Evaluating PCSK9 Binding antiBody Influence oN coGnitive HeAlth in High cardiovascUlar Risk Subjects

PHASE3CompletedINTERVENTIONAL
Enrollment

1,974

Participants

Timeline

Start Date

September 10, 2014

Primary Completion Date

November 11, 2016

Study Completion Date

November 11, 2016

Conditions
Dyslipidemia
Interventions
BIOLOGICAL

Evolocumab

Administered subcutaneously using a spring-based prefilled 1.0 mL autoinjector/pen.

DRUG

Placebo

Administered subcutaneously using a spring-based prefilled 1.0 mL autoinjector/pen.

DRUG

Background Statin Therapy

Participants were required to be on a stable, high- to moderate-intensity statin background therapy consisting of an effective statin dose, ie, at least atorvastatin 20 mg daily or equivalent, and where locally approved, highly effective statin therapy (defined as at least atorvastatin 40 mg daily or equivalent) was recommended.

Trial Locations (416)

1012

Research Site, Riga

1020

Research Site, Brussels

1036

Research Site, Budapest

1070

Research Site, Brussels

1619

Research Site, Kempton Park

1724

Research Site, Johannesburg

2020

Research Site, Skedsmokorset

2196

Research Site, Johannesburg

2300

Research Site, København S

2317

Research Site, Hamar

2605

Research Site, Woden

2650

Research Site, Hvidovre

2750

Research Site, Ballerup Municipality

2820

Research Site, Bonheiden

3076

Research Site, Epping

3128

Research Site, Box Hill

3143

Research Site, Tauranga

3220

Research Site, Geelong

3402

Research Site, Liepāja

3420

Research Site, Lierskogen

3710

Research Site, Skien

3800

Research Site, Szikszó

4000

Research Site, Liège

4005

Research Site, Stavanger

4066

Research Site, Auchenflower

4100

Research Site, Berettyóújfalu

4400

Research Site, Nyíregyháza

4600

Research Site, Køge

5000

Research Site, Adelaide

5001

Research Site, Ogre

5035

Research Site, Ashford

5063

Research Site, Fullarton

5417

Research Site, Daugavpils

5600

Research Site, Békéscsaba

6003

Research Site, Ålesund

6534

Research Site, Gozée

6700

Research Site, Esbjerg

6725

Research Site, Szeged

6850

Research Site, Worcester

7000

Research Site, Hobart

7100

Research Site, La Louvière

Research Site, Vejle

Research Site, Szekszárd

7130

Research Site, Somerset West

7505

Research Site, Parow

7530

Research Site, Cape Town

7624

Research Site, Pécs

7646

Research Site, Paarl

8011

Research Site, Christchurch

8900

Research Site, Ieper

Research Site, Zalaegerszeg

9000

Research Site, Aalborg

9300

Research Site, Aalst

10128

Research Site, Tallinn

10138

Research Site, Tallinn

10323

Research Site, Vilnius

10567

Research Site, Cortlandt Manor

10787

Research Site, Berlin

11042

Research Site, New Hyde Park

11206

Research Site, Brooklyn

11521

Research Site, Athens

12180

Research Site, Troy

12553

Research Site, New Windsor

12559

Research Site, Berlin

13353

Research Site, Berlin

13419

Research Site, Tallinn

14215

Research Site, Buffalo

14221

Research Site, Williamsville

14224

Research Site, West Seneca

14233

Research Site, Athens

14561

Research Site, Athens

14609

Research Site, Rochester

15206

Research Site, Pittsburgh

15706

Research Site, Santiago de Compostela

17011

Research Site, Camp Hill

17201

Research Site, Chambersburg

18536

Research Site, Piraeus

19053

Research Site, Feasterville

19152

Research Site, Philadelphia

20100

Research Site, Turku

20246

Research Site, Hamburg

21204

Research Site, Towson

21804

Research Site, Salisbury

22015

Research Site, Burke

22042

Research Site, Falls Church

23219

Research Site, Richmond

23294

Research Site, Richmond

23435

Research Site, Suffolk

23860

