A Study of PF-06438179 (Infliximab-Pfizer) and Infliximab in Combination With Methotrexate in Subjects With Active Rheumatoid Arthritis (REFLECTIONS B537-02).

PHASE3CompletedINTERVENTIONAL
Enrollment

650

Participants

Timeline

Start Date

August 26, 2014

Primary Completion Date

June 29, 2016

Study Completion Date

June 1, 2017

Conditions
Rheumatoid Arthritis
Interventions
BIOLOGICAL

PF-06438179

PF-06438179 will be administered by intravenous infusion at an initial dose of 3 mg/kg at 0, 2 and 6 weeks, then every 8 weeks.

BIOLOGICAL

Infliximab

Infliximab will be administered by intravenous infusion at an initial dose of 3 mg/kg at 0, 2 and 6 weeks, then every 8 weeks.

Trial Locations (184)

1000

Medical Center Manila, Manila

Philippine General Hospital, Manila

1007

Rabta Hospital, Tunis

1036

Qualiclinic Kft., Budapest

1102

St. Luke's Medical Center, Quezon

1229

Makati Medical Center, Makati City

1612

"University Multiprofile Hospital for Active Treatment (UMHAT) Sv. Ivan Rilski EAD", Sofia

2010

Mohamed Kassab Institute of orthopedics, Manouba

2193

Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg

4000

Multiprofile Hospital for Active Treatment Trimontium OOD, Plovdiv

4002

"University Multiprofile Hospital for Active Treatment (UMHAT) Kaspela EOOD", Plovdiv

4215

Gold Coast Private Hospital Pty Ltd, Southport

HPS Pharmacies, Southport

Paradise Arthritis and Rheumatology Pty Ltd, Southport

5011

The Queen Elizabeth Hospital, Woodville South

6017

CliniPath Pathology, Osborne Park

6100

R.K. Will Pty Ltd, Victoria Park

7405

Arthritis Clinical Research Unit, Cape Town

Vincent Pallotti Hospital, Cape Town

8000

Southern Philippines Medical Center, Davao City

8230

DRC Gyógyszervizsgáló Központ Kft., Balatonfüred

11150

El Ayachi Hospital, Salé

Groupe Radiologique de Salé, Salé

Laboratoire les Arcades d'Analyses Médicales, Salé

11152

Jordan Hospital, Amman

14059

Schlosspark-Klinik, Berlin

16635

Altoona Center for Clinical Research, Duncansville

18205

"Institute for Treatment and Rehabilitation Niska Banja", Niška Banja

19610

Clinical Research Center of Reading, LLC, Wyomissing

19713

Javed Rheumatology Associates, Inc, Newark

20902

The Center for Rheumatology and Bone Research, Wheaton

21018

Vinnytska oblasna klinichna likarnia im. M.I.Pyrohova, revmatolohichne, M. Vinnytsia

22110

King Abdullah University Hospital, Irbid

23502

Pharmacy Services, Sentara Leigh Hospital, Norfolk

Sentara Medical Group, Clinical Research, Norfolk

29000

Khmelnytska oblasna likarnia, Khmelnytskyi

29406

Low Country Rheumatology, PA, Charleston

30165

Harbin Clinic, Rome

32117

International Medical Research, Daytona Beach

Daytona Beach

32960

Alastair C. Kennedy, MD, Vero Beach

Indian River Primary Care, Vero Beach

33015

San Marcus Research Clinic, Inc., Miami

33165

Advance Medical Research Services Corporation, Miami

33180

Arthritis and Rheumatic Disease Specialties, Aventura

34239

Sarasota Arthritis Research Center, Sarasota

35015

Chungnam National University Hospital, Daejeon

35216

Achieve Clinical Research, LLC, Birmingham

35406

Clinical and Translational Research Center of Alabama, PC, Tuscaloosa

38119

Ramesh C Gupta, MD, Memphis

38305

West Tennessee Research Institute, Jackson

40022

"Komunalnyi zaklad Sumskoi oblasnoi rady Sumska oblasna klinichna likarnia", M. Sumy

40878

Rheumazentrum Ratingen, Ratingen

42101

Gilbert-Graves Clinic, Bowling Green

Graves-Gilbert Clinic Bowling Green, Bowling Green

49015

Western Michigan University Homer Stryker MD School of Medicine Center for Clinical Research, Battle Creek

49027

"Derzhavna ustanova Ukrainskyi derzhavnyi naukovo-doslidnyi instytut", Dnipropetrovsk

50056

"Komunalnyi zaklad Kryvorizka miska klinichna likarnia #2 Dnipropetrovskoi oblasnoi rady", M. Kryvyi Rih

