A Study to Evaluate Long-term Outcomes Following Treatment With ABT-450/Ritonavir/ABT-267 (ABT-450/r/ABT-267) and ABT-333 With or Without Ribavirin (RBV) in Adults With Genotype 1 Chronic Hepatitis C Virus (HCV) Infection

PHASE3CompletedINTERVENTIONAL
Enrollment

1,596

Participants

Timeline

Start Date

October 30, 2014

Primary Completion Date

May 13, 2021

Study Completion Date

May 13, 2021

Conditions
Chronic Hepatitis C Virus (HCV) Infection Genotype 1
Interventions
DRUG

ABT-450/r/ABT-267

Tablet for oral use

DRUG

ABT-333

Tablet for oral use

DRUG

Ribavirin (RBV)

Ribavirin was provided as 200 mg tablets, and dosed based on weight,1000 to 1200 mg divided twice daily per local label. For example, for participants weighing \< 75 kg, RBV may have been taken orally as 2 tablets in the morning and 3 tablets in the evening which corresponds to a 1000 mg total daily dose. For participants weighing ≥ 75 kg, RBV may have been taken orally as 3 tablets in the morning and 3 tablets in the evening which corresponds to a 1200 mg total daily dose.

Trial Locations (187)

1070

Cliniques Universitaires de Bruxelles Hopital Erasme /ID# 131020, Brussels

1090

Medizinische Universitaet Wien /ID# 131015, Vienna

1200

UCL Saint-Luc /ID# 131019, Woluwe-Saint-Lambert

1407

Tokuda Hospital Sofia /ID# 131022, Sofia

1431

UMHAT Sveti Ivan Rilski /ID# 131026, Sofia

1478

Akershus Universitetssykehus_MAIN /ID# 132212, Lorenskog

1527

Univ Hosp for Active Treat /ID# 131023, Sofia

1612

Diagnostic Consultative Center /ID# 131027, Sofia

2010

St Vincent's Hospital Sydney /ID# 131001, Darlinghurst

2145

Westmead Hospital /ID# 130997, Westmead

2650

Kobenhavns Universitet - Hvidovre Hospital (HH) /ID# 131031, Hvidovre

2747

Nepean Hospital /ID# 130999, Kingswood

3000

Universitair Ziekenhuis Leuven /ID# 131021, Leuven

3010

Inselspital, Universitätsspital Bern /ID# 132294, Bern

3050

The Royal Melbourne Hospital /ID# 130998, Parkville

3065

St Vincent's Hospital Melbourne /ID# 131000, Fitzroy Melbourne

4010

Ordensklinikum Linz GmbH Elisabethinen /ID# 131017, Linz

4029

Royal Brisbane and Women's Hospital /ID# 131004, Herston

4068

Stavanger University Hospital /ID# 132211, Stavanger

4120

Greenslopes Private Hospital /ID# 131003, Greenslopes

5000

Royal Adelaide Hospital /ID# 131002, Adelaide

Odense University Hospital /ID# 131029, Odense C

7006

St. Olavs Hospital HF /ID# 132213, Trondheim

8036

Medizinische Universitaet Graz /ID# 131018, Graz

8091

Universitätsspital Zürich /ID# 134881, Zurich

8200

Aarhus Univ Hospital, Skejby /ID# 131030, Aarhus

9007

Kantonsspital St. Gallen /ID# 131148, Sankt Gallen

9010

UMHAT Sveta Marina /ID# 131025, Varna

10126

A.O.U. Citta della Salute e della Scienza di Torino /ID# 131100, Turin

11426

Ministry Nat Guard Hosp Health /ID# 145126, Riyadh

11472

King Khalid University Hospita /ID# 132291, Riyadh

11527

General Hospital of Athens Ippokratio /ID# 131057, Athens

General Hospital of Athens Laiko /ID# 131088, Athens

13008

Hopital Saint Joseph /ID# 132177, Marseille

13353

Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie /ID# 131053, Berlin

14000

Instituto Nacional de Clencias Medicas y Nutricion Salvador Zubrian Departament /ID# 130975, Distrito Federal

