Study of RTXM83 Plus CHOP Chemotherapy Versus a Rituximab Plus CHOP Therapy in Patients With Non Hodgkin's Lymphoma

PHASE3CompletedINTERVENTIONAL
Enrollment

272

Participants

Timeline

Start Date

May 31, 2013

Primary Completion Date

May 31, 2016

Study Completion Date

July 31, 2017

Conditions
Diffuse Large B-cell Lymphoma
Interventions
BIOLOGICAL

RTXM83

Rituximab biosimilar (RTXM83) will be administered in combination with CHOP chemotherapy regimen (Cyclophosphamide 750 mg/m2, Doxorubicin 50 mg/m2 and Vincristine 1.4 mg/m2 up to a maximum of 2 mg on Day 1 plus Prednisone 40 mg/m2 or 100 mg per day from Day 1 to 5) at a dose of 375 mg/m2 on Day 1 of each 3 week cycle, for 6 cycles, although the administration of 2 additional cycles may be allowed.

BIOLOGICAL

Mabthera

Mabthera will be administered in combination with CHOP chemotherapy regimen (Cyclophosphamide 750 mg/m2, Doxorubicin 50 mg/m2 and Vincristine 1.4 mg/m2 up to a maximum of 2 mg on Day 1 plus Prednisone 40 mg/m2 or 100 mg per day from Day 1 to 5) at a dose of 375 mg/m2 on Day 1 of each 3 week cycle, for 6 cycles, although the administration of 2 additional cycles may be allowed.

Trial Locations (87)

11200

Mount Miriam Cancer Hospital, Pulau Pinang

59100

University Malaya Medical Centre - UMMC, Kuala Lumpur

Unknown

"Hosp. Interzonal R Carrillo", Ciudadela

Clinica Radiologica del Sur, Cipolletti

Clinica Viedma, Viedma

Hospital Britanico, Buenos Aires

Hospital Gral. de Agudos Donación Francisco Santojanni, Buenos Aires

Instituto Roffo, Buenos Aires

Centro Oncologico Riojano Integral (CORI), Córdoba

Hospital Nacional de Clinicas, Córdoba

Hospital Privado de Cordoba, Córdoba

Sanatorio Allende, Córdoba

Ctr. Oncologico de Rosario, Rosario

Inst. Cardiovascular Rosario, Rosario

Instituto de Hematología y Medicina Clínica Dr. Rubén Dávoli, Rosario

Sanatorio Parque, Rosario

Hospital Angel Padilla, San Miguel de Tucumán

Fundación ARS Médica, San Salvador de Jujuy

Hospital J. B. Iturraspe, Santa Fe

Hospital de Caridade de Ijuí, Ijuí

Hospital da Cidade de Passo Fundo, Passo Fundo

Hospital São Lucas da PUCRS, Porto Alegre

Hospital Clinicas Porto Alegre, Pôrto Alegre

Hospital Santa Marcelina, Itaquera

Hospital Amaral Carvalho Jaú, Jaú

Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo-HCFMRP, Ribeirão Preto

CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia / Faculdade de Medicina do ABC, Santo André

Fundação Antônio Prudente - AC Camargo Câncer Center, São Paulo

Hospital das Clinicas-UFMG, Belo Horizonte

UNICAMP-Univ Zeferino Vaz, Campinas

Hospital Uniao Oeste Paranaense de Estudos e Comabte ao Cancer (UOPECCAN), Cascavel

Hospital Erasto Gaertner CEPEP, Curitiba

Hospital das Clínicas da Universidade Federal de Goiás, Goiânia

Santa Casa de Porto Alegre, Porto Alegre

Hospital Universitário Clemente Fraga Filho - UFRJ, Rio de Janeiro

Instituto COI de Educação e Pesquisa, Rio de Janeiro

Instituto Est. de Hematologia Arthur de Siqueira Cavalcanti, Rio de Janeiro

Monte Tabor - Hospital São Rafael, Salvador

Hospital de Base de São José, São José do Vale do Rio Preto

Centro de Pesquisa do Instituto Brasileiro de Controle do Câncer - IBCC, São Paulo

Hospital Clinica Faculdade Medicina USP, São Paulo

Inst. Nacional de Cancerologia, Bogotá

Hospital Pablo Tobon Uribe, Medellín

Fundación Valle de Lili, Santiago de Cali

Srinivasam Cancer Care Hospital, Bangalore

Cancer Institute, Chennai

Rajiv Gandhi Cancer Institute and Research Centre, Delhi

Bibi General Hospital&Canc Ct, Hyderabad

Birla Cancer Center - SMS Hospital, Jaipur

Health Point Multi-specialty Hospital, Kolkata

Institute of Hematology and Transfusion Medicine, Kolkata

Netaji Subhash Chandra Bose Cancer Research Institute, Kolkata

Acharya Tulsi Regional Cancer Treatment and Research Institute, Madurai

Guru Hospital, Madurai

Meenakshi Mission Hospital, Madurai

Kailash Cancer Hospital and Research Centre, Vadodara

Dr. Hasan Sadikin Hospital, Bandung

Dharmais N. C. Center, Jakarta

Imam Khomeini Complex Hospital - Cancer Institute, Tehrān

Hospital Sultanah Aminah, Johor Bahru

Hospital Pulau Pinang, Pulau Pinang

Insituto Nacional de Cancerología, Mexico City

Instituto Privado de Hematologia e Investigaciona Clinica, Asunción

Cebu Doctors University Hospital, Cebu

Perpetual Succour Hospital, Cebu

Davao Doctors Hospital, Davao City

National Kidney and Transplant Institute, Quezon City

Veterans Memorial Medical Center, Quezon City

Arkhangelsk Clinical Oncology Dispensary, Arkhangelsk

Kursk regional clinical oncology dispensary, Kursk

N.N. Blokhin Russian Cancer Research Cente, Moscow

National Medical Surgical Center n.a. N.I. Pirogov, Moscow

Murmansk regional oncology dispensary, Murmansk

"State Budgetary Healthcare Institution of Stavropol region Pyatigorsk oncology center", Pyatigorsk

Rostov Scientific Research Oncology Institute, Rostov-on-Don

Russian Research Center for Radiology and Surgical Technologies, Saint Petersburg

"Saint-Petersburg State Budgetary Institution City Clinical Oncology Dispensary", Saint Petersburg

Scientific Research Institute of Oncology n.a. N.N. Petrov, Saint Petersburg

Oncology Center # 2, Sochi

Komi Republican Oncology Dispensary, Syktyvkar

"State Healthcare Institution of Tula region Tula regional clinical hospital", Tula

Republican Clinical Oncology Dispensary, Ufa

Volgograd Regional Clinical Oncology Center, Volgograd

Tygerberg Academic Hosp, Cape Town

Rainbow Oncology Centre, eManzimtoti

GVI Oncology, Port Elizabeth

Chris Hani Baragwanath Hospital, Soweto

All Listed Sponsors
collaborator

Pisa® Farmacéutica

UNKNOWN

collaborator

Laboratorios de Productos Éticos C.E.I.S.A.

UNKNOWN

collaborator

Laboratorio Elea Phoenix S.A.

INDUSTRY

collaborator

Tecnoquimicas S.A

UNKNOWN

collaborator

Innogene Kalbiotech Pte. Ltd

INDUSTRY

collaborator

Libbs Farmacêutica LTDA

INDUSTRY

collaborator

Key Oncologics (Pty) Ltd

UNKNOWN

collaborator

Nanolek LLC

OTHER

collaborator

Actoverco

OTHER

lead

mAbxience Research S.L.

INDUSTRY