606
Participants
Start Date
December 4, 2014
Primary Completion Date
December 31, 2025
Study Completion Date
December 31, 2025
3-Dimensional Conformal Radiation Therapy
Undergo standard-dose 3D-CRT
Intensity-Modulated Radiation Therapy
Undergo standard-dose IMRT
Intensity-Modulated Radiation Therapy
Undergo dose-escalated and -intensified photon IMRT
Laboratory Biomarker Analysis
Correlative studies
Photon Beam Radiation Therapy
Undergo dose-escalated and -intensified photon IMRT
Proton Beam Radiation Therapy
Undergo dose-escalated and -intensified proton beam radiation therapy
Quality-of-Life Assessment
Ancillary studies
Questionnaire Administration
Ancillary studies
Temozolomide
Given PO
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York
Memorial Sloan Kettering Cancer Center, New York
Montefiore Medical Center - Moses Campus, The Bronx
Memorial Sloan Kettering Westchester, Harrison
Northwell Health/Center for Advanced Medicine, Lake Success
New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn
Memorial Sloan Kettering Commack, Commack
Sechler Family Cancer Center, Lebanon
UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg
Adams Cancer Center, Gettysburg
WellSpan Health-York Cancer Center, York
Ephrata Cancer Center, Ephrata
Saint Luke's University Hospital-Bethlehem Campus, Bethlehem
Northeast Radiation Oncology Center, Dunmore
University of Pennsylvania/Abramson Cancer Center, Philadelphia
Thomas Jefferson University Hospital, Philadelphia
Jefferson Torresdale Hospital, Philadelphia
Reading Hospital, West Reading
UM Upper Chesapeake Medical Center, Bel Air
Central Maryland Radiation Oncology in Howard County, Columbia
UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie
Maryland Proton Treatment Center, Baltimore
University of Maryland/Greenebaum Cancer Center, Baltimore
VCU Massey Comprehensive Cancer Center, Richmond
Wheeling Hospital/Schiffler Cancer Center, Wheeling
Novant Health Forsyth Medical Center, Winston-Salem
Wake Forest University Health Sciences, Winston-Salem
Mission Hospital, Asheville
Prisma Health Cancer Institute - Spartanburg, Boiling Springs
Medical University of South Carolina, Charleston
Prisma Health Cancer Institute - Faris, Greenville
Prisma Health Cancer Institute - Eastside, Greenville
Self Regional Healthcare, Greenwood
Prisma Health Cancer Institute - Greer, Greer
Prisma Health Cancer Institute - Seneca, Seneca
Emory Proton Therapy Center, Atlanta
Emory University Hospital Midtown, Atlanta
Emory University Hospital/Winship Cancer Institute, Atlanta
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah
Baptist MD Anderson Cancer Center, Jacksonville
University of Florida Health Science Center - Jacksonville, Jacksonville
Baptist Medical Center South, Jacksonville
University of Florida Health Science Center - Gainesville, Gainesville
Miami Cancer Institute, Miami
Boca Raton Regional Hospital, Boca Raton
Moffitt Cancer Center, Tampa
University of Alabama at Birmingham Cancer Center, Birmingham
Tennessee Cancer Specialists-Dowell Springs, Knoxville
University of Mississippi Medical Center, Jackson
Norton Hospital Pavilion and Medical Campus, Louisville
Ohio State University Comprehensive Cancer Center, Columbus
Riverside Methodist Hospital, Columbus
University of Toledo, Toledo
Geauga Hospital, Chardon
Mercy Cancer Center-Elyria, Elyria
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor
Case Western Reserve University, Cleveland
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
UHHS-Chagrin Highlands Medical Center, Beachwood
Hillcrest Hospital Cancer Center, Mayfield Heights
University Hospitals Parma Medical Center, Parma
UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights
Cleveland Clinic Cancer Center Independence, Independence
Cleveland Clinic Cancer Center Strongsville, Strongsville
UHHS-Westlake Medical Center, Westlake
Cleveland Clinic Foundation, Cleveland
Cleveland Clinic Akron General, Akron
Cleveland Clinic Wooster Family Health and Surgery Center, Wooster
