140
Participants
Start Date
July 11, 2014
Primary Completion Date
June 30, 2019
Study Completion Date
December 23, 2025
Doxorubicin
Given IV
Doxorubicin Hydrochloride
Given IV
Ifosfamide
Given IV
Pazopanib
Given PO
Pazopanib Hydrochloride
Given PO
Radiation Therapy
Undergo radiation therapy
Therapeutic Conventional Surgery
Undergo surgery
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
Mount Sinai Hospital, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York
NYP/Weill Cornell Medical Center, New York
Montefiore Medical Center-Einstein Campus, The Bronx
Montefiore Medical Center-Weiler Hospital, The Bronx
Montefiore Medical Center - Moses Campus, The Bronx
New York Medical College, Valhalla
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park
NYU Langone Hospital - Long Island, Mineola
Albany Medical Center, Albany
Glens Falls Hospital, Glens Falls
State University of New York Upstate Medical University, Syracuse
Roswell Park Cancer Institute, Buffalo
University of Rochester, Rochester
Allegheny General Hospital, Pittsburgh
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
Penn State Children's Hospital, Hershey
Geisinger Medical Center, Danville
Lehigh Valley Hospital - Muhlenberg, Bethlehem
Lehigh Valley Hospital-Cedar Crest, Allentown
Lankenau Medical Center, Wynnewood
Drexel University School of Medicine, Philadelphia
Children's Hospital of Philadelphia, Philadelphia
Thomas Jefferson University Hospital, Philadelphia
Fox Chase Cancer Center, Philadelphia
Saint Christopher's Hospital for Children, Philadelphia
Alfred I duPont Hospital for Children, Wilmington
MedStar Georgetown University Hospital, Washington D.C.
Children's National Medical Center, Washington D.C.
Sinai Hospital of Baltimore, Baltimore
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
Inova Fairfax Hospital, Falls Church
University of Virginia Cancer Center, Charlottesville
VCU Massey Comprehensive Cancer Center, Richmond
Children's Hospital of The King's Daughters, Norfolk
Carilion Children's, Roanoke
West Virginia University Charleston Division, Charleston
West Virginia University Healthcare, Morgantown
Wake Forest University Health Sciences, Winston-Salem
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
Duke University Medical Center, Durham
East Carolina University, Greenville
Matthews Radiation Oncology Center, Matthews
Carolinas Medical Center/Levine Cancer Institute, Charlotte
Novant Health Presbyterian Medical Center, Charlotte
Mission Hospital, Asheville
Prisma Health Richland Hospital, Columbia
Prisma Health Cancer Institute - Spartanburg, Boiling Springs
Medical University of South Carolina, Charleston
Greenville Health System Cancer Institute-Andrews, Greenville
Saint Francis Hospital, Greenville
BI-LO Charities Children's Cancer Center, Greenville
Prisma Health Cancer Institute - Butternut, Greenville
Prisma Health Cancer Institute - Faris, Greenville
Prisma Health Greenville Memorial Hospital, Greenville
Saint Francis Cancer Center, Greenville
Prisma Health Cancer Institute - Eastside, Greenville
Prisma Health Cancer Institute - Greer, Greer
Prisma Health Cancer Institute - Seneca, Seneca
Emory University Hospital Midtown, Atlanta
Emory University Hospital/Winship Cancer Institute, Atlanta
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta
Augusta University Medical Center, Augusta
Memorial Health University Medical Center, Savannah
Nemours Children's Clinic-Jacksonville, Jacksonville
Nemours Children's Clinic - Pensacola, Pensacola
University of Florida Health Science Center - Gainesville, Gainesville
AdventHealth Orlando, Orlando
Nemours Children's Hospital, Orlando
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
Nicklaus Children's Hospital, Miami
Saint Mary's Medical Center, West Palm Beach
UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
Moffitt Cancer Center, Tampa
Johns Hopkins All Children's Hospital, St. Petersburg
Golisano Children's Hospital of Southwest Florida, Fort Myers
Children's Hospital of Alabama, Birmingham
University of Alabama at Birmingham Cancer Center, Birmingham
The Kirklin Clinic at Acton Road, Birmingham
The Children's Hospital at TriStar Centennial, Nashville
Vanderbilt University/Ingram Cancer Center, Nashville
T C Thompson Children's Hospital, Chattanooga
East Tennessee Childrens Hospital, Knoxville
Saint Jude Children's Research Hospital, Memphis
University of Mississippi Medical Center, Jackson
Norton Children's Hospital, Louisville