52403

Physician's Clinic of Iowa, P.C., Cedar Rapids

57701

Regional Health Clinical Research, Rapid City

Regional Medical Clinic, Rapid City

58701

Trinity Health Center-Medical Arts, Minot

59939

Elisabeth-Klinik gGmbH, Olsberg

61176

"Komunalnyi zaklad okhorony zdorovia Kharkivska miska klinichna likarnia #8", Kharkiv

61469

Chonnam National University Hospital, Gwangju

61636

Methodist Medical Center of IL, Peoria

65025

"Komunalna ustanova Odeska oblasna klinichna likarnia", Odesa

65026

Bahatoprofilnyi medychnyi tsentr (Universytetska klinika #1), Odesa

66346

Knappschaftsklinikum Saar GmbH, Püttlingen

69600

"Komunalna ustanova Zaporizka oblasna klinichna likarnia Zaporizkoi oblasnoi rady", Zaporizhzhia

70809

Ochsner Clinic Baton Rouge, Baton Rouge

71000

Clinical Center University of Sarajevo, Sarajevo

"General Hospital Prim.dr.Abdulah Nakas", Sarajevo

71203

Arthritis and Diabetes Clinic, Inc., Monroe

75000

University Clinical Center Tuzla, Tuzla

75231

Metroplex Clinical Research Center, Dallas

76008

Oblasna klinichna likarnia, revmatolohichne viddilennia, Derzhavnyi vyshchyi navchalnyi zaklad, Ivano-Frankivsk

77034

Accurate Clinical Research, Inc., Houston

77058

Accurate Clinical Research, Nassau Bay

78000

University Hospital Clinical Center Banja Luka, Banja Luka

78213

Centro de Alta Especialidad en Reumatología e Investigación del Potosí, S.C., San Luis de Potosí

78731

Austin Regional Clinic, Austin

79014

Klinichnyi hospital Derzhavnoi prykordonnoi sluzhby Ukrainy, Lviv

80336

Klinikum der Universität München, München

83642

Advanced Clinical Research, Meridian

85037

Arizona Arthritis & Rheumatology Associates, P.C., Phoenix

85381

Sun Valley Arthritis Center, Ltd., Peoria

90623

Arthritis & Osteoporosis Medical Center, La Palma

91120

Hadassah Medical Organization, Hadassah Medical Center, Ein-Karem, Jerusalem

91786

Inland Rheumatology Clinical Trials, Inc., Upland

92395

Desert Valley Medical Group, Victorville

92835

St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare, Fullerton

98133

The Seattle Arthritis Clinic, Seattle

129327

GBUZ of city of Moscow, Moscow

150002

"GBKUZ of Yaroslavl region City hospital n. a. N.A. Semashko", Yaroslavl

185019

"GBUZ Republican hospital n.a. V.A.Baranov", Petrozavodsk

190068

"Spb GBUZ Clinical rheumatology hospital # 25 City CDC prevention of osteoporosis", Saint Petersburg

305007

"GMU Kursk regional clinical hospital of the Committee of Healthcare of the Kursk region", Kursk

390026

"GBOU VPO Ryazan State medical university n.a. academician I.P.Pavlov", Ryazan

"GBOUVPO Ryazan State Medical University n.a. Academician I.P.Pavlov", Ryazan

"GBU of Ryazan region Regional clinical cardiology dispanser", Ryazan

390039

"GBOU of Ryazan region Regional clinical hospital", Ryazan

410053

"GUZ Regional clinical hospital", Saratov

540136

Spitalul Clinic Judetean de Urgenta Targu Mures, Târgu Mureş

600023

"GBUZ VO 'Regional clinical hospital", Vladimir

650000

"GAUZ of Kemerovo Region Regional clinical hospital for war veterans", Kemerovo

660014

"KGBUZ Krasnoyarsk Interdistrict Clinical Hospital #20 n.a. I.S.Berzon", Krasnoyarsk

