Study of Ozanimod (RPC1063) in Relapsing Multiple Sclerosis (MS)

PHASE3CompletedINTERVENTIONAL
Enrollment

1,346

Participants

Timeline

Start Date

December 3, 2014

Primary Completion Date

December 22, 2016

Study Completion Date

December 22, 2016

Conditions
Multiple Sclerosis
Interventions
DRUG

Ozanimod

Capsules for oral administration once a day

DRUG

Interferon beta-1a

Administered by intramuscular injection once a week

DRUG

Placebo to ozanimod

Matching placebo capsules administered orally once a day

DRUG

Placebo to interferon beta-1a

Placebo intramuscular injection once a week

Trial Locations (224)

179

Khechinashvili University Hospital, Tbilisi

1023

Auckland City Hospital, Auckland

1113

Multiprofile Hospital for Active Treatment of Neurology and Psychiatry Sv Naum EAD, Sofia

1309

Multiprofile Hospital for Active Treatment National Cardiology Hospital EAD, Sofia

1407

Multiprofile Hospital for Active Treatment Tokuda Hospital Sofia, Sofia

1431

University Multiprofile Hospital for Active Treatment Aleksandrovska EAD, Sofia

University Multiprofile Hospital for Active Treatment Sveti Ivan Rilski EAD, Sofia

1527

University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna ISUL EAD, Sofia

1606

Military Medical Academy - MHAT, Sofia

2001

Waikato Hospital, Hamilton

2004

IMSP Institutul de Medicina Urgenta, Chisinau

2005

Municipal Clinical Hospital Sf Arhanghel Mihail, Chisinau

2028

Institutul de Neurologie si Neurochirurgie, Chisinau

2143

Pest Megyei Flor Ferenc Korhaz, Kistarcsa

3110

Kyiv City Clinical Hospital 4, Kyiv

4043

Kenezy Gyula Korhaz es Rendelointezet, Debrecen

5800

Military Medical Academy HBAT, Pleven

6972

Municipal Institution City Clinical Hospital 2, Zaporizhya

8011

Christchurch Hospital, Christchurch

9010

Multiprofile Hospital for Active Treatment Sveta Marina EAD, Varna

10000

Clinical Hospital Center Zagreb, Zagreb

Clinical Hospital Dubrava, Zagreb

Clinical Hospital Sestre Milosrdnice, Zagreb

Clinical Hospital Sveti duh, Zagreb

10008

Regional Clinical Hospital na OFHerbachevskyi of Zhytomyr Regional Council, Zhytomyr

10138

East Tallinn Central Hospital, Tallinn

10617

West Tallinn Central Hospital, Tallinn

11000

Clinical Center of Serbia, Belgrade

Clinical Hospital Centar Zvezdara, Belgrade

Military Medical Academy, Belgrade

11080

Clinical Hospital Centre Zemun, Belgrade

12163

Praxis Dr. Wilfried Luer, Berlin

13088

St. Joseph Krankenhaus Berlin, Berlin

13790

Neuro Medical Care Associates PLLC, Johnson City

14001

Hospital 4 of Chernihiv City Council, Chernihiv

14029

Municipal Treatment and Preventive Institution Chernihiv Regional Clinical Hospital, Chernihiv

14471

St. Josefs-Krankenhaus Potsdam-Sanssouci GmbH, Potsdam

15755

Asklepios Fachklinikum Teupitz, Brandenburg

18000

Clinical Center Nis, Niš

18009

MI Cherkasy Regional Hospital of Cherkasy Regional Council, Cherkasy

19104

University of Pennsylvania, Philadelphia

20125

Colentina Clinical Hospital, Bucharest

21005

Municipal Institution Vinnytsia Regional Psychoneurological Hospital na OI Yushchenko, Vinnytsia

