The Effect of Rifampin on the Metabolism of Istradefylline in Healthy Volunteers.

PHASE1CompletedINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

June 30, 2014

Primary Completion Date

August 31, 2014

Study Completion Date

December 31, 2014

Conditions
Parkinson's Disease
Interventions
DRUG

Istradefylline 40 mg

On Day 1, istradefylline 1 × 40-mg tablet administered alone

DRUG

Rifampin 300mg BID + istradefylline 40mg Day 8 only

On Days 1 - 20, rifampin 300mg BID; On Day 8, istradefylline 40 mg administered first with rifampin about 2 hours after istradefylline administration

Trial Locations (1)

85283

Celerion, Inc., Tempe

Sponsors
All Listed Sponsors
collaborator

Kyowa Hakko Kirin Pharma, Inc.

INDUSTRY

lead

Kyowa Kirin Co., Ltd.

INDUSTRY