Nivolumab Combined With Ipilimumab Versus Sunitinib in Previously Untreated Advanced or Metastatic Renal Cell Carcinoma (CheckMate 214)

PHASE3CompletedINTERVENTIONAL
Enrollment

1,390

Participants

Timeline

Start Date

October 16, 2014

Primary Completion Date

June 26, 2017

Study Completion Date

March 21, 2025

Conditions
Advanced Renal Cell CarcinomaMetastatic Renal Cell Carcinoma
Interventions
BIOLOGICAL

Nivolumab

BIOLOGICAL

Ipilimumab

DRUG

Sunitinib

Trial Locations (189)

0

Local Institution - 0080, Bogotá

Local Institution - 0162, Medellín

Local Institution - 0015, Wilton

Local Institution - 0017, Dublin

Local Institution - 0018, Dublin

24

Local Institution - 0016, Dublin

100

Local Institution - 0179, Taipei

112

Local Institution - 0180, Taipei

333

Local Institution - 0181, Taoyuan District

1090

Local Institution - 0109, Vienna

1122

Local Institution - 0083, Budapest

1181

Local Institution - 0139, Ciudad Autonoma de Buenos Aire

1426

Local Institution - 0097, CABA

1431

Local Institution - 0098, Capital Federal

1880

Local Institution - 0099, Berazategui

2145

Local Institution - 0070, Westmead

2217

Local Institution - 0073, Kogarah

2730

Local Institution - 0158, Herlev

3000

Local Institution - 0019, Leuven

3128

Local Institution - 0072, Box Hill

3168

Local Institution - 0071, Clayton

4000

Local Institution - 0095, San Miguel de Tucumán

Local Institution - 0096, San Miguel de Tucumán

4020

Local Institution - 0108, Linz

4029

Local Institution - 0076, Herston

4032

Local Institution - 0082, Debrecen

4215

Local Institution - 0075, Southport

4600

Local Institution - 0107, Wels

5000

Local Institution - 0100, Córdoba

Local Institution - 0137, Odense

5112

Local Institution - 0140, Elizabeth Vale

5700

Local Institution - 0184, Gyula

6009

Local Institution - 0104, Nedlands

6150

Local Institution - 0074, Murdoch

7624

Local Institution - 0084, Pécs

8200

Local Institution - 0136, Aarhus N

9000

Local Institution - 0020, Ghent

10065

Local Institution - 0001, New York

13273

Local Institution - 0060, Marseille

14050

Local Institution - 0168, Mexico City

14263

Local Institution - 0036, Buffalo

15232

Local Institution - 0031, Pittsburgh

18105

Local Institution - 0054, Allentown

19111

Local Institution - 0005, Philadelphia

20007

Local Institution - 0034, Washington D.C.

20133

Local Institution - 0023, Milan

20246

Local Institution - 0147, Hamburg

21201

Local Institution - 0048, Baltimore

21287

Local Institution - 0004, Baltimore

25030

Local Institution - 0170, Besançon

27100

Local Institution - 0025, Pavia

27710

Local Institution - 0045, Durham

28034

Local Institution - 0086, Madrid

28040

Local Institution - 0085, Madrid

28041

Local Institution - 0087, Madrid

28204

Local Institution - 0008, Charlotte

29425

Local Institution - 0055, Charleston

30322

Local Institution - 0068, Atlanta

30625

Local Institution - 0142, Hanover

31059

Local Institution - 0059, Toulouse

31096

Local Institution - 0120, Haifa

33011

Local Institution - 0111, Oviedo

33075

Local Institution - 0062, Bordeaux

33521

Local Institution - 0028, Tampere

33612

Local Institution - 0049, Tampa

34890

Local Institution - 0122, Istanbul

35128

Local Institution - 0079, Padua

37203

Local Institution - 0066, Nashville

37403

Local Institution - 0159, Chattanooga

39120

Local Institution - 0143, Magdeburg

41013

Local Institution - 0090, Seville

43210

Local Institution - 0164, Columbus

44195

Local Institution - 0007, Cleveland

44281

Local Institution - 0117, Kfar Saba

44805

Local Institution - 0063, Saint-Herblain

46202

Local Institution - 0038, Indianapolis

47014

Local Institution - 0024, Meldola (fc)

