12, 2017
Primary Completion Date
May 31, 2027
Study Completion Date
November 30, 2027
ILND - Inguinal Lymph Node Dissection
Surgery to remove the lymph nodes in the groin near to where the cancer first appeared.
Paclitaxel
Dose 175mg/m2 as part of TIP regimen.
Ifosfamide
Dose 900mg/m2 as part of TIP regimen.
Cisplatin
Dose 15mg/m2 as part of TIP regimen (neoadjuvant chemotherapy arm) Dose 40mg/m2 for use concurrently with raditotherapy (chemoradiotherapy arm)
Intensity modulated radiation treatment (IMRT)
Treatment with very high energy X-rays (radiotherapy).
Prophylactic PLND - pelvic lymph node dissection
Surgery to remove the lymph nodes deeper in the pelvis, further away from where the cancer first appeared, that are at high risk of harbouring cancer.
ACTIVE_NOT_RECRUITING
Fox Chase Cancer Center, Philadelphia
ACTIVE_NOT_RECRUITING
Grady Health System, Atlanta
RECRUITING
Emory University Hospital/Winship Cancer Institute, Atlanta
RECRUITING
Moffitt Cancer Center, Tampa
ACTIVE_NOT_RECRUITING
Ohio State University Comprehensive Cancer Center, Columbus
RECRUITING
Mayo Clinic, Rochester
ACTIVE_NOT_RECRUITING
University of Chicago Comprehensive Cancer Center, Chicago
ACTIVE_NOT_RECRUITING
University of Oklahoma Health Sciences Center, Oklahoma City
RECRUITING
University of Texas M.D. Anderson Cancer Center, Houston
RECRUITING
Los Angeles County-USC Medical Center, Los Angeles
RECRUITING
USC / Norris Comprehensive Cancer Center, Los Angeles
RECRUITING
Velindre NHS Trust, Cardiff
RECRUITING
University Hospitals of Leicester NHS Trust, Leicester
ACTIVE_NOT_RECRUITING
The Royal Marsden NHS Foundation Trust, London
RECRUITING
St George's Hospital NHS Foundation Trust, London
RECRUITING
Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich
ACTIVE_NOT_RECRUITING
Swansea Bay University Health Board, Swansea
National Cancer Institute (NCI)
NIH
ECOG-ACRIN Cancer Research Group
NETWORK
Institute of Cancer Research, United Kingdom
OTHER