An Efficacy and Safety Study of Lanabecestat (LY3314814) in Early Alzheimer's Disease

PHASE2/PHASE3TerminatedINTERVENTIONAL
Enrollment

2,218

Participants

Timeline

Start Date

September 30, 2014

Primary Completion Date

October 4, 2018

Study Completion Date

October 4, 2018

Conditions
Alzheimer´s Disease
Interventions
DRUG

Lanabecestat

Administered orally

DRUG

Placebo

Administered orally

Trial Locations (254)

1020

Hopital Universitaire Brugmann Brussel, Brussels

1070

Hospital Universitaire Erasme Brussel, Brussels

1083

Semmelweis Medical University, Budapest

1097

Del-pesti Centrumkorház - Orszagos Hematologiai és Infektologiai Intezet, Budapest

1200

Cliniques Universitaires Saint-Luc, Brussels

2217

Southern Neurology, Kogarah

2650

Universitair Ziekenhuis Antwerpen, Edegem

3000

Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg, Leuven

3052

The Florey Institute of Neuroscience and Mental Health, Parkville

3081

Heidelberg Repatriation Hospital, Heidelberg

3128

Box Hill Hospital, Box Hill

3146

Delmont Private Hospital, Glen Iris

3174

Neuro Trials Victoria Pty Ltd, Noble Park

3500

Jessa Ziekenhuis, Hasselt

4031

Debreceni Egyetem Kenezy Gyula Egyetemi Korhaz, Debrecen

4032

Debreceni Egyetem Klinikai Kozpont, Debrecen

4222

Griffith University, Gold Coast

5000

Royal Adelaide Hospital, Adelaide

6009

Australian Alzheimer's Research Foundation, Nedlands

6725

Univerisity of Szeged, Szeged

7623

PTE KK Pszichiatriai es Pszichoterapias Klinika, Pécs

8800

Heilig Hartziekenhuis, Roeselare

10019

Clinilabs, Inc (New York), New York

10032

Columbia University Medical Center, New York

10126

Azienda Ospedaliera Citta della Salute della Scienza Torino, Torino

10600

Hospital Virgen Del Puerto, Plasencia

11229

Integrative Clinical Trials, LLC, Brooklyn

11235

SPRI Clinical Trials, LLC., Brooklyn

11923

Hanyang University Guri Hospital, Guri-si

12110

Empire Neurology, PC, Latham

12163

Gemeinschaftspraxis Dr. R. Ehret & Dr. W. von Pannwitz, Berlin

12203

Charité Universitätsmedizin Berlin, Berlin

13353

Charité Universitätsmedizin Berlin, Berlin

13385

CHU Hopital de la Timone, Marseille

13620

Seoul National University Bundang Hospital, Seongnam-si

13875

Ospedale Degli Infermi ASR USSL 12, Ponderano

14004

Hospital Reina Sofia, Córdoba

14203

Alzheimer's Disease and Memory Disorders Center, Buffalo

14620

University of Rochester, Rochester

14647

The Catholic University of Korea-Bucheon St. Mary's Hospital, Bucheon-si

16132

Ente Ospedaliero Ospedali Galliera, Genova

18103

Lehigh Valley Hospital, Allentown

20009

Fundacion CITA Alzheimer, Donostia / San Sebastian

20057

Georgetown University Medical Center, Washington D.C.

