1,152
Participants
Start Date
August 31, 2014
Primary Completion Date
December 31, 2016
Study Completion Date
December 31, 2016
Tofacitinib with methotrexate
Tofacitinib 5 mg twice daily, oral for 12 months Methotrexate (previous stable dose 15-25 mg) every week, oral for 12 months Placebo for adalimumab every other week, subcutaneous for 12 months
Tofacitinib without methotrexate
Tofacitinib 5 mg twice daily, oral for 12 months Placebo for methotrexate (previous stable dose) every week, oral for 12 months Placebo for adalimumab every other week, subcutaneous for 12 months
Adalimumab with methotrexate
Placebo for tofacitinib twice daily, oral for 12 months Methotrexate (previous stable dose 15-25 mg) every week, oral for 12 months Adalimumab 40 mg every other week, subcutaneous for 12 months
ABK REUMAR S.R.L. de Medicentro Biociencias_ BIO CIENCIAS PERU S.R.L., Lima
Instituto Peruano del Hueso y la Articulacion, Lima
Investigaciones Clinicas S.A.C., Lima
Chung Shan Medical University Hospital, Taichung
Kaohsiung Medical University Chung-Ho Memorial Hospital - New, Kaohsiung City
University of the Philippines Manila-Philippine General Hospital, Manila
Jose R. Reyes Memorial Medical Center-Rayuma Klinik, Manila
Organizacion Medica de Investigacion S.A - OMI, Buenos Aires
St. Luke's Medical Center, Quezon City
Far Eastern University - NRMF Medical Center, Quezon City
NMTH Tsar Boris Clinic of Internal Diseases, Sofia
MHAT Lyulin EAD, Sofia
LCS Clinical Research Unit, Johannesburg
Royal Prince Alfred Hospital, Camperdown
WCR: Wits Clinical Research Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg
WCR: Wits Clinical Research, Johannesburg
Charlotte Maxeke Johannesburg Academic Hospital, Parktown, Johannesburg
Emeritus Research, Malvern East
Centro Medico Privado de Reumatologia, San Miguel de Tucumán
Centro Radiologico Luis Mendez Collado SRL, San Miguel de Tucumán
Netcare St Augustine's Hospital, Durban
"MHAT Kaspela EOOD", Plovdiv
MHAT EUROHOSPITAL Plovdiv, Plovdiv
Pacific Private Clinic, Southport
QML Pathology, Southport
Mary Mediatrix Medical Center, Lipa City
Iloilo Doctors' Hospital, Inc, Iloilo City
St. Paul's Hospital of Iloilo, Inc., Iloilo City
The Queen Elizabeth Hospital, Woodville South
CER San Juan, Centro Polivalente de Asistencia e Investigacion Clinica, San Juan
MHAT Akta Medika OOD, Rousse
"UMHAT Dr. Georgi Stranski EAD", Pleven
Perpetual Succour Hospital, Cebu City
RK Will Pty Ltd, Victoria Park
MHAT Ruse AD, Rousse
Arthritis Clinical Research Trials, Cape Town
Panorama Medical Centre, Cape Town
Wineland Medical Research Centre, Stellenbosch
"MHAT Targovishte AD", Targovisthe
Brokenshire Integrated Health Ministries, Inc., Davao City
Davao Doctors Hospital, Davao City
Iatros International, Bloemfontein
MHAT Shumen AD, Shumen
Phramongkutklao Hospital, Bangkok
Cardiology Unit,Department of Medicine, Faculty of Medicine, Ramathibodi Hospital,Mahidol University, Bangkok
Div. of Allergy Immunology and Rheumatology, Dept. of Medicine,, Bangkok
Siriraj Hospital Mahidol University, Bangkok
Taipei Veterans General Hospital, Taipei
East-Tallinn Central Hospital Ltd, Tallinn
Dr. Prem C. Chatpar M.D.,LLC, Plainview
CINTRE, Centro de Investigacion y Tratamiento Reumatologico S.C. Consultorio Medico de Reumatologia, Mexico City
North Estonia Medical Centre Foundation, Tallinn
Complexo Hospitalario Universitario A Coruna, A Coruña
Complejo Hospitalario Universitario de Santiago de Compostela, Hospital Clinico Universitario, Santiago de Compostela
Altoona Center For Clinical Research, Duncansville
Arthritis Treatment Center, Frederick
Inha University Hospital, Jung-Gu
Unidad de Enfermedades Reumaticas y Cronico Degenerativas S. C., Torreón
Hospital Universitario Fundacion Jimenez Diaz, Madrid
PMG Research of Salisbury, LLC, Salisbury
Rowan Diagnostic Clinic, Salisbury
PMG Research of Wilmington, Wilmington
Hospital Regional Universitario de Malaga, Málaga
Low Country Rheumatology, PA, Charleston
