Safety and Cardiovascular Efficacy of Spironolactone in Dialysis-Dependent ESRD Trial

PHASE2CompletedINTERVENTIONAL
Enrollment

129

Participants

Timeline

Start Date

November 30, 2014

Primary Completion Date

June 30, 2017

Study Completion Date

July 30, 2017

Conditions
End-Stage Renal Disease
Interventions
DRUG

Spironolactone

The trial will be conducted in 2 phases - a dose escalation phase (6 weeks) and a treatment phase (30 weeks). At the end of the dose escalation phase, participants will continue treatment based on the randomized dose assignment for an additional 30 weeks (treatment phase) such that the total duration of study medication is 36 weeks.

Trial Locations (4)

20037

The George Washington University, Washington D.C.

37232

Vanderbilt University Medical Center, Nashville

98104

Kidney Research Institute, University of Washington, Seattle

02120

Brigham and Women's Hospital, Boston

All Listed Sponsors
collaborator

Brigham and Women's Hospital

OTHER

collaborator

George Washington University

OTHER

collaborator

Vanderbilt University

OTHER

collaborator

University of Washington

OTHER

lead

University of Pennsylvania

OTHER

NCT02285920 - Safety and Cardiovascular Efficacy of Spironolactone in Dialysis-Dependent ESRD Trial | Biotech Hunter | Biotech Hunter