660022

Krasnoyarsk State Medical University n.a.Prof.V.F.Voyno-Yasenetsky, Krasnoyarsk

700656

Spitalul Clinic de Recuperare Iasi, Iași

800578

"Spitalul Clinic Judetean de Urgenta Galati Sf. Apostol Andrei", Galati

3109601

Rambam Health Care Campus, Haifa

4428164

Meir Medical Center, Kfar Saba

08043

Arthritis, Rheumatic & Back Disease Associates, Voorhees Township

80030-110

CETI - Centro de Estudos em Terapias Inovadoras, Curitiba

05652-900

Hospital Israelita Albert Einstein, São Paulo

N8X 2C9

Clinical Research and Arthritis Center, Windsor

602 00

CCBR Czech Brno, s.r.o., Brno

Lekarna Lancier, s.r.o., Brno

530 02

BENU Lekarna, Pardubice

CCBR-SYNARC a.s., Pardubice

130 00

CCBR Czech Prague, s.r.o., Prague

Lekarna U Robina, s.r.o., Prague

686 01

Lekarna Hradebni s.r.o., Uherské Hradiště

MEDICAL PLUS, s.r.o., Uherské Hradiště

0159

LTD Tbilisi Central Hospital, Tbilisi

LTD Unimedi Kakheti, Tbilisi

Tbilisi Heart and Vascular Clinic LTD, Tbilisi

0160

LTD MediClubGeorgia, Tbilisi

0186

LTD Adapti, Tbilisi

"LTD Medulla Chemotherapy and Immunotherapy Clinic", Tbilisi

01010

Clínica Médica Especializada en Medicina Interna y Reumatología, Guatemala City

01011

Clínica Médica especializada en Medicina Interna, Guatemala City

01015

Centro de Nutricion y Rehabilitacion Cardiorespiratoria, S.A. (NUCARE), Guatemala City

Therapeutic Research Institute and Lab S.A, Guatemala City

446-8602

Anjo Kosei Hospital, Anjo-shi

820-8505

Aso Iizuka Hospital, Iiduka

370-0053

Inoue Hospital, Takasaki

735-8585

Mazda Hospital, Aki-gun

060-8604

Sapporo City General Hospital, Sapporo

060-8648

Hokkaido University Hospital, Sapporo

673-1462

Matsubara Mayflower Hospital, Katoh

252-0392

National Hospital Organization Sagamihara National Hospital, Sagamihara

236-0037

Yokohama Minami Kyosai Hospital, Yokohama

856-8562

National Hospital Organization Nagasaki Medical Center, Ōmura

857-1195

Sasebo Chuo Hospital, Sasebo

710-0016

Kurashiki Sweet Hospital, Kurashiki

901-0243

Yuaikai Tomishiro Central Hospital, Tomigusuku

350-8550

Saitama Medical Center, Kawagoe-shi

359-1111

Hirose Clinic, Tokorozawa-shi

411-8611

National Hospital Organization Shizuoka Medical Center, Sunto-gun

104-8560

St. Luke's International Hospital, Chuo-ku

153-8515

Toho University Ohashi Medical Center, Meguro-ku

142-8666

Showa University Hospital, Shinagawa-ku

260-8712

National Hospital Organization Chiba-East Hospital, Chiba

810-0001

Kondo clinic for rheumatism and orthopaedics, Fukuoka

810-8563

National Hospital Organization Kyushu Medical Center, Fukuoka

862-0976

Kumamoto Orthopaedic Hospital, Kumamoto

LT-50009

LSMUL Kauno klinikos, Kaunas

CP 78240

"Unidad de Investigaciones Reumatológicas A.C - Hospital Central Dr. Ignacio Morones Prieto", Zona Universitaria

CP 97000

Unidad Reumatologica Las Americas S.C.P, Mérida

Lima 29

Hospital María Auxiliadora - Centro de Investigaciones Medicas, San Juan de Miraflores

Lima 33

Instituto de Ginecología y Reproducción & Cirugía Mínimamente Invasiva, Santiago de Surco

CP656

Centro de diagnóstico por imágenes, Radiología General y Especial, Arequipa

Unidad de Investigación en Medicina Interna y Enfermedades Críticas, Arequipa

Lima 27

Centro de Investigación Reumatología CAA, Lima

Lima 31

Clinica Medica Cayetano Heredia, Lima

Servicio de Inmunología y Reumatología, Lima

4217/043

Mary Mediatrix Medical Center, Lipa City

85-168

Szpital Uniwersytecki nr 2 im. dr. Jana Biziela w Bydgoszczy, Bydgoszcz

31-121

Szpital Specjalistyczny im. J. Dietla Malopolskie Centrum Reumatologii Immunologii i Rehabilitacji, Krakow

05-830

NZOZ Lecznica MAK-MED. S.C., Nadarzyn

67-100

Twoja Przychodnia - Centrum Medyczne Nowa Sol, Nowa Sól

02-106

MTZ Clinical Research Sp. z o.o., Warsaw

11 000

Clinical Hospital Center Bezanijska Kosa, Belgrade

Military Medical Academy, Belgrade

0002

Jakaranda Hospital, Pretoria

0084

Emmed Research, Pretoria

03080

Seoul National University Hospital, Seoul

04763

Hanyang University Seoul Hospital, Seoul

120-752

Severance Hospital, Yonsei University Health System, Seoul

143-729

Konkuk University Medical Center, Seoul

03680

Kyivska miska klinichna likarnia #6, Kyiv

WN6 9EP

Wrightington Hospital, Wigan

ME16 9QQ

Maidstone Hospital, Maidstone and Tunbridge wells NHS Trust, Maidstone

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT02222493 - A Study of PF-06438179 (Infliximab-Pfizer) and Infliximab in Combination With Methotrexate in Subjects With Active Rheumatoid Arthritis (REFLECTIONS B537-02). | Biotech Hunter | Biotech Hunter