Study to Explore the Safety, Tolerability and Efficacy of MK-3475 in Combination With INCB024360 in Participants With Selected Cancers

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

444

Participants

Timeline

Start Date

July 17, 2014

Primary Completion Date

November 26, 2018

Study Completion Date

November 6, 2020

Conditions
Microsatellite-instability (MSI) High Colorectal Cancer (CRC)Endometrial CancerHead and Neck CancerHepatocellular Carcinoma (HCC)Gastric CancerLung CancerLymphomaRenal Cell Carcinoma (RCC)Ovarian CancerSolid TumorsUC (Urothelial Cancer)MelanomaBladder CancerTriple Negative Breast Cancer (TNBC)
Interventions
DRUG

MK-3475

IV infusion

DRUG

INCB024360

Oral daily dosing

Trial Locations (24)

15232

University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh

19104

University of Pennsylvania Hospital, Philadelphia

20817

The Center for Cancer and Blood Disorders (RCCA MD LLC- Maryland Division), Bethesda

21204

Greater Baltimore Cancer Center, Baltimore

21229

St. Agnes Hospital Cancer Institute, Baltimore

22031

Virginia Cancer Specialists, Arlington

29605

Greenville Health System Cancer Institute, Greenville

30342

Georgia Cancer Specialists affiliated with Northside Hospital Cancer Institute, Atlanta

33176

Miami Cancer Institute at Baptist Health, Inc, Miami

38120

West Cancer Center, Germantown

45219

The Christ Hospital Hematology Oncology, Lindner Research Center, Cincinnati

48109

University of Michigan Hospital and Health Systems, Ann Arbor

55426

Health Partners Institute, Saint Louis Park

60637

The University of Chicago Medicine, Chicago

66618

St. Francis Cancer Center, Topeka

75390

University Of Texas Southwestern Medical Center At Dallas, Dallas

80045

University Of Colorado Cancer Center, Aurora

90025

The Angeles Clinic and Research Institute, Los Angeles

92093

UC San Diego Moores Cancer Center, La Jolla

95817

US Davis Cancer Center, Sacramento

06030-1601

University of Connecticut Health Center Carole And Ray Neag Comprehensive Cancer Center, Farmington

07601

Hackensack University Medical Center - John Theurer Cancer Center, Hackensack

19111-2497

Fox Chase Cancer Center, Philadelphia

37203-2173

Sarah Cannon Research Institute at Tennessee Oncology, Nashville

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Incyte Corporation

INDUSTRY