Temozolomide With or Without Veliparib in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

447

Participants

Timeline

Start Date

December 15, 2014

Primary Completion Date

December 1, 2021

Study Completion Date

December 26, 2025

Conditions
GlioblastomaGliosarcoma
Interventions
OTHER

Laboratory Biomarker Analysis

Correlative studies

OTHER

Placebo Administration

Given PO

OTHER

Quality-of-Life Assessment

Ancillary studies

DRUG

Temozolomide

Given PO

DRUG

Veliparib

Given PO

Trial Locations (393)

10029

Mount Sinai Hospital, New York

10467

Montefiore Medical Center - Moses Campus, The Bronx

13210

State University of New York Upstate Medical University, Syracuse

13326

Mary Imogene Bassett Hospital, Cooperstown

14263

Roswell Park Cancer Institute, Buffalo

14642

University of Rochester, Rochester

15212

Allegheny General Hospital, Pittsburgh

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

17109

UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg

17602

Lancaster General Hospital, Lancaster

17701

UPMC Susquehanna, Williamsport

17822

Geisinger Medical Center, Danville

18103

Lehigh Valley Hospital-Cedar Crest, Allentown

18711

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

18840

Guthrie Medical Group PC-Robert Packer Hospital, Sayre

19001

Jefferson Abington Hospital, Abington

19010

Bryn Mawr Hospital, Bryn Mawr

19096

Lankenau Medical Center, Wynnewood

19301

Paoli Memorial Hospital, Paoli

21133

Northwest Hospital Center, Randallstown

21215

Sinai Hospital of Baltimore, Baltimore

21401

Luminis Health Anne Arundel Medical Center, Annapolis

21801

TidalHealth Peninsula Regional, Salisbury

22042

Inova Fairfax Hospital, Falls Church

22908

University of Virginia Cancer Center, Charlottesville

24541

Danville Regional Medical Center, Danville

25701

Edwards Comprehensive Cancer Center, Huntington

26506

West Virginia University Healthcare, Morgantown

27157

Wake Forest University Health Sciences, Winston-Salem

27834

East Carolina University, Greenville

28501

ECU Health Oncology Kinston, Kinston

28801

Mission Hospital, Asheville

29303

Spartanburg Medical Center, Spartanburg

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29341

Gibbs Cancer Center-Gaffney, Gaffney

29401

Roper Hospital, Charleston

29403

Charleston Oncology - Roper, Charleston

29406

Lowcountry Hematology Oncology PA-North Charleston, Charleston

29414

Bon Secours Saint Francis Hospital, Charleston

Charleston Oncology - Saint Francis, Charleston

Lowcountry Hematology Oncology PA-West Ashley, Charleston

29425

Medical University of South Carolina, Charleston

29464

Lowcountry Hematology Oncology PA-Mount Pleasant, Mt. Pleasant

29601

Greenville Health System Cancer Institute-Andrews, Greenville

Saint Francis Hospital, Greenville

29605

Prisma Health Cancer Institute - Butternut, Greenville

Prisma Health Cancer Institute - Faris, Greenville

Prisma Health Greenville Memorial Hospital, Greenville

29607

Saint Francis Cancer Center, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29640

