6
Participants
Start Date
July 22, 2015
Primary Completion Date
December 19, 2019
Study Completion Date
February 7, 2020
cyclophosphamide
All patients will receive a single IV dose of 50 mg/kg of cyclophosphamide on day -6
fludarabine phosphate
Given by IV during prep at 40mg/m2 for 5 days
total-body irradiation
Undergo single fraction of reduced intensity conditioning (RIC) regimen of 200 cGy TBI without shielding on day -1
cyclosporine
Initiated in patients on the day -5. Cyclosporine will be administered orally or intravenously at 2 mg/kg/dose every 12 hours for 2-hour period. Cyclosporine will continue until day +100
mycophenolate mofetil
Given at 1g intravenously or orally twice daily from day -5 to +100, or as clinically indicated.
umbilical cord blood transplantation
Following RIC, on day T+0, dimethylsulphoxide will be removed from the cord blood cells and given as transplant.
mesenchymal stem cell transplantation
The total dosage of hMSC will be 2x10\^6cells/kg (+/-20%).
Case Comprehensive Cancer Center, Cleveland
National Cancer Institute (NCI)
NIH
Case Comprehensive Cancer Center
OTHER