Safety and Tolerability During Open-label Treatment With LCZ696 in Patients With CHF and Reduced Ejection Fraction

PHASE3CompletedINTERVENTIONAL
Enrollment

1,980

Participants

Timeline

Start Date

October 16, 2014

Primary Completion Date

December 28, 2017

Study Completion Date

December 28, 2017

Conditions
Chronic Heart Failure With Reduced Ejection Fraction
Interventions
DRUG

LCZ696

Angiotensin receptor antagonist neprilysin inhibitor (ARNI) with target dose of 200 mg bid

Trial Locations (394)

11

Novartis Investigative Site, Jesus Maria

12

Novartis Investigative Site, La Molina

27

Novartis Investigative Site, San Isidro

32

Novartis Investigative Site, San Miguel

41

Novartis Investigative Site, San Borja

114

Novartis Investigative Site, Taipei

1096

Novartis Investigative Site, Budapest

1100

Novartis Investigative Site, Quezon City

Novartis Investigative Site, Quezon City

1102

Novartis Investigative Site, Quezon City

1122

Novartis Investigative Site, Budapest

1125

Novartis Investigative Site, Budapest

1134

Novartis Investigative Site, Budapest

1145

Novartis Investigative Site, Budapest

1233

Novartis Investigative Site, Sofia

1309

Novartis Investigative Site, Sofia

1431

Novartis Investigative Site, Sofia

1449

Novartis Investigative Site, Alberton

1527

Novartis Investigative Site, Sofia

1605

Novartis Investigative Site, Pasig

1606

Novartis Investigative Site, Sofia

1620

Novartis Investigative Site, Kempton Park

2000

Novartis Investigative Site, Rosario

2013

Novartis Investigative Site, Soweto

2193

Novartis Investigative Site, Johannesburg

2930

Novartis Investigative Site, Brasschaat

3000

Novartis Investigative Site, Leuven

4000

Novartis Investigative Site, Plovdiv

4032

Novartis Investigative Site, Debrecen

4052

Novartis Investigative Site, Durban

4110

Novartis Investigative Site, Durban

4217

Novartis Investigative Site, Lipa City

4400

Novartis Investigative Site, Nyiregyháza

4818

Novartis Investigative Site, Breda

5000

Novartis Investigative Site, Córdoba

5700

Novartis Investigative Site, Svendborg

5800

Novartis Investigative Site, Pleven

6300

Novartis Investigative Site, Haskovo

6850

Novartis Investigative Site, Worcester

7100

Novartis Investigative Site, La Louvière

Novartis Investigative Site, Vejle

Novartis Investigative Site, Szekszárd

7405

Novartis Investigative Site, Cape Town

Novartis Investigative Site, Cape Town

7505

Novartis Investigative Site, Cape Town

8900

Novartis Investigative Site, Zalaegerszeg

8930

Novartis Investigative Site, Randers

9000

Novartis Investigative Site, Ghent

9010

Novartis Investigative Site, Varna

9301

Novartis Investigative Site, Bloemfontein

Novartis Investigative Site, Bloemfontein

9600

Novartis Investigative Site, Ronse

9700

Novartis Investigative Site, Shumen

10002

Novartis Investigative Site, Taipei

10032

Novartis Investigative Site, New York

10100

Novartis Investigative Site, Prague 10, Vrsovice

10369

Novartis Investigative Site, Berlin

11000

Novartis Investigative Site, Taladkwan

11100

Novartis Investigative Site, Aosta

11217

Novartis Investigative Site, Taipei

11422

Novartis Investigative Site, Rosedale

12120

Novartis Investigative Site, Muang

12808

