PATH-2: Platelet Rich Plasma in Achilles Tendon Healing

NACompletedINTERVENTIONAL
Enrollment

230

Participants

Timeline

Start Date

July 31, 2015

Primary Completion Date

September 18, 2017

Study Completion Date

March 8, 2018

Conditions
Achilles Tendon Rupture
Interventions
PROCEDURE

PRP Injection into Achilles tendon rupture gap

PRP injection delivered into the tendon rupture gap Intervention - PRP Injection: The injection is the intervention. A blood sample is withdrawn from patient. Away from patient part of sample is spun down in centrifuge to produce 'Platelet Rich Plasma' (PRP). Patient returns to treatment area and their own PRP is then injected into tendon rupture gap. This is carried out by a surgeon or extended scope physiotherapist, generally in the outpatient clinic, after a local anaesthetic has been applied. Patient is lying face down during procedure, unaware of treatment given to tendon at back of leg. Remaining blood sample sent for analysis.

PROCEDURE

Imitation Injection into Achilles tendon rupture gap

Imitation injection delivered into the tendon rupture gap Sham - Imitation Injection: The injection is the intervention. A blood sample is withdrawn from patient. Treatment is prepared. Patient returns to treatment area and a needle (no syringe) is inserted and held into tendon rupture gap to mimic injection (after local anaesthetic has been applied). No active ingredient given. Carried out by surgeon or extended scope physiotherapist, generally in the outpatient clinic. Patient is lying face down during procedure, unaware of treatment given to tendon at back of leg. Blood sample sent for analysis.

Trial Locations (18)

OX3 9DU

John Radcliffe Hospital, Oxford, Oxford

SS16 5NL

Basildon University Hospital, Basildon

BS10 5NB

Southmead Hospital, Bristol

CF14 4XW

University Hospital of Wales, Cardiff

CV3 2DX

University Hospital Coventry, Coventry

Unknown

Leighton Hospital, Crewe

Royal Devon & Exeter Hospital, Exeter

Royal Surrey Hospital, Guildford

Aintree Hospital, Liverpool

University Hospital South Manchester, Manchester

Northern General Hospital, Sheffield

Morriston Hospital, Swansea

LE1 5WW

Leicester Royal Infirmary, Leicester

L7 8XP

Royal Liverpool University Hospital, Liverpool

E1 1BB

Royal London Hospital, London

PE3 9GZ

Peterborough City Hospital, Peterborough

TA1 5DA

Musgrove Park Hospital, Taunton

WA5 1QG

Warrington & Halton Hospitals Trust, Warrington

All Listed Sponsors
collaborator

National Institute for Health Research, United Kingdom

OTHER_GOV

lead

University of Oxford

OTHER

NCT02302664 - PATH-2: Platelet Rich Plasma in Achilles Tendon Healing | Biotech Hunter | Biotech Hunter