Study of Efficacy and Safety in Premenopausal Women With Hormone Receptor Positive, HER2-negative Advanced Breast Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

672

Participants

Timeline

Start Date

November 20, 2014

Primary Completion Date

August 21, 2017

Study Completion Date

April 20, 2023

Conditions
Advanced Metastatic Breast Cancer
Interventions
DRUG

Ribociclib

Ribociclib (600 mg, in three 200 mg hard gelatin capsules) was administered orally once daily on Days 1-21 of each 28-day cycle.

DRUG

Tamoxifen

Tamoxifen (20 mg, tablets) was administered orally on a continuous daily schedule (days 1-28 of each 28-day cycle)

DRUG

Letrozole

Letrozole (2.5 mg, tablets) was administered orally once daily on a continuous daily schedule (days 1-28 of each 28-day cycle)

DRUG

Anastrozole

Anastrozole (1 mg, tablets) was administered orally once daily on a continuous daily schedule (days 1-28 of each 28-day cycle)

DRUG

Goserelin

Goserelin (3.6 mg, subcutaneous implant) was administered on day 1 of every 28-day cycle

DRUG

Placebo

Placebo (hard gelatin capsules) was administered orally once daily on Days 1-21 of each 28-day cycle.

Trial Locations (183)

652

Novartis Investigative Site, Saida

1000

Novartis Investigative Site, Brussels

1134

Novartis Investigative Site, Budapest

1205

Novartis Investigative Site, Geneva

1303

Novartis Investigative Site, Sofia

2298

Novartis Investigative Site, Waratah

2610

Novartis Investigative Site, Wilrijk

3000

Novartis Investigative Site, Leuven

3084

Novartis Investigative Site, Heidelberg

3128

Novartis Investigative Site, Box Hill

4032

Novartis Investigative Site, Debrecen

4600

Novartis Investigative Site, San Salvador de Jujuy

5000

Novartis Investigative Site, Namur

5300

Novartis Investigative Site, La Rioja

6009

Novartis Investigative Site, Nedlands

6150

Novartis Investigative Site, Murdoch

6720

Novartis Investigative Site, Szeged

9010

Novartis Investigative Site, Varna

10002

Novartis Investigative Site, Taipei

10060

Novartis Investigative Site, Candiolo

10330

Novartis Investigative Site, Bangkok

10408

Novartis Investigative Site, Gyeonggi-do

10449

Novartis Investigative Site, Taipei

10700

Novartis Investigative Site, Bangkok

10999

Novartis Investigative Site, Beirut

11042

Clinical Research Alliance ., Lake Success

11217

Novartis Investigative Site, Taipei

11426

Novartis Investigative Site, Riyadh

13620

Novartis Investigative Site, Bundang Gu

14021

Novartis Investigative Site, Caen

15706

Novartis Investigative Site, Santiago de Compostela

16132

Novartis Investigative Site, Genova

17033

Penn State University Milton S Hershey Medical Center, Hershey

20080

Novartis Investigative Site, Donostia / San Sebastian

20141

Novartis Investigative Site, Milan

21000

Novartis Investigative Site, Diyarbakır

21231

Sidney Kimmel CCC At JH Dept of Onc., Baltimore

22030

Novartis Investigative Site, Edirne

23114

Bon Secours Virginia Health System, Midlothian

23561

Novartis Investigative Site, New Taipei City

24105

Novartis Investigative Site, Kiel

26100

Novartis Investigative Site, Cremona

27100

Novartis Investigative Site, Pavia

27710

Duke Univ Medical Center Duke (SC), Durham

28033

Novartis Investigative Site, Madrid

28034

Novartis Investigative Site, Madrid

28040

Novartis Investigative Site, Madrid

28922

Novartis Investigative Site, Alcorcón

29010

Novartis Investigative Site, Málaga

29607

Bon Secours Cancer Center SC, Greenville

30060

NorthWest Georgia Oncology Centers IRB, Marietta

31059

Novartis Investigative Site, Toulouse

33021

Memorial Cancer Institute SC, Hollywood

33100

Novartis Investigative Site, Udine

33136

University Of Miami Univ Miami 2, Miami

33305

Novartis Investigative Site, Taoyuan District

33901

Florida Cancer Specialists Onc Dept, Fort Myers

Florida Cancer Specialists SC-2, Fort Myers

34098

Novartis Investigative Site, Istanbul

34298

Novartis Investigative Site, Montpellier

35040

Novartis Investigative Site, Izmir

37000

Novartis Investigative Site, León

37203

SCRI Oncology Partners Tennessee Oncology (3), Nashville

37403

Erlanger Medical Center SC, Chattanooga

40138

Novartis Investigative Site, Bologna

40202

Norton Cancer Institute SC, Louisville

44100

Novartis Investigative Site, Cona

45136

Novartis Investigative Site, Essen

46010

Novartis Investigative Site, Valencia

47014

Novartis Investigative Site, Meldola

48109

University of Michigan Comprehensive Cancer Center Onc Dept, Ann Arbor

48903

Novartis Investigative Site, Barakaldo

50006

Novartis Investigative Site, Changhua

53111

Novartis Investigative Site, Bonn

54645

Novartis Investigative Site, Thessaloniki

55100

Novartis Investigative Site, Lucca

59020

Novartis Investigative Site, Lille

59100

Novartis Investigative Site, Prato

Novartis Investigative Site, Kuala Lumpur

60637

University of Chicago SC-3, Chicago

62100

Novartis Investigative Site, Macerata

63069

Novartis Investigative Site, Offenbach