25198

Hospital Arnau de Vilanova, Lleida

27607

Raleigh Neurology Associates PA, Raleigh

30134

West Georgia Sleep Disorder Center and Neurology Associates, Douglasville

31000

Clinical Hospital Osijek, Osijek

31008

Complejo Hospitalario de Navarra, Pamplona/ Navarra

32174

Neurology Associates of Ormond Beach, Ormond Beach

32751

Neurology Associates PA, Maitland

33060

Infinity Clinical Research LLC, Pompano Beach

33609

Axiom Clinical Research of Florida, Tampa

33634

Meridien Research, Tampa

33952

Neurostudies Inc, Port Charlotte

34000

Clinical Center Kragujevac, Kragujevac

34243

Roskamp Institute, Sarasota

35043

Klinikum der Philipps Universitat Marburg, Marburg

36024

Regional Clinical Hospital na NV Sklifosovskyi, Poltava

37922

Hope Neurology MS Center, Knoxville

40207

Norton Healthcare, Louisville

40225

Heinrich Heine Universitat Dusseldorf, Düsseldorf

40513

Associates In Neurology, Lexington

42000

General Hospital Varazdin, Varaždin

43024

Volyn Regional Clinical Hospital, Lutsk

43221

Neurological Research Institute Inc, Columbus

44320

Neurology and Neuroscience Associates Inc., Akron

46010

Hospital Clinico Universitario de Valencia, Valencia

48202

Henry Ford Health System, Detroit

48824

Michigan State University, East Lansing

49027

Municipal Institution Dnipropetrovsk Regional Clinical Hospital na I.I. Mechnykov, Dnipropetrovsk

50935

DataMed GmbH, Cologne

51000

Clinical Center Banja Luka, Banja Luka

53215

Center for Neurological Disorders, Milwaukee

54292

Krankenhaus der Barmherzigen Brueder, Trier

55422

Minneapolis Clinic of Neurology, Golden Valley

58018

Municipal Institution Chernivtsi Regional Psychiatric Hospital, Chernivtsi

60062

Consultants In Neurology, Northbrook

61018

State Treatment and Prevention Institution Central Clinical Hospital of Ukrzaliznytsya, Kharkiv

61022

Regional Clinical Hospital Center for Emergency Medical Care and Disaster Medicine, Kharkiv

61176

Municipal Institution of Health Care Kharkiv Clinical City Hospital 7, Kharkiv

63110

Washington University, St Louis

65009

Center for Reconstructive and Rehabilitation Medicine University Clinic of ONMedU, Odesa

65025

Municipal Institution Odesa Regional Clinical Hospital, Odesa

66160

University of Kansas Medical Center, Kansas City

66214

MidAmerica Neuroscience Research Foundation, Lenexa

67063

Klinikum der Stadt Ludwigshafen gGmbH, Ludwigshafen am Rhein

69035

Municipal Institution 6th City Clinical Hospital of Zaporizhzhia City Council, Zaporizhzhia

69600

Municipal Institution Zaporizhzhia, Zaporizhzhia

71000

Clinical Center University of Sarajevo, Sarajevo

75000

University Clinical Center Tuzla, Tuzla

76000

Ivano Frankivsk City Clinical Hospital 1, Ivano-Frankivsk

76008

Regional Clinical Hospital., Ivano-Frankivsk

77030

University of Texas Health Science Center at Houston, Houston

79010

Lviv Regional Clinical Hospital, Lviv

79044

Municipal City Clinical Hospital 5, Lviv

79410

Bhupesh Dihenia MD PA, Lubbock

80210

Denver Neurological Clinic, Denver

85004

Xenosciences Inc, Phoenix

85013

St Josephs Hospital and Medical Center, Phoenix

85712

Northwest Neuro Specialists PLLC, Tucson

88018

Regional Clinical Center of Neurosurgery and Neurology, Uzhhorod

89079

NeuroPoint Akademie, Ulm

89106

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas

90806

Collaborative Neuroscience Network Inc, Long Beach

94158

Multiple Sclerosis Center at UCSF, San Francisco

94705

Alta Bates Summit Medical Center, Berkeley

95817

University of California Davis Medical Center, Sacramento

97225

Providence Multiple Sclerosis Center, Portland

98034

EvergreenHealth, Kirkland

98104

The Polyclinic, Seattle

98405

Neurology of Neurosurgery Associates of Tacoma, Tacoma

107150

Central Clinical Hospital 2 na NA Semashko OAO RZhD, Moscow

117997

City Clinical Hospital 24, Moscow

119049

City Clinical Hospital 1 na NIPirogov, Moscow

125170

Regional State Budget Institution of Healthcare Tver Regional Clinical Hospital, Tver'