Research Site, Hopewell

25030

Research Site, Besançon

27100

Research Site, Pavia

27103

Research Site, Winston-Salem

27310

Research Site, Gaziantep

27609

Research Site, Raleigh

28034

Research Site, Madrid

28117

Research Site, Mooresville

28463

Research Site, Tabor City

28467

Research Site, Calabash

28601

Research Site, Hickory

28602

Research Site, Hickory

28630

Research Site, Le Coudray

29461

Research Site, Moncks Corner

29464

Research Site, Mt. Pleasant

29582

Research Site, North Myrtle Beach

29707

Research Site, Fort Mill

30024

Research Site, Suwanee

30159

Research Site, Hanover

30342

Research Site, Atlanta

30501

Research Site, Gainesville

30909

Research Site, Augusta

31059

Research Site, Toulouse

31406

Research Site, Savannah

32003

Research Site, Fleming Island

32081

Research Site, Ponte Vedra

32117

Research Site, Daytona Beach

32216

Research Site, Jacksonville

33021

Research Site, Hollywood

33024

Research Site, Hollywood

33025

Research Site, Pembroke Pines

33100

Research Site, Tampere

33144

Research Site, Miami

33401

Research Site, West Palm Beach

33442

Research Site, Deerfield Beach

33472

Research Site, Boynton Beach

33604

Research Site, Pessac

33614

Research Site, Tampa

33713

Research Site, St. Petersburg

34096

Research Site, Istanbul

34232

Research Site, Sarasota

34295

Research Site, Montepellier Cedex

34429

Research Site, Crystal River

34684

Research Site, Palm Harbor

34865

Research Site, Istanbul

35100

Research Site, Izmir

35294

Research Site, Birmingham

35801

Research Site, Huntsville

36200

Research Site, Vigo

36608

Research Site, Mobile

37203

Research Site, Nashville

37388

Research Site, Tullahoma

38305

Research Site, Jackson

40100

Research Site, Jyväskylä

40503

Research Site, Lexington

41110

Research Site, Larissa

41380

Research Site, Kocaeli

42117

Research Site, Wuppertal

42303

Research Site, Owensboro

43201

Research Site, Columbus

43215

Research Site, Columbus

43615

Research Site, Toledo

44093

Research Site, Nantes

44708

Research Site, Canton

44787

Research Site, Bochum

45219

Research Site, Cincinnati

45414

Research Site, Dayton

45500

Research Site, Ioannina

45505

Research Site, Springfield

46010

Research Site, Valencia

46320

Research Site, Hammond

48106

Research Site, Ann Arbor

48912

Research Site, Lansing

48960

Research Site, Galdakao

49418

Research Site, Grandville

49444

Research Site, Muskegon

50009

Research Site, Zaragoza

50702

Research Site, Waterloo

50937

Research Site, Cologne

54301

Research Site, Green Bay

55102

Research Site, Saint Paul

56000

Research Site, Kuala Lumpur

57701

Research Site, Rapid City

58201

Research Site, Grand Forks

58455

Research Site, Witten

59100

Research Site, Kuala Lumpur

59405

Research Site, Great Falls

59901

Research Site, Kalispell

60101

Research Site, Addison

60596

Research Site, Frankfurt am Main

60616

Research Site, Chicago

62052

Research Site, Jerseyville

62220

Research Site, Belleville

63117

Research Site, St Louis

63128

Research Site, St Louis

65109

Research Site, Jefferson City

67502

Research Site, Hutchinson

68100

Research Site, Alexandroupoli

70006

Research Site, Metairie

70100

Research Site, Kuopio

70376

Research Site, Stuttgart

70403

Research Site, Hammond

70458

Research Site, Slidell

70508

Research Site, Lafayette

70808

Research Site, Baton Rouge

71201

Research Site, Monroe

72713

Research Site, Paide

74362

Research Site, Pryor

75013

Research Site, Paris

75024

Research Site, Plano

75216

Research Site, Dallas

76301

Research Site, Wichita Falls

77025

Research Site, Houston

77030

