Non-inferiority Study to Compare the Efficacy and Safety of Mylan's Insulin Glargine With Lantus® in Type 1 Diabetes Mellitus Patients (INSTRIDE 1)

PHASE3CompletedINTERVENTIONAL
Enrollment

558

Participants

Timeline

Start Date

June 30, 2014

Primary Completion Date

July 31, 2016

Study Completion Date

July 31, 2016

Conditions
Type 1 Diabetes
Interventions
DRUG

Mylan's insulin glargine

All patients will be shifted from their current mealtime insulin to insulin lispro at the start of the run-in period, and will continue on this for the complete trial. During the 6 week run-in period the doses of Lantus® and insulin lispro will be titrated (if required) to ensure diabetes control. After the run-in period, patients will be randomized to receive either Mylan's insulin glargine (in place of Lantus®), or to continue on Lantus®. During the period from 12 to 24 weeks dose titration will be kept to a minimum.

DRUG

Lantus®

All patients will be shifted from their current mealtime insulin to insulin lispro at the start of the run-in period; and will continue on this for the complete trial. During the 6week run-in period the doses of Lantus® and insulin lispro will be titrated (if required) to ensure diabetes control. After the run-in period, patients will be randomized to receive either Mylan's insulin glargine (in place of Lantus®), or to continue on Lantus®. During the period from 12 to 24 weeks dose titration will be kept to a minimum.

Trial Locations (162)

