Efficacy and Safety Study of Lenalidomide Plus R-CHOP Chemotherapy Versus Placebo Plus R-CHOP Chemotherapy in Untreated ABC Type Diffuse Large B-cell Lymphoma

PHASE3CompletedINTERVENTIONAL
Enrollment

570

Participants

Timeline

Start Date

February 17, 2015

Primary Completion Date

March 15, 2019

Study Completion Date

July 28, 2022

Conditions
Lymphoma, Large B-Cell, Diffuse
Interventions
DRUG

lenalidomide

DRUG

Placebo

DRUG

Rituximab

DRUG

Cyclophosphamide

DRUG

Doxorubicin

DRUG

prednisone

DRUG

vincristine

Trial Locations (158)

4

Local Institution - 893, Dublin

1200

Local Institution - 301, Brussels

1211

Local Institution - 320, Geneva

2135

Local Institution - 357, Hoofddorp

2640

Local Institution - 004, Albury

3168

Local Institution - 008, Clayton

3199

Local Institution - 003, Frankston

3220

Local Institution - 002, Geelong

4000

Local Institution - 307, Liège

4414

Local Institution - 243, Palmerston

6500

Local Institution - 323, Bellinzona

8011

Local Institution - 240, Christchurch

8400

Local Institution - 321, Winterthur

8800

Local Institution - 305, Roeselare

9100

Local Institution - 303, Sint-Niklaas

10002

Local Institution - 252, Taipei, Zhongzheng Dist.

