Efficacy and Safety of Benralizumab in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With Exacerbation History

PHASE3CompletedINTERVENTIONAL
Enrollment

2,255

Participants

Timeline

Start Date

June 25, 2014

Primary Completion Date

April 9, 2018

Study Completion Date

April 9, 2018

Conditions
Moderate to Very Severe Chronic Obstructive Pulmonary Disease
Interventions
DRUG

Benralizumab Arm A

Benralizumab subcutaneously on study week 0 until study week 48 inclusive

DRUG

Benralizumab Arm B

Benralizumab subcutaneously on study week 0 until study week 48 inclusive

DRUG

Benralizumab Arm C

Benralizumab subcutaneously on study week 0 until study week 48 inclusive

DRUG

Placebo

Benralizumab subcutaneously on study week 0 until study week 48 inclusive

Trial Locations (356)

41

Research Site, Lima

112

Research Site, Taipei

500

Research Site, Changhua

1000

Research Site, Manila

Research Site, Ljubljana

1002

Research Site, Sofia

1020

Research Site, Brussels

1051

Research Site, Greenlane

1100

Research Site, Quezon City

1101

Research Site, Quezon City

1109

Research Site, Quezon City

1241

Research Site, Kamnik

1408

Research Site, Sofia

1425

Research Site, Ciudad de Buenos Aires

1426

Research Site, CABA

1638

Research Site, Florida

1646

Research Site, San Fernando

1888

Research Site, San Juan Bautista

2000

Research Site, Maribor

2025

Research Site, Auckland

2250

Research Site, Gosford

2300

Research Site, Turnhout

Research Site, Pernik

2310

Research Site, New Lambton

2400

Research Site, København NV

2600

Research Site, Dupnitsa

2800

Research Site, Sandanski

2850

Research Site, Petrich

3000

Research Site, Leuven

Research Site, Vratsa

Research Site, Celje

3060

Research Site, Svelvik

3112

Research Site, Tauranga

3168

Research Site, Clayton

3204

Research Site, Hamilton West

3260

Research Site, Concepción del Uruguay

3320

Research Site, Kozloduy

3400

Research Site, Corrientes

3600

Research Site, Genk

3700

Research Site, Vidin

4000

Research Site, Roskilde

4002

Research Site, Plovdiv

4102

Research Site, Woolloongabba

4204

Research Site, Golnik

4400

Research Site, Pazardzhik

4700

Research Site, Næstved

4960

Research Site, Malmedy

5000

Research Site, Odense C

Research Site, Iloilo City

5100

Research Site, Jambes

5500

Research Site, Mendoza

6009

Research Site, Nedlands

6150

Research Site, Murdoch

7002

Research Site, Rousse

7600

Research Site, Mar del Plata

8200

Research Site, Aarhus N

8600

Research Site, Yambol

Research Site, Silkeborg

8630

Research Site, Veurne

9016

Research Site, Dunedin

10016

Research Site, New York

10459

Research Site, The Bronx

10461

Research Site, The Bronx

10600

Research Site, Bangkok

10700

Research Site, Bangkoknoi

11000

Research Site, Belgrade

Research Site, Nonthaburi

11023

Research Site, Great Neck

11236

Research Site, Brooklyn

11501

Research Site, Mineola

12553

Research Site, New Windsor

13676

Research Site, Potsdam

13915

Research Site, Marseille

14050

Research Site, México

15033

Research Site, Lima

15146

Research Site, Monroeville

15213

Research Site, Pittsburgh

15243

Research Site, Pittsburgh

15401

Research Site, Uniontown

16059

Research Site, Bursa

17001

Research Site, Manizales

18009

Research Site, Cherkasy

19142

Research Site, Philadelphia

21001

Research Site, Vinnytsia

21093

Research Site, Lutherville

21152

Research Site, Malmo

21162

Research Site, White Marsh

22056

Research Site, New Taipei City

23220

Research Site, Richmond

23235

Research Site, Richmond

24210

Research Site, Abingdon

26357

Research Site, Kingwood

26505

Research Site, Morgantown

27215

Research Site, Burlington

28117

Research Site, Mooresville

28150

Research Site, Shelby

28277

Research Site, Charlotte

28467

Research Site, Calabash

28562

Research Site, New Bern

28601

Research Site, Hickory

29303

Research Site, Spartanburg

29412

Research Site, Charleston

29609

Research Site, Brest

29653

Research Site, Hodges

30029

Research Site, Nîmes

30046

Research Site, Lawrenceville

30189

Research Site, Woodstock