Investigacion y Biomedica de Chihuahua, SC, Chihuahua City
Bnai Zion Medical Center, Haifa
Riverside Clinical Research, Edgewater
Jacksonville Center for Clinical Research, Jacksonville
Gulf Region Clinical Research Institute Llc, Pensacola
Omega Research Consultants, LLC, Orlando
The Center for Arthritis and Rheumatism, Vero Beach
The Office of Alastair C. Kennedy, MD, Vero Beach
AARDS Research, Inc., Aventura
Arthritis and Rheumatic Disease Specialties, Aventura
Chang Gung Medical Foundation - Linkou Branch, Taoyuan
Centre for Rheumatology, Immunology and Arthritis, Fort Lauderdale
West Broward Rheumatology Associates, Inc., Tamarac
BayCare Medical Group Inc, Tampa
Arthritis Center, Inc., Palm Harbor
Advanced Clinical Research of Orlando, Inc., Winter Garden
Rheumatology Associates of North Alabama, PC, Huntsville
West Tennessee Research Institute, Jackson
Arthritis and Osteoporosis Treatment and Research Center, Flowood
Hospital Infanta Luisa, Seville
Kyungpook National University Hospital, Daegu
Daegu Catholic University Medical Center, Daegu
Centro Integral en Reumatologia, SA de CV, Guadalajara
Centro de Integral en Reumatologia SA de CV, Jalisco
Diagnostic Rheumatology and Research PC, Indianapolis
Jasper Clinic, Kalamazoo
Ondokuz Mayis Universitesi Tip Fakultesi Saglik Uyg. ve Eg., Samsun
Ondokuz Mayis Universitesi Tip Fakultesi Saglik Uygulama ve Egitim Merkezi, Samsun
Cumhuriyet Universitesi Tip Fakultesi Hastanesi, Sivas
Trinity Health Center - Medical Arts, Minot
Deerbrook Medical Associates, Vernon Hills
Chonnam National University Hospital, Gwangju
St. Louis Center For Clinical Research Barbara Caciolo, MD, St Louis
Revmatologie s.r.o., Brno
Clinvest/ A Division of Banyan Group, Inc., Springfield
Ochsner Clinic Baton Rouge, Baton Rouge
Arthritis and Diabetes Clinic, Inc, Monroe
Lynn Health Science Institute, Oklahoma City
University Clinical Center Tuzla, Tuzla
Southwest Rheumatology Research, LLC., Mesquite
Arthritis Care And Diagnostic Center, P.A., Dallas
Metroplex Clinical Research Center, Dallas
Accurate Clinical Management, LLC, Houston
Rheumatology Clinic of Houston, PA, Houston
Houston Institute For Clinical Research, Houston
Accurate Clinical Management, LLC, Baytown
University Hospital Clinical Center Banja Luka, Banja Luka
Centro de Alta Especialidad en Reumatologia e Investigacion del Potosi, S.C., San Luis Potosí City
Accurate Clinical Research, Inc., San Antonio
Arthritis & Osteoporosis Center of South Texas, San Antonio
Unidad de Investigaciones Reumatologicas A.C., San Luis Potosí City
Arthritis & Osteoporosis Associates, LLP, Lubbock
Centro de Investigacion de Tratamientos Innovadores de Sinaloa S.C., Culiacán
Centro de Investigacion en Tratamientos Innovadores de Sinaloa S.C., Culiacán
Foundation Parnu Hospital, Pärnu
Kaohsiung Veterans General Hospital, Kaohsiung City
Institute of Arthritis Research, Idaho Falls
Coeur D'Alene Arthritis Clinic, Coeur d'Alene
Arthrocare, Arthritis Care & Research, PC, Gilbert
Keck Medicine of USC - Division of Rheumatology, Los Angeles
University of Southern California (USC) Norris Comprehensive Cancer Center, Los Angeles
Ronald Reagan UCLA Medical Center - Drug Information Center, Los Angeles
UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles
Songklanagarind Hospital - Prince of Songkhla University, Songkhla
Medvin Clinical Research, Whittier
Hadassah Medical Center, Jerusalem
Medvin Clinical Research, Van Nuys
Medvin Clinical Research, Covina
Inland Rheumatology Clinical Trials, Inc., Upland
San Diego Arthritis Medical Clinic, San Diego
HealthCare Partners Medical Group, Huntington Beach
St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare, Fullerton
Medvin Clinical Research, Placentia
Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien City
Centro Multidisciplinario para el Desarrollo Especializado de la Invetigacion Clinica en Yucatan, Mérida
Departamento de Imagen de Hospital Star Medica Merida, Mérida
