Study Comparing Veliparib Plus Carboplatin and Paclitaxel Versus Investigator's Choice of Standard Chemotherapy in Adults Receiving First Cytotoxic Chemotherapy for Metastatic or Advanced Non-Squamous Non-Small Cell Lung Cancer (NSCLC) and Who Are Current or Former Smokers

PHASE3CompletedINTERVENTIONAL
Enrollment

595

Participants

Timeline

Start Date

September 30, 2014

Primary Completion Date

November 14, 2019

Study Completion Date

February 21, 2020

Conditions
Non-squamous Non-small Cell Lung Cancer
Interventions
DRUG

Paclitaxel

Administered by Intravenous infusion on Day 1 of each 21-day cycle

DRUG

Carboplatin

Administered by Intravenous infusion on Day 1 of each 21-day cycle

DRUG

Cisplatin

Administered by Intravenous infusion on Day 1 of each 21-day cycle

DRUG

Veliparib

Oral capsule, administered twice daily for 7 days in each 21-day cycle

DRUG

Pemetrexed

Administered by Intravenous infusion on Day 1 of each 21-day cycle

Trial Locations (140)

622

Dalin Tzu Chi General Hospital /ID# 131872, Dalin Township

1122

Orszagos Koranyi Pulmonologiai Intezet /ID# 132738, Budapest XII

1884

Coiba /Id# 132153, Berazategui, Buenos Aires

2000

Hospital Britanico /ID# 134874, Rosario, Santa FE

Instituto de Oncologia de Rosa /ID# 132150, Rosario, Santa FE

2196

Sandton Oncology Medical Group /ID# 131774, Johannesburg

2217

St George Hospital /ID# 132481, Kogarah

2500

Southern Medical Day Care Ctr /ID# 132482, Wollongong

2700

Centro Investigacion Pergamino /ID# 132152, Pergamino

3233

Matrahaza Gyogyintezet /ID# 132743, Kékesteto

3529

CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 133441, Miskolc

3780

Koch Robert Hospital /ID# 133440, Edelény

4032

Debreceni Egyetem Klinikai Kozpont /ID# 132742, Debrecen

4091

The Oncology Centre /ID# 131773, Durban

5000

Odense Universitets Hospital /ID# 131912, Odense C

5042

Flinders Centre for Innovation /ID# 134288, Bedford Park

6006

GVI Oncology /ID# 133268, Port Elizabeth

6021

Wellington Hospital (Capital and Coast District Health Board) /ID# 132470, Wellington