Novartis Investigative Site, Prague

13100

Novartis Investigative Site, Safed

13125

Novartis Investigative Site, Buch

13405

Novartis Investigative Site, Berlin

13419

Novartis Investigative Site, Tallinn

15006

Novartis Investigative Site, A Coruña

15706

Novartis Investigative Site, Santiago de Compostela

16132

Novartis Investigative Site, Genova

16499

Novartis Investigative Site, Suwon

20230

Novartis Investigative Site, Aguascalientes

21044

Novartis Investigative Site, Columbia

22291

Novartis Investigative Site, Hamburg

22765

Novartis Investigative Site, Hamburg

24047

Novartis Investigative Site, Treviglio

24127

Novartis Investigative Site, Bergamo

26058

Novartis Investigative Site, Yilan

26426

Novartis Investigative Site, Wŏnju

27100

Novartis Investigative Site, Pavia

27610

Novartis Investigative Site, Raleigh

28007

Novartis Investigative Site, Madrid

28222

Novartis Investigative Site, Madrid

28805

Novartis Investigative Site, Alcalá de Henares

28844

Novartis Investigative Site, Weyhe

28935

Novartis Investigative Site, Móstoles

29010

Novartis Investigative Site, Málaga

29600

Novartis Investigative Site, Marbella

32584

Novartis Investigative Site, Löhne

33520

Novartis Investigative Site, Tampere

34059

Novartis Investigative Site, Montpellier

34093

Novartis Investigative Site, Istanbul

34304

Novartis Investigative Site, Istanbul

35040

Novartis Investigative Site, Izmir

35340

Novartis Investigative Site, Izmir

35584

Novartis Investigative Site, Wetzlar-Naunheim

35662

Novartis Investigative Site, Muscle Shoals

35801

Novartis Investigative Site, Huntsville

36211

Novartis Investigative Site, Vigo

37480

Novartis Investigative Site, Karlshamn

38100

Novartis Investigative Site, Hadera

38836

Novartis Investigative Site, Huy / OT Anderbeck

40002

Novartis Investigative Site, Khon Kaen

40447

Novartis Investigative Site, Taichung

41014

Novartis Investigative Site, Seville

41380

Novartis Investigative Site, Kocaeli

43302

Novartis Investigative Site, Marion

44100

Novartis Investigative Site, Cona

45468

Novartis Investigative Site, Muehlheim An Der Ruhr

46010

Novartis Investigative Site, Valencia

46015

Novartis Investigative Site, Valencia

48601

Novartis Investigative Site, Saginaw

49100

Novartis Investigative Site, Petah Tikva

50006

Novartis Investigative Site, Changhua

50314

Novartis Investigative Site, Des Moines

50400

Novartis Investigative Site, Kuala Lumpur

50410

Novartis Investigative Site, Tartu

51017

Novartis Investigative Site, Pescia

52044

Novartis Investigative Site, Cortona

53188

Novartis Investigative Site, Waukesha

55041

Novartis Investigative Site, Lido di Camaiore

55218

Novartis Investigative Site, Ingelheim

55417

Novartis Investigative Site, Minneapolis

56126

Novartis Investigative Site, Pisa

57701

Novartis Investigative Site, Rapid City

58140

Novartis Investigative Site, Sivas

59100

Novartis Investigative Site, Kuala Lumpur

59185

Novartis Investigative Site, Motala

60488

Novartis Investigative Site, Frankfurt

61348

Novartis Investigative Site, Bad Homburg

63073

Novartis Investigative Site, Offenbach

65779

Novartis Investigative Site, Kelkheim

65929

Novartis Investigative Site, Frankfurt

