100
Participants
Start Date
November 30, 2014
Primary Completion Date
January 31, 2016
Study Completion Date
January 31, 2016
Intraoperative Intravenous Lidocaine Infusion
Lidocaine 1.5 mg/kg bolus with anesthesia induction followed by 2 mg/kg/hr infusion before the start of surgical incision and stopped at surgical closure.
Perioperative Pregabalin
Pregabalin 300 mg preoperatively (e.g. 2 hours prior to the start of surgery) and 75 mg twice a day for 9 days after surgery.
Perioperative Pregabalin Placebo
Pregabalin placebo 300 mg preoperatively (e.g. 2 hours prior to the start of surgery) and 75 mg twice a day for 9 days after surgery.
Intraoperative Intravenous Lidocaine Placebo Infusion
Lidocaine placebo 1.5 mg/kg bolus with anesthesia induction followed by 2 mg/kg/hr infusion before the start of surgical incision and stopped at surgical closure.
Juravinski Hospital, Hamilton
Sunnybrook Health Sciences Centre, Toronto
Hamilton Health Sciences Corporation
OTHER
McMaster University
OTHER