A Study of MHAA4549A in Combination With Oseltamivir Versus Oseltamivir in Participants With Severe Influenza A Infection

PHASE2CompletedINTERVENTIONAL
Enrollment

168

Participants

Timeline

Start Date

January 14, 2015

Primary Completion Date

May 23, 2017

Study Completion Date

May 23, 2017

Conditions
Influenza
Interventions
DRUG

MHAA4549A

Participants will receive a single dose of MHAA4549A by IV infusion on Day 1

DRUG

Oseltamivir

Participants will receive oseltamivir capsule either 75 mg or 150 mg BID orally for minimum of 5 days. Dosage and administration should follow local prescribing information for oseltamivir.

DRUG

Placebo

Participants will receive a single IV dose of placebo matched to MHAA4549A on Day 1

Trial Locations (171)

84

Hospital Regional del Cusco, Cusco

Hospital Nacional Adolfo Guevara Velasco, Cuzco

116

Wanfang Hospital, Taipei

149

"National Institute for Infectious Diseases L. Spallanzani", Rome

220

Far East Memorial Hospital, New Taipei City

333

Chang Gung Medical Foundation Linkou Branch, Taoyuan

807

Kaohsiung Medical University Hospital, Cancer Center, Kaohsiung City

1000

CHU St Pierre (St Pierre), Brussels

1070

Hospital Erasme; Neurologie, Brussels

1124

Auckland City Hospital, Auckland

1336

MHAT Lyulin EAD, Department of internal diseases, Sofia

1407

MHAT TOKUDA SOFIA/ICU-Intensive Care Unit, Sofia

1606

5th Multifunctional Hospital for Active treatment, Sofia

Military Medical Academy- MHAT, Sofia

University Multiprofile Hospital for Active Treatment and Emergency Medicine N. I. Pirogov EAD, Sofia

2084

Pest Megyei Flor Ferenc Korhaz, Kistarcsa

2196

Milpark Hospital, Parktown West

2600

Jávorszky Ödön Hospital, Vác

3000

UZ Leuven Gasthuisberg, Leuven

3143

Tauranga Hospital, Tauranga

4005

"University Multiprofile Hospital for Active Treatment St. George", Plovdiv

5000

Multiprofile District Hospital for Active Treatment Dr. Stefan Cherkezov AD, Veliko Tarnovo

5300

"MHAT Dr. Tota Venkova- Gabrovo", Gabrovo

5400

Multiprofile Hospital for Active Treatment AKTA-MEDIKA EOOD, Sevlievo

5530

CHU UCL Mont-Godinne, Mont-godinne

6202

Archet 1 university Hospital, Nice

6850

Clinical Projects Research, Worcester

7002

SHATPPD Dr. Dimitar Gramatikov, Ruse Ltd., Rousse

8011

Christchurch Hospital, Christchurch

8200

Csolnoky Ferenc Kórház, Veszprém

8900

Zala County Hospital ICU, Zalaegerszeg

9010

MBAL St Marina Dep Pulmonology, ICU, Varna

10002

Municipal Institution Central City Hospital #1 City of Zhytomyr, Zhytomyr

13011

Clinica Peruana Americana, Trujillo

14000

Instituto Nacional de Ciencias; Medicas y Nutricion; Salvador Zubiran, Mexico City

