A Study to Assess the Safety and Tolerability of Atezolizumab in Combination With Other Immune-Modulating Therapies in Participants With Locally Advanced or Metastatic Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

158

Participants

Timeline

Start Date

August 18, 2014

Primary Completion Date

November 25, 2019

Study Completion Date

November 25, 2019

Conditions
Solid Cancers
Interventions
DRUG

Atezolizumab

Participant will receive atezolizumab 600 milligrams (mg) or 1200 mg by IV infusion q3w.

DRUG

Bevacizumab

Participant will receive Bevacizumab 15 milligrams per kilograms (mg/kg) IV infusion q3w.

DRUG

Interferon alfa-2b

Participants will receive Interferon alfa-2b 3, 5, or 10 million international units subcutaneously every other day for up to 3 doses per week.

DRUG

Ipilimumab

Participants will receive Ipilimumab 1, or 3 mg/kg IV, single dose, or multiple-dose regimen q3w for up to 4 cycles (Cycle = 21 days).

DRUG

Obinutuzumab

Obinutuzumab 1000 milligrams will be administered as pre-treatment on 2 consecutive days (Day -13 and Day -12) prior to treatment start with atezolizumab on Cycle 1, Day 1 (cycle length=21 days). An additional two doses of obinutuzumab will be administered on Days 85 and 86 of study treatment (Cycle 5, Day 1 and Cycle 5, Day 2).

DRUG

PEG-interferon alfa-2a

Participant will receive PEG-interferon alfa-2a 180 micrograms subcutaneous injection q3w for a total of 6 cycles (Cycle = 21 days).

Trial Locations (9)

27599

University of North Carolina at Chapel Hill, Chapel Hill

32224

Mayo Clinic-Jacksonville, Jacksonville

37203

Sarah Cannon Research Inst., Nashville

85258

HonorHealth Research Institute - Bisgrove, Scottsdale

85259

Mayo Clinic- Scottsdale, Scottsdale

90095

UCLA, Los Angeles

06510

Yale University, New Haven

37232-7610

Vanderbilt Medical Center, Nashville

1066 CX

The Netherlands Cancer Institute of Amsterdam, Amsterdam

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT02174172 - A Study to Assess the Safety and Tolerability of Atezolizumab in Combination With Other Immune-Modulating Therapies in Participants With Locally Advanced or Metastatic Solid Tumors | Biotech Hunter | Biotech Hunter