48109

Local Institution - 0046, Ann Arbor

48149

Local Institution - 0146, Münster

48201

Local Institution - 0043, Detroit

49100

Local Institution - 0121, Petah Tikva

52074

Local Institution - 0125, Aachen

52100

Local Institution - 0022, Arezzo

52242

Local Institution - 0042, Iowa City

52621

Local Institution - 0118, Ramat Gan

60590

Local Institution - 0141, Frankfurt

64460

Local Institution - 0171, Monterrey

66205

Local Institution - 0163, Fairway

66424

Local Institution - 0127, Homburg

67091

Local Institution - 0065, Strasbourg

68000

Local Institution - 0167, Oaxaca City

69126

Local Institution - 0123, Heidelberg

70300

Local Institution - 0119, Ẕerifin

75015

Local Institution - 0061, Paris

75246

Local Institution - 0056, Dallas

76090

Local Institution - 0175, Querétaro City

80131

Local Institution - 0064, Napoli

81675

Local Institution - 0124, München

85925

Local Institution - 0169, La Roche-sur-Yon

89075

Local Institution - 0130, Ulm

90033

Local Institution - 0044, Los Angeles

90048

Local Institution - 0035, Los Angeles

91010

Local Institution - 0006, Duarte

91054

Local Institution - 0126, Erlangen

94305

Local Institution - 0067, Stanford

94805

Local Institution - 0058, Villejuif

97239

Local Institution - 0039, Portland

98109

Local Institution - 0041, Seattle

1138431

Local Institution - 0197, Bunkyo-ku

1138655

Local Institution - 0195, Bunkyo-ku

1358550

Local Institution - 0207, Koto-ku

1608582

Local Institution - 0185, Shinjuku-Ku

1628666

Local Institution - 0193, Shinjuku-ku

2360004

Local Institution - 0186, Yokohama

3058576

Local Institution - 0205, Tsukuba

4313192

Local Institution - 0208, Hamamatsu

5898511

Local Institution - 0190, Osakasayamashi

6028566

Local Institution - 0191, Kyoto

6500017

Local Institution - 0206, Kobe

7008558

Local Institution - 0204, Okayama

8128582

Local Institution - 0196, Fukuoka

8420383

Local Institution - 0101, Santiago

8608556

Local Institution - 0189, Kumamoto

9518520

Local Institution - 0199, Niigata

9909585

Local Institution - 0203, Yamagata

92093-0698

Local Institution - 0057, La Jolla

06520

Local Institution - 0138, New Haven

02111

Local Institution - 0135, Boston

02215

Local Institution - 0110, Boston

Local Institution - 0161, Boston

Local Institution - 0173, Boston

75390-8852

Local Institution - 0032, Dallas

77030-4009

Local Institution - 0003, Houston

30130-090

Local Institution - 0152, Belo Horizonte

90035-903

Local Institution - 0150, Porto Alegre

91610-000

Local Institution - 0151, Porto Alegre

01321-001

Local Institution - 0153, São Paulo

20793-080

Local Institution - 0157, Rio de Janeiro

01406-100

Local Institution - 0155, São Paulo

01509-010

Local Institution - 0156, São Paulo

T2N 4N2

Local Institution - 0149, Calgary

T6G 1Z2

Local Institution - 0133, Edmonton

V1Y 5L3

Local Institution - 0182, Kelowna

V5Z 4E6

Local Institution - 0128, Vancouver

E1C 8X3

Local Institution - 0131, Moncton

M4N 3M5

Local Institution - 0172, Toronto

M5G 2M9

Local Institution - 0148, Toronto

H3T 1E2

Local Institution - 0132, Montreal

Unknown

Local Institution - 0102, Santiago

Local Institution - 0144, Santiago

254 0364

Local Institution - 0103, Viña del Mar

MEDELLIN

Local Institution - 0081, Medellín

460 63

Local Institution - 0050, Liberec

656 53

Local Institution - 0053, Brno

500 05

Local Institution - 0051, Hradec Králové

779 00

Local Institution - 0052, Olomouc

00290

Local Institution - 0027, Helsinki

07747

Local Institution - 0129, Jena

00149

Local Institution - 0026, Roma

010-8542

Local Institution - 0192, Akita

036-8563

Local Institution - 0209, Hirosaki

260-8717

Local Institution - 0187, Chiba

060-8543

Local Institution - 0188, Sapporo

060-8648

Local Institution - 0183, Sapporo

0208505

Local Institution - 0200, Morioka

565-0871

Local Institution - 0201, Suita-shi

770-8503

Local Institution - 0194, Tokushima

113-8603

Local Institution - 0202, Bunkyo-ku

113-8519

Local Institution - 0198, Tokyo

1066 CX

Local Institution - 0029, Amsterdam

9713 GZ

Local Institution - 0040, Groningen

6525 GA

Local Institution - 0030, Nijmegen

31-115

Local Institution - 0093, Krakow

60-569

Local Institution - 0112, Poznan

50-556

Local Institution - 0106, Wroclaw

03080

Local Institution - 0178, Seoul

05505

Local Institution - 0177, Seoul

120-752

Local Institution - 0176, Seoul

08025

Local Institution - 0089, Barcelona

08035

Local Institution - 0088, Barcelona

171 76

Local Institution - 0134, Stockholm

06230

Local Institution - 0115, Ankara

07070

Local Institution - 0114, Antalya

SW3 6JJ

Local Institution - 0010, London

G12 0YN

Local Institution - 0009, Glasgow

EC1A 7BE

Local Institution - 0077, London

M20 4BX

Local Institution - 0021, Manchester

HA6 2RN

Local Institution - 0011, Northwood

SA2 8QA

Local Institution - 0012, Swansea

Sponsors
All Listed Sponsors
collaborator

Ono Pharmaceutical Co. Ltd

INDUSTRY

lead

Bristol-Myers Squibb

INDUSTRY

NCT02231749 - Nivolumab Combined With Ipilimumab Versus Sunitinib in Previously Untreated Advanced or Metastatic Renal Cell Carcinoma (CheckMate 214) | Biotech Hunter | Biotech Hunter