445
Participants
Start Date
December 31, 2014
Primary Completion Date
August 17, 2018
Study Completion Date
August 31, 2025
Chlorambucil
Chlorambucil 0.5 milligrams per kilogram (mg/kg) orally at Day 1 and Day 15 at of each 28 day cycle for 12 cycles.
Venetoclax
Venetoclax, oral tablet: 20 mg daily during Cycle 1, Day 22-28; 50 mg daily during Cycle 2, Day 1-7; 100 mg daily during Cycle 2, Day 8-14; 200 mg daily during Cycle 2, Day 15-21; 400 mg daily during Cycle 2, Day 22-28 and on Day 1-28 for all subsequent cycles until the end of Cycle 12.
Obinutuzumab
Obinutuzumab, IV infusion: 100 mg or 1000 mg, depending on splitting rules, at Cycle 1, Day 1 (if 100 mg was received on Day 1, 900 mg will be administered on Cycle 1, Day 2); 1000 mg at Cycle 1, Day 8 and Day 15; 1000 mg at Day 1 for all subsequent cycles until the end of Cycle 6
Medizinische Universität Wien, Vienna
Hanusch-Krankenhaus, Vienna
"University Multiprofile Hospital For Active Treatment Sveti Ivan Rilski EAD", Sofia
Liverpool Hospital, Liverpool BC
Rigshospitalet, København Ø
Tweed Hospital, Tweed Heads
Herlev Hospital, Herlev
MHAT Hristo Botev, Vratsa
Inselspital Bern, Bern
The Northern Hospital, Epping
Box Hill Hospital, Box Hill
Monash Medical Centre, Melbourne
Sjaellands Universitetshospital, Roskilde, Roskilde
"UMHAT Sveti Georgi Plovdiv - Clinic of Oncology and Hematology", Plovdiv
University Hospital Sv.Georgi Clnic of Hematology, Plovdiv
Princess Alexandra Hospital Woolloongabba, Woolloongabba
Midcentral District Health Board, Palmerston North
The Townsville Hospital, Douglas
Royal Adelaide Hospital, Adelaide
Ashford Cancer Centre Research, Ashford
Samodzielny Publiczny Szpital Kliniczny Nr 1 we Wroc?awiu, Wroclaw
UMHAT Dr Georgi Stranski, Pleven
Luzerner Kantonsspital, Hämatologie, Lucerne
Wellington Hospital, Wellington
Tiroler Landeskrankenanstalten Ges.M.B.H., Innsbruck
Sygehus Lillebælt, Vejle, Vejle
Canterbury Health Laboratories, Christchurch
Universitätsspital Zürich Medizin Hämatologie, Zurich
Wojewódzki Szpital Specjalistyczny im. Miko?aja Kopernika, Lodz
University Hospital Center Zagreb, Zagreb
University Hospital Merkur Clinic for Internal Medicine/ Hematology, Zagreb
AOU Città della Salute e della Scienza di Torino - Presidio Le Molinette, Torino
Charite - Campus Virchow-Klinikum, Berlin
Charite - Universitätsmedizin Berlin, Berlin
North Estonia medical Centre, Tallinn
Institut d'Hématologie de Basse Normandie, Caen
Klinikum Frankfurt/Oder, Frankfurt (Oder)
Ospedale San Raffaele, Milan
Hospital Universitario de la Princesa, Madrid
Hospital Universitario Ramón y Cajal, Madrid
Hospital Univ. 12 de Octubre, Madrid
Hospital Universitario La Paz, Madrid
Ospedale dell' Angelo, Venezia Mestre
Winship Cancer Institute, Atlanta
Complejo Hospitalario de Navarra, Pamplona
Brüderkrankenhaus St. Josef Paderborn, Paderborn
Hôpital Saint Eloi, Montpellier
CHU de Grenoble, Grenoble
Hospital Universitario de Canarias, San Cristóbal de La Laguna
Hospital Universitario Virgen del Rocio, Seville
Kliniken Maria Hilf GmbH Innere Medizin I, Mönchengladbach
Hopital Hotel Dieu Et Hme, Nantes
Arcispedale S. Anna, Ferrara
Stiftung Kathol. Krankenhaus Marienhospital Herne Klinik Mitte, Herne
Complejo Hospitalario de Toledo- H. Virgen de la Salud, Toledo
Universitätsklinikum Essen, Essen
Hospital Clinico Universitario de Valencia, Valencia
Universitätsklinikum Köln, Cologne
Tartu Uni Hospital, Tartu
Uniklinik RWTH Aachen, Aachen
Praxisklinik für Hämatologie und Onkologie Koblenz, Koblenz
Ingalls Memorial Hospital, Harvey
Universitaetsklinikum Heidelberg, Heidelberg
Centre Leon Berard, Lyon
Marienhospital, Stuttgart
Robert-Bosch-Krankenhaus, Stuttgart
Centre Jean Bernard, Le Mans
Universitätsklinikum Tübingen, Tübingen
Klinikum Schwäbisch Gmünd, Mutlangen
Klinik Esslingen, Esslingen am Neckar
Hopital Saint Louis, Paris
Centre Henri Becquerel, Rouen
Uniklinikum Freiburg, Freiburg im Breisgau
Hospital General de Culiacan, Culiacán
München Klinik Schwabing, München
CH de Toulon Hôpital Sainte Musse, Toulon
Klinikum der Universität München, Campus Großhadern, München
Banner MD Anderson Cancer Center, Gilbert
Universtitätsklinikum Ulm, Ulm
Krankenhaus Barmherzige Bruder Regensburg, Regensburg
Hopital Henri Mondor, Créteil
Institut Gustave Roussy - Hematologie, Villejuif
Republican Clinical Oncologic Dispensary of Republic Of Tatarstan, Kazan'
Penza Regional Oncology Dispensary, Penza
Spitalul Clinic Judetean de Urgenta Targu-Mures, Târgu Mureş
Regional Clinical Hospital N.A. Semashko, Nizhny Novgorod
Institutul Regional de Oncologie Iasi, Iași
Moffitt Cancer Center, Tampa
Henry Ford Hospital, Detroit
Hospital Italiano, Buenos Aires
Hospital das Clinicas - UFRGS, Porto Alegre
Instituto de Ensino e Pesquisa Sao Lucas - IEP, São Paulo
Hospital das Clinicas - FMUSP, São Paulo
Arthur J.E. Child Comprehensive Cancer Center, Calgary
Queen Elizabeth II Health Sciences Centre, Halifax
Jewish General Hospital, Montreal
BAG Freiberg-Richter, Jacobasch, Illmer, Wolf, Dresden
"Uniklinikum Carl Gustav Carus;Med. Klinik 1", Dresden
Uni Cattolica, Rome
Az. Osp. S. Maria, Terni
Dunedin Hospital, Dunedin
Samodzielny Public Zaklad, Chorzów
Wojewodzki Szpital Specjalistyczny im. J. Korczaka, Słupsk
Fundeni Clinical Inst., Bucharest
Hospital del Mar, Barcelona
Hospital Universitari Vall d'Hebron, Barcelona
Hospital Clínic i Provincial, Barcelona
Birmingham Heartlands Hospital, Birmingham
Boston Pilgrim Hospital, Boston,Lincolnshire
Western General Hospital, Edinburgh
Lincoln County Hospital, Lincoln
University Hospital Southampton NHS Foundation Trust, Southhampton
Collaborators (1)
AbbVie
INDUSTRY
German CLL Study Group
OTHER
Hoffmann-La Roche
INDUSTRY