Study of the Intravitreal Implantation of NT-503-3 Encapsulated Cell Technology (ECT) for the Treatment of Recurrent Choroidal Neovascularization (CNV) Secondary to Age-related Macular Degeneration (AMD)

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

September 30, 2014

Primary Completion Date

April 30, 2016

Study Completion Date

April 30, 2016

Conditions
Macular Degeneration
Interventions
DRUG

NT-503-3 ECT implantation

NT-503-3 ECT implantation is a biological sustained drug delivery device that could provide continuous delivery of an anti-VEGF therapy

DRUG

Eylea® injected intravitreally administered every 8 weeks

The first part, stage 1, Phase I is open label with the experimental treatment arm only. Eylea® injected intravitreally is only used as a comparator in the stage 2, Phase II, portion of the study.

Trial Locations (38)

19107

Mid Atlantic Retina, Philadelphia

20815

The Retina Group of Washington, Chevy Chase

21740

Cumberland Valley Retina Consultants, PC, Hagerstown

27157

Wake Forest Baptist Health Eye Center, Winston-Salem

28803

Western Carolina Retinal Associates, Asheville

29501

Palmetto Retina Center, LLC, Florence

30060

Georgina Retina, P.C., Marietta

30909

Southeast Retina Center, PC, Augusta

33880

Center for Retina and Macular Disease, Winter Haven

33907

Retina Health Center, Fort Myers

33912

National Ophthalmic Research Institute, Fort Myers

40509

Retina Associates of Kentucky, Lexington

44195

Cleveland Clinic, Cleveland

44281

Meir Medical Center, Kfar Saba

48073

William Beaumont Hospital-Ophthalmology Research, Royal Oak

48105

University of Michigan, Kellogg Eye Center, Ann Arbor

49100

Rabin Medical Center, Petah Tikva

53226

Medical College of Wisconsin, Milwaukee

57701

Black Hills Regional Eye Institute, Rapid City

60304

Illinois Retina Associates, Oak Park

60435

Illinois Retina Associates, S.C., Joliet

63017

Lifelong Vision Foundation, Chesterfield

64239

Sourasky Medical Center,, Tel Aviv

76100

Kaplan Medical Center, Rehovot

78240

Medical Center Ophthalmology Associates, San Antonio

78503

Valley Retina Institute, PA, McAllen

80401

Colorado Retina Associates, Golden

85020

Associated Retina Consultants, Ltd., Phoenix

89502

Sierra Eye Associates, Reno

90211

Retina-Vitreous Associates Medical Group, Beverly Hills

91120

Hadassah-Hebrew University Medical Center, Jerusalem

92093

Jacobs Retina Center at UCSD, La Jolla

92697

University of California, Irvine, The Gavin Herbert Eye Institute, Irvine

97210

Retina Northwest, PC, Portland

02114

Ophthalmic Consultants of Boston, Boston

07003

Retina Center of New Jersey, LLC, Bloomfield

08901

NJ Retina, New Brunswick

Unknown

Soroka Medical Center, Beersheba

Sponsors
All Listed Sponsors
lead

Neurotech Pharmaceuticals

INDUSTRY

NCT02228304 - Study of the Intravitreal Implantation of NT-503-3 Encapsulated Cell Technology (ECT) for the Treatment of Recurrent Choroidal Neovascularization (CNV) Secondary to Age-related Macular Degeneration (AMD) | Biotech Hunter | Biotech Hunter