30331

Research Site, Atlanta

30513

Research Site, Blue Ridge

32117

Research Site, Daytona Beach

32132

Research Site, Edgewater

32204

Research Site, Jacksonville

32504

Research Site, Pensacola

32626

Research Site, Chiefland

32713

Research Site, DeBary

32720

Research Site, DeLand

33010

Research Site, Hialeah

33012

Research Site, Hialeah

33013

Research Site, Hialeah

33066

Research Site, Coconut Creek

33126

Research Site, Miami

33130

Research Site, Homestead

33134

Research Site, Coral Gables

33143

Research Site, South Miami

33144

Research Site, Miami

33147

Research Site, Miami

33155

Research Site, Miami

33165

Research Site, Miami

33172

Research Site, Doral

33174

Research Site, Miami

33186

Research Site, Miami

33308

Research Site, Fort Lauderdale

33343

Research Site, Mersin

33604

Research Site, Pessac

33759

Research Site, Clearwater

33765

Research Site, Clearwater

33952

Research Site, Port Charlotte

34020

Research Site, Istanbul

34098

Research Site, Istanbul

34239

Research Site, Sarasota

34295

Research Site, Montpellier

34362

Research Site, Haifa

34744

Research Site, Kissimmee

34844

Research Site, Istanbul

35100

Research Site, Izmir

35110

Research Site, Izmir

35216

Research Site, Birmingham

36117

Research Site, Montgomery

36542

Research Site, Gulf Shores

37388

Research Site, Tullahoma

38700

Research Site, La Tronche

39150

Research Site, Port Gibson

39466

Research Site, Picayune

40002

Research Site, Khon Kaen

40447

Research Site, Taichung

40705

Research Site, Taichung

41345

Research Site, Gothenburg

42303

Research Site, Owensboro

42420

Research Site, Henderson

43000

Research Site, Lutsk

43080

Research Site, Durango

43213

Research Site, Columbus

43214

Research Site, Columbus

43302

Research Site, Marion

43617

Research Site, Toledo

44024

Research Site, Chardon

44130

Research Site, Guadalajara

44200

Research Site, Guadalajara

44250

Research Site, Petrinja

45100

Research Site, Orléans

45242

Research Site, Cincinnati

48085

Research Site, Troy

49009

Research Site, Kalamazoo

49051

Research Site, Dnipropetrovsk

49100

Research Site, Petah Tikva

49620

Research Site, Buckley

55000

Research Site, Muang,

55125

Research Site, Woodbury

55432

Research Site, Fridley

55435

Research Site, Edina

57702

Research Site, Rapid City

58000

Research Site, Chernivtsi

58022

Research Site, Chernivtsi

59037

Research Site, Lille

59808

Research Site, Missoula

60305

Research Site, River Forest

60805

Research Site, Evergreen Park

61035

Research Site, Kharkiv

61039

Research Site, Kharkiv

61602

Research Site, Peoria

62269

Research Site, O'Fallon

63033

Research Site, Florissant

63136

Research Site, St Louis

64012

Research Site, Belton

64460

Research Site, Monterrey

65025

Research Site, Odesa

66465

Research Site, Monterrey

66606

Research Site, Topeka

68025

Research Site, Fremont

68124

Research Site, Omaha

69063

Research Site, Zaporizhzhya

69065

Research Site, Zaporizhzhya

69068

Research Site, Zaporizhzhya

69317

Research Site, Lyon

70570

Research Site, Opelousas

70584

Research Site, Sunset

71106

Research Site, Shreveport

73103

Research Site, Oklahoma City

73112

Research Site, Oklahoma City

75069

Research Site, McKinney

75071

Research Site, McKinney

75093

Research Site, Plano

75110

Research Site, Corsicana

75116

Research Site, Duncanville

75216

Research Site, Dallas

75604

Research Site, Longview

75904

Research Site, Lufkin

76012

Research Site, Ivano-Frankivsk

76031

Research Site, Bois-Guillaume

76104

Research Site, Fort Worth

76543

Research Site, Killeen

76550

Research Site, Lampasas

77024

Research Site, Houston

77034

Research Site, Houston

77036

Research Site, Houston

77043

Research Site, Houston

77055

Research Site, Houston

77063

Research Site, Houston

77340

Research Site, Huntsville

77474

Research Site, Sealy

78756

Research Site, Houston

79066

Research Site, Lviv

80001

Research Site, Barranquilla

80112

Research Site, Centennial

80246

Research Site, Denver

80907

Research Site, Colorado Springs