14004

Hospital Universitario Reina Sofia /ID# 131135, Córdoba

14050

CIF-BIOTEC/Medica Sur /ID# 134971, Mexico City

14308

Instituto Metropolitano de Inv /ID# 132201, Tlalpan

14380

ITESM campus Ciudad de Mexico /ID# 132383, Mexico City

15006

Hospital Universitario A Coruna - CHUAC /ID# 131137, A Coruña

16000

CHU Bab El Oued /ID# 145420, Algiers

CHU Bologhine Hospital /ID# 145421, Algiers

CHU Mustapha Bacha /ID# 132130, Algiers

16059

Uludag University Medical Faculty /ID# 132297, Bursa

20014

Hospital Donostia /ID# 131144, Donostia / San Sebastian

20122

Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 131097, Milan

20123

Ospedale S Giuseppe /ID# 132194, Milan

20132

Ospedale San Raffaele IRCCS /ID# 131093, Milan

20142

ASST Santi Paolo e Carlo/Presidio Ospedale San Paolo /ID# 132198, Milan

20157

ASST Fatebenefratelli Sacco-Ospedale Sacco /ID# 134372, Milan

20162

Azienda Ospedaliera Niguarda Ca' Granda Hospital /ID# 131104, Milan

20246

Universitaetsklinikum Hamburg-Eppendorf (UKE) /ID# 131051, Hamburg

20520

Turku University Hospital /ID# 131032, Turku

21423

King Abdulaziz Medical City /ID# 145129, Jeddah

22680

Hospital General de Tijuana /ID# 130972, Tijuana

24127

Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni /ID# 132188, Bergamo

28006

Hospital Universitario de la Princesa /ID# 131131, Madrid

28041

Hospital Universitario 12 de Octubre /ID# 131133, Madrid

28046

Hospital Universitario La Paz /ID# 131132, Madrid

29010

Hospital Universitario Virgen de la Victoria /ID# 131136, Málaga

30202

Hospital General Universitario Santa Lucia /ID# 131139, Cartagena

30625

Medizinische Hochschule Hannover /ID# 131054, Hanover

31059

Hopital Universitaire Purpan Hopital Rangueil /ID# 131035, Toulouse

33011

Hospital Universitario Central de Asturias /ID# 131138, Oviedo

33100

Azienda Ospedaliera Universitaria Friuli Centrale/Presidio Ospedaliero Universit /ID# 132196, Udine

33604

Hopital Haut-Lévêque /ID# 131036, Pessac

34093

Istanbul University Istanbul Medical Faculty /ID# 131153, Istanbul

34295

Hopital Saint Eloi /ID# 131037, Montpellier

34362

The Lady Davis Carmel Medical Center /ID# 131091, Haifa

35033

CHRU Pontchaillou /ID# 132173, Rennes

35040

Ege University Medical Faculty /ID# 132298, Izmir

35180

Izmir Tepecik Training and Research Hospital /ID# 134968, Konak

38700

CHU Grenoble - Hopital Michallon /ID# 131041, La Tronche

39008

Hospital Unversitario Marques de Valdecilla /ID# 131141, Santander

40138

Duplicate_A.O.U. Policlinico S.Orsola-Malpighi /ID# 131095, Bologna

40237

Zentru fur HIV und Heaptogastroenterologie /ID# 131052, Düsseldorf

41013

Hospital Universitario Virgen del Rocio /ID# 131134, Seville

43126

Azienda Ospedaliero-Universitaria di Parma /ID# 132183, Parma

44000

CHU de Nantes, Hotel Dieu -HME /ID# 132179, Nantes

44124

Azienda Ospedaliero-Universitaria di Ferrara-Arcispedale Sant Anna /ID# 131102, Cona

44160

Cife /Id# 130974, Guadalajara

44623

Gastroenterologische Gemeinschaftspraxis Herne /ID# 131050, Herne

45147

Universitaetsklinikum Essen /ID# 131048, Essen

48143

Centrum für interdisziplinaere Medizin /ID# 131046, Münster

48903

OSI Ezkerraldea-Enkarterri-Cruces /ID# 131143, Barakaldo

50009

Hospital Clinico Universitario Lozano Blesa /ID# 132292, Zaragoza

50134

Azienda Ospedaliero Universitaria Careggi /ID# 132197, Florence

60590

Universitaetsklinikum Frankfurt /ID# 131055, Frankfurt am Main

61000

Karadeniz University /ID# 131152, Trabzon

67091

CHU Strasbourg - Hopital Civil /ID# 132174, Strasbourg

68100

General University Hospital of Alexandroupolis /ID# 131056, Alexandroupoli

69004

HCL - Hopital de la Croix-Rousse /ID# 131042, Lyon

69120

Universitaetsklinik Heidelberg /ID# 134371, Heidelberg

71013

Fondazione di Religione e di Culto Casa Sollievo della Sofferenza /ID# 132190, San Giovanni Rotondo