Norton Hospital Pavilion and Medical Campus, Louisville
Norton Suburban Hospital and Medical Campus, Louisville
University of Kentucky/Markey Cancer Center, Lexington
Nationwide Children's Hospital, Columbus
Ohio State University Comprehensive Cancer Center, Columbus
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
Case Western Reserve University, Cleveland
Rainbow Babies and Childrens Hospital, Cleveland
UHHS-Chagrin Highlands Medical Center, Beachwood
Cleveland Clinic Foundation, Cleveland
Children's Hospital Medical Center of Akron, Akron
Dayton Physicians LLC-Atrium, Franklin
Cincinnati Children's Hospital Medical Center, Cincinnati
Oncology Hematology Care Inc-Kenwood, Cincinnati
Oncology Hematology Care Inc-Blue Ash, Cincinnati
Dayton Physicians LLC-Wayne, Greenville
Wayne Hospital, Greenville
Dayton Physicians LLC - Troy, Troy
Upper Valley Medical Center, Troy
Dayton Children's Hospital, Dayton
Good Samaritan Hospital - Dayton, Dayton
Miami Valley Hospital, Dayton
Greater Dayton Cancer Center, Kettering
Dayton Physician LLC - Englewood, Dayton
Miami Valley Hospital North, Dayton
Kettering Medical Center, Kettering
Indu and Raj Soin Medical Center, Beavercreek
Wright-Patterson Medical Center, Wright-Patterson Air Force Base
Dayton Physicians LLC-Miami Valley South, Centerville
Miami Valley Hospital South, Centerville
Springfield Regional Cancer Center, Springfield
Springfield Regional Medical Center, Springfield
Armes Family Cancer Center, Findlay
Blanchard Valley Hospital, Findlay
Orion Cancer Care, Findlay
Riley Hospital for Children, Indianapolis
Ascension Saint Vincent Indianapolis Hospital, Indianapolis
Reid Health, Richmond
Henry Ford Macomb Hospital-Clinton Township, Clinton Township
Corewell Health Children's, Royal Oak
C S Mott Children's Hospital, Ann Arbor
Henry Ford Cancer Institute-Downriver, Brownstown
Wayne State University/Karmanos Cancer Institute, Detroit
Henry Ford Hospital, Detroit
Henry Ford Health Saint John Hospital, Detroit
Henry Ford West Bloomfield Hospital, West Bloomfield
Hurley Medical Center, Flint
Michigan State University, East Lansing
University of Michigan Health - Sparrow Lansing, Lansing
Bronson Methodist Hospital, Kalamazoo
West Michigan Cancer Center, Kalamazoo
Bronson Battle Creek, Battle Creek
Beacon Kalamazoo, Kalamazoo
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph
Corewell Health Lakeland Hospitals - Niles Hospital, Niles
Allegiance Health, Jackson
Trinity Health Muskegon Hospital, Muskegon
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
Trinity Health Grand Rapids Hospital, Grand Rapids
Corewell Health Reed City Hospital, Reed City
Munson Medical Center, Traverse City
Blank Children's Hospital, Des Moines
Iowa Methodist Medical Center, Des Moines
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines
Broadlawns Medical Center, Des Moines
Iowa Lutheran Hospital, Des Moines
Siouxland Regional Cancer Center, Sioux City
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
Aurora Health Care Germantown Health Center, Germantown
Aurora Cancer Care-Grafton, Grafton
Aurora Medical Center in Summit, Summit
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan
Aurora Cancer Care-Southern Lakes VLCC, Burlington
Aurora Cancer Care-Kenosha South, Kenosha
Aurora Cancer Care-Waukesha, Waukesha
Aurora Cancer Care-Milwaukee, Milwaukee
Aurora Saint Luke's Medical Center, Milwaukee
Children's Hospital of Wisconsin, Milwaukee
Medical College of Wisconsin, Milwaukee
Aurora Cancer Care-Milwaukee West, Wauwatosa
Aurora West Allis Medical Center, West Allis
Aurora Sinai Medical Center, Milwaukee
Aurora Cancer Care-Racine, Racine
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Aurora Bay Area Medical Group-Marinette, Marinette
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers
Aurora BayCare Medical Center, Green Bay
Marshfield Medical Center-Marshfield, Marshfield
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh
Aurora Health Center-Fond du Lac, Fond du Lac
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
University of Minnesota/Masonic Cancer Center, Minneapolis
Essentia Health Cancer Center, Duluth
Mayo Clinic in Rochester, Rochester
Sanford Broadway Medical Center, Fargo
Advocate Children's Hospital-Park Ridge, Park Ridge
Northwestern Medicine Cancer Center Delnor, Geneva
Loyola University Medical Center, Maywood
UC Comprehensive Cancer Center at Silver Cross, New Lenox
Advocate Children's Hospital-Oak Lawn, Oak Lawn
