Platform Drug Discovery Technology
Total Trials
75
As Lead Sponsor
36
As Collaborator
39
Total Enrollment
9,646
NCT00456794
12-Week, Double-Blind, Placebo-Controlled Study of 20 and 60 mg/Day Istradefylline in Parkinson's Disease Patients on Levodopa/Carbodopa
Phase: Phase 2
Role: Lead Sponsor
Start: Mar 31, 2002
Completion: Oct 31, 2003
NCT00456586
12-Week, Double-Blind, Placebo-Controlled, Randomized Study of the Efficacy of 40 mg/Day KW-6002 in Parkinson's Disease Patients on Levodopa/Carbidopa
Start: Apr 30, 2002
Completion: Jun 30, 2003
NCT00955045
A Long-Term, Safety Study With a Flexible Dose Range of KW-6002 in Patients With Motor Response Complications on Levodopa/Carbidopa Therapy
Phase: Phase 2/3
Start: Aug 31, 2002
NCT00199407
A Study of Istradefylline (KW-6002) for the Treatment of Parkinson's Disease in Patients Taking Levodopa
Phase: Phase 3
Start: Jun 30, 2004
Completion: Jan 31, 2006
NCT00199420
A Study of Istradefylline (KW-6002) in Treating Patients With Parkinson's Disease on Levodopa
Start: Jul 31, 2004
Completion: Dec 31, 2005
NCT00199368
An Extension of Istradefylline in Parkinson's Disease Patients Who Have Completed Studies 6002-EU-007, 6002-US-013 or 6002-US-018
Start: Oct 31, 2004
Completion: May 31, 2007
Role: Collaborator
NCT00199342
A Study of a Monoclonal Antibody, KW-2871, in Patients With Advanced Melanoma
Phase: Phase 1/2
Start: Nov 30, 2004
Completion: Not specified
NCT00199394
A Study of Istradefylline (KW-6002) for the Treatment of Parkinson's Disease
Completion: Nov 30, 2005
NCT00199433
A Study of Istradefylline (KW-6002) as Monotherapy in Parkinson's Disease (PD) Patients
Start: May 31, 2005
Completion: Aug 31, 2006
NCT00199446
Study of Istradefylline (KW-6002) for the Treatment of Restless Legs Syndrome
Start: Jul 31, 2005
Completion: Oct 31, 2006
NCT00199381
An Extension of Istradefylline in North American Parkinson's Disease Patients Who Have Completed Study 6002-INT-001
Start: Oct 31, 2005
Completion: Oct 31, 2008
NCT00346632
An Ascending Dose Study of KW-2449 in Acute Leukemias, Myelodysplastic Syndromes, and Chronic Myelogenous Leukemia
Phase: Phase 1
Start: Jun 30, 2006
Completion: Apr 30, 2008
NCT00457782
A Phase I Safety, PK and PD Study of KW-2478 in Patients With Multiple Myeloma, Chronic Lymphocytic Leukaemia or B-cell Non-Hodgkin's Lymphoma
Start: Apr 30, 2007
Completion: Jan 31, 2011
NCT00575562
Phase I Study of KRN330 Monoclonal Antibody in Patients With Colorectal Cancer
Start: Jun 30, 2007
Completion: Jan 31, 2010
NCT00775502
Phase 1/2 Study of Anti GM-2 Monoclonal Antibody To Treat Multiple Myeloma
Start: Oct 31, 2008
Completion: Oct 31, 2011
NCT00952094
Pharmacokinetic, Pharmacodynamic and Safety Evaluation After Single Oral Administration of KRN1493
Start: Nov 30, 2008
Completion: Jun 30, 2009
NCT00830674
A Study of KRN23 in X-linked Hypophosphatemia
Start: Dec 31, 2008
Completion: May 31, 2013
NCT00838578
Phase I/II Study of KRN330 Plus Irinotecan in Patients With Metastatic Colorectal Cancer
Start: Mar 31, 2009
Completion: Oct 31, 2012
NCT00938288
A Study of KW-3357 in Congenital Antithrombin Deficiency
Start: Apr 30, 2009
Completion: Apr 30, 2011
NCT00888927
Safety Study to Evaluate Monoclonal Antibody KW-0761 in Subjects With Peripheral T-cell Lymphoma
Start: May 31, 2009
Completion: Sep 30, 2012
NCT00921336
Safety Study to Evaluate KW-2450 in Subjects With Advanced Solid Tumor
Start: Jun 30, 2009
Completion: Aug 31, 2010
NCT01063907
A Study of KW-2478 in Combination With Bortezomib in Subjects With Relapsed and/or Refractory Multiple Myeloma
Start: Mar 31, 2010
Completion: Nov 30, 2013
NCT01226472
