LGX818 and MEK162 in Combination With a Third Agent (BKM120, LEE011, BGJ398 or INC280) in Advanced BRAF Melanoma

PHASE2CompletedINTERVENTIONAL
Enrollment

158

Participants

Timeline

Start Date

July 23, 2014

Primary Completion Date

January 10, 2023

Study Completion Date

January 10, 2023

Conditions
Melanoma
Interventions
DRUG

LGX818

Combination of LGX818 and MEK162 (Part I)

DRUG

MEK162

Combination of LGX818 and MEK162 (Part I)

DRUG

LEE011

Combination of LGX818 + MEK162 + LEE011 (Part II)

DRUG

BGJ398

Combination of LGX818 + MEK162 + BGJ398 (Part II)

DRUG

BKM120

Combination of LGX818 + MEK162 + BKM120 (Part II)

DRUG

INC280

Combination of LGX818 + MEK162 + INC280 (Part II)

Trial Locations (32)

3000

Peter MacCallum Cancer Centre, Melbourne

3183

East St Kilda Eye Clinic, Melbourne

8058

Universitätsspital Zürich, Zurich Flughafen

10065

Memorial Sloan Kettering Cancer Center Attn: Geny O'neill, New York

Memorial Sloan Kettering Cancer Center Inpatient Hospital & Main Campus, New York

Memorial Sloan Kettering Cancer Center- Outpatient Clinic, New York

37203

Sarah Cannon Research Institute, Nashville

Tennessee Oncology, PLLC, Nashville

50937

Uniklinik Köln, Cologne

69120

University Clinic Heidelberg PPDS, Heidelberg

80131

Azienda Ospedaliera Monaldi, Napoli

U.O.C. Oncologia Medica e Terapie Innovative Dipartimento di Melanoma IRCCS Fondazione G. Pascale, Napoli

80337

Städtisches Klinikum München, München

90024

University of California Los Angeles, Los Angeles

90095

Cancer Care Center, Los Angeles

Doris Stein Research Center Building, Los Angeles

Ronald Reagan UCLA Medical Center Drug Information Center Department of Pharmaceutical Services, Los Angeles

UCLA Dermatology Clinic, Los Angeles

UCLA Oncology Center, Los Angeles

UCLA Radiology, Los Angeles

97080

Universitätsklinikum Würzburg, Würzburg

Universitätsklinikum Würzburg, Würzburg

97201

OHSU Knight Cancer Institute, Portland

97239

OHSU Center for Health and Healing 2, Portland

OHSU Center for Health and Healing, Portland

OHSU Research Pharmacy Services, Portland

Oregon Health and Science University, Portland

M5G 2M9

Princess Margaret Cancer Center, Toronto

H3T 1E2

Sir Mortimer B. Davis-Jewish General Hospital, Monteral

1066 CX

Het Nederlands Kanker Instituut Antoni Van Leeuwenhoek Ziekenhuis, Amsterdam

08035

Hospital Universitario Vall d'Hebrón - PPDS, Barcelona Cataluna

OX2 7JL

Churchill Hospital, Oxford

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT02159066 - LGX818 and MEK162 in Combination With a Third Agent (BKM120, LEE011, BGJ398 or INC280) in Advanced BRAF Melanoma | Biotech Hunter | Biotech Hunter