158
Participants
Start Date
August 18, 2014
Primary Completion Date
November 25, 2019
Study Completion Date
November 25, 2019
Atezolizumab
Participant will receive atezolizumab 600 milligrams (mg) or 1200 mg by IV infusion q3w.
Bevacizumab
Participant will receive Bevacizumab 15 milligrams per kilograms (mg/kg) IV infusion q3w.
Interferon alfa-2b
Participants will receive Interferon alfa-2b 3, 5, or 10 million international units subcutaneously every other day for up to 3 doses per week.
Ipilimumab
Participants will receive Ipilimumab 1, or 3 mg/kg IV, single dose, or multiple-dose regimen q3w for up to 4 cycles (Cycle = 21 days).
Obinutuzumab
Obinutuzumab 1000 milligrams will be administered as pre-treatment on 2 consecutive days (Day -13 and Day -12) prior to treatment start with atezolizumab on Cycle 1, Day 1 (cycle length=21 days). An additional two doses of obinutuzumab will be administered on Days 85 and 86 of study treatment (Cycle 5, Day 1 and Cycle 5, Day 2).
PEG-interferon alfa-2a
Participant will receive PEG-interferon alfa-2a 180 micrograms subcutaneous injection q3w for a total of 6 cycles (Cycle = 21 days).
University of North Carolina at Chapel Hill, Chapel Hill
Mayo Clinic-Jacksonville, Jacksonville
Sarah Cannon Research Inst., Nashville
HonorHealth Research Institute - Bisgrove, Scottsdale
Mayo Clinic- Scottsdale, Scottsdale
UCLA, Los Angeles
Yale University, New Haven
Vanderbilt Medical Center, Nashville
The Netherlands Cancer Institute of Amsterdam, Amsterdam
Hoffmann-La Roche
INDUSTRY