Laboratorio clínico del Hospital Star Medica Merida, Mérida
Storage for lab kits and study materials, Mérida
Arthritis Northwest, PLLC, Spokane
SBEI HPE First Moscow State Medical University n.a.I.M.Sechenov of MoH of RF based on UCH#1, Moscow
"CJSC European Medical Center", Moscow
State Autonomous Healthcare lnstitution of Yarostavl Region, Yaroslavl
"State Budgetary Healthcare Institution of Yaroslavl Region Clinical Hospital #3", Yaroslavl
Republic Hospital n.a. V.A. Baranov, Petrozavodsk
"State Budgetary Healthcare Institution of Karelia Republic Republic Hospital n.a. V.A. Baranov", Petrozavodsk
Limited Liability Company AVA-PETER, Saint Petersburg
"Non-state Healthcare Institution Regional Hospital at Smolensk Station of OJSC Russian Railways", Smolensk
"State Budgetary Institution of Ryazan Region Regional Clinical Cardiology Dispensary", Ryazan
Spitalul Clinic Judetean de Urgenta Cluj Napoca Reumatologie, Cluj-Napoca
"State Institution of Healthcare Regional Clinical Hospital", Saratov
"Spitalul Judetean de Urgenta Dr. Constantin Opris", Baia Mare
S.C. Clinica Somesan S.R.L., Baia Mare
"State Budgetary Institution of Healthcare Samara Regional Clinical Hospital n.a. V.D. Seredavin", Samara
"State Budgetary Healthcare Institution Orenburg Regional Clinical Hospital", Orenburg
Covamed Serv SRL, Sfântu Gheorghe
SBEI HPE Novosibirsk State Medical University of MoH of RF, Novosibirsk
"SAHI of KR Kemerovo Regional Clinical Hospital", Kemerovo
Spitalul Clinic de Recuperare Iasi, Iași
"Spitalul Clinic Judetean de Urgenta - Sf.Apostol Andrei Galati", Galati
Estudios Clinicos Quinta Region Ltda., Viña del Mar
Rambam Health Care Campus, Haifa
The Chaim Sheba Medical Center, Tel Litwinsky
Quantum Research Ltda, Puerto Varas
Quantum Research, Puerto Varas
Prosalud, Santiago
Joao M. A. Nascimento, Bridgeport
Arthritis Group, Philadelphia
Atencion Integral en Reumatologia (AIR), CABA
Kw Musculoskeletal Research Inc, Kitchener
Centre de Recherche Musculo-Squelettique, Trois-Rivières
Revmacentrum MUDr. Mostera, s.r.o., Brno - Zidenice
Revmatologicka ambulance, Česká Lípa
Vesalion, s.r.o., Ostrava- Moravska Ostrava
Revmatologie, Prague
Health Center 4, Riga
ORTO clinic Ltd, Riga
Alytaus District S. Kudirkos Hospital, Alytus
"VAKK Clinic of Dr. Kilda", Kaunas
PI Republican Siauliai Hospital, Šiauliai
Unidad de Investigacion en Medicina Interna y Enfermedades criticas-Hogar Clinica San Juan de Dios, Arequipa
Medica Pro Familia Sp. z o.o. S.K.A. Oddzial Krakow, Krakow
Centrum Medyczne Amed, Warsaw
Szpital Uniwersytecki nr 2 im. dr Jana Biziela w Bydgoszczy,, Bydgoszcz
Centrum Medyczne SILESIANA Sp. z o.o., Bytom
Nzoz Bif-Med, Bytom
Centrum Kliniczno-Badawcze J.Brzezicki, B.Gornikiewicz-Brzezicka, Elblag
Synexus Polska Sp. z o.o. Oddzial w Gdyni, Gdynia
Synexus Polska Sp. z o.o. Oddzial w Katowicach, Katowice
Centrum Terapii Wspolczesnej J.M. Jasnorzewska Spolka Komandytowo-Akcyjna, Lodz
Lecznica MAK-MED, NZOZ, Nadarzyn
Prywatna Praktyka Lekarska, Poznan
Synexus Polska Sp. z o.o. Oddzial w Warszawie, Warsaw
MTZ Clinical Research Sp. z o.o., Warsaw
Synexus Polska Sp. z o.o. Oddzial we Wroclawiu, Wroclaw
Ianuli Med Consult SRL, Reumatologie, Bucharest
Spitalul Clinic Sf. Maria, Medicina interna - Reumatologie, Bucharest
Spitalul Clinic Sf. Maria, Bucharest
"Spitalul Clinic Dr. I. Cantacuzino", Bucharest
"Centrul Clinic de Boli Reumatismale Dr. Ion Stoia", Bucharest
Clinical Research Unit, University of Pretoria, Pretoria
Netcare Jakaranda Hospital, Pretoria
University of Pretoria, Pretoria
Hanyang University Seoul Hospital, Seoul
Konkuk University Medical Center, Seoul
Hospital Clinic de Barcelona, Barcelona
Ankara Universitesi Tip Fakultesi Ibn-i Sina Hastanesi, Ankara
The Dudley Group NHS Foundation Trust, Dudley
The Royal Wolverhamptons NHS Trust, Cannock
The Leeds Teaching Hospitals NHS Trust, Leeds
Aintree University Hospital NHS Foundation Trust, Liverpool
Royal Free London NHS Foundation Trust, London
Lead Sponsor
Pfizer
INDUSTRY