80
Participants
Start Date
January 31, 2014
Primary Completion Date
July 31, 2021
Study Completion Date
July 31, 2021
Carfilzomib
"DOSING REGIMEN.~The regimen will have 2 parts:~Part 1. Induction. Nine 5 weeks cycles (35-days each) of weekly Carfilzomib Melphalan Prednisone are planned Carfilzomib. 36, 45, 56 or 70 mg/m² on days 1, 8, 15, 22 IV route followed by a 13-day rest period per 35-days cycle. Patients will start the first cycle day 1 with 20mg/m².~In combination with oral Melphalan 0.25mg/kg/j and oral prednisone 60mg/m², both on days 1 to 4.~Part 2. Maintenance. Carfilzomib. 36 mg/m² weekly, every two weeks IV route for 1 year. Melphalan and Prednisone is not pursued at this phase of the study."
Hématologie, Institut Paoli Calmette, Marseille
Hématologie Clinique, CHU, Hôpital d'Enfants, Dijon
Unité de Recherche Clinique - CH Perigueux, Périgueux
Hôpital Jean Minjoz, Besançon
CHU Nimes CAREMEAU, Nîmes
Hématologie, IUCT oncopole, Toulouse
Institut Bergonie, Bordeaux
Polyclinique Bordeaux Nord Aquitaine, Bordeaux
Hôpital Haut-Leveque, Pessac
CHRU, Hôtel Dieu, Nantes
Hématologie Clinique, Hôpital Robert Debré, CHU Reims, Reims
CHRU, Hôpitaux de Brabois, Vandœuvre-lès-Nancy
Hôpital Notre Dame de Bon Secours, Metz
Hôpital St Vincent de Paul - GH-ICL, Lille
Chru Lille, Lille
Centre Hospitalier de la côte basque, Bayonne
CH Louis Pasteur, Colmar
Hôpital E Muller, Mulhouse
Centre Hospitalier Lyon Sud -1, Pierre-Bénite
Centre Hospitalier William Morey, Chalon-sur-Saône
Centre Jean Bernard, Le Mans
Centre Hospitalier de Chambery, Chambéry
Hôpital St Antoine, Paris
Groupe hospitalier Pitié Salpétrière, Paris
Hopital J Monod, Montivilliers
CH Meaux, Meaux
Centre Hospitalier H. Duffaut, Avignon
Centre hospitalier départemental La Roche sur Yon, La Roche-sur-Yon
CHU de Limoges, Limoges
CH Francilien, Corbeil-Essonnes
Hôpital St Antoine Béclére, Clamart
CHU Henri Mondor, Créteil
Centre de NICE 2/ Hôpital Archet, Nice
Collaborators (1)
Amgen
INDUSTRY
University Hospital, Lille
OTHER