A Safety and Pharmacology Study of Atezolizumab (MPDL3280A) Administered With Obinutuzumab or Tazemetostat in Participants With Relapsed/Refractory Follicular Lymphoma and Diffuse Large B-cell Lymphoma

PHASE1CompletedINTERVENTIONAL
Enrollment

96

Participants

Timeline

Start Date

December 18, 2014

Primary Completion Date

January 21, 2020

Study Completion Date

January 21, 2020

Conditions
Lymphoma
Interventions
DRUG

Atezolizumab

During safety evaluation stage, atezolizumab will be administered as 1200 milligrams (mg) intravenous (IV) infusion. During expansion stage, atezolizumab will be administered as either 1200 mg IV infusion or at dose decided from safety evaluation stage.

DRUG

Obinutuzumab

During safety evaluation stage, obinutuzumab will be administered as 1000 mg IV infusion. During expansion stage, obinutuzumab will be administered as either 1000 mg IV infusion or at dose decided from safety evaluation stage.

DRUG

Tazemetostat

Tazemetostat 800 mg will be administered orally, twice daily, on Days 1 to 21.

Trial Locations (15)

10126

Azienda Ospedaliera Città della Salute e della Scienza di Torino, Turin

27599

University of North Carolina at Chapel Hill, Chapel Hill

34295

Hopital Saint Eloi, Montpellier

46805

Fort Wayne Neurological Center, Fort Wayne

59037

Hopital Claude Huriez - CHU Lille; Service des maladies du sang, Lille

69495

Centre Hospitalier Lyon Sud, Pierre-Bénite

75475

Hôpital Saint-Louis, Paris

77030

MD Anderson Cancer Center, Houston

79106

Universitaetsklinikum Freiburg, Freiburg im Breisgau

91010

City of Hope National Medical Center, Duarte

94805

Institut Gustave Roussy, Villejuif

98109

UW- Fred Hutchinson Cancer Center, Seattle

07601

Hackensack University Medical Center, Hackensack

10065-6007

Sloan Kettering Cancer Center, New York

E1 2EF

Barts Hospital, London

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT02220842 - A Safety and Pharmacology Study of Atezolizumab (MPDL3280A) Administered With Obinutuzumab or Tazemetostat in Participants With Relapsed/Refractory Follicular Lymphoma and Diffuse Large B-cell Lymphoma | Biotech Hunter | Biotech Hunter