North Coast Cancer Care, Sandusky
UH Seidman Cancer Center at Firelands Regional Medical Center, Sandusky
University of Cincinnati Cancer Center-West Chester, West Chester
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati
IU Health Methodist Hospital, Indianapolis
Community Cancer Center East, Indianapolis
Community Cancer Center South, Indianapolis
Community Cancer Center North, Indianapolis
Radiation Oncology Associates PC, Fort Wayne
Parkview Hospital Randallia, Fort Wayne
Parkview Regional Medical Center, Fort Wayne
IU Health Ball Memorial Hospital, Muncie
McLaren Cancer Institute-Macomb, Mount Clemens
Corewell Health William Beaumont University Hospital, Royal Oak
Corewell Health Beaumont Troy Hospital, Troy
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor
University of Michigan Comprehensive Cancer Center, Ann Arbor
Corewell Health Dearborn Hospital, Dearborn
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia
Henry Ford Hospital, Detroit
Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac
McLaren Cancer Institute-Lapeer Region, Lapeer
McLaren Cancer Institute-Flint, Flint
McLaren Cancer Institute-Bay City, Bay City
McLaren Cancer Institute-Central Michigan, Mount Pleasant
McLaren Cancer Institute-Owosso, Owosso
West Michigan Cancer Center, Kalamazoo
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids
Trinity Health Grand Rapids Hospital, Grand Rapids
McLaren Cancer Institute-Northern Michigan, Petoskey
Iowa Methodist Medical Center, Des Moines
Mercy Hospital, Cedar Rapids
Froedtert Menomonee Falls Hospital, Menomonee Falls
UW Cancer Center at ProHealth Care, Waukesha
Medical College of Wisconsin, Milwaukee
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Aspirus Regional Cancer Center, Wausau
Langlade Hospital and Cancer Center, Antigo
Gundersen Lutheran Medical Center, La Crosse
Regions Hospital, Saint Paul
Saint Luke's Hospital of Duluth, Duluth
Mayo Clinic in Rochester, Rochester
Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud
Sanford Joe Lueken Cancer Center, Bemidji
Sanford Roger Maris Cancer Center, Fargo
Sanford Bismarck Medical Center, Bismarck
Billings Clinic Cancer Center, Billings
Advocate Lutheran General Hospital, Park Ridge
Northwestern Medicine Cancer Center Kishwaukee, DeKalb
Northwestern Medicine Cancer Center Delnor, Geneva
UC Comprehensive Cancer Center at Silver Cross, New Lenox
Northwestern Medicine Cancer Center Warrenville, Warrenville
Northwestern University, Chicago
John H Stroger Jr Hospital of Cook County, Chicago
Rush University Medical Center, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
OSF Saint Francis Medical Center, Peoria
Decatur Memorial Hospital, Decatur
Springfield Memorial Hospital, Springfield
Washington University School of Medicine, St Louis
North Kansas City Hospital, Kansas City
University of Kansas Cancer Center - North, Kansas City
University of Kansas Cancer Center, Kansas City
University of Kansas Cancer Center-Overland Park, Overland Park
Ochsner Medical Center Jefferson, New Orleans
Willis-Knighton Medical and Cancer Center, Shreveport
University of Arkansas for Medical Sciences, Little Rock
University of Oklahoma Health Sciences Center, Oklahoma City
Texas Oncology - Denison Cancer Center, Denison
Texas Oncology-Flower Mound, Flower Mound
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Texas Oncology - Tyler, Tyler
Texas Oncology - Fort Worth Cancer Center, Fort Worth
Memorial Hermann Memorial City Medical Center, Houston
M D Anderson Cancer Center, Houston
Texas Oncology Cancer Center Sugar Land, Sugar Land
UTMB Cancer Center at Victory Lakes, League City
University of Texas Health Science Center at San Antonio, San Antonio
Texas Oncology-Seton Williamson, Round Rock
Texas Oncology - Round Rock Cancer Center, Round Rock
Dell Seton Medical Center at The University of Texas, Austin
Austin Cancer Centers-Central Austin, Austin
Texas Oncology-Austin Midtown, Austin
Texas Oncology - Central Austin Cancer Center, Austin
