20
Participants
Start Date
May 31, 2015
Primary Completion Date
August 31, 2016
Study Completion Date
May 31, 2021
Rest (Sitting on chair)
Study participants will sit on a chair for 60min. This is to simulate physical resting condition.
Cycling exercise
Study participants will exercise on a cycle ergometer for 45min. Participants will start their 30-min long constant workload exercise test test 60-min after the drug intervention. The exercise test will be set to a resistance of 50% of the maximal wattage that was reached on the graded exercise test on the screening day. The cycling exercise intervention will follow the rest-intervention.
Salbutamol inhalation
Study participants will be exposed to 400ug of salbutamol prior to entering the air pollution chamber.
Placebo inhalation
Study participants will inhale a placebo (placebo for salbutamol) prior to entering the air pollution chamber
Diesel Exhaust Exposure
Participants will be exposed to PM2.5 of 300 μg/m3
Filtered air
Participants will be breathing filtered air
University of British Columbia, Environmental Physiology Laboratory, Vancouver
Canadian Academy of Sport and Exercise Medicine (CASEM)
UNKNOWN
Natural Sciences and Engineering Research Council, Canada
OTHER
Fraser Basin Council
UNKNOWN
University of British Columbia
OTHER