7000

Royal Hobart Hospital /ID# 132477, Hobart

7460

Netcare Oncology Intervent Ctr /ID# 131777, Cape Town

7570

Cape Town Oncology Trials /ID# 132734, Cape Town

7700

GVI Rondebosch Oncology Centre /ID# 132732, Cape Town

8011

Canterbury District Health Boa /ID# 132469, Christchurch

8582

Veszprem Megyei Tudogyogyintez /ID# 132739, Farkasgyepű

9023

Petz Aladar Megyei Oktato Korh /ID# 132741, Győr

11031

Taipei Medical University Hospital /ID# 133817, Taipei

11217

Taipei Veterans General Hosp /ID# 131871, Taipei

12203

Charite-Univ. Berlin, Benjamin-Franklin /ID# 131927, Berlin

13620

Seoul National Univ Bundang ho /ID# 131610, Seongnam

15212

Allegheny General Hospital /ID# 134049, Pittsburgh

16059

Uludag University Medical Faculty /ID# 131915, Bursa

19141

Albert Einstein Medical Center /ID# 134498, Philadelphia

20246

Univ Klinik Eppendorf Hamburg /ID# 131926, Hamburg

21200

Dicle Universitesi Tip /ID# 136570, Diyarbakır

22332

Inha University Hospital /ID# 147924, Junggu

22927

Lungen Clinic Grosshansdorf /ID# 131928, Großhansdorf

27310

Gaziantep Universitesi Med /ID# 131917, Gaziantep

28033

MD Anderson Madrid /ID# 132905, Madrid

28046

Hospital Universitario La Paz /ID# 132870, Madrid

28050

Hospital Universitario HM Sanchinarro /ID# 132869, Madrid

28500

Satakunnan Sairaanhoitopiiri /ID# 133632, Pori

28644

Chungbuk National Univ Hosp /ID# 131611, Cheongju-si

28922

Hospital Universitario Fundacion Alcorcon /ID# 132909, Alcorcón

32610

University of Florida - Archer /ID# 132408, Gainesville

35110

Dr. Suat Seren Gogus Has /ID# 136568, Izmir

35805

Clearview Cancer Institute /ID# 131434, Huntsville

36617

University of South Alabama /ID# 131518, Mobile

38138

The Jones Clinic, PC /ID# 130215, Germantown

40202

University of Louisville /ID# 130217, Louisville

40447

China Medical University Hosp /ID# 131870, Taichung

44280

Inonu University /ID# 136569, Malatya

44718

Gabrail Cancer Center Research /ID# 130205, Canton

46010

Hospital Clinico Universitario de Valencia /ID# 132873, Valencia

46526

Goshen Center for Cancer Care /ID# 130216, Goshen

48202

Henry Ford Health System /ID# 130234, Detroit

48912

Herbert Herman Cancer Center /ID# 130239, Lansing

49201

Dong-A University Hospital /ID# 131609, Busan

60201

NorthShore University HealthSystem - Evanston Hospital /ID# 130200, Evanston

61469

Chonnam National University Hospital /ID# 131612, Gwangju

63110

Washington University-School of Medicine /ID# 131651, St Louis

65130

Vaasa Central Hospital /ID# 131930, Vaasa

70300

Assaf Harofeh Medical Center /ID# 132830, Be’er Ya‘aqov

70503

Cancer Center of Acadiana /ID# 133611, Lafayette

72762

Highlands Oncology Group /ID# 131250, Springdale

73104

Univ Oklahoma HSC /ID# 132888, Oklahoma City

74245

Klinik Loewenstein GmbH /ID# 131925, Löwenstein

78229

Univ Texas HSC San Antonio /ID# 132972, San Antonio

90017

LA Hem-Oncology Med Group /ID# 131639, Los Angeles

90603

Icri /Id# 132942, Whittier

91031

Shaare Zedek Medical Center /ID# 132834, Jerusalem

92024

California Cancer Assoc. R&E /ID# 131392, Encinitas

California Cancer Assoc. R&E /ID# 131949, Encinitas

93309

CBCC Global Research, Inc. at /ID# 132709, Bakersfield

95403

St Jude Hospital dba St Joseph /ID# 132943, Santa Rosa

115478

Federal State Budgetary Scientific Institution N.N. Blokhin Russian Cancer Resea /ID# 137085, Moscow

125284

Moscow Res Onc Inst Hertsen /ID# 132370, Moscow

143900

Moscow Regional Onc Dispensary /ID# 132381, Balashikha

163045

archangel Clinical Oncology /ID# 132376, Arkhangelsk

183047

"State Regional Budgetary Healthcare Institution Murmansk Regional Oncology Dis /ID# 137087", Murmansk