20122

Fondazione IRCCS Ca'Granda Ospedale Maggiore Policinico, Milan

20900

Azienda Ospedaliera San Gerardo, Monza

21033

CHU Dijonon, Dijon

21565

Gachon University Gil Medical Center, Namdong

22332

Inha University Hospital, Incheon

25125

IRCCS San Giovanni di Dio Fatebenefratelli, Brescia

25411

Centrum Zdrowia Psychicznego, Kielce

26655

Studienzentrum Nord-West, Westerstede

28006

Hospital De La Princesa, Madrid

28034

Hospital Universitario Ramon y Cajal, Madrid

28222

Hospital Puerta De Hierro, Majadahonda

28270

Alzheimer's Memory Center, Charlotte

28905

Hospital Universitario De Getafe, Madrid

29401

Roper St. Francis Healthcare, Charleston

29651

Radiant Research, Greer

30080

Carman Research, Smyrna

30327

The Multiple Sclerosis Center of Atlanta, Atlanta

30331

Atlanta Center of Medical Research, Atlanta

30463

Policlinica CCBR S.R.L., Bucharest

31052

CHU de Toulouse, Toulouse

31059

CHU de Toulouse Hopital Purpan, Toulouse

32162

Compass Research, The Villages

32806

Compass Research, Orlando

33012

Direct Helpers Medical Center, Hialeah

33016

Berma Research, Hialeah

Galiz Research, Hialeah

33018

MaxBlue Institute, Hialeah

33137

Miami Jewish Health Systems, Miami

33144

Medical Research Center, Miami

33155

Allied Biomedical Research Institute, Inc., Miami

33157

IMIC, Inc., Palmetto Bay

33174

Advance Medical Research Institute, Miami

33175

New Horizon Research Center, Miami

33186

JDH Medical Group, LLC, Miami

33351

Infinity Clinical Research, LLC, Sunrise

33407

Premiere Research Institute at Palm Beach Neurology, West Palm Beach

33445

Brain Matters Research, Delray Beach

33449

Alzheimer's Research and Treatment Center, Lake Worth

33613

Stedman Clinical Trials, Tampa

33614

Olympian Clinical Research, Tampa

33713

Suncoast Neuroscience Associates, St. Petersburg

34243

Roskamp Institute, Sarasota

37605

Quillen College of Medicine, East TN State University, Johnson City

39120

Universitätsklinikum Otto-von-Guericke-Universität, Magdeburg

39401

Hattiesburg Clinic, Hattiesburg

41010

Nuovo Ospedale Civile Sant'Agostino Estense, Modena

43204

Hospital Univ Sant Joan de Reus, S.A., Reus

43221

Ohio State University Medical Center, Columbus

44093

Chu de Nantes Hopital Laennec, Nantes

44787

Praxis Dr. Lauter, Bochum

44791

St Josef-Hospital Bochum, Bochum

45219

Christ Hospital, Cincinnati

45459

Valley Medical Primary Care, Centerville

46011

Community Clinical Research Center, Anderson

46017

Hospital Doctor Peset, Valencia

46026

Hospital Universitario La Fe de Valencia, Valencia

46202

Indiana University School of Medicine, Indianapolis

48993

Centro de Atencion Especializada (CAE) OROITU, Getxo

49201

Dong-A University Medical Center, Seogu

50935

Gemeinschaftspraxis für Neurologie Prof. Gereon Nelles, Cologne

50937

Universitätsklinikum Köln, Cologne

53105

Universitätsklinikum Bonn, Bonn

56126

Universita Di Pisa, Pisa

57076

Neurologische Praxis Siegen, Siegen

59037

CHRU Lille - Hopital Roger Salengro, Lille

60007

Alexian Brothers Medical Center, Elk Grove Village

60126

Università Politecnica delle Marche Torrette, Ancona

60637

University of Chicago Medical Center, Chicago

63141

Millennium Psychiatric Associates, LLV, St Louis

St. Louis Clinical Trials, LC, St Louis

66100

Fondazione Universitaria degli Studi G D'Annunzio, Chieti

66421

Universitätsklinikum des Saarlandes, Homburg

69100

Hopital des Charpennes, Villeurbanne

69677

