Reduced-Dose Intensity-Modulated Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Oropharyngeal Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

316

Participants

Timeline

Start Date

October 31, 2014

Primary Completion Date

June 10, 2019

Study Completion Date

September 4, 2025

Conditions
Stage III Oropharyngeal Squamous Cell CarcinomaStage IVA Oropharyngeal Squamous Cell CarcinomaStage IVB Oropharyngeal Squamous Cell CarcinomaStage IVC Oropharyngeal Squamous Cell CarcinomaTongue Carcinoma
Interventions
DRUG

Cisplatin

40 mg/m2 IV (intravenously) weekly for 6 weeks

RADIATION

IMRT 6 weeks

Intensity-modulated radiation therapy (IMRT), 30 fractions over 6 weeks, 5 fractions per week, 2 Gray per fraction to total dose of 60 Gy

RADIATION

IMRT 5 weeks

Intensity-modulated radiation therapy (IMRT), 30 fractions over 5 weeks, 6 fractions per week, 2 Gray per fraction to total dose of 60 Gy

Trial Locations (222)

6

Saint Lukes Hospital, Dublin

10065

Memorial Sloan Kettering Cancer Center, New York

10601

Dickstein Cancer Treatment Center, White Plains

10604

Memorial Sloan Kettering Westchester, Harrison

11211

King Faisal Specialist Hospital and Research Centre, Riyadh

11553

Memorial Sloan Kettering Nassau, Uniondale

11725

Memorial Sloan Kettering Commack, Commack

15009

UPMC-Heritage Valley Health System Beaver, Beaver

15108

UPMC Hillman Cancer Center in Coraopolis, Moon Township

15132

UPMC Cancer Center at UPMC McKeesport, McKeesport

15215

UPMC-Saint Margaret, Pittsburgh

15232

UPMC-Shadyside Hospital, Pittsburgh

15237

UPMC-Passavant Hospital, Pittsburgh

15301

UPMC Washington Hospital Radiation Oncology, Washington

15401

UPMC Uniontown Hospital Radiation Oncology, Uniontown

15601

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

15901

UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown

16346

UPMC Cancer Center at UPMC Northwest, Seneca

19001

Jefferson Abington Hospital, Abington

19111

Fox Chase Cancer Center, Philadelphia

19611

Reading Hospital, West Reading

19718

Christiana Care Health System-Christiana Hospital, Newark

19971

Beebe Health Campus, Rehoboth Beach

21204

Greater Baltimore Medical Center, Baltimore

22908

University of Virginia Cancer Center, Charlottesville

23298

Virginia Commonwealth University/Massey Cancer Center, Richmond

28401

Novant Health Cancer Institute Radiation Oncology - Wilmington, Wilmington

28462

Novant Cancer Institute Radiation Oncology - Supply, Supply

28501

ECU Health Oncology Kinston, Kinston

28801

Mission Hospital, Asheville

29303

Spartanburg Medical Center, Spartanburg

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29425

Medical University of South Carolina, Charleston

29605

Prisma Health Cancer Institute - Faris, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29650

Prisma Health Cancer Institute - Greer, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