83301

Research Site, Kaohsiung City

83687

Research Site, Nampa

84010

Research Site, Bountiful

84102

Research Site, Salt Lake City

85018

Research Site, Phoenix

86001

Research Site, Flagstaff

89146

Research Site, Las Vegas

90048

Research Site, Los Angeles

90110

Research Site, Hat Yai

90274

Research Site, Rolling Hills Estates

90505

Research Site, Peninsula

90716

Research Site, Hawaiian Gardens

91007

Research Site, Arcadia

91120

Research Site, Jerusalem

91324

Research Site, Northridge

92647

Research Site, Huntington Beach

92683

Research Site, Westminster

92801

Research Site, Anaheim

92835

Research Site, Fullerton

92870

Research Site, Placentia

93301

Research Site, Bakersfield

93551

Research Site, Palmdale

93721

Research Site, Fresno

97504

Research Site, Medford

98208

Research Site, Everett

98405

Research Site, Tacoma

100000

Research Site, Hanoi

110221

Research Site, Bogotá

111511

Research Site, Bogotá

630004

Research Site, Armenia

700000

Research Site, Ho Chi Minh City

900000

Research Site, Can Tho

2260000

Research Site, Quillota

3341643

Research Site, Curicó

3465584

Research Site, Talca

5001000

Research Site, Medellín

7500698

Research Site, Santiago

7500800

Research Site, Santiago

7661041

Research Site, Rehovot

9372212

Research Site, Jerusalem

60864190

Research Site, Fortaleza

76001000

Research Site, Santiago de Cali

04401

Research Site, Bangor

02720

Research Site, Fall River

01752

Research Site, Marlborough

08053

Research Site, Marlton

07083

Research Site, Union

97015-6804

Research Site, Clackamas

C1414AIF

Research Site, Buenos Aires

C1056ABJ

Research Site, CABA

C1425BEN

Research Site, CABA

C1431FWO

Research Site, CABA

C1440BRR

Research Site, Ciudad Autónoma de Buenos Aire

X5003DCE

Research Site, Córdoba

X5014KEH

Research Site, Córdoba

B7600GNY

Research Site, Mar del Plata

M5500GIP

Research Site, Mendoza

B6500EZL

Research Site, Nueve de Julio

B1878FNR

Research Site, Quilmes

S2000DEJ

Research Site, Rosario

T4000IAR

Research Site, San Miguel de Tucumán

90035-074

Research Site, Porto Alegre

90470-340

Research Site, Porto Alegre

90610-000

Research Site, Porto Alegre

91350-200

Research Site, Porto Alegre

22271-100

Research Site, Rio de Janeiro

09080-110

Research Site, Santo André

04020060

Research Site, São Paulo

04023-062

Research Site, São Paulo

05403-000

Research Site, São Paulo

18040-425

Research Site, Sorocaba

29055-450

Research Site, Vitória

Unknown

Research Site, Silistra

Research Site, Bogotá

Research Site, Medillin

Research Site, Piura

Research Site, Lipa City

Research Site, Kaohsiung City

Research Site, Taipei

IL-

Research Site, Tel Aviv

0626

Research Site, Auckland

N-8092

Research Site, Bodø

N-4816

Research Site, Kolbjørnsvik

CUSCO 01

Research Site, Cusco

L27

Research Site, Lima

L41

Research Site, Lima

LIMA 1

Research Site, Lima

LIMA 21

Research Site, Lima

LIMA 31

Research Site, Lima

LIMA 33

Research Site, Lima

15-044

Research Site, Bialystok

15-351

Research Site, Bialystok

85-231

Research Site, Bydgoszcz

80-952

Research Site, Gdansk

66-400

Research Site, Gorzów Wlkp

05-825

Research Site, Grodzisk Mazowiecki

05-480

Research Site, Karczew

40-648

Research Site, Katowice

30-901

Research Site, Krakow

27-400

Research Site, Ostrowiec Świętokrzyski

63-400

Research Site, Ostrów Wielkopolski

41-707

Research Site, Ruda Śląska

96-100

Research Site, Skierniewice

41-200

Research Site, Sosnowiec

27-200

Research Site, Starachowice

70-111

Research Site, Szczecin

62-400

Research Site, Słupca

55-100

Research Site, Trzebnica

51-162

Research Site, Wroclaw

53-301

Research Site, Wroclaw

88-400

Research Site, Żnin

405 30

Research Site, Gothenburg

252 20

Research Site, Helsingborg

221 85

Research Site, Lund

114 46

Research Site, Stockholm

751 85

Research Site, Uppsala

01330

Research Site, Adana

06280

Research Site, Ankara

03680

Research Site, Kyiv

04107

Research Site, Kyiv

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

MedImmune LLC

INDUSTRY

lead

AstraZeneca

INDUSTRY