68025

Novartis Investigative Site, Fremont

68601

Novartis Investigative Site, Uherské Hradiště

70433

Novartis Investigative Site, Covington

72204

Novartis Investigative Site, Little Rock

74653

Novartis Investigative Site, Künzelsau

75015

Novartis Investigative Site, Paris

75235

Novartis Investigative Site, Dallas

75251

Novartis Investigative Site, Dallas

76100

Novartis Investigative Site, Rehovot

76800

Novartis Investigative Site, San Juan del Río

77351

Novartis Investigative Site, Livingston

78200

Novartis Investigative Site, San Luis Potosí City

78278

Novartis Investigative Site, Ashkelon

79189

Novartis Investigative Site, Bad Krozingen

82445

Novartis Investigative Site, Kaohsiung City

84131

Novartis Investigative Site, Salerno

84453

Novartis Investigative Site, Mühldorf

86077

Novartis Investigative Site, Pozzilli

87100

Novartis Investigative Site, Cosenza

91120

Novartis Investigative Site, Jerusalem

92056

Novartis Investigative Site, Oceanside

92161

Novartis Investigative Site, San Diego

92262

Novartis Investigative Site, Palm Springs

93401

Novartis Investigative Site, Levice

95405

Novartis Investigative Site, Santa Rosa

98057

Novartis Investigative Site, Milazzo

99204

Novartis Investigative Site, Spokane

101990

Novartis Investigative Site, Moscow

110080

Novartis Investigative Site, Delhi

115280

Novartis Investigative Site, Moscow

115516

Novartis Investigative Site, Moscow

117198

Novartis Investigative Site, Moscow

119881

Novartis Investigative Site, Moscow

121309

Novartis Investigative Site, Moscow

121552

Novartis Investigative Site, Moscow

127473

Novartis Investigative Site, Moscow

141002

Novartis Investigative Site, Ludhiana

153012

Novartis Investigative Site, Ivanovo

169609

Novartis Investigative Site, Singapore

191144

Novartis Investigative Site, Saint Petersburg

194017

Novartis Investigative Site, Saint Petersburg

194044

Novartis Investigative Site, Saint Petersburg

194295

Novartis Investigative Site, Saint Petersburg

194354

Novartis Investigative Site, S-Petersburg

196084

Novartis Investigative Site, Saint Petersburg

197022

Novartis Investigative Site, Saint Petersburg

197341

Novartis Investigative Site, Saint Petersburg

199106

Novartis Investigative Site, Saint Petersburg

200497

Novartis Investigative Site, Craiova

200642

Novartis Investigative Site, Craiova

214018

Novartis Investigative Site, Smolensk

300041

Novartis Investigative Site, Timișoara

300053

Novartis Investigative Site, Tula

300362

Novartis Investigative Site, Timișoara

300736

Novartis Investigative Site, Timișoara

308433

Novartis Investigative Site, Singapore

330084

Novartis Investigative Site, Deva

334003

Novartis Investigative Site, Bikaner

344022

Novartis Investigative Site, Rostov-on-Don

350012

Novartis Investigative Site, Krasnodar

380054

Novartis Investigative Site, Ahmedabad

388325

Novartis Investigative Site, Anand

390015

Novartis Investigative Site, Vadodara

395002

Novartis Investigative Site, Surat

400012

Novartis Investigative Site, Mumbai

Novartis Investigative Site, Nagpur

410012

Novartis Investigative Site, Saratov

411011

Novartis Investigative Site, Pune

420012

Novartis Investigative Site, Kazan'