30303

Grady Health System, Atlanta

30308

Emory University Hospital Midtown, Atlanta

30309

Piedmont Hospital, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

Emory Saint Joseph's Hospital, Atlanta

31405

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah

33021

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood

33028

Memorial Hospital West, Pembroke Pines

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33176

Miami Cancer Institute, Miami

33331

Cleveland Clinic-Weston, Weston

33612

Moffitt Cancer Center, Tampa

35233

University of Alabama at Birmingham Cancer Center, Birmingham

37909

Tennessee Cancer Specialists-Dowell Springs, Knoxville

40202

The James Graham Brown Cancer Center at University of Louisville, Louisville

40245

UofL Health Medical Center Northeast, Louisville

43210

Ohio State University Comprehensive Cancer Center, Columbus

43560

ProMedica Flower Hospital, Sylvania

44024

Geauga Hospital, Chardon

44035

Mercy Cancer Center-Elyria, Elyria

44060

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

Case Western Reserve University, Cleveland

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44122

UHHS-Chagrin Highlands Medical Center, Beachwood

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

44129

University Hospitals Parma Medical Center, Parma

44130

UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights

44131

Cleveland Clinic Cancer Center Independence, Independence

44136

Cleveland Clinic Cancer Center Strongsville, Strongsville

44145

UHHS-Westlake Medical Center, Westlake

44195

Cleveland Clinic Foundation, Cleveland

44691

Cleveland Clinic Wooster Family Health and Surgery Center, Wooster

44870

North Coast Cancer Care, Sandusky

UH Seidman Cancer Center at Firelands Regional Medical Center, Sandusky

45069

University of Cincinnati Cancer Center-West Chester, West Chester

45219

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

46601

Memorial Hospital of South Bend, South Bend

46804

Radiation Oncology Associates PC, Fort Wayne

46805

Parkview Hospital Randallia, Fort Wayne

48038

Henry Ford Macomb Hospital-Clinton Township, Clinton Township

48106

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48154

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48183

Henry Ford Cancer Institute-Downriver, Brownstown

48202

Henry Ford Hospital, Detroit

48322

Henry Ford West Bloomfield Hospital, West Bloomfield

49085

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph

49444

Trinity Health Muskegon Hospital, Muskegon

49503

Trinity Health Grand Rapids Hospital, Grand Rapids

53038

University of Wisconsin Carbone Cancer Center - Johnson Creek, Johnson Creek

53051

Froedtert Menomonee Falls Hospital, Menomonee Falls

53081

HSHS Saint Nicholas Hospital, Sheboygan

53095

Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend

53226

Medical College of Wisconsin, Milwaukee

53405

Ascension All Saints Hospital, Racine

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54301

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54494

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids

54601

Gundersen Lutheran Medical Center, La Crosse

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55379

Saint Francis Regional Medical Center, Shakopee

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55433

Mercy Hospital, Coon Rapids

56303

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

59804

Community Medical Center, Missoula

60026

NorthShore University HealthSystem-Glenbrook Hospital, Glenview

60035

NorthShore University HealthSystem-Highland Park Hospital, Highland Park

60153

Loyola University Medical Center, Maywood

60201

NorthShore University HealthSystem-Evanston Hospital, Evanston

60611

Northwestern University, Chicago

60612

John H Stroger Jr Hospital of Cook County, Chicago

62526

Decatur Memorial Hospital, Decatur

63110

Washington University School of Medicine, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