125367

Research Center of Neurology of RAMS, Moscow

127018

City Clinical Hospital 11, Moscow

150030

Yaroslavl Clinical Hospital 8, Yaroslavl

163045

Arkhangelsk Regional Clinical Hospital, Arkhangelsk

185019

Republican Hospital na VA Baranov, Petrozavodsk

194354

City Hospital 31, Saint Petersburg

City Hospital Nikolaevskaya Bolnitsa, Saint Petersburg

St. Petersburg Multi Field City Hospital 2, Saint Petersburg

197022

First St Petersburg State Medical University na IP Pavlov, Saint Petersburg

197376

Institute of Human Brain RAN, Saint Petersburg

197706

City Clinical Hospital 40, Saint Petersburg

210023

Vitebsk Regional Diagnostic Centre, Vitebsk

210037

Vitebsk Regional Clinical Hospital, Vitebsk

214018

Smolensk State Medical Academy, Smolensk

220026

Minsk Municipal Clinical Hospital 5, Minsk

220114

Republican Scientific and Practical Centre of Neurology and Neurosurgery, Minsk

220116

Minsk City Clinical Hospital 9, Minsk

230017

Grodno Clinical Regional Hospital, Grodno

241033

Bryansk Regional Hospital 1, Bryansk

300736

Timisoara Emergency County Clinical Hospital, Timișoara

305007

Kursk Regional Clinical Hospital, Kursk

308007

Belgorod Regional Clinical Hospital, Belgorod

344015

Rostov Regional Clinical Hospital, Rostov-on-Don

357538

Pyatigorsk City Hospital 2, Pyatigorsk

400012

Cluj Clinical County Hospital, Cluj-Napoca

420097

Research Medical Complex Vashe Zdorovie, Kazan'