422002

Novartis Investigative Site, Nashik

422005

Novartis Investigative Site, Nashik

440010

Novartis Investigative Site, Nagpur

452014

Novartis Investigative Site, Indore

460000

Novartis Investigative Site, Orenburg

460040

Novartis Investigative Site, Orenburg

522001

Novartis Investigative Site, Guntur

600020

Novartis Investigative Site, Vladimir

603003

Novartis Investigative Site, Nizhny Novgorod

603005

Novartis Investigative Site, N.Novgorod

603126

Novartis Investigative Site, Nizhny Novgorod

610027

Novartis Investigative Site, Kirov

614097

Novartis Investigative Site, Perm

620137

Novartis Investigative Site, Yekaterinburg

630117

Novartis Investigative Site, Novosibirsk-117

650002

Novartis Investigative Site, Kemerovo

705703

Novartis Investigative Site, Daegu

3436212

Novartis Investigative Site, Haifa

3525408

Novartis Investigative Site, Haifa

4780000

Novartis Investigative Site, Temuco

33472-2952

Novartis Investigative Site, Boynton Beach

C1221ADC

Novartis Investigative Site, CABA

C1119ACN

Novartis Investigative Site, Ciudad Autonoma de Bs As

B7600FZN

Novartis Investigative Site, Mar del Plata

B1878DVB

Novartis Investigative Site, Quilmes

C1179AAB

Novartis Investigative Site, CABA

Y4600ABF

Novartis Investigative Site, San Salvador de Jujuy

A4406BPF

Novartis Investigative Site, Salta

S2000AII

Novartis Investigative Site, Rosario

S2000QID

Novartis Investigative Site, Rosario

W3400CLH

Novartis Investigative Site, Corrientes

X5000AAX

Novartis Investigative Site, Córdoba

X5016KET

Novartis Investigative Site, Córdoba

P3600

Novartis Investigative Site, Formosa

P3634XAR

Novartis Investigative Site, Formosa

M5500CHC

Novartis Investigative Site, Mendoza

D5702JRS

Novartis Investigative Site, San Luis

S3000EOZ

Novartis Investigative Site, Santa Fe

S3000FWO

Novartis Investigative Site, Santa Fe

G4200AQK

Novartis Investigative Site, Santiago del Estero

41810-010

Novartis Investigative Site, Salvador

70390-903

Novartis Investigative Site, Brasília

74223-130

Novartis Investigative Site, Goiânia

74605 050

Novartis Investigative Site, Goiânia

74823-470

Novartis Investigative Site, Goiânia

65020-070

Novartis Investigative Site, São Luís

38411-186

Novartis Investigative Site, Uberlândia

20180-090

Novartis Investigative Site, Belo Horizonte

30150-221

Novartis Investigative Site, Belo Horizonte

66087-660

Novartis Investigative Site, Belém

52051-380

Novartis Investigative Site, Recife

22280-020

Novartis Investigative Site, Rio de Janeiro

90880-480

Novartis Investigative Site, Porto Alegre

17515-000

Novartis Investigative Site, Marília

14055-370

Novartis Investigative Site, Ribeirão Preto

09190-615

Novartis Investigative Site, Santo André

15015-750

Novartis Investigative Site, São José do Rio Preto

01323 000

Novartis Investigative Site, São Paulo

05403-000

Novartis Investigative Site, São Paulo

15500-003

Novartis Investigative Site, Votuporanga

V8R4R2

Novartis Investigative Site, Victoria

B3H 2Y9

Novartis Investigative Site, Halifax

N2M 5N4

Novartis Investigative Site, Kitchener

M5B 1W8

Novartis Investigative Site, Toronto

M9N 1W4

Novartis Investigative Site, Weston

G6V 4Z5

Novartis Investigative Site, Lévis

H3G 1A4

Novartis Investigative Site, Montreal

H3T 1E2

Novartis Investigative Site, Montreal

G5Y 4T8

Novartis Investigative Site, St-Georges Beauce

266 01

Novartis Investigative Site, Beroun

250 01

Novartis Investigative Site, Brandýs nad Labem

460 05

Novartis Investigative Site, Liberec V Kristianova

779 00

Novartis Investigative Site, Olomouc

674 01

Novartis Investigative Site, Třebíč

743 01

Novartis Investigative Site, Bílovec

280 20

Novartis Investigative Site, Kolín

150 30

Novartis Investigative Site, Prague

DK-2100

Novartis Investigative Site, Copenhagen

DK-6700

Novartis Investigative Site, Esbjerg

DK-2900

Novartis Investigative Site, Hellerup

DK-8800

Novartis Investigative Site, Viborg

01099

Novartis Investigative Site, Dresden

06846

Novartis Investigative Site, Dessau

01307

Novartis Investigative Site, Dresden

01309

Novartis Investigative Site, Dresden

04910

Novartis Investigative Site, Elsterwerda

06366

Novartis Investigative Site, Köthen

04109

Novartis Investigative Site, Leipzig

04129

Novartis Investigative Site, Leipzig

04315

Novartis Investigative Site, Leipzig

04779

Novartis Investigative Site, Wermsdorf

01010

Novartis Investigative Site, Guatemala City

Novartis Investigative Site, Guatemala City

01015

Novartis Investigative Site, Guatemala City

HONG KONG

Novartis Investigative Site, Hong Kong

Unknown

Novartis Investigative Site, Hong Kong SAR

Novartis Investigative Site, Panama City

Novartis Investigative Site, Bucharest

H-8000

Novartis Investigative Site, Székesfehérvár