Mercy Hospital Saint Louis, St Louis

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

64064

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64116

North Kansas City Hospital, Kansas City

64131

The University of Kansas Cancer Center-South, Kansas City

64154

University of Kansas Cancer Center - North, Kansas City

65401

Delbert Day Cancer Institute at PCRMC, Rolla

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66044

Lawrence Memorial Hospital, Lawrence

66061

Olathe Health Cancer Center, Olathe

66160

University of Kansas Cancer Center, Kansas City

66210

University of Kansas Cancer Center-Overland Park, Overland Park

67214

Ascension Via Christi Hospitals Wichita, Wichita

68114

Nebraska Methodist Hospital, Omaha

68124

Alegent Health Bergan Mercy Medical Center, Omaha

68130

Alegent Health Lakeside Hospital, Omaha

68198

University of Nebraska Medical Center, Omaha

68803

Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island

73104

University of Oklahoma Health Sciences Center, Oklahoma City

73120

Mercy Hospital Oklahoma City, Oklahoma City

77030

M D Anderson Cancer Center, Houston

77079

MD Anderson West Houston, Houston

77384

MD Anderson in The Woodlands, Conroe

77573

MD Anderson League City, League City

UTMB Cancer Center at Victory Lakes, League City

80045

UCHealth University of Colorado Hospital, Aurora

80113

Swedish Medical Center, Englewood

80138

Parker Adventist Hospital, Parker

80304

Rocky Mountain Cancer Centers-Boulder, Boulder

80524

Poudre Valley Hospital, Fort Collins

80631

Banner North Colorado Medical Center, Greeley

80907

Penrose-Saint Francis Healthcare, Colorado Springs

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

84106

Utah Cancer Specialists-Salt Lake City, Salt Lake City

84107

Intermountain Medical Center, Murray

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

84403

McKay-Dee Hospital Center, Ogden

85234

Banner MD Anderson Cancer Center, Gilbert

85719

Banner University Medical Center - Tucson, Tucson

87106

University of New Mexico Cancer Center, Albuquerque

89106

Radiation Oncology Centers of Nevada Central, Las Vegas

89502

Renown Regional Medical Center, Reno

89503

Saint Mary's Regional Medical Center, Reno

90027

Kaiser Permanente Los Angeles Medical Center, Los Angeles

91010

City of Hope Comprehensive Cancer Center, Duarte

91030

City of Hope South Pasadena, South Pasadena

92093

UC San Diego Moores Cancer Center, La Jolla

92134

Naval Medical Center -San Diego, San Diego

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

94010

Mills-Peninsula Medical Center, Burlingame

94080

Kaiser Permanente Cancer Treatment Center, South San Francisco

94086

Palo Alto Medical Foundation-Sunnyvale, Sunnyvale

94115

UCSF Medical Center-Mount Zion, San Francisco

94301

Palo Alto Medical Foundation Health Care, Palo Alto

94304

Stanford Cancer Institute Palo Alto, Palo Alto

94574

Saint Helena Hospital, St. Helena

94598

John Muir Medical Center-Walnut Creek, Walnut Creek

94611

Kaiser Permanente Oakland-Broadway, Oakland

94704

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

94904

Marin General Hospital, Greenbrae

94928

Rohnert Park Cancer Center, Rohnert Park

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95124

Stanford Cancer Center South Bay, San Jose

95355

Memorial Medical Center, Modesto

95661

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville

95670

Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova

95678

The Permanente Medical Group-Roseville Radiation Oncology, Roseville

95682

Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park

95816

Sutter Medical Center Sacramento, Sacramento

95817

University of California Davis Comprehensive Cancer Center, Sacramento

95823

South Sacramento Cancer Center, Sacramento

96161

Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee

96813

Queen's Medical Center, Honolulu

96817

The Cancer Center of Hawaii-Liliha, Honolulu

97030

Legacy Mount Hood Medical Center, Gresham

97405

Tacoma/Valley Radiation Oncology Centers-Jackson Hall, Tacoma

98101

Virginia Mason Medical Center, Seattle

98332

Tacoma/Valley Radiation Oncology Centers-Gig Harbor, Gig Harbor

98405

MultiCare Tacoma General Hospital, Tacoma

Tacoma/Valley Radiation Oncology Centers-Saint Joe's, Tacoma

98686

Legacy Salmon Creek Hospital, Vancouver

06520

Yale University, New Haven

02118

Boston Medical Center, Boston

01805

Lahey Hospital and Medical Center, Burlington

03820

Wentworth-Douglass Hospital, Dover

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

07039

Saint Barnabas Medical Center, Livingston

08060

Virtua Memorial, Mount Holly

08043

Virtua Voorhees, Voorhees Township

17033-0850

Penn State Milton S Hershey Medical Center, Hershey

77555-0565

University of Texas Medical Branch, Galveston

05819

Dartmouth Cancer Center - North, Saint Johnsbury

T2N 4N2

Tom Baker Cancer Centre, Calgary

T6G 1Z2

Cross Cancer Institute, Edmonton

V8R 6V5

BCCA-Vancouver Island Cancer Centre, Victoria

L8V 5C2

Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton

K7L 2V7

Kingston Health Sciences Centre, Kingston

M4N 3M5

Odette Cancer Centre- Sunnybrook Health Sciences Centre, Toronto

M5G 2M9

University Health Network-Princess Margaret Hospital, Toronto

N8W 2X3

Windsor Regional Cancer Centre, Windsor

H2L 4M1

CHUM - Hopital Notre-Dame, Montreal

H2W 1S6

McGill University Department of Oncology, Montreal

H3T 1E2

Jewish General Hospital, Montreal

S4T 7T1

Allan Blair Cancer Centre, Regina

S7N 4H4

Saskatoon Cancer Centre, Saskatoon

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

NRG Oncology

OTHER

NCT02254278 - Reduced-Dose Intensity-Modulated Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Oropharyngeal Cancer | Biotech Hunter | Biotech Hunter