Hopital Neuro Pierre Wertheimer, Bron

72076

Universitätsklinikum Tübingen, Tübingen

75013

Hopital Broca, Paris

Hopital de la Pitie Salpetriere, Paris

75231

Texas Health Physicians Group, Dallas

75475

Hopital Lariboisière, Paris

76104

Medical Group of Texas, Fort Worth

77054

University of Texas Health Services Center - Houston, Houston

78757

Senior Adults Specialty Research Inc, Austin

80218

Mile High Research Center, Denver

80331

Studien und Gedächtniszentrum München, München

81675

Klinikum Rechts der Isar der TU München, München

83209

Neurozentrum Prien, Prien am Chiemsee

84108

University of Utah School of Medicine, Salt Lake City

85006

Banner Alzheimer's Institute, Phoenix

85013

St Josephs Hospital and Medical Center, Phoenix

85351

Banner Sun Health Research Institute, Sun City

85704

Territory Neurology & Research Institute, Tucson

89081

Universitätsklinikum Ulm, Ulm

90015

Fondazione San Raffaele Giglio di Cefalu, Cefalù

90402

Institut fur Psychogerontologie, Nuremberg

90806

Collaborative Neuroscience Network - CNS, Long Beach

92103

Pacific Research Network Inc, San Diego

92216

Medycyna Milorzab, Lodz

92653

Alliance Research Centers, Laguna Hills

Senior Clinical Trials, Inc., Laguna Hills

93173

Institut für Neuropsychiatrie INP3, Wenzenbach

94109

San Francisco Clinical Research Center, San Francisco

94538

Positron Research International, Fremont

97330

The Corvallis Clinic P.C., Corvallis

300166

SC Med Life SA, Timișoara

06510

Institute for Neurodegenerative Disorders, New Haven

01844

ActivMed Practices & Research, Inc, Methuen

02459

Boston Center for Memory, Newton

01104

Springfield Neurology Associates, Springfield

07724

Memory Enhancement Center of America, Inc., Eatontown

08648

AdvanceMed Research, Lawrenceville

08759

Alzheimer's Research Company, Paterson

07081

The Cognitive and Research Center of NJ, Springfield

08755

Advanced Memory Research Institute of New Jersey, Toms River

Bio Behavioral Health, Toms River

07764

Neurology Specialists of Monmouth County, West Long Branch

02914

Rhode Island Mood & Memory Research Institute, East Providence

05201

The Memory Clinic, Bennington

V2C 1K7

The Medical Arts Health Research Group, Kamloops

V1Y 1Z9

Okanagan Clinical Trials, Kelowna

V6T 2B5

University of British Columbia, Vancouver

V8R 158

Royal Jubilee Hospital, Victoria

B3S1M7

True North Clinical Research Halifax, LLC, Halifax

K1N 5C8

Bruyere Continuing Care, Ottawa

K9H2P4

Kawartha Regional Memory Clinic, Peterborough

M3B2S7

Toronto Memory Program, Toronto

M5T2S8

Toronto Western Hospital, Toronto

J1J3H5

CSSS-Institut Universitaire Gériatric de Sherbrooke, Sherbrooke

J8T 8J1

Clinique de la Memoire de l'Outaouais, Gatineau

J4V 2J2

NeuroSearch Developements, Greenfield Park

H1T 2M4

Hopital Maisonneure-Rosemount, Montreal

G1J 1Z4

Hopital de L'Enfant Jesus, Québec

J1J 2G2

Q&T Research Sherbrooke Inc, Sherbrooke

09648

Pharmakologisches Studienzentrum Chemnitz, Mittweida

06097

Martin-Luther-Universität Halle-Wittenberg, Halle

07551

Arztpraxis Dr. Christian Oehlwein, Gera

00168

Policlinico Univ. Agostino Gemelli, Roma

00185

Dip.to Med. Sperimentale -Polic.Umberto I -Univ. La Sapienza, Roma

00186

Ospedale San Giovanni Calibita Fatebenefratelli, Roma

00189

Policlinico Ospedale S. Andrea, Roma

474-0038

National Institute for Longevity Sciences NCGG, Ōbu

260-8712

National Chiba-East-Hospital, Chuo-ku

070-8644

National Hospital Organization Asahikawa Medical Center, Asahikawa

305-8576

Tsukuba University Hospital, Tsukuba

020-8505

Iwate Medical University Hospital, Morioka

247-8533

Shonan Kamakura General Hospital, Kamakura

210-0852

Nihon Kokan Hospital, Kawasaki

236-0004

Yokohama City University Hospital, Yokohama

602-8566

Kyoto Prefectural University of Medicine, Kyoto

607-8113

Rakuwakai Otowarehabilitation Hospital, Kyoto

396-8555

Ina Central Hospital, Ina

399-0021

Matsumoto Medical Center, Matsumoto

701-0192

Katayama Medical Clinic, Kurashiki

901-2102

Shiroma Clinic, Urasoe

567-0011

Koshokai aino hospital, Ibaraki

593-8301

Sakaguchi Clinic, Sakai

560-8552

National Sanatorium Toneyama Hospital, Toyonaka

350-0495

Saitama Medical University Hospital, Iruma-Gun

113-8603

Nippon Medical School Hospital, Bunkyo-Ku

113-8655

The University of Tokyo Hospital, Bunkyo-ku

181-0013

Nozomi Memory Clinic, Mitaka-shi

154-0004

Sangenjaya Nakamura Mental Clinic, Setagaya City

160-0023

Kanauchi Medical Clinic, Shinjuku-ku

162-8666

Tokyo Women's Medical University Hospital, Shinjuku-ku

305 8576

Memory Clinic Ochanomizu, Tsukuba

939-1893

National Sanatorium Hokuriku Hospital, Nanto

814-0180

Fukuoka University Hospital, Fukuoka

606-8507

Kyoto University Hospital, Kyoto

610-0113

Kyoto Minami Hospital, Kyoto

616-8255

Utano Hospital, Kyoto

545-8586

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Osaka

53 139

NZOZ Wroclawskie Centrum Alzheimerowskie, Wroclaw

15-732

Podlaskie Centrum Psychogeriatrii, Bialystok

85-796

NZOZ Dom Sue Ryder - Pallmed Sp. z o.o., Bydgoszcz

40-123

NZOZ Wielospecjalistyczna Poradnia Lekarska, Katowice

40-588

Specjalistyczna Praktyka Lekarska prof. Grzegorz Opala, Katowice

31-505

Centrum Neurologii Klinicznej, Krakow

20-064

NZOZ Neuromed M. I M. Nastaj sp. P., Lublin

20-090

Instytut Medycyny Wsi, Lublin

41-100

NEURO-CARE Sp. z o.o. Sp. Komandytowa, Siemianowice Śląskie

01-697

Centrum Medyczne, Warsaw

02-507

Centralny Szpital Kliniczny MSW, Warsaw

00961

Santa Cruz Behavioral PSC, Bayamón

00918

Instituto de Neurologia Dra. Ivonne Fraga, San Juan

Michel A. Woodbury-Farina, MD., San Juan

00984

Ivonne Z. Jimenez-Velazquez, MD, Carolina

010719

SC Med Life SA, Bucharest

011025

SC Centrul Medical Sana SRL, Bucharest

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

06591

Seoul St. Mary's Hospital, Seoul

03203

Hospital General Universitario de Elche, Elche

08190

Hospital General de Catalunya, Sant Cugat del Vallès

08003

Hospital del Mar, Barcelona

08025

Hospital Santa Creu I Sant Pau, Barcelona

08028

Fundacion ACE-Institut Catala de Neurociences Aplicades, Barcelona

08036

Hospital Clinic de Barcelona, Barcelona

08907

Hospital Universitari de Bellvitge, Barcelona

07010

Hospital Son Espases, Palma de Mallorca

PL6 8BX

Plymouth Hospitals NHS Trust, Plymouth

TN6 1HB

Cognitive Treatment & Research Unit, Crowborough

SO30 3JB

Southern Health NHS, Southampton

FY20JH

MAC UK Neuroscience Ltd, Blackpool

LS10 1DU

MAC Clinical Research, Stourton

WS11 0BN

MAC Clinical Research, Cannock

TW8 8DS

West London Mental Health NHS Trust, Brentford

G20 0XA

Glasgow Memory Clinic, Glasgow

W12 0NN

Hammersmith Hospital, London

W1G 9JF

Guildford Nuffield Hospital, London

W1G 9RU

Re-Cognition Health Ltd, London

M13 9NQ

MAC Clinical Research, Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Eli Lilly and Company

INDUSTRY

lead

AstraZeneca

INDUSTRY