63110

Washington Uni School of Med SC, St Louis

64710

Novartis Investigative Site, Monterrey Nuevo Leon

67000

Novartis Investigative Site, Strasbourg

67100

Novartis Investigative Site, L’Aquila

69373

Novartis Investigative Site, Lyon

73100

Novartis Investigative Site, Lecce

73730

Novartis Investigative Site, Esslingen am Neckar

75015

Novartis Investigative Site, Paris

76038

Novartis Investigative Site, Rouen

76104

The Center for Cancer and Blood Disorders SC, Fort Worth

77030

Methodist Hospita Methodist Can Cen Dept of Oncology, Houston

Uni of TX MD Anderson Cancer Cntr SC-5, Houston

78229

Mays Cancer Ctr Uthsa Mdacc SC-4, San Antonio

78234

Brooke Army Medical Center SC, San Antonio

80131

Novartis Investigative Site, Napoli

80218

Comprehensive Cancer Center at Saint Joseph Hospital SC, Denver

81100

Novartis Investigative Site, Johor Bahru

81377

Novartis Investigative Site, München

82100

Novartis Investigative Site, Benevento

83301

Novartis Investigative Site, Kaohsiung City

87106

University of New Mexico Hospital SC-2, Albuquerque

88214

Novartis Investigative Site, Ravensburg

89081

Novartis Investigative Site, Ulm

90095

University Of California Los Angeles Dept of Onc, Los Angeles

91054

Novartis Investigative Site, Erlangen

93309

Comprehensive Blood and Cancer SC-2, Bakersfield

95124

Novartis Investigative Site, Catania

96817

Moanalua Medical Center. Attn: Oncology Dept SC, Honolulu

98201

Providence Regional Cancer Partnership, Everett

98405

Northwest Medical Specialties Dept of Onc, Tacoma

99336

Kadlec Clinic Hematology and Onco Kadlec Clinic Hematology & Onc, Kennewick

99974

Novartis Investigative Site, Mühlhausen

103616

Novartis Investigative Site, Taipei

110221

Novartis Investigative Site, Bogotá

119228

Novartis Investigative Site, Singapore

163045

Novartis Investigative Site, Arkhangelsk

166378

Novartis Investigative Site, Beirut

166830

Novartis Investigative Site, El Achrafiyé

168583

Novartis Investigative Site, Singapore

192148

Novartis Investigative Site, Saint Petersburg

230004

Novartis Investigative Site, Montería

1503201002

Novartis Investigative Site, El Chouf

06810

Danbury Hospital SC, Danbury

02114

Massachusetts General Hospital Onc Dept, Boston

07754

Meridian Health Systems SC, Neptune City

84403-3105

Northern Utah Cancer Associates, Ogden

53792-6164

University of Wisconsin / Paul P. Carbone Comp Cancer Center Univ Wisc 3, Madison

X5004FHP

Novartis Investigative Site, Córdoba

86015-520

Novartis Investigative Site, Londrina

98700-000

Novartis Investigative Site, Ijuí

99010-260

Novartis Investigative Site, Passo Fundo

14784 400

Novartis Investigative Site, Barretos

01317-002

Novartis Investigative Site, São Paulo

01509-900

Novartis Investigative Site, São Paulo

04014-002

Novartis Investigative Site, São Paulo

T6G 1Z2

Novartis Investigative Site, Edmonton

V5Z 4E6

Novartis Investigative Site, Vancouver

K1H 8L6

Novartis Investigative Site, Ottawa

M4N 3M5

Novartis Investigative Site, Toronto

H3G 1L5

Novartis Investigative Site, Montreal

G1S 4L8

Novartis Investigative Site, Québec

01307

Novartis Investigative Site, Dresden

04103

Novartis Investigative Site, Leipzig

711 10

Novartis Investigative Site, Heraklion Crete

Unknown

Novartis Investigative Site, Hong Kong

Novartis Investigative Site, Kowloon

Novartis Investigative Site, Wan Chai

Novartis Investigative Site, Al Ain Abu Dhabi

H 1122

Novartis Investigative Site, Budapest

H-1032

Novartis Investigative Site, Budapest

H-5000

Novartis Investigative Site, Szolnok

560 095

Novartis Investigative Site, Bangalore

422 004

Novartis Investigative Site, Nashik

700 053

Novartis Investigative Site, Kolkata

400 012

Novartis Investigative Site, Mumbai

06129

Novartis Investigative Site, Perugia

00168

Novartis Investigative Site, Roma

05100

Novartis Investigative Site, Terni

1107 2020

Novartis Investigative Site, Beirut

01722

Novartis Investigative Site, Metepec

80 952

Novartis Investigative Site, Gdansk

62 500

Novartis Investigative Site, Konin

1099 023

Novartis Investigative Site, Lisbon

1400-038

Novartis Investigative Site, Lisbon

1500 650

Novartis Investigative Site, Lisbon

4200 319

Novartis Investigative Site, Porto

4200-072

Novartis Investigative Site, Porto

03080

Novartis Investigative Site, Seoul

03722

Novartis Investigative Site, Seoul

05505

Novartis Investigative Site, Seoul

06351

Novartis Investigative Site, Seoul

03203

Novartis Investigative Site, Elche

04009

Novartis Investigative Site, Almería

07198

Novartis Investigative Site, Mallorca

08208

Novartis Investigative Site, Sabadell

08970

Novartis Investigative Site, Sant Joan Despí

08916

Novartis Investigative Site, Badalona

08003

Novartis Investigative Site, Barcelona

08035

Novartis Investigative Site, Barcelona

01160

Novartis Investigative Site, Adana

06100

Novartis Investigative Site, Ankara

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY