Incomplete Response in Late-Life Depression: Getting to Remission With Buprenorphine

slow titration to a maximum of 300 mg per day. will remain on venlafaxine XR for upto 32 weeks.

randomized to either buprenorphine or placebo, dose range from 0.2 mg qd/ to 1.2 mg qd

patients will remain on venlafaxine XR and be randomzied to receive either placebo or buprenorphine for 8 weeks. at the end of 8 weeks those who did not receive buprenorphine will be given an opportunity to try it.