192148

Strategic medical systems LLC /ID# 206383, Saint Petersburg

197342

LLC BioEq Ltd. /ID# 132372, Saint Petersburg

197758

N.N. Petrov Research Inst Onc /ID# 137084, Saint Petersburg

308010

Belgorod Oncology Dispensary /ID# 142638, Belgorod

430005

Ogarev Mordovia State Univ /ID# 132377, Saransk

460021

Orenburg Regional Clinical Onc /ID# 132371, Orenburg

620043

Sverdlovsk Regional Oncology Center Dispensary /ID# 132375, Yekaterinburg

4428164

Meir Medical Center /ID# 132832, Kfar Saba

5239424

Sheba Medical Center /ID# 132833, Ramat Gan

08103

MD Anderson Cancer Center at Cooper - Camden /ID# 131490, Camden

75390-7208

UT Southwestern Medical Center /ID# 130236, Dallas

B3H 1V7

Qe Ii Hsc /Id# 133408, Halifax

N6A 4L6

Victoria Hospital /ID# 132161, London

N9C 3Z4

Windsor Regional Hospital /ID# 135989, Windsor

G6V 3Z1

CSSS Alphonse-Desjardins, CHAU de Levis /ID# 132155, Québec

602 00

Krajska nemocnice Liberec a.s. /ID# 132694, Liberec

708 52

Univ Hosp Ostrava-Poruba /ID# 132690, Ostrava

532 03

Multiscan s.r.o. /ID# 132689, Pardubice

128 08

Vseobecna Fakultni Nemocnice /ID# 135118, Prague

464-8681

Aichi Cancer Center Hospital /ID# 134129, Nagoya

830-0011

Kurume University Hospital /ID# 134117, Kurume-shi

060-8648

Hokkaido University Hospital /ID# 134123, Sapporo

236-0051

Kanagawa Cardiovascular and Respiratory Center /ID# 134127, Yokohama

980-0873

Sendai Kousei Hospital /ID# 135491, Sendai

534-0021

Osaka City General Hospital /ID# 134115, Osaka

589-8511

Kindai University Hospital /ID# 134112, Osaka-sayama-shi

104-0045

National Cancer Center Hospital /ID# 135129, Chuo-ku

135-8550

The Cancer Institute Hospital Of JFCR /ID# 135492, Koto-ku

755-0241

Yamaguchi - Ube Medical Center /ID# 135284, Ube-shi

730-8518

Hiroshima Citizens Hospital /ID# 135130, Hiroshima

596-8501

Kishiwada City Hospital /ID# 136548, Kishiwada

5223 GZ

Jeroen Bosch Ziekenhuis /ID# 131968, 's-Hertogenbosch

1081 HV

Vrije Universiteit Medisch Centrum /ID# 131967, Amsterdam

5623 EJ

Catharina Ziekenhuis /ID# 131966, Eindhoven

3844 DG

Ziekenhuis St. Jansdal /ID# 131965, Harderwijk

3435 CM

St. Antonius Ziekenhuis /ID# 133635, Nieuwegein

0044

Dr Albert, Bouwer and Jordaan Incorporated /ID# 131775, Pretoria

0181

Mary Potter Oncology Centre /ID# 131776, Pretoria

06351

Samsung Medical Center /ID# 132471, Seoul

08907

Hospital Duran i Reynals /ID# 132879, L'Hospitalet de Llobregat

03010

Hospital General Universitario Alicante /ID# 132881, Alicante

08028

Hospital Universitario Dexeus - Grupo Quironsalud /ID# 132876, Barcelona

08035

Hospital Universitario Vall d'Hebron /ID# 132871, Barcelona

06100

Hacettepe University Medical Faculty /ID# 131913, Ankara

06590

Ankara Univ Medical Faculty /ID# 131914, Ankara

LE1 5WW

Leicester Royal Infirmary /ID# 133930, Leicester

GL53 7AN

Cheltenham General Hospital /ID# 131951, Cheltenham

NR4 7UY

Norfolk and Norwich Univ Hosp /ID# 131953, Norwich

BA1 3NG

Royal United Hospitals Bath /ID# 132851, Bath

BT9 7AB

Belfast City Hospital /ID# 132858, Belfast

B9 5SS

Heart of England NHS Foundation Trust /ID# 132855, Birmingham

BB2 3HH

Royal Blackburn Hospital /ID# 132853, Blackburn

CO4 5JL

Colchester General Hospital /ID# 133929, Colchester

HU16 5JQ

Castle Hill Hospital /ID# 135489, Cottingham

DN15 7BH

Scunthorpe General Hospital /ID# 133931, Doncaster

NR31 6LA

James Paget University Hosp /ID# 131954, Great Yarmouth

NP20 2UB

Royal Gwent Hospital /ID# 133935, Gwent

HD3 3EA

Huddersfield Royal Infirmary /ID# 132854, Huddersfield

W6 8RF

Charing Cross Hospital /ID# 131959, London

NE7 7DN

The Newcastle Upon Tyne Hospitals NHS Foundation Trust Freeman Hospital /ID# 131661, Newcastle upon Tyne

YO31 8HE

York Hospital /ID# 132859, York

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