Chronic Hypertension and Pregnancy (CHAP) Project

PHASE4CompletedINTERVENTIONAL
Enrollment

2,408

Participants

Timeline

Start Date

June 30, 2015

Primary Completion Date

April 1, 2022

Study Completion Date

December 16, 2022

Conditions
Hypertension
Interventions
DRUG

Anti-hypertensive therapy

1st line anti-hypertensive (Labetalol or Nifedipine ER) started; escalate to maximum dose and a preferred 2nd line medication if needed (nifedipine ER or Labetalol)

OTHER

No anti-hypertensive therapy (unless BP is severe)

Treatment will not be started if blood pressure remains \<160/105; for blood pressure ≥160/105, treatment with labetalol or Nifedipine ER will be initiated and maintained at lowest dose needed to keep blood pressure under 160/105.

Trial Locations (72)

10032

Columbia University, New York

10065

Weill Cornell, New York

11355

New York Presbyterian Queens, Flushing

11501

Winthrop University Hospital, Mineola

15201

University of Pittsburg/Magee Women's Center, Pittsburgh

17822

Geisinger Clinic, Danville

18015

St. Luke's University Health Network, Bethlehem

18101

Lehigh Valley Hospital/Health Network, Allentown

19019

Drexel University College of Medicine, Philadelphia

19104

Hospital of the University of Pennsylvania, Philadelphia

Pennsylvania Hospital, Philadelphia

University of Pennsylvania, Philadelphia

19140

Temple University, Philadelphia

19713

Christiana Care Health Services, Newark

27599

University of North Carolina, Chapel Hill

27610

WakeMed, Raleigh

27704

Duke Regional Medical Center, Durham

27705

Duke University, Durham

29425

Medical University of South Carolina, Charleston

30322

Emory University, Atlanta

33606

University of South Florida, Tampa

35294

University of Alabama at Birmingham, Clinical Coordinating Center, Birmingham

University of Alabama at Birmingham, Data Coordinating Center, Birmingham

36604

University of South Alabama, Mobile

37232

Vanderbilt University, Nashville

38103

University of Tennessee Health Science Center, Memphis

39216

University of Mississippi Medical College, Jackson

40536

University of Kentucky, Lexington

43210

Ohio State University, Columbus

44109

Case Western/Metro Health, Cleveland

44111

Cleveland Clinic Fairview, Cleveland

44124

Cleveland Clinic-Hillcrest Hospital, Mayfield Heights

45220

TriHealth, Inc, Cincinnati

45409

Miami Valley Hospital, Dayton

47405

Indiana University, Bloomington

48073

Beaumont Hospital, Royal Oak

52242

University of Iowa, Iowa City

53226

Medical College of Wisconsin, Milwaukee

53233

Aurora Research Institute, Milwaukee

53715

Unity Point Health-Meriter Hospital, Madison

54449

Marshfield Clinic, Marshfield

54601

Gundersen Health System, La Crosse

60208

Northwestern, Evanston

63110

Washington University, St Louis

66045

University of Kansas Medical Center, Lawrence

70112

Tulane, New Orleans

70115

Ochsner Health System/Medical Center, New Orleans

72205

University of Arkansas for Medical Sciences, Little Rock

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75390

UT Southwestern, Dallas

77030

Baylor College of Medicine, Houston

UT Houston, Houston

77555

UT Medical Branch, Galveston

80204

University of Colorado, Boulder

Denver Health, Denver

84132

Intermountain Healthcare, Salt Lake City

University of Utah, Salt Lake City

84143

LDS Hospital, Salt Lake City

84403

McKay Dee Hospital, Ogden

84604

Utah Valley Regional Medical Center, Provo

92110

University of California, San Diego, San Diego

92324

Arrowhead Regional Medical Center, Colton

94110

General Hospital of San Francisco, San Francisco

94143

University of California San Francisco, San Francisco

94305

Stanford University, Stanford

97239

Oregon Health & Science University, Portland

06511

Yale University, New Haven

08901

Robert Wood Johnson Medical School, New Brunswick

St. Peters University Hospital, New Brunswick

07103

New Jersey Medical School, Newark

08080

Virtua Medical Group, Sewell

02912

Brown (WIHRI), Providence

All Listed Sponsors
collaborator

Columbia University

OTHER

collaborator

Drexel University College of Medicine

OTHER

collaborator

Rutgers, The State University of New Jersey

OTHER

collaborator

Lehigh Valley Hospital

OTHER

collaborator

Saint Peters University Hospital

OTHER

collaborator

Christiana Care Health Services

OTHER

collaborator

Washington University School of Medicine

OTHER

collaborator

Duke University

OTHER

collaborator

University of Texas Southwestern Medical Center

OTHER

collaborator

The University of Texas Health Science Center, Houston

OTHER

collaborator

Stanford University

OTHER

collaborator

University of Pennsylvania

OTHER

collaborator

The University of Texas Medical Branch, Galveston

OTHER

collaborator

University of Utah

OTHER

collaborator

Intermountain Health Care, Inc.

OTHER

collaborator

University of California, San Francisco

OTHER

collaborator

Johns Hopkins University

OTHER

collaborator

University of Pittsburgh

OTHER

collaborator

Ochsner Health System

OTHER

collaborator

University of North Carolina, Chapel Hill

OTHER

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

WakeMed Health and Hospitals

OTHER

collaborator

San Francisco General Hospital

OTHER

collaborator

McKay-Dee Hospital

OTHER

collaborator

Winthrop University Hospital

OTHER

collaborator

New York Hospital Queens

OTHER

collaborator

Latter Day Saints Hospital

OTHER

collaborator

Lyndon B Johnson General Hospital

OTHER

collaborator

Virtua Medical Group

OTHER

collaborator

Duke Regional Hospital

OTHER

collaborator

Utah Valley Regional Medical Center

OTHER

collaborator

Northwestern University

OTHER

collaborator

Women and Infants Hospital of Rhode Island

OTHER

collaborator

Baylor College of Medicine

OTHER

collaborator

Case Western/Metro Health

UNKNOWN

collaborator

Ohio State University

OTHER

collaborator

University of Iowa

OTHER

collaborator

University of California, San Diego

OTHER

collaborator

Indiana University

OTHER

collaborator

Meriter Foundation

OTHER

collaborator

Weill Medical College of Cornell University

OTHER

collaborator

University of Oklahoma

OTHER

collaborator

Medical University of South Carolina

OTHER

collaborator

Beaumont Hospital

OTHER

collaborator

University of Colorado, Denver

OTHER

collaborator

University of Kansas Medical Center

OTHER

collaborator

Denver Health and Hospital Authority

OTHER

collaborator

Gundersen Health System

OTHER

collaborator

Wake Forest University Health Sciences

OTHER

collaborator

Oregon Health and Science University

OTHER

collaborator

Medical College of Wisconsin

OTHER

collaborator

Temple University

OTHER

collaborator

New Jersey Medical School

OTHER

collaborator

University of South Alabama

OTHER

collaborator

Vanderbilt University

OTHER

collaborator

University of Arkansas

OTHER

collaborator

Emory University

OTHER

collaborator

St. Luke's Hospital and Health Network, Pennsylvania

OTHER

collaborator

The Cleveland Clinic

OTHER

collaborator

University of Tennessee

OTHER

collaborator

TriHealth Inc.

OTHER

collaborator

Tulane University

OTHER

collaborator

Yale University

OTHER

collaborator

Arrowhead Regional Medical Center

OTHER

collaborator

Geisinger Clinic

OTHER

collaborator

Miami Valley Hospital

OTHER

lead

University of Alabama at Birmingham

OTHER