16100

Nazareth EMMS Hospital, Nazareth

18012

Hospital Universitario San Cecilio, Granada

18101

Haemek Medical Center, Afula

20001

Hospital de la Amistad Peru Corea II-2 Santa Rosa, Piura

20127

Ospedale San Raffaele - Milano, Milan

21079

Service de Réanimation médicale - Bocage Central, Dijon

22100

Galilee Medical Center, Nahariya

22320

Hospital General de Tijuana, Tijuana

26100

Asst Di Cremona, Cremona

28040

Hosp. Clinico San Carlos, Madrid

28905

Hospital Univ. de Getafe.Servicio de Neurologia, Madrid

36011

Poltava Regional Clinical Infectious Hospital, Poltava

37044

Service de réanimation médicale, Hôpital Bretonneau, Tours

39008

Hospital Universitario Marques de Valdecilla, Santander

40127

Clinic of Infectious Diseases, Bologna

41125

University Hospital Modena, Intensive Care Unit, Modena

41650

Uppsala University Hospital, Department of Infectious Diseases, Gothenburg

43005

Joan XXIII University Hospital, Tarragona

44280

Hospital Civil de Guadalajara Dr Juan I Menchaca, Guadalajara

Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara

46026

Servicio de Medicina Intensiva Hospital Universitario la Fe, Valencia

50931

Uniklinik Köln, Medizinischen Klinik I, Cologne

52661

Chaim Sheba Medical Center, Tel Litwinsky

54035

CHRU Nancy, Nancy

55131

Uniklinikum Mainz, Mainz

58100

Wolfson Medical Center, Holon

59037

CHRU Lille, Lille

60590

Universitätsklinikum Frankfurt Goethe Universität, Frankfurt

62500

The University Hospital Brno, Brno

63000

Centre Hospitalier Universitaire de Clermont Ferrand, Clermont-Ferrand

64239

Tel-Aviv Sourasky Medical Center, Tel Aviv

64460

CEPREP; Hospital Universitario, Monterrey

65023

Municipal Institution City Clinical Infectious Diseases Hospital, Odesa

67000

Réanimation médicale NHC, Strasbourg

67098

Hopital Universitaire Hautepierre, Strasbourg

69120

Universitätsklinikum Heidelberg, Heidelberg

72076

Uniklinik Tübingen, Tübingen

75014

HOPITAL COCHIN university hospital, Paris

84101

Soroka University Medical Centre, Beersheba

84131

A.O.U. S. Giovanni di Dio e Ruggi d'Aragona, Salerno

85025

CHD Vendée, La Roche-sur-Yon

87043

Réanimation Polyvalente, CHU Limoges, Limoges

91020

Centro de Especialidades Medicas Del Estado de Veracruz Dr Rafael Lucio, Xalapa

91999

Hadasit Medical Research Services and Development Ltd, Jerusalem

92380

APHP Raymond Poincare, Garches

95107

CH Victor Dupouy, Argenteuil

194044

Medical Military Academy n.a S.M.Kirov, Saint Petersburg

413124

"Municipal Healthcare Institution City Hospital №2", Engel's

454000

Municipal Clinical Hospital #8, Chelyabinsk

690002

Paciific state medical university, Vladivostok

1311001

Ziv Medical Center, Safed

2540364

Clinica Renaca, Viña del Mar

4781151

Hospital Dr. Hernan Henriquez Aravena, Temuco

4941492

Rabin Medical Center, Petah Tikva

7661041

Kaplan Medical Center, Rehovot

460 63

Anesthesia and Intensive Care Dept., Regional Hospital Liberec, Liberec

T1Y 6J4

Peter Lougheed Centre, Calgary

T2N 4N2

Alberta Health Services, Calgary

T2N 4Z6

Foothills Medical Centre, Calgary

T2V 1P9

Rockyview General Hospital, Calgary

V3L 3W7

Royal Columbian Hospital, New Westminster

V6Z 1Y6

St. Paul's Hospital, Providence Health Care, Vancouver

V8Z 6R5

Victoria General Hospital, Victora

V8R 1J8

Royal Jubilee Hospital Victoria general Hospital, Victoria

E1C 6Z8

Moncton Hospital, Moncton

N6A 5A5

LHSC - University Hospital; Research Pharmacy, London

L1G 2B9

Lakeridge Health, Oshawa

K1Y 4E9

Ottawa Hospital Research Institute, Ottawa

The Ottawa Hospital - Civic Campus, Ottawa

M4C 3E7

Toronto East General, Toronto

M5G 2N2

University Health Network, Toronto

M5T 2S8

Toronto Western Hospital, Toronto

G1V 4G5

Centre Hospitalier de la Universite Laval, Québec

G1V 4G2

Pavillion Chul-Chuq, Sainte-Foy

G9A1Y1

Centre de santé et de services sociaux de Trois-Rivières, Trois-Rivières

500 05

Fakultni nemocnice Hradec Kralove, Hradec Králové

30150-221

Santa Casa de Misericordia; de Belo Horizonte, Belo Horizonte

99010-080

Hospital Sao Vicente de Paulo, Passo Fundo

13060-904

PUC Campinas, Campinas

15090-000

FUNFARME, São José do Rio Preto

01323-020

Hospital Alemao Oswaldo Cruz; Oncologia, São Paulo

04038-905

Hospital Edmundo Vasconcelos, Vila Clementino

708 52

University hospital Ostrava, Clinic of infectious medicine, Ostrava

100 34

Fakultni nemocnice Kralovske Vinohrady, Klinika anesteziologie a resuscitace, Prague