Research Site, Houston

78758

Research Site, Austin

79189

Research Site, Bad Krozingen

80012

Research Site, Aurora

80218

Research Site, Denver

80909

Research Site, Colorado Springs

83814

Research Site, Coeur d'Alene

84088

Research Site, West Jordan

85018

Research Site, Phoenix

85306

Research Site, Glendale

90029

Research Site, OYS

90100

Research Site, Oulu

90710

Research Site, Harbor City

90732

Research Site, San Pedro

90807

Research Site, Long Beach

90822

Research Site, Long Beach

91356

Research Site, Tarzana

91360

Research Site, Thousand Oaks

91801

Research Site, Alhambra

92056

Research Site, Oceanside

92220

Research Site, Banning

92262

Research Site, Palm Springs

92653

Research Site, Laguna Hills

93030

Research Site, Oxnard

95661

Research Site, Roseville

95816

Research Site, Sacramento

97225

Research Site, Portland

97239

Research Site, Portland

97701

Research Site, Bend

98195

Research Site, Seattle

117292

Research Site, Moscow

121552

Research Site, Moscow

153012

Research Site, Ivanovo

191015

Research Site, Saint Petersburg

192242

Research Site, Saint Petersburg

196601

Research Site, Pushkin

197022

Research Site, Saint Petersburg

199106

Research Site, Saint Petersburg

410054

Research Site, Saratov

426063

Research Site, Izhevsk

603076

Research Site, Nizhny Novgorod

610014

Research Site, Kirov

620144

Research Site, Yekaterinburg

630089

Research Site, Novosibirsk

634012

Research Site, Tomsk

644018

Research Site, Omsk

650002

Research Site, Kemerovo

650099

Research Site, Kemerovo

06610

Research Site, Bridgeport

04005

Research Site, Biddeford

01830

Research Site, Haverhill

02459

Research Site, Newton

08043

Research Site, Voorhees Township

07675

Research Site, Westwood

02860

Research Site, Pawtucket

A1B 3V6

Research Site, St. John's

N6C 0A7

Research Site, London

L3Y 5G8

Research Site, Newmarket

L3Y 8C3

Research Site, Newmarket

K9J 0B2

Research Site, Peterborough

N7T 4X3

Research Site, Sarnia

G7H 7K9

Research Site, Chicoutimi

J8Y 6S8

Research Site, Gatineau

H9R 3J1

Research Site, Pointe-Claire

G1V 4M6

Research Site, Québec

J3A 1C3

Research Site, Saint-Jean-sur-Richelieu

J7Z 5T3

Research Site, Saint-Jérôme

266 01

Research Site, Beroun

743 01

Research Site, Bílovec

250 01

Research Site, Brandýs nad Labem

602 00

Research Site, Brno

636 00

Research Site, Brno

638 00

Research Site, Brno

430 02

Research Site, Chomutov

580 22

Research Site, Havlíčkův Brod

695 01

Research Site, Hodonín

339 01

Research Site, Klatovy IV

460 63

Research Site, Liberec

570 14

Research Site, Litomyšl

789 85

Research Site, Mohelnice

779 00

Research Site, Olomouc

703 00

Research Site, Ostrava - Vitkovice

530 02

Research Site, Pardubice

101 00

Research Site, Prague

128 08

Research Site, Prague

130 00

Research Site, Prague

140 21

Research Site, Prague

150 00

Research Site, Praha 5 - Smichov

750 02

Research Site, Přerov

686 01

Research Site, Uherské Hradiště

00180

Research Site, Helsinki

00290

Research Site, Helsinki

01307

Research Site, Dresden

04103

Research Site, Leipzig

Unknown

Research Site, Hong Kong

491-8551

Research Site, Ichinomiya-shi

487-0031

Research Site, Kasugai-shi

451-8511

Research Site, Nagoya

457-8511

Research Site, Nagoya

460-0001

Research Site, Nagoya

440-8510

Research Site, Toyohashi

271-0077

Research Site, Matsudo-shi

793-0030

Research Site, Saijo-shi

811-1244

Research Site, Chikushi-gun

814-0180

Research Site, Fukuoka

814-8522

Research Site, Fukuoka

819-1104

Research Site, Itoshima-shi

060-0031

Research Site, Sapporo

672-8043

Research Site, Himeji-shi

302-0022