1033

Mylan Investigational Site, Budapest

1083

Mylan Investigational Site, Budapest

1088

Mylan Investigational Site, Budapest

1501

Mylan Investigational Site, Johannesburg

1619

Mylan Investigational Site, Johannesburg

1739

Mylan Investigational Site, Krugersdorp

2198

Mylan Investigational Site, Johannesburg

3300

Mylan Investigational Site, Eger

3530

Mylan Investigational Site, Miskolc

4001

Mylan Investigational Site, Limbaži

4091

Mylan Investigational Site, Durban

4281

Mylan Investigational Site, Létavértes

5700

Mylan Investigational Site, Gyula

6500

Mylan Investigational Site, Baja

6722

Mylan Investigational Site, Szeged

7570

Mylan Investigational Site, Cape Town

7580

Mylan Investigational Site, Cape Town

7708

Mylan Investigational Site, Cape Town

9301

Mylan Investigational Site, Bloemfontein

10301

Mylan Investigational Site, Staten Island

11501

Mylan Investigational Site, Mineola

12206

Mylan Investigational Site, Albany

13210

Mylan Investigational Site, Syracuse

13419

Mylan Investigational Site, Tallinn

20110

Mylan Investigational Site, Manassas

21073

Mylan Investigational Site, Hamburg

22603

Mylan Investigational Site, Hamburg

23321

Mylan Investigational Site, Chesapeake

27215

Mylan Investigational Site, Burlington

27408

Mylan Investigational Site, Greensboro

27834

Mylan Investigational Site, Greenville

28401

Mylan Investigational Site, Wilmington

28557

Mylan Investigational Site, Morehead City

28601

Mylan Investigational Site, Hickory

28803

Mylan Investigational Site, Asheville

30318

Mylan Investigational Site, Atlanta

31904

Mylan Investigational Site, Columbus

33012

Mylan Investigational Site, Hialeah

33021

Mylan Investigational Site, Hollywood

33024

Mylan Investigational Site, Cooper City

33142

Mylan Investigational Site, Miami

33156

Mylan Investigational Site, Miami

33401

Mylan Investigational Site, West Palm Beach

34208

Mylan Investigational Site, Bradenton

34652

Mylan Investigational Site, New Port Richey

34684

Mylan Investigational Site, Palm Harbor

37411

Mylan Investigational Site, Chattanooga

38119

Mylan Investigational Site, Memphis

40503

Mylan Investigational Site, Lexington

44060

Mylan Investigational Site, Mentor

45236

Mylan Investigational Site, Cincinnati

46011

Mylan Investigational Site, Anderson

47304

Mylan Investigational Site, Muncie

48145

Mylan Investigational Site, Münster

50314

Mylan Investigational Site, Des Moines

51014

Mylan Investigational Site, Tartu

51501

Mylan Investigational Site, Council Bluffs

55016

Mylan Investigational Site, Broumov

59101

Mylan Investigational Site, Billings

60012

Mylan Investigational Site, Crystal Lake

60525

Mylan Investigational Site, LaGrange

60596

Mylan Investigational Site, Frankfurt am Main

62704

Mylan Investigational Site, Springfield

63739

Mylan Investigational Site, Aschaffenburg

66210

Mylan Investigational Site, Overland Park

66386

Mylan Investigational Site, Sankt Ingbert

66606

Mylan Investigational Site, Topeka

68114

Mylan Investigational Site, Omaha

68131

Mylan Investigational Site, Omaha

75231

Mylan Investigational Site, Dallas

77900

Mylan Investigational Site, Olomouc

78258

Mylan Investigational Site, San Antonio

78681

Mylan Investigational Site, Round Rock

Texas Diabetes & Endocrinology, Round Rock

78731

Mylan Investigational Site, Austin

79925

Mylan Investigational Site, El Paso

80018

Mylan Investigational Site, Pärnu

82106

Mylan Investigational Site, Bratislava

83331

Mylan Investigational Site, Bratislava

83404

Mylan Investigational Site, Idaho Falls

84095

Mylan Investigational Site, South Jordan

84102

Mylan Investigational Site, Salt Lake City

84109

Mylan Investigational Site, Salt Lake City

84121

Mylan Investigational Site, Salt Lake City

84405

Mylan Investigational Site, Ogden

85101

Mylan Investigational Site, Bratislava

88239

Mylan Investigational Site, Wangen

89128

Mylan Investigational Site, Las Vegas

90201

Mylan Investigational Site, Bell Gardens

90807

Mylan Investigational Site, Long Beach

90901

Mylan Investigational Site, Skalica

91324

Mylan Investigational Site, Northridge

91345

Mylan Investigational Site, Mission Hills

91501

Mylan Investigational Site, Nové Mesto nad Váhom

91942

Mylan Investigational Site, La Mesa

91950

Mylan Investigational Site, National City

92037

Mylan Investigational Site, La Jolla

92780

Mylan Investigational Site, Tustin

93401

Mylan Investigational Site, Levice

93720

Mylan Investigational Site, Fresno

Mylan Investigational Site, Greenbrae

94002

Mylan Investigational Site, Nové Zámky

94598

Mylan Investigational Site, Walnut Creek

95032

Mylan Investigational Site, Los Gatos

96814

Mylan Investigational Site, Honolulu

97101

Mylan Investigational Site, Prievidza

97330

Mylan Investigational Site, Corvallis

97421

Mylan Investigational Site, Schweinfurt

97517

Mylan Investigational Site, Banská Bystrica

97701

Mylan Investigational Site, Bend

97901

Mylan Investigational Site, Rimavská Sobota

98057

Mylan Investigational Site, Renton

98405

Mylan Investigational Site, Tacoma

98664

Mylan Investigational Site, Vancouver

120203

Mylan Investigational Site, Buzău

300456

Mylan Investigational Site, Timișoara

400349

Mylan Investigational Site, Cluj-Napoca

410169

Mylan Investigational Site, Oradea

410469

Mylan Investigational Site, Oradea

430222

Mylan Investigational Site, Baia Mare

600164

Mylan Investigational Site, Bacau

700503

Mylan Investigational Site, Iași

800578

Mylan Investigational Site, Galati

T4N 6V7

Mylan Investigational Site, Red Deer

V6E IM7

Mylan Investigational Site, Vancouver

R3E 3P4

Mylan Investigational Site, Winnipeg

H7T 2P5

Mylan Investigational Site, Laval

J7J 2K8

Mylan Investigational Site, Mirabel

H3A 1A1

Mylan Investigational Site, Montreal

625 00

Mylan Investigational Site, Brno

656 91

Mylan Investigational Site, Brno

792 01

Mylan Investigational Site, Bruntál

370 00

Mylan Investigational Site, České Budějovice

530 02

Mylan Investigational Site, Pardubice

100 00

Mylan Investigational Site, Prague

100 34

Mylan Investigational Site, Prague

06679

Mylan Investigational Site, Hohenmölsen

01307

Mylan Investigational Site, Dresden

H-6900

Mylan Investigational Site, Makó

LC-3301

Mylan Investigational Site, Kuldīga

LV-5001

Mylan Investigational Site, Ogre

LV-1011

Mylan Investigational Site, Riga

LV-1050

Mylan Investigational Site, Riga

LV1002

Mylan Investigational Site, Riga

LV-3200

Mylan Investigational Site, Sigulda

Mylan Investigational Site, Talsi

010825

Mylan Investigational Site, Bucharest

061072

Mylan Investigational Site, Bucharest

08501

Mylan Investigational Site, Bardejov

02601

Mylan Investigational Site, Dolný Kubín

04011

Mylan Investigational Site, Košice

03491

Mylan Investigational Site, Ľubochňa

08001

Mylan Investigational Site, Prešov

01852

Mylan Investigational Site, Pruské

08301

Mylan Investigational Site, Sabinov

943 01

Mylan Investigational Site, Štúrovo

07501

Mylan Investigational Site, Trebišov

01001

Mylan Investigational Site, Žilina

0002

Mylan Investigational Site, Pretoria

PL6 8DH

Mylan Investigational Site, Plymouth

LE5 4PW

Mylan Investigational Site, Leicester

SA6 6NL

Mylan Investigational Site, Swansea

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Mylan GmbH

INDUSTRY

lead

Mylan Inc.

INDUSTRY