380 051

Novartis Investigative Site, Ahmedabad

395 002

Novartis Investigative Site, Surat

422 005

Novartis Investigative Site, Nashik

411 011

Novartis Investigative Site, Pune

500 063

Novartis Investigative Site, Hyderabad

00041

Novartis Investigative Site, Ariccia

00163

Novartis Investigative Site, Roma

07100

Novartis Investigative Site, Sassari

LV-5417

Novartis Investigative Site, Daugavpils

LV-3601

Novartis Investigative Site, Ventspils

LT-49387

Novartis Investigative Site, Kaunas

LT-57164

Novartis Investigative Site, Kėdainiai

LT-08661

Novartis Investigative Site, Vilnius

5223 GZ

Novartis Investigative Site, 's-Hertogenbosch

3813 TZ

Novartis Investigative Site, Amersfoort

6815 AD

Novartis Investigative Site, Arnhem

1261 AN

Novartis Investigative Site, Blaricum

2625 AD

Novartis Investigative Site, Delft

6716 RP

Novartis Investigative Site, Ede

4204 AA

Novartis Investigative Site, Gorinchem

7770 AA

Novartis Investigative Site, Hardenberg

3840 AC

Novartis Investigative Site, Harderwijk

8441 PW

Novartis Investigative Site, Heerenveen

7555 DL

Novartis Investigative Site, Hengelo

8601 ZK

Novartis Investigative Site, Sneek

5022 GC

Novartis Investigative Site, Tilburg

5504 DB

Novartis Investigative Site, Veldhoven

0816-02351

Novartis Investigative Site, Panama City

CALLAO 02

Novartis Investigative Site, Bellavista

AREQ01

Novartis Investigative Site, Arequipa

81-472

Novartis Investigative Site, Gdynia

81-548

Novartis Investigative Site, Gdynia

20-857

Novartis Investigative Site, Lublin

5000-508

Novartis Investigative Site, Vila Real

6200-251

Novartis Investigative Site, Covilha

4835-044

Novartis Investigative Site, Guimarães

1449-005

Novartis Investigative Site, Lisbon

7300-853

Novartis Investigative Site, Portalegre

4200-319

Novartis Investigative Site, Porto

2910-446

Novartis Investigative Site, Setúbal

014461

Novartis Investigative Site, Bucharest

011728

Novartis Investigative Site, Bucharest

050098

Novartis Investigative Site, Bucharest

977 42

Novartis Investigative Site, Brezno

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Novartis Investigative Site, Košice

08001

Novartis Investigative Site, Prešov

08901

Novartis Investigative Site, Svidník

821 07

Novartis Investigative Site, Bratislava

842 31

Novartis Investigative Site, Bratislava

851 07

Novartis Investigative Site, Bratislava

040 01

Novartis Investigative Site, Košice

984 01

Novartis Investigative Site, Lučenec

036 01

Novartis Investigative Site, Martin

0121

Novartis Investigative Site, Pretoria

0184

Novartis Investigative Site, Pretoria

05505

Novartis Investigative Site, Seoul

06591

Novartis Investigative Site, Seoul

705 718

Novartis Investigative Site, Daegu

05355

Novartis Investigative Site, Seoul

156-707

Novartis Investigative Site, Seoul

08003

Novartis Investigative Site, Barcelona

08035

Novartis Investigative Site, Barcelona

08970

Novartis Investigative Site, Sant Joan Despí

141 86

Novartis Investigative Site, Stockholm

416 85

Novartis Investigative Site, Gothenburg

DH1 5TW

Novartis Investigative Site, Durham

DT1 2JY

Novartis Investigative Site, Dorchester

RG24 9NA

Novartis Investigative Site, Basingstoke

PO6 3LY

Novartis Investigative Site, Portsmouth

IV2 3RE

Novartis Investigative Site, Inverness

OL1 2JH

Novartis Investigative Site, Oldham

LE2 7LX

Novartis Investigative Site, Leicester

BT63 5QQ

Novartis Investigative Site, Craigavon

DD1 9SY

Novartis Investigative Site, Dundee

TA1 5DA

Novartis Investigative Site, Taunton

BA21 4AT

Novartis Investigative Site, Yeovil

S10 2JF

Novartis Investigative Site, Sheffield

RH1 5RH

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NE34 0PL

Novartis Investigative Site, South Shields

SR4 7TP

Novartis Investigative Site, Sunderland

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Novartis Investigative Site, Dudley

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Novartis Investigative Site, Cheshire

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Novartis Investigative Site, Coventry

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Novartis Investigative Site, Exeter

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Novartis Investigative Site, Kent

M13 9WL

Novartis Investigative Site, Manchester

MK6 5LD

Novartis Investigative Site, Milton Keynes

NP20 2UB

Novartis Investigative Site, Newport

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Novartis Investigative Site, Newport

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BH15 2JB

Novartis Investigative Site, Poole

S60 2OD

Novartis Investigative Site, Rotherham

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Novartis Investigative Site, Worcester

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