Liver Enzyme Abnormalities and Risk Factors in Taking Herbal Medicine

CompletedOBSERVATIONAL
Enrollment

6,894

Participants

Timeline

Start Date

December 31, 2005

Primary Completion Date

December 31, 2013

Study Completion Date

December 31, 2013

Conditions
Drug-Induced Liver InjuryMusculoskeletal Diseases
Interventions
DRUG

Herbal medicine

Herbal medicine was taken 3 times daily in dried powder (2g) and water-base decoction form (120ml) (Ostericum koreanum, Eucommia ulmoides, Acanthopanax sessiliflorus, Achyranthes bidentata, Psoralea corylifolia, Peucedanum japonicum, Cibotium barometz, Lycium chinense, Boschniakia rossica, Cuscuta chinensis, and Atractylodes japonica).

PROCEDURE

Acupuncture

Acupuncture treatment was administered 1-2 times daily using mainly Ah-shi points and local acupuncture points.

PROCEDURE

Pharmacopuncture

Select ingredients similar to those included in the oral herbal medicine (Ostericum koreanum, Eucommia ulmoides, Acanthopanax Sessiliflorus, Achyranthes bidentata, Psoralea corylifolia, Peucedanum japonicum, Cibotium barometz, Lycium chinense, Boschniakia rossica, Cuscuta chinensis, and Atractylodes japonica) were freeze dried into powder form after decoction, then diluted in normal saline and adjusted for acidity and pH to be used in injections. The pharmacopuncture injections were injected once daily to the amount of 1 cc and Ah-shi points and local acupuncture points (CPL, 1 cc, 26G x 1.5 syringe, Shinchang medical co., Korea).

PROCEDURE

Bee venom pharmacopuncture

Bee venom pharmacopuncture was applied after confirming a negative reaction to the hypersensitivity skin test. Diluted bee venom (saline:bee venom ratio, 10,000:1) was injected at 4-5 acupoints at the physician's discretion. Each acupuncture point was injected with approximately 0.2 cc to a total of 0.5-1 cc using disposable injection needles (CPL, 1 cc, 26G x 1.5 syringe, Shinchang medical co., Korea).

PROCEDURE

Chuna manipulation

Chuna was administered 3-5 times a week. Chuna is a Korean version of spinal manipulation that incorporates conventional spinal manipulation techniques for mobilization involving high-velocity, low amplitude thrusts to joints slightly beyond the passive range of motion and gentle force to joints within the passive range of movement.

Trial Locations (1)

135-896

Jaseng Hospital of Korean Medicine, Seoul

All Listed Sponsors
lead

Jaseng Hospital of Korean Medicine

OTHER

NCT02299739 - Liver Enzyme Abnormalities and Risk Factors in Taking Herbal Medicine | Biotech Hunter | Biotech Hunter