Unknown

University of Hong Kong, Hong Kong

University Division of Infective and Tropical Diseases, University of Brescia, Italy, Brescia

Gachon University Gil Hospital, Incheon

5223 GZ

Jeroen Bosch Ziekenhuis, 's-Hertogenbosch

7334 DV

Gelre Ziekenhuizen Apeldoorn; Hospitals Pharmacy, Apeldoorn

2300 ZA

LUMC, Leiden

6500 HB

UMC Radboud Nijmegen, Nijmegen

3000 CA

Erasmus Medical Centre; Department of Virology L-359, Rotterdam

3083AN

Ikazia Hospital, Rotterdam

3508 GA

UMCU, Utrecht

8025 AB

Isala, Zwolle

Lima 13

Hospital Guillermo Almenara Irigoyen Hospital Guillermo Almenara Irigoyen Hospital Guillermo Almen, La Victoria

Lima 01

Clinica Internacional Sede Lima, Lima

Hospital Nacional; Arzobispo Loayza, Lima

Lima 10

Hospital Nacional Hipolito; Unanue, Lima

Lima 18

Hospital Central Fuerza; Aerea del Peru, Lima

Lima 29

Hospital Maria Auxiliadora, Lima

Lima 32

Clínica San Gabriel, Lima

Lima 41

Clinica San Borja, Lima

LIMA 29

Clinica Divino Nino Jesus; Orden de Malta, San Juán de Miraflores

91-347

Oddział Anestezjologii i Intensywnej Terapii Wojewódzki Specjalistyczny Szpital im dr Wł Biegańsk, Lodz

20-718

Wojewodzki Szpital Specjalistyczny, Lublin

70-111

Icu Spsk - 2, Szczecin

87-100

Oddział Anestezjologii i Intensywnej Terapii;Wojewódzki Szpital Zespolony im. L. Rydygiera, Torun

0084

Emmed Research, Pretoria

602-739

Pusan National University Hospital, Busan

02841

Korea University Anam Hospital, Seoul

08308

Korea University Guro Hospital, Seoul

120-752

Yonsei University Health System/Severance Hospital, Seoul

150-950

Hallym university Kangnam Sacred Heart Hospital; Infectious devision, Seoul

220-701

Wonju Severance Christian Hospital, Wŏnju

07010

Hospital Universitario Son Espases, Palma de Mallorca

08221

Mutua de Terrassa, Terrassa

08036

Hospital Clinic, Barcelona

08304

Hospital de Mataro, Mataro

08003

Hospital del Mar, Barcelona

08035

Hospital Universitari Vall d'Hebron, Barcelona

08907

Bellvitge University Hospital, Barcelona

413 45

Sahlgrenska Universitetssjukhuset, Gothenburg

205 02

Skånes Universitetssjukhus, Mamö

901 85

Norrland Universitetssjukhus, Umeå

03110

Kyiv City Clinical Hospital #4, Kyiv

04060

Kyiv City Clinical Hospital #9, Kyiv

B15 2TH

Queen Elizabeth Hospital, Birmingham

B9 5SS

Heart of England NHS Trust, Birmingham

G51 4TF

Queen Elizabeth University Hospital, Glasgow

LS1 3EX

Leeds General Infirmary, Anaesthetic Department, D Floor, Leeds

SE5 9RS

King College Hospital NHS Foundation Trust, London

WC1E 6AU

University College London Hospitals NHS Foundation Trust - University College Hospital, London

SO16 6YD

Southampton University Hospitals NHS Trust, Southampton

ST4 6QG

University Hospitals of North Midlands NHS Trust-Royal Stoke University Hospital, Stoke-on-Trent

TA1 5DA

Taunton and Somerset NHS Foundation Trust Musgrove Park Hospital, Taunton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Genentech, Inc.

INDUSTRY