Research Site, Toride-shi

305-8558

Research Site, Tsukuba

615-0035

Research Site, Kyoto

904-8585

Research Site, Okinawa-shi

901-0493

Research Site, Shimajiri-gun

901-2132

Research Site, Urasoe-shi

530-0001

Research Site, Osaka

543-0035

Research Site, Osaka

840-8571

Research Site, Saga

849-0917

Research Site, Saga

332-8558

Research Site, Kawaguchi-shi

773-8502

Research Site, Komatsushima-shi

103-0027

Research Site, Chuo-ku

LV-3301

Research Site, Kuldīga

LV-5003

Research Site, Ogre

LV-1001

Research Site, Riga

6815 AD

Research Site, Arnhem

6716 RP

Research Site, Ede

5623 EJ

Research Site, Eindhoven

1625 HV

Research Site, Hoorn

5406 PT

Research Site, Uden

0450

Research Site, Oslo

80-952

Research Site, Gdansk

81-384

Research Site, Gdynia

81-402

Research Site, Gdynia

40-018

Research Site, Katowice

40-040

Research Site, Katowice

40-084

Research Site, Katowice

25-020

Research Site, Kielce

31-216

Research Site, Krakow

32-082

Research Site, Krakow

90-368

Research Site, Lodz

91-347

Research Site, Lodz

20-857

Research Site, Lublin

10-010

Research Site, Olsztyn

60-702

Research Site, Poznan

24-100

Research Site, Puławy

41-709

Research Site, Ruda Śląska

28-200

Research Site, Staszów

21-040

Research Site, Świdnik

33-100

Research Site, Tarnów

87-100

Research Site, Torun

01-192

Research Site, Warsaw

02-507

Research Site, Warsaw

04-730

Research Site, Warsaw

50-088

Research Site, Wroclaw

50-349

Research Site, Wroclaw

51-685

Research Site, Wroclaw

87-800

Research Site, Włocławek

22-400

Research Site, Zamość

2801-951

Research Site, Almada

2790-134

Research Site, Carnaxide

3000-075

Research Site, Coimbra

6200-251

Research Site, Covilha

085 01

Research Site, Bardejov

977 42

Research Site, Brezno

040 22

Research Site, Košice

984 01

Research Site, Lučenec

045 01

Research Site, Moldava nad Bodvou

940 01

Research Site, Nové Zámky

979 01

Research Site, Rimavská Sobota

048 01

Research Site, Rožňava

069 01

Research Site, Snina

08901

Research Site, Svidník

911 01

Research Site, Trenčín

917 01

Research Site, Trnava

0158

Research Site, Centurion

0184

Research Site, Pretoria

0183

Research Site, Pretoria West

08907

Research Site, L'Hospitalet de Llobregat

251 87

Research Site, Helsingborg

581 85

Research Site, Linköping

222 21

Research Site, Lund

111 35

Research Site, Stockholm

171 76

Research Site, Stockholm

451 50

Research Site, Uddevalla

721 89

Research Site, Västerås

01330

Research Site, Adana

06100

Research Site, Ankara

BT7 2EB

Research Site, Belfast

B15 2SQ

Research Site, Birmingham

B18 7QH

Research Site, Birmingham

BH7 7DW

Research Site, Bournemouth

CF14 5GJ

Research Site, Cardiff

S40 4AA

Research Site, Chesterfield

SN15 2SB

Research Site, Chippenham

PR7 7NA

Research Site, Chorley

DN9 1EP

Research Site, Doncaster

G20 0SP

Research Site, Glasgow

G45 9AW

Research Site, Glasgow

NE46 1QJ

Research Site, Hexham

LE3 9QP

Research Site, Leicester

L22 0LG

Research Site, Liverpool

L9 7AL

Research Site, Liverpool

EC1M 6BQ

Research Site, London

W2 1LA

Research Site, London

M15 6SX

Research Site, Manchester

M23 9LT

Research Site, Manchester

PO30 5TG

Research Site, Newport

CV10 7DJ

Research Site, Nuneaton

RG2 0TG

Research Site, Reading

CW11 1EQ

Research Site, Sandbach

S5 7AU

Research Site, Sheffield

B71 4HJ

Research Site, West Bromwich

YO21 1SD

Research Site, Whitby

WR5 1DD

Research Site, Worcester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY

NCT02207634 - Evaluating PCSK9 Binding antiBody Influence oN coGnitive HeAlth in High cardiovascUlar Risk Subjects | Biotech Hunter | Biotech Hunter