Prisma Health Cancer Institute - Easley, Easley

29650

Prisma Health Cancer Institute - Greer, Greer

29651

Gibbs Cancer Center-Pelham, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

30309

Piedmont Hospital, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

Northside Hospital, Atlanta

30501

Northeast Georgia Medical Center-Gainesville, Gainesville

31904

John B Amos Cancer Center, Columbus

32803

AdventHealth Orlando, Orlando

32806

Orlando Health Cancer Institute, Orlando

33021

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood

33028

Memorial Hospital West, Pembroke Pines

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33140

Mount Sinai Medical Center, Miami Beach

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

33486

Boca Raton Regional Hospital, Boca Raton

33612

Moffitt Cancer Center, Tampa

33805

Lakeland Regional Health Hollis Cancer Center, Lakeland

35233

University of Alabama at Birmingham Cancer Center, Birmingham

37232

Vanderbilt University/Ingram Cancer Center, Nashville

37660

Wellmont Holston Valley Hospital and Medical Center, Kingsport

37920

University of Tennessee - Knoxville, Knoxville

39216

University of Mississippi Medical Center, Jackson

40207

Baptist Health Louisville, Louisville

40503

Baptist Health Lexington, Lexington

40536

University of Kentucky/Markey Cancer Center, Lexington

40701

Baptist Health Corbin, Corbin

42003

Baptist Health Paducah, Paducah

42431

Baptist Health Madisonville/Merle Mahr Cancer Center, Madisonville

43210

Ohio State University Comprehensive Cancer Center, Columbus

43213

Mount Carmel East Hospital, Columbus

43214

Riverside Methodist Hospital, Columbus

43215

Grant Medical Center, Columbus

43537

Toledo Clinic Cancer Centers-Maumee, Maumee

43551

Mercy Health - Perrysburg Hospital, Perrysburg

43560

ProMedica Flower Hospital, Sylvania

43616

Saint Charles Hospital, Oregon

43623

Mercy Health - Saint Anne Hospital, Toledo

Toledo Clinic Cancer Centers-Toledo, Toledo

44195

Cleveland Clinic Foundation, Cleveland

44307

Cleveland Clinic Akron General, Akron

44708

Cleveland Clinic Mercy Hospital, Canton

45069

University of Cincinnati Cancer Center-West Chester, West Chester

45219

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

45331

Wayne Hospital, Greenville

45406

Good Samaritan Hospital - Dayton, Dayton

45409

Miami Valley Hospital, Dayton

45415

Dayton Physician LLC - Englewood, Dayton

Miami Valley Hospital North, Dayton

45601

Adena Regional Medical Center, Chillicothe

45840

Armes Family Cancer Center, Findlay

Blanchard Valley Hospital, Findlay

Orion Cancer Care, Findlay

46237

Franciscan Health Indianapolis, Indianapolis

46601

Memorial Hospital of South Bend, South Bend

46805

Parkview Hospital Randallia, Fort Wayne

47374

Reid Health, Richmond

48073

Corewell Health William Beaumont University Hospital, Royal Oak

48075

Henry Ford Health Providence Southfield Hospital, Southfield

48106

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48154

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48236

Henry Ford Health Saint John Hospital, Detroit

48341

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48374

Henry Ford Health Providence Novi Hospital, Novi

48503

Genesys Hurley Cancer Institute, Flint

48601

MyMichigan Medical Center Saginaw, Saginaw

48912

University of Michigan Health - Sparrow Lansing, Lansing

49007

West Michigan Cancer Center, Kalamazoo

49085

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph

49503

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

Trinity Health Grand Rapids Hospital, Grand Rapids

49519

University of Michigan Health - West, Wyoming

49677

Corewell Health Reed City Hospital, Reed City

49684

Munson Medical Center, Traverse City

49829

OSF Saint Francis Hospital and Medical Group, Escanaba

50266

Mercy Medical Center-West Lakes, West Des Moines

50309

Iowa Methodist Medical Center, Des Moines

50314

Mercy Medical Center - Des Moines, Des Moines

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50325

Mercy Cancer Center-West Lakes, Clive

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

50401

Mercy Medical Center - North Iowa, Mason City

51101

Siouxland Regional Cancer Center, Sioux City

52402

Physicians' Clinic of Iowa PC, Cedar Rapids

53022

Aurora Health Care Germantown Health Center, Germantown

53024

Aurora Cancer Care-Grafton, Grafton

53066

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

Aurora Medical Center in Summit, Summit

53081

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53105

Aurora Cancer Care-Southern Lakes VLCC, Burlington

53149

ProHealth D N Greenwald Center, Mukwonago

53188

Aurora Cancer Care-Waukesha, Waukesha

ProHealth Waukesha Memorial Hospital, Waukesha

UW Cancer Center at ProHealth Care, Waukesha

53209

Aurora Cancer Care-Milwaukee, Milwaukee

53215

Aurora Saint Luke's Medical Center, Milwaukee

53226

Medical College of Wisconsin, Milwaukee

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

Aurora West Allis Medical Center, West Allis

53233

Aurora Sinai Medical Center, Milwaukee

53406

Aurora Cancer Care-Racine, Racine

53548

Mercyhealth Hospital and Cancer Center - Janesville, Janesville

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54143

Aurora Bay Area Medical Group-Marinette, Marinette

54154

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls

54241

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54301

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54311

Aurora BayCare Medical Center, Green Bay

54449

Marshfield Medical Center-Marshfield, Marshfield

Marshfield Medical Center, Marshfield

54476

Diagnostic and Treatment Center, Weston

Marshfield Medical Center - Weston, Weston

54548

Marshfield Medical Center - Minocqua, Minocqua

54601

Gundersen Lutheran Medical Center, La Crosