Effects of Tipranavir (With Ritonavir) Capsule and Liquid Formulation on Cytochrome P450 and P-glycoprotein Activity in Healthy Volunteers

PHASE1CompletedINTERVENTIONAL
Enrollment

34

Participants

Timeline

Start Date

January 31, 2006

Primary Completion Date

July 31, 2006

Conditions
Healthy
Interventions
DRUG

Tipranavir capsule

DRUG

Tipranavir solution

DRUG

Ritonavir capsule

DRUG

Caffeine

DRUG

Warfarin sodium

DRUG

Vitamin K

DRUG

Omeprazole

DRUG

Dextromethorphan hydrobromide

DRUG

Midazolam injection

DRUG

Midazolam oral solution

DRUG

Digoxin tablet

DRUG

Digoxin injection

Sponsors
All Listed Sponsors
lead

Boehringer Ingelheim

INDUSTRY