A Study Evaluating the Safety and Efficacy of Venetoclax (GDC-0199) Plus Bendamustine + Rituximab (BR) in Comparison With BR or Venetoclax Plus Rituximab in Participants With Relapsed and Refractory Follicular Non-Hodgkin's Lymphoma (fNHL)

PHASE2CompletedINTERVENTIONAL
Enrollment

163

Participants

Timeline

Start Date

December 1, 2014

Primary Completion Date

September 27, 2016

Study Completion Date

March 16, 2018

Conditions
Follicular Lymphoma
Interventions
DRUG

Venetoclax

Venetoclax will be administered as per the schedule specified under arm description.

DRUG

Bendamustine

Bendamustine will be administered as per the schedule specified under arm description.

DRUG

Rituximab

Rituximab will be administered as per the schedule specified under arm description.

Trial Locations (71)

1200

Cliniques Universitaires St-Luc, Brussels

2050

Royal Prince Alfred Hospital; Medical Oncology, Camperdown

2060

ZNA Stuivenberg, Antwerp

2065

Royal North Shore Hospital, St Leonards

2145

Westmead Hospital; Haematology, Sydney

2217

St George Hospital, Kogarah, New South Wales

2298

Calvary Mater Newcastle, Waratah

3168

Monash Medical Centre, Clayton

4102

Princess Alexandra Hospital, Woolloongabba

4184

Townsville General Hospital, Douglas

5011

Queen Elizabeth Hospital; Haematology, Woodville South

7000

Royal Hobart Hospital, Hobart

8000

AZ Sint Jan, Bruges

10126

Azienda Ospedale San Giovanni, Turin

14642

James P. Wilmot Cancer Center, Rochester

15212

Allegheny General Hospital, Pittsburgh

15213

University of Pittsburgh, Pittsburgh

19104

University of Pennsylvania; School of Medicine, Philadelphia

20162

Ospedale Niguarda Milano, Milan

21000

CHU de Dijon - Hopital le Bocage, Dijon

22903

University of Virginia, Charlottesville

23562

Universitätsklinikum Schleswig-Holstein / Campus Lübeck, Med. Klinik I, Hämatologie/Onkologie, Lübeck

24100

Asst Papa Giovanni XXIII, Bergamo

26506

West Virginia Uni Med. Center - Robert Byrd Health Science, Morgantown

27100

Irccs Policlinico San Matteo; Divisione Di Ematologia, Pavia

30106

Nothwest Georgia Oncology Centers P.C, Austell

34295

CHU Montpellier, Montpellier

36608

Southern Cancer Center, PC, Mobile

40138

A.O. Universitaria Policlinico S.Orsola-Malpighi Di Bologna, Bologna

45122

Universitätsklinik Essen; Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Essen

47014

IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica, Meldola

47900

Ospedale Infermi di Rimini, Rimini

48100

Ospedale di Ravenna, Ravenna

49933

Institut de Cancerologie de l'Ouest, Angers

50135

Az. Osp. Di Careggi; Divisione Di Ematologia, Florence

50937

Universitätsklinikum Köln; Klinik I für Innere Medizin, Cologne

55131

Uni. der Johannes Gutenberg-Universitaet Mainz; III. Medizinische Klinik und Poliklinik, Mainz

60426

Primary Healthcare Associates SC - Harvey, Harvey

60611

Northwestern University, Chicago

63003

CHU Clermont Ferrand - Hôpital d'Estaing, Clermont-Ferrand

66205

University of Kansas; Medical Center & Medical pavilion, Westwood

69495

Centre Hospitalier Lyon Sud; Hematolgie, Pierre-Bénite

72015

Centre Jean Bernard, Le Mans

85719

Arizona Cancer Center, Tucson

89075

Universitätsklinikum Ulm; Apotheke, Ulm

90095

UCLA School of Medicine; Hematology/Oncology, Los Angeles

94010

Hopital Henri Mondor, Créteil

97080

Universitätsklinikum Würzburg; Medizinische Klinik und Poliklinik II; Hämatologie / Onkologie, Würzburg

60612-7302

University of Illinois at Chicago College of Medicine, Chicago

21231-1000

Sidney Kimmel Comp Cancer Ctr, Baltimore

07601

Hackensack University Medical Center, Hackensack

23298-003

VCU Massey Cancer Center, Richmond

T6G 1Z2

Cross Cancer Institute, Edmonton

V1Y 5L3

British Columbia Cancer Agency, Kelowna

M5G 2M9

University Health Network; Princess Margaret Hospital; Medical Oncology Dept, Toronto

H1T 2M4

Hopital Maisonneuve- Rosemont; Oncology, Montreal

H2L 4M1

Chum Hopital Notre Dame; Centre D'Oncologie, Montreal

H3T 1E2

Jewish General Hospital, Montreal

S7N 4H4

Saskatoon Cancer Centre; Uni of Saskatoon Campus, Saskatoon

09116

Klinikum Chemnitz gGmbH; Klinik f. Innere Medizin III, Chemnitz

06847

Städtisches Klinikum Dessau, Dessau

01307

BAG Freiberg-Richter, Jacobasch, Illmer, Wolf; Gemeinschaftspraxis Hämatologie-Onkologie, Dresden

07747

Universitätsklinikum Jena; Klinik für Innere Medizin II, Jena

FY3 8NR

Blackpool Victoria Hospital, Blackpool

LS9 7TF

St James University Hospital, Leeds

LE1 5WW

Leicester Royal Infirmary; Dept. of Medical Oncology, Leicester

NW1 2PG

University College London, Department of Haematology, London

SW3 6JJ

Royal Marsden Nhs Trust; Consultant Cancer Physician, London

M20 4QL

Christie Hospital; Breast Cancer Research Office, Manchester

OX3 7LJ

Churchill Hospital; Oxford Cancer and Haematology Centre, Oxford

SM2 5PT

Royal Marsden NHS Foundation Trust, Sutton

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

AbbVie

INDUSTRY

lead

Hoffmann-La Roche

INDUSTRY