71122

Azienda Ospedaliera Universitaria Ospedali Riuniti /ID# 132195, Foggia

72076

Universitaetsklinikum Tuebingen Medizinische Klinik /ID# 131045, Tübingen

79106

Universitaetsklinikum Freiburg /ID# 131044, Freiburg im Breisgau

80131

Azienda Ospedaliera Universitaria Federico II /ID# 131096, Napoli

Azienda Ospedaliera Universitaria Federico II /ID# 132191, Napoli

81377

LMU Klinikum der Universitat Muchen /ID# 131049, Munich

84131

"Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi d'Aragona /ID# 132192", Salerno

87042

CHU Limoges - Dupuytren 1 /ID# 131038, Limoges

90127

Azienda Ospedaliera Universitaria Paolo Giaccone /ID# 132184, Palermo

93140

Hopital Jean Verdier /ID# 135877, Bondy

98125

A.O.U. Policlinico G. Martino /ID# 132193, Messina

111123

Moscow Clinical Scientific Center n.a. Loginov /ID# 132266, Moscow

117593

Central Clinical Hospital of Russian Academy of Science /ID# 132289, Moscow

119991

I. M. Sechenov First Moscow State Medical University /ID# 132275, Moscow

127015

City Clinical Hospital #24 /ID# 132268, Moscow

129090

Research Institute of Emergency Medicine named after V.I. N.V. Sklifosovsky /ID# 132288, Moscow

300310

Spitalul Clinic de Boli Infectioase Si Pneumoftiziologie Dr. Victor Babes /Id# 131126, Timișoara

355017

Stavropol State Medical University /ID# 132279, Stavropol

420140

Republican Clinical Infectious Diseases Hospital n.a. Professor A. F. Agafonov /ID# 132270, Kazan'

443063

Medical Company Hepatolog /ID# 132277, Samara

443099

Samara State Medical University /ID# 136913, Samara

445009

Tolyatti City Clinical Hospital #1 /ID# 132273, Tolyatti

454052

South-Ural State Med. Academy /ID# 132274, Chelyabinsk

620102

Sverdlovsk Regional Clinical Hospital #1 /ID# 132267, Yekaterinburg

625026

Multidisciplinary Consultative and Diagnostic Center /ID# 131130, Tyumen

630099

Clinical Infectious Diseases Hospital #1 /ID# 132272, Novosibirsk

650056

Kuzbass Center for Prevention and Fight agains AIDS /ID# 132269, Kemerovo

660049

Krasnoyarsk Regional Center for the Prevention and Control of AIDS /ID# 132278, Krasnoyarsk

700506

SC Gastromedica SRL /ID# 131127, Iași

3109601

Rambam Health Care Campus /ID# 131090, Haifa

5265601

The Chaim Sheba Medical Center /ID# 131092, Ramat Gan

6423906

Tel Aviv Sourasky Medical Center /ID# 132182, Tel Aviv

T2N 4Z6

University of Calgary /ID# 134370, Calgary

T5H 4B9

GI Research & Associates /ID# 132169, Edmonton

V5Z 1H3

LAIR Centre /ID# 130970, Vancouver

V6Z 2C7

Vancouver Infectious Diseases Centre /ID# 134369, Vancouver

V6Z 2K5

GIRI Gastrointestinal Research Institute /ID# 132171, Vancouver

R3E 3P4

University of Manitoba / Health Scuience Centre / John Buhler Research Centre /ID# 130969, Winnipeg