10003

Local Institution - 796, Cáceres

10015

Local Institution - 667, Ivrea

10126

Local Institution - 662, Torino

12100

Local Institution - 674, Cuneo

15100

Local Institution - 659, Allessandria

16132

Local Institution - 652, Genova

19111

Local Institution - 161, Philadelphia

20070

Local Institution - 435, Denizli

20132

Local Institution - 666, Milan

20133

Local Institution - 653, Milan

20162

Local Institution - 676, Milan

20817

Center For Cancer And Blood Disorders, Bethesda

22030

Local Institution - 428, Edirne

25123

Local Institution - 658, Brescia

27100

Local Institution - 651, Pavia

27710

Local Institution - 103, Durham

28007

Local Institution - 783, Madrid

28034

Local Institution - 785, Madrid

28040

Local Institution - 787, Madrid

28050

Local Institution - 788, Madrid

28100

Local Institution - 655, Novara

31059

Local Institution - 587, Toulose

31096

Local Institution - 274, Haifa

33021

Local Institution - 128, Hollywood

33076

Local Institution - 585, Bordeaux

33100

Local Institution - 692, Udine

33604

Local Institution - 588, Pessac

34093

Local Institution - 432, Istanbul

34295

Local Institution - 583, Montpellier

35128

Local Institution - 685, Padua

36100

Local Institution - 672, Vicenza

37007

Local Institution - 797, Salamanca

37134

Local Institution - 682, Verona

40447

Local Institution - 255, Taichung

41013

Local Institution - 790, Seville

41014

Local Institution - 800, Seville

42100

Local Institution - 668, Reggio Emilia

44281

Local Institution - 275, Kfar Saba

46010

Local Institution - 793, Valencia

46026

Local Institution - 802, Valencia

47014

Local Institution - 684, Meldola

47900

Local Institution - 683, Rimini

48121

Local Institution - 679, Ravenna

49100

Local Institution - 277, Petah Tikva

50134

Local Institution - 664, Florence

54511

Local Institution - 581, Vandœuvre-lès-Nancy

55416

Local Institution - 101, Minneapolis

55455

Local Institution - 138, Minneapolis

55905

Local Institution - 112, Rochester

64109

Local Institution - 576, Bayonne

64239

Local Institution - 278, Tel Aviv

66205

Local Institution - 143, Fairway

70300

Local Institution - 270, Ẕerifin

71103

Local Institution - 158, Shreveport

72703

Local Institution - 177, Fayetteville

73039

Local Institution - 681, Tricase

75010

Local Institution - 582, Paris

75235

Local Institution - 951, Dallas

80131

Local Institution - 657, Napoli, Campania

83301

Local Institution - 253, Niao-Sung Hsiang Kaohsiung County

84016

Local Institution - 686, Pagani

84101

Local Institution - 273, Beersheba

84106

Local Institution - 146, Salt Lake City

91120

Local Institution - 272, Jerusalem

92868

Local Institution - 136, Orange

95817

Local Institution - 127, Sacramento

98026

Local Institution - 905, Edmonds

98029

Local Institution - 903, Issaquah

98104

Local Institution - 162, Seattle

98107

Local Institution - 904, Seattle

100044

Local Institution - 209, Beijing

100142

Local Institution - 206, Beijing

100191

Local Institution - 215, Beijing

100730

Local Institution - 200, Beijing

115478

Local Institution - 052, Moscow

130021

Local Institution - 211, Changchun

150081

Local Institution - 207, Harbin, Heilongjiang

197758

Local Institution - 051, Saint Petersburg

200032

Local Institution - 214, Shanghai

210009

Local Institution - 205, Nanjing, Jiangsu

210029

Local Institution - 212, Nanjing

215006

Local Institution - 219, Suzhu

300060

Local Institution - 221, Tianjin

310003

Local Institution - 204, Hangzhou

350001

Local Institution - 202, Fuzhou

400037

Local Institution - 213, Chongqing

420029

Local Institution - 050, Kazan'

430030

Local Institution - 203, Wuhan

510080

Local Institution - 217, Guangzhou, Guangdong

610041

Local Institution - 210, Chengdu

1358550

Local Institution - 509, Koto-ku

06510

Local Institution - 169, New Haven

50010-3014

McFarland Clinic, Ames

51101-1733

Siouxland Hematology-Oncology Associates, LLP, Sioux City

75390-9068

Local Institution - 151, Dallas

T2N 4N2

Local Institution - 368, Calgary

V3T 0H1

Local Institution - 373, Surrey

E2L 3L6

Local Institution - 366, Saint John

J4V 2H1

Local Institution - 362, Greenfield Park

H1T 2M4

Local Institution - 365, Montreal

625 00

Local Institution - 376, Brno

500 05

Local Institution - 377, Hradec Králové

775 20

Local Institution - 379, Olomouc

100 34

Local Institution - 380, Prague

128 08

Local Institution - 378, Prague

ST46QG

Local Institution - 894, Galway

05100

Local Institution - 690, Terni

00128

Local Institution - 689, Roma

00161

Local Institution - 694, Roma

00189

Local Institution - 673, Roma

00152

Local Institution - 656, Rome

01012

Local Institution - 671, Torino

104-0045

Local Institution - 508, Chuo-ku

105-8470

Local Institution - 502, Minato-ku

010-8543

Local Institution - 513, Akita

812-8582

Local Institution - 511, Fukuoka

259-1193

Local Institution - 505, Isehara City, Kanagawa

277-8577

Local Institution - 501, Kashiwa

602-8566

Local Institution - 510, Kyoto

811-1347

Local Institution - 506, Minami-Ku, Fukuoka

464-8681

Local Institution - 507, Nagoya

983-8520

Local Institution - 515, Sendai

990-9585

Local Institution - 504, Yamagata

5223 GZ

Local Institution - 353, 's-Hertogenbosch

1081 HV

Local Institution - 358, Amsterdam

4818 CK

Local Institution - 359, Breda

8934 AD

Local Institution - 354, Leeuwarden

3118 JH

Local Institution - 350, Schiedam

3094-001

Local Institution - 730, Figueira da Foz Municipality

1099-023

Local Institution - 732, Lisbon

1400-038

Local Institution - 729, Lisbon

2801-951

Local Institution - 727, Pragal

00918

Local Institution - 115, San Juan

410-769

Local Institution - 830, Gyeonggi-do

06591

Local Institution - 826, Seoul

135-710

Local Institution - 829, Seoul

138-736

Local Institution - 828, Seoul

08025

Local Institution - 776, Barcelona

08916

Local Institution - 780, Barcelona

01330

Local Institution - 429, Adana

06590

Local Institution - 431, Ankara

07058

Local Institution - 430, Antalya

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Celgene

INDUSTRY