Extension Study in Subjects Who Relapsed After Complete Response on Study KW-0761-001
Start: Aug 31, 2010
NCT01199367
Safety, Tolerability, and Efficacy Study in Subjects With Advanced or Metastatic Breast Cancer
Start: Dec 31, 2010
Completion: Dec 31, 2012
NCT01279291
Study of Anti-HB-EGF Antibody KHK2866 in Subjects With Advanced Solid Tumors and Ovarian Cancer
Start: Jan 31, 2011
Completion: Nov 30, 2012
NCT01447732
Phase 1 Study of CEP-37250/KHK2804 in Subjects With Advanced Solid Tumors
Start: Oct 31, 2011
Completion: Jan 31, 2015
NCT01571596
An Extension Study of KRN23 in Adults With X-Linked Hypophosphatemia
Start: Feb 29, 2012
Completion: Jun 30, 2014
NCT01611142
Study of KW-0761 (Mogamulizumab) in Subjects With Previously Treated Peripheral T-cell Lymphoma (PTCL)
Start: Apr 30, 2012
Completion: May 31, 2015
NCT01626664
KW-0761 or Investigator's Choice in Subjects With Previously Treated Adult T-cell Leukemia-Lymphoma (ATL)
Start: Jun 30, 2012
Completion: Feb 28, 2018
NCT01728805
Study of KW-0761 Versus Vorinostat in Relapsed/Refractory CTCL
Start: Nov 30, 2012
Completion: Feb 17, 2021
NCT01968031
A 12-week Randomized Study to Evaluate Oral Istradefylline in Subjects With Moderate to Severe Parkinson's Disease
Start: Oct 31, 2013
Completion: Oct 31, 2016
NCT02181699
Study of KHK2823 in Patients With Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)
Start: Jun 30, 2014
Completion: May 10, 2019
NCT02174250
The Effect of Rifampin on the Metabolism of Istradefylline in Healthy Volunteers.
Completion: Dec 31, 2014
NCT02163577
Study of KRN23 (Burosumab), a Recombinant Fully Human Monoclonal Antibody Against Fibroblast Growth Factor 23 (FGF23), in Pediatric Subjects With X-linked Hypophosphatemia (XLH)
Start: Jul 2, 2014
Completion: Oct 30, 2018
NCT02127476
A Study of Single and Multiple Doses of KHK6640 in Subjects With Prodromal or Mild to Moderate Alzheimer's Disease
Start: Jul 31, 2014
Completion: May 31, 2017
NCT02256033
Effect of Mild Hepatic Impairment on the Pharmacokinetics of Istradefylline
Start: Aug 31, 2014
NCT02281409
Safety, Tolerability, and Immunoregulatory Activity of Mogamulizumab (KW-0761) in Subjects With Advanced and/or Metastatic Solid Tumors
Start: Oct 31, 2014
Completion: Feb 29, 2020
NCT02301130
Study of Mogamulizumab + MEDI4736 (Durvalumab) and Mogamulizumab + Tremelimumab in Subjects w/ Advanced Solid Tumors
Start: Nov 26, 2014
Completion: Mar 5, 2018
NCT02312687
Long-Term Extension Study of KRN23 in Adult Subjects With X-Linked Hypophosphatemia (XLH)
Start: Jan 30, 2015
Completion: Nov 30, 2018
NCT02358473
Study of Mogamulizumab + Docetaxel in Subjects With Non-small Cell Lung Cancer
Start: Jan 31, 2015
Completion: Dec 31, 2016
NCT02304367
Study of Burosumab (KRN23) in Adults With Tumor-Induced Osteomalacia (TIO) or Epidermal Nevus Syndrome (ENS)
Start: Mar 24, 2015
Completion: Jan 21, 2021
NCT02526160
Study of KRN23 in Adults With X-linked Hypophosphatemia (XLH)
Start: Oct 22, 2015
Completion: Dec 6, 2018
NCT02537431
Open Label Study of KRN23 on Osteomalacia in Adults With X-linked Hypophosphatemia (XLH)
Start: Dec 23, 2015
Completion: Dec 13, 2018
NCT02610231
Long Term Study of Istradefylline in Subjects With Moderate to Severe Parkinson's Disease
Start: Dec 31, 2015
Completion: Dec 20, 2017
NCT02609477
A Study to Evaluate Abuse Potential of Istradefylline
Start: Jan 31, 2016
Completion: Jul 31, 2016
NCT02705105
Study of Mogamulizumab + Nivolumab in Subjects w/Locally Advanced or Metastatic Solid Tumors
Start: Feb 29, 2016
Completion: Oct 10, 2018
NCT02750618
Study of the Safety, Pharmacodynamics (PD) and Efficacy of KRN23 in Children From 1 to 4 Years Old With X-linked Hypophosphatemia (XLH)
