NCT02246127 - Sequentiality of Everolimus and STZ-5FU in Advanced Pancreatic Neuroendocrine Tumor | Biotech Hunter

Enrollment

141

Participants

Timeline

Start Date

October 27, 2014

Primary Completion Date

November 18, 2020

Study Completion Date

July 12, 2021

Conditions

Neuroendocrine Tumors

Interventions

DRUG

Drug: Everolimus

10mg/daily, oral. Number of Cycles: until progression or unacceptable toxicity develops.

DRUG

STZ-5FU

"0,5g/m2 STZ on days 1-5 and 400mg/m2 5-FU on days 1-5 every 6 weeks (Moertel) or 0,5g/m2 STZ on days 1-5 and 400mg/m2 5-FU on days 1-3, and then 1 day with 1g/m2 and 1 day 400mg/m2 5-FU every 3 weeks (Uppsala).~Number of Cycles: until progression or unacceptable toxicity develops."

Trial Locations (37)

2100

Rigshospitalet NET CoE, University of Copenhagen, Copenhagen

5000

Odense University Hospital, Odense

8000

Aarhus Aarhus University Hospital NET Centre (AUH-NET), Aarhus

20246

Medizinische Klinik und Poliklinik , Universitätsklinikum Hamburg-Eppendorf, Hamburg

29010

HCU Virgen de la Victoria, Málaga

29609

Brest Hopital Augustin Morvan, Institut de Cancero-Hemato, Brest

33006

Hospital Central de Asturias, Oviedo

33075

University Hospital of Bordeaux Hôpital Saint-André, Bordeaux

35033

Marburg Universitätsklinikum Giessen und Marburg GmbH, Marburg

39120

Magdeburg Universitätsklinikum Magdeburg A. ö. R, Magdeburg

41013

Hospital Universitario Virgen del Rocío, Seville

50937

Köln Universitätsklinikum Köln (AöR), Cologne

67098

Hôpitaux Universitaires de Strasbourg Hôpital de Hautepierre, Strasbourg

75185

University Hospital, Uppsala

80131

Istituto Nazionale Tumori (Fondazione G Pascale), Napoli

81377

Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM) at the University of Munich, München

81675

Medizin II am Klinik und Poliklinik rechts der Isar, München

92118

Clichy Neuroendocrine Tumor (NET) Center Hôpital Beaujon, Clichy

99437

Bad Berka ChA Klinik für Innere Medizin, Bad Berka

Unknown

Institut Gustave-Roussy, Villejuif

UTTIOM Unité Transversale de Thérapeutiques Innovantes en Oncologie Médicale CHU Angers, Angers

Hôpital Edouard Herriot, Lyon

Hôpital La Timone, Marseille

Berlin Charité Universitätsmedizin, Berlin

UKM Facharzt für Innere Medizin Gastroenterologie, Onkologische Gastroenterologie (DGVS), Halle

Mainz Universitätsmedizin, Mainz

Istituto Europeo di Oncologia- IRCCS, Milan

UMCG / University of Groningen, Groningen

Maastricht UMC, Maastricht

Hospital Universitario Germans Trias i Pujol, Badalona

Hospital Universitario 12 de Octubre, Madrid

Beatson West of Scotland Cancer Centre, Glasgow

1105AZ

Amsterdam Academic Medical Center, Amsterdam

08908

Instituto Catalán de Oncología de Hospitalet, L'Hospitalet de Llobregat

08025

Hospital de la Santa Creu i Sant Pau, Barcelona

08035

Hospital Universitario Vall d'Hebron, Barcelona

SM2 5PT

The Royal Marsden, Sutton