Northwestern Medicine Cancer Center Warrenville, Warrenville
Lurie Children's Hospital-Chicago, Chicago
Northwestern University, Chicago
Rush University Medical Center, Chicago
University of Illinois, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
Saint Jude Midwest Affiliate, Peoria
Saint John's Hospital, Springfield
Southern Illinois University School of Medicine, Springfield
Springfield Memorial Hospital, Springfield
SSM Health Good Samaritan, Mount Vernon
Cardinal Glennon Children's Medical Center, St Louis
Washington University School of Medicine, St Louis
Siteman Cancer Center at West County Hospital, Creve Coeur
Mercy Hospital Saint Louis, St Louis
University of Kansas Cancer Center - Lee's Summit, Lee's Summit
Children's Mercy Hospitals and Clinics, Kansas City
The University of Kansas Cancer Center-South, Kansas City
Research Medical Center, Kansas City
University of Kansas Cancer Center - North, Kansas City
Freeman Health System, Joplin
University of Missouri Children's Hospital, Columbia
Mercy Clinic-Rolla-Cancer and Hematology, Rolla
Phelps Health Delbert Day Cancer Institute, Rolla
Central Care Cancer Center - Bolivar, Bolivar
Mercy Hospital Springfield, Springfield
CoxHealth South Hospital, Springfield
The University of Kansas Cancer Center - Olathe, Olathe
University of Kansas Cancer Center, Kansas City
University of Kansas Hospital-Westwood Cancer Center, Westwood
University of Kansas Cancer Center-Overland Park, Overland Park
University of Kansas Health System Saint Francis Campus, Topeka
Mercy Hospital Pittsburg, Pittsburg
Newman Regional Health, Emporia
Salina Regional Health Center, Salina
Central Care Cancer Center - Great Bend, Great Bend
Saint Rose Ambulatory and Surgery Center, Great Bend
HaysMed, Hays
Central Care Cancer Center - Garden City, Garden City
Saint Catherine Hospital, Garden City
Children's Hospital and Medical Center of Omaha, Omaha
University of Nebraska Medical Center, Omaha
Children's Hospital New Orleans, New Orleans
Ochsner Medical Center Jefferson, New Orleans
University of Oklahoma Health Sciences Center, Oklahoma City
Mercy Hospital Oklahoma City, Oklahoma City
Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa
Medical City Dallas Hospital, Dallas
Parkland Memorial Hospital, Dallas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Cook Children's Medical Center, Fort Worth
Scott and White Memorial Hospital, Temple
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
M D Anderson Cancer Center, Houston
Children's Hospital of San Antonio, San Antonio
Methodist Children's Hospital of South Texas, San Antonio
University of Texas Health Science Center at San Antonio, San Antonio
Driscoll Children's Hospital, Corpus Christi
Dell Children's Medical Center of Central Texas, Austin
Covenant Children's Hospital, Lubbock
UMC Cancer Center / UMC Health System, Lubbock
Texas Tech University Health Sciences Center-Lubbock, Lubbock
El Paso Children's Hospital, El Paso
Children's Hospital Colorado, Aurora
UCHealth University of Colorado Hospital, Aurora
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver
Poudre Valley Hospital, Fort Collins
UCHealth Memorial Hospital Central, Colorado Springs
Saint Luke's Cancer Institute - Twin Falls, Twin Falls
Saint Luke's Cancer Institute - Fruitland, Fruitland
Saint Luke's Cancer Institute - Meridian, Meridian
Saint Luke's Cancer Institute - Nampa, Nampa
Saint Luke's Cancer Institute - Boise, Boise
South Jordan Health Center, South Jordan
Huntsman Cancer Institute/University of Utah, Salt Lake City
Primary Children's Hospital, Salt Lake City
Phoenix Childrens Hospital, Phoenix
Banner Children's at Desert, Mesa
Banner University Medical Center - Tucson, Tucson
University of New Mexico Cancer Center, Albuquerque
Radiation Oncology Centers of Nevada Central, Las Vegas
GenesisCare USA - Las Vegas, Las Vegas
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas
Summerlin Hospital Medical Center, Las Vegas
Comprehensive Cancer Centers of Nevada, Las Vegas
Renown Regional Medical Center, Reno
Saint Mary's Regional Medical Center, Reno
Radiation Oncology Associates, Reno
Children's Hospital Los Angeles, Los Angeles
Kaiser Permanente Los Angeles Medical Center, Los Angeles
Los Angeles General Medical Center, Los Angeles
USC / Norris Comprehensive Cancer Center, Los Angeles
Cedars Sinai Medical Center, Los Angeles
UCLA / Jonsson Comprehensive Cancer Center, Los Angeles