E2L 4L2

Saint John Regional Hospital /ID# 131210, Saint John

K1H 8L6

Ottawa Hospital Research Institute /ID# 132170, Ottawa

M5G 2C4

Toronto General Hospital /ID# 132134, Toronto

M6H 3M1

Toronto Liver Centre /ID# 132168, Toronto

L4L 4Y7

Toronto Digestive Disease Asso /ID# 130968, Vaughan

H2L 4P9

Clinique Medicale L'Actuel /ID# 132167, Montreal

H3T 1E2

Jewish General Hospital /ID# 132165, Montreal

H4A 3J1

Royal Victoria Hospital / McGill University Health Centre /ID# 132166, Montreal

G1V 4G2

CHU de Quebec-Université Laval hôpital CHUL /ID# 132132, Québec

00290

Helsinki University Hospital /ID# 131034, Helsinki

06202

Duplicate_Hopital lArchet 2 /ID# 131040, Nice

D09 XR63

Beaumont Hospital /ID# 131089, Beaumont

D08 NHY1

St James Hospital /ID# 132180, Dublin

D04 T6F4

St Vincent's University Hospital /ID# 132181, Elm Park

00168

Policlinico Agostino Gemelli /ID# 131098, Rome

00133

Fondazione PTV Policlinico Tor Vergata /ID# 132185, Rome

3015 GD

Erasmus Medisch Centrum /ID# 132206, Rotterdam

1105 AZ

Academisch Medisch Centrum /ID# 132205, Amsterdam

2333 ZA

Leids Universitair Medisch Centrum /ID# 132204, Leiden

85-030

Wojewodzki Szpital Obserwacyjno-Zakazny im. Tadeusza Browicza /ID# 131106, Bydgoszcz

20-081

Samodzielny Publiczny Szpital Kliniczny Nr 1 w Lublinie /ID# 131115, Lublin

01-201

Wojewodzki Szpital Zakazny /ID# 131112, Warsaw

15-276

Uniwersytecki Szpital Kliniczny w Bialymstoku /ID# 131108, Bialystok

41-406

ID Clinic /ID# 131111, Mysłowice

91-347

Wojewodzki Specjalistyczny Szpital im. dr. W. Bieganskiego /ID# 131107, Lodz

3000-075

Centro Hospitalar e Universitario de Coimbra, EPE /ID# 131119, Coimbra

1169-050

Centro Hospitalar Universitario Lisboa Central, EPE - Hospital dos Capuchos /ID# 131116, Lisbon

1649-035

Centro Hospitalar Universitário de Lisboa Norte, EPE - Hospital de Santa Maria /ID# 131118, Lisbon

4099-001

Centro Hospitalar Universitário do Porto, EPE - Hospital Santo António /ID# 131117, Porto

021105

Duplicate_Institutul National de Boli Infectioase Prof. Dr. Matei Bals /ID# 131120, Sector 2

022328

Institutul Clinic Fundeni /ID# 131121, Sector 2

010825

Institutul Nat. de Boli Infectioase /ID# 131124, Bucharest

07120

Hospital Universitari Son Espases /ID# 131140, Palma de Mallorca

08916

Hospital Universitario Germans Trias i Pujol /ID# 132293, Badalona

214 28

Skane University hospital /ID# 131146, Malmo

171 64

Karolinska University Hospital Solna /ID# 131145, Solna

413 45

Sahlgrenska University Hospital /ID# 131147, Gothenburg

06100

Hacettepe University Faculty of Medicine /ID# 131150, Ankara

06590

Ankara Univ Medical Faculty /ID# 131151, Ankara

BH15 2JB

Duplicate_University Hospitals Dorset NHS Foundation Trust /ID# 132306, Poole

SO16 6YD

University Hospital Southampton NHS Foundation Trust /ID# 131161, Southampton

E1 2ES

Barts Health NHS Trust /ID# 132302, London

NW3 2QG

The Royal Free London NHS Foundation Trust /ID# 131159, London

NG5 1PB

Duplicate_Nottingham University Nottingham University Hospitals NHS Trust /ID# 131155, Nottingham

G12 0XH

NHS Greater Glasgow and Clyde /ID# 131162, Glasgow

B15 2TH

University Hospitals Birmingham NHS Foundation Trust /ID# 131154, Birmingham

DD2 1UB

Duplicate_NHS Tayside /ID# 132300, Dundee

EH3 9HE

NHS Lothian /ID# 134368, Edinburgh

LS9 7TF

Leeds Teaching Hospitals NHS Trust /ID# 132305, Leeds

SE5 9RS

King's College Hospital NHS Foundation Trusts /ID# 131157, London

PL6 5FP

University Hospital Plymouth NHS Trust /ID# 131160, Plymouth

PO6 3LY

Portsmouth Hospitals University NHS Trust /ID# 131158, Portsmouth

M6 8HD

Northern Care Alliance NHS Group /ID# 131156, Salford

SW17 0QT

St George's University Hospitals NHS Foundation Trust /ID# 132301, Tooting

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