440026

Penza Regional Clinical Hospital na NN Burdenko, Penza

443095

Samara Regional Clinical Hospital named after MI Kalinin, Samara

450005

Kuvatov Republican Clinical Hospital, Ufa

454136

Chelyabinsk City Clinical Hospital 3, Chelyabinsk

550166

Sibiu Emergency County Clinical Hospital, Sibiu

603076

Nizhniy Novgorod City Hospital 33, Nizhny Novgorod

603155

City Clinical Hospital 3 Nizhniy Novgorod Geriatrics Centre, Nizhny Novgorod

610014

Kirov City Clinical Hospital 1, Kirov

614045

Perm State Medical Academy, Perm

620102

Sverdlovsk Regional Clinical Hospital 1, Yekaterinburg

625000

Neftyanik Medical and Sanitary Unit, Tyumen

628012

Regional Clinical Hospital, Khanty-Mansiysk

630007

Siberian Regional Medical Center, Novosibirsk

630087

Novosibirsk State Medical University, Novosibirsk

634050

Siberian State Medical University, Tomsk

650066

Kemerovo Regional Clinical Hospital, Kemerovo

656024

Regional Clinical Hospital, Barnaul

660022

Krasnoyarsk State Medical Academy, Krasnoyarsk

900123

Cai Ferate Clinical Hospital, Constanța

07764

Neurology Specialists of Monmouth County PA, West Long Branch

J9J 0A5

Clinique Neuro Outaouais, Gatineau

625 00

University Hospital Brno, Brno

656 91

Fakultni nemocnice u sv Anny v Brne, Brno

500 05

Private Neurological Practice Radomir Talab MD, Hradec Králové

University Hospital Hradec Kralove, Hradec Králové

586 33

Nemocnice Jihlava prispevkova organizace, Jihlava

775 20

Fakultni Nemocnice Olomouc, Olomouc

128 21

Vseobecna Fakultni Nemocnice v Praze, Prague

415 29

Krajska zdravotni as Nemocnice Teplice oz, Teplice

EE-51014

Tartu University Hospital, Tartu

0160

Aversi Clinic LTD, Tbilisi

¿0112

LTD MediClubGeorgia, Tbilisi

Sarajishvili Institute of Neurology, Tbilisi

¿0186

Curatio JSC, Tbilisi

Ltd DEKA, Tbilisi

01307

Universitatsklinikum Carl Gustav Carus an der TU Dresden, Dresden

04103

Universitatsklinikum Leipzig, Leipzig

LV-1015

Latvian Maritime Medicine Centre, Riga

LV-1038

Riga East Clinical University Hospital clinic Gailezers, Riga

LV1002

Pauls Stradins Clinical University Hospital, Riga

LT-50009

Hospital of Lithuanian University of Health Sciences Kaunas Clinics, Kaunas

LT-5808

Klaipeda University Hospital, Klaipėda

6162 BG

Zuyderland Medisch Centrum, Sittard-Geleen

85-795

B&B Robert Bonek, Pawel Bochniak, Spolka Cywilna, Bydgoszcz

41-250

Powiatowy Zespol Zakladow Opieki Zdrowotnej Szpital w Czeladzi, Czeladź

80-803

Copernicus Podmiot Leczniczy Sp. z o.o., Gdansk

37-500

Akson Clinical Research Maciejowski Bielecki Sp. Jawna, Jarosław

40-555

Niepubliczny Zaklad Opieki Zdrowotnej NEURO-MEDIC, Katowice

40-595

M.A.- Lek A.M.Maciejowscy Spolka Cywilna, Katowice

40-650

Novo-Med Zielinski i wsp. Sp.J., Katowice

40-749

NEURO- CARE Site Management Organization Gabriela Klodowska-Duda, Katowice

25-726

RESMEDICA Spolka z o.o., Kielce

05-510

Niepubliczny Zespol Leczniczo-Rehabilitacyjny Centrum Kompleksowej Rehabilitacji, Konstancin-Jeziorna

90-324

Centrum Neurologii Krzysztof Selmaj, Lódzkie

20-059

NZOZ NEUROMED M. I M. Nastaj Spolka Partnerska, Lublin

20-718

Wojewodzki Szpital Specjalistyczny im Stefana Kardynala Wyszynskiego, Lublin

02-097

Samodzielny Publiczny Centralny Szpital Kliniczny, Mazowieckie

62-064

Neurologiczny NZOZ Centrum Leczenia SM Osrodek Badan Klinicznych Dr n med Hanka Hertmanowska, Plewiska

15-402

Niepubliczny Zaklad Opieki Zdrowotnej KENDRON, Podlaskie

80-299

Indywidualna Specjalistyczna Praktyka Lekarska dr nmed Monika Lyczak, Pomorskie

61-853

Niepubliczny Zaklad Opieki Zdrowotnej NEUROKARD Ilkowski i Partnerzy Spolka Partnerska Lekarzy, Poznan

44-200

SPZOZ Wojewodzki Szpital Specjalistyczny nr 3 w Rybniku, Rybnik

35-055

Centrum Medyczne Medyk, Rzeszów

10-443

Indywidualna Specjalistyczna Praktyka Lekarska Zbigniew Cebulski, Warminsko-mazurskie

00-739

Szpital Czerniakowski Samodzielny Publiczny Zaklad Opieki Zdrowotnej, Warsaw

01-697

Centrum Medyczne NeuroProtect, Warsaw

02-957

Instytut Psychiatrii i Neurologii, Warsaw

05-077

Centrum Medyczne doktorA, Warsaw

2805-267

Hospital Garcia de Orta, Almada

4710-243

Hospital de Braga, Braga

3000-075

Centro Hospitalar E Universitario de Coimbra EPE, Coimbra

2674-514

Hospital Beatriz Angelo, Loures

2560-280

Campus Neurologico Senior, Torres Vedras

022328

Fundeni Clinical Institute, Bucharest

08035

Hospital Universitario Vall D hebron, Barcelona

08970

Hospital Moises Broggi, Sant Joan Despí

SE-41345

Sahlgrenska Universitetssjukhuset, Gothenburg

SE-17176

Karolinska Universitetssjukhuset Solna, Stockholm

03115

National Research Center for Radiation Medicine, Institute of Clinical Radiology, Kyiv

CF14 4XW

University Hospital of Wales, Cardiff

IV2 3UJ

Raigmore Hospital, Inverness

SE5 9RS

Kings College Hospital, London

S10 2JF

Royal Hallamshire Hospital Sheffield Teaching Hospitals NHS Trust, Sheffield

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Celgene

INDUSTRY