Start: May 5, 2016
Completion: Sep 10, 2019
NCT02647866
Study of a Monoclonal Antibody KHK4083 in Moderate Ulcerative Colitis
Start: Jun 30, 2016
Completion: Oct 31, 2018
NCT02867007
KHK2455 Alone and in Combination With Mogamulizumab in Subjects With Locally Advanced or Metastatic Solid Tumors
Start: Aug 31, 2016
Completion: Dec 15, 2019
NCT02915705
Efficacy and Safety of Burosumab Versus Oral Phosphate and Active Vitamin D Treatment in Pediatric Patients With XLH
Start: Sep 8, 2016
Completion: Jul 15, 2019
NCT04350112
Study of Opioid-Induced Constipation 1 Project
Phase: N/A
Start: Aug 21, 2017
Completion: Aug 30, 2019
NCT04404933
Study of Opioid-Induced Constipation 2 Project
NCT03703102
Study of an Anti-OX40 Monoclonal Antibody (KHK4083) in Subjects With Moderate to Severe Atopic Dermatitis
Start: Oct 22, 2018
Completion: Nov 12, 2020
NCT04501211
Open Label Transdermal Granisetron to Relieve Chronic Nausea and Emesis
Start: Jan 1, 2019
Completion: Dec 31, 2021
NCT04147910
Phase 1, Open-label Study of the Absorption, Metabolism, and Excretion of [14C]-KW-6356
Start: Aug 21, 2019
Completion: Oct 2, 2019
NCT04014374
Post-authorization Safety Study of Allogeneic Hematopoietic Stem Cell Transplantation in Patients Treated With Mogamulizumab
Start: Sep 10, 2019
Completion: Feb 28, 2030
NCT03915405
KHK2455 (IDO Inhibitor) Plus Avelumab in Adult Subjects With Advanced Bladder Cancer
Start: Sep 26, 2019
Completion: Nov 15, 2022
NCT04190654
Single-dose Study to Investigate the Plasma PK of KW-6356 and Its Major Metabolite
Start: Nov 26, 2019
Completion: Mar 20, 2020
NCT04946409
Burden of Disease and Functional Impairment in XLH
Start: Oct 1, 2020
Completion: Oct 31, 2026
NCT04695860
Anti-FGF23 (Burosumab) in Adult Patients With XLH
Start: Jan 7, 2021
Completion: Mar 17, 2023
NCT05027646
Study to Assess Bioequivalence and Adhesion Properties Between Two Granisetron Transdermal Patches.
Start: Jul 6, 2021
Completion: Jan 19, 2022
NCT04745832
Phase 3 Study of Zandelisib (ME-401) in Combination With Rituximab in Patients With iNHL - (COASTAL)
Start: Aug 13, 2021
Completion: Mar 20, 2023
NCT04745234
Mogamulizumab Q4week Dosing in Participants With R/R CTCL
Start: Aug 16, 2021
Completion: May 31, 2025
NCT05333549
Istradefylline for Parkinson Disease With Cognitive Impairment
Start: Jul 18, 2022
Completion: Jun 9, 2025
NCT05182151
Effect of Istradefylline Treatment on Behavioral Measures of Apathy in Parkinson's Disease.
Start: Jul 29, 2022
Completion: Dec 1, 2023
NCT05209308
Rituximab Plus Venetoclax in Combination With Zandelisib in Subjects With CLL
Start: Nov 22, 2022
Completion: Mar 15, 2023
NCT05885360
Istradefylline Effect Protocol on Parkinson's Disease Tremor
Phase: Phase 4
Start: Jan 20, 2023
Completion: Feb 21, 2025
NCT05414500
Mogamulizumab and Brentuximab Vedotin in CTCL and Mycosis Fungoides
Start: May 1, 2023
Completion: Jul 31, 2026
NCT06235281
Phototherapy and Mogamulizumab in Early Stage MF (PLIGHT)
Phase: Early Phase 1
Start: Jan 18, 2024
Completion: Sep 1, 2029
NCT06266299
A Study of KK2269 in Adult Participants With Solid Tumors
Completion: Dec 31, 2027
NCT05996185
Study of Mogamulizumab With DA-EPOCH in Patients With Aggressive T Cell Lymphoma
Start: Oct 9, 2024
Completion: Nov 30, 2027
NCT06525636
A First-in-human Study of KK8123 in Adults With X-linked Hypophosphatemia
Completion: May 10, 2028
NCT07192471
A First-in-Human Study of KK2223 in Participants With Relapsed or Refractory T Cell Non-Hodgkin Lymphoma
Start: Jan 23, 2026
Completion: Sep 30, 2030
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