Kaiser Permanente Downey Medical Center, Downey
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance
Miller Children's and Women's Hospital Long Beach, Long Beach
City of Hope Comprehensive Cancer Center, Duarte
Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank
Kaiser Permanente-San Marcos, San Marcos
Kaiser Permanente-San Diego Zion, San Diego
Rady Children's Hospital - San Diego, San Diego
Loma Linda University Medical Center, Loma Linda
Kaiser Permanente-Riverside, Riverside
Kaiser Permanente-Anaheim, Anaheim
Children's Hospital of Orange County, Orange
AIS Cancer Center at San Joaquin Community Hospital, Bakersfield
Valley Children's Hospital, Madera
UCSF Medical Center-Mission Bay, San Francisco
Lucile Packard Children's Hospital Stanford University, Palo Alto
Stanford Cancer Institute Palo Alto, Palo Alto
UCSF Benioff Children's Hospital Oakland, Oakland
Kaiser Permanente-Oakland, Oakland
Kaiser San Rafael-Gallinas, San Rafael
Sutter Medical Center Sacramento, Sacramento
University of California Davis Comprehensive Cancer Center, Sacramento
Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee
Straub Clinic and Hospital, Honolulu
Kaiser Permanente Moanalua Medical Center, Honolulu
Kapiolani Medical Center for Women and Children, Honolulu
Clackamas Radiation Oncology Center, Clackamas
Providence Portland Medical Center, Portland
Providence Saint Vincent Medical Center, Portland
Legacy Emanuel Children's Hospital, Portland
Oregon Health and Science University, Portland
Bay Area Hospital, Coos Bay
Saint Charles Health System, Bend
Swedish Cancer Institute-Issaquah, Issaquah
Seattle Children's Hospital, Seattle
Swedish Medical Center-Ballard Campus, Seattle
Kaiser Permanente Washington, Seattle
Swedish Medical Center-First Hill, Seattle
Providence Regional Cancer Partnership, Everett
PeaceHealth Saint Joseph Medical Center, Bellingham
Madigan Army Medical Center, Tacoma
Providence Regional Cancer System-Lacey, Lacey
Anchorage Associates in Radiation Medicine, Anchorage
Providence Regional Cancer System-Aberdeen, Aberdeen
Providence Regional Cancer System-Centralia, Centralia
PeaceHealth Saint John Medical Center, Longview
PeaceHealth Southwest Medical Center, Vancouver
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
Kadlec Clinic Hematology and Oncology, Kennewick
Providence Saint Mary Regional Cancer Center, Walla Walla
Alaska Breast Care and Surgery LLC, Anchorage
Alaska Oncology and Hematology LLC, Anchorage
Alaska Women's Cancer Care, Anchorage
Anchorage Oncology Centre, Anchorage
Katmai Oncology Group, Anchorage
Providence Alaska Medical Center, Anchorage
Arkansas Children's Hospital, Little Rock
Connecticut Children's Medical Center, Hartford
Yale University, New Haven
Methodist West Hospital, West Des Moines
Eastern Maine Medical Center, Bangor
Maine Children's Cancer Program, Scarborough
Walter Reed National Military Medical Center, Bethesda
Massachusetts General Hospital Cancer Center, Boston
Dana-Farber Cancer Institute, Boston
UMass Memorial Medical Center - University Campus, Worcester
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
Hackensack University Medical Center, Hackensack
Morristown Medical Center, Morristown
Saint Peter's University Hospital, New Brunswick
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick
Newark Beth Israel Medical Center, Newark
Saint Joseph's Regional Medical Center, Paterson
Atrium Medical Center-Middletown Regional Hospital, Franklin
Rhode Island Hospital, Providence
Sanford USD Medical Center - Sioux Falls, Sioux Falls
Central Vermont Medical Center/National Life Cancer Treatment, Berlin Corners
University of Vermont Medical Center, Burlington
University of Vermont and State Agricultural College, Burlington
Cross Cancer Institute, Edmonton
British Columbia Children's Hospital, Vancouver
CancerCare Manitoba, Winnipeg
Janeway Child Health Centre, St. John's
IWK Health Centre, Halifax
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton
Children's Hospital, London
Hospital for Sick Children, Toronto
CIUSSSEMTL-Hopital Maisonneuve-Rosemont, Montreal
CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal
The Montreal Children's Hospital of the MUHC, Montreal
Centre Hospitalier Universitaire Sainte-Justine, Montreal
Allan Blair Cancer Centre, Regina
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Québec
San Jorge Children's Hospital, San Juan
University Pediatric Hospital, San Juan
National Cancer Institute (NCI)
NIH