Texas Oncology - South Austin Cancer Center, Austin
Austin Cancer Centers-North, Austin
Covenant Medical Center-Lakeside, Lubbock
Poudre Valley Hospital, Fort Collins
UCHealth Memorial Hospital Central, Colorado Springs
Saint Alphonsus Cancer Care Center-Boise, Boise
Intermountain Medical Center, Murray
Huntsman Cancer Institute/University of Utah, Salt Lake City
Logan Regional Hospital, Logan
McKay-Dee Hospital Center, Ogden
Utah Valley Regional Medical Center, Provo
Saint George Regional Medical Center, St. George
Saint Joseph's Hospital and Medical Center, Phoenix
Mayo Clinic Hospital in Arizona, Phoenix
Mayo Clinic in Arizona, Scottsdale
Arizona Oncology Associates-West Orange Grove, Tucson
Banner University Medical Center - Tucson, Tucson
Comprehensive Cancer Centers of Nevada, Las Vegas
Renown Regional Medical Center, Reno
Saint Mary's Regional Medical Center, Reno
Los Angeles General Medical Center, Los Angeles
USC / Norris Comprehensive Cancer Center, Los Angeles
Cedars Sinai Medical Center, Los Angeles
Pomona Valley Hospital Medical Center, Pomona
Loma Linda University Medical Center, Loma Linda
Saint Joseph Hospital - Orange, Orange
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
AIS Cancer Center at San Joaquin Community Hospital, Bakersfield
Fresno Cancer Center, Fresno
Kaiser Permanente Cancer Treatment Center, South San Francisco
Palo Alto Medical Foundation-Sunnyvale, Sunnyvale
California Pacific Medical Center-Pacific Campus, San Francisco
Palo Alto Medical Foundation Health Care, Palo Alto
Eden Hospital Medical Center, Castro Valley
John Muir Medical Center-Walnut Creek, Walnut Creek
Kaiser Permanente Oakland-Broadway, Oakland
Alta Bates Summit Medical Center-Herrick Campus, Berkeley
Marin General Hospital, Greenbrae
Rohnert Park Cancer Center, Rohnert Park
Palo Alto Medical Foundation-Santa Cruz, Santa Cruz
Memorial Medical Center, Modesto
Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn
Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville
Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova
The Permanente Medical Group-Roseville Radiation Oncology, Roseville
Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park
Sutter Medical Center Sacramento, Sacramento
University of California Davis Comprehensive Cancer Center, Sacramento
South Sacramento Cancer Center, Sacramento
Fremont - Rideout Cancer Center, Marysville
Legacy Mount Hood Medical Center, Gresham
Legacy Good Samaritan Hospital and Medical Center, Portland
Willamette Valley Cancer Center, Eugene
FHCC at Northwest Hospital, Seattle
FHCC Proton Therapy Center, Seattle
University of Washington Medical Center - Montlake, Seattle
Compass Oncology Vancouver, Vancouver
Legacy Salmon Creek Hospital, Vancouver
Hartford Hospital, Hartford
Tufts Medical Center, Boston
Massachusetts General Hospital Cancer Center, Boston
Boston Medical Center, Boston
Mass General/North Shore Cancer Center, Danvers
Lowell General Hospital, Lowell
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon
Memorial Sloan Kettering Basking Ridge, Basking Ridge
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick
Rutgers Cancer Institute of New Jersey, New Brunswick
Capital Health Medical Center-Hopewell, Pennington
ProCure Proton Therapy Center-Somerset, Somerset
Virtua Voorhees, Voorhees Township
Sanford USD Medical Center - Sioux Falls, Sioux Falls
University of Texas Medical Branch, Galveston
Central Vermont Medical Center/National Life Cancer Treatment, Berlin Corners
University of Vermont Medical Center, Burlington
Dartmouth Cancer Center - North, Saint Johnsbury
BCCA-Vancouver Island Cancer Centre, Victoria
Ottawa Hospital and Cancer Center-General Campus, Ottawa
Windsor Regional Cancer Centre, Windsor
CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal
The Research Institute of the McGill University Health Centre (MUHC), Montreal
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Québec
Saskatoon Cancer Centre, Saskatoon
Lead Sponsor
National Cancer Institute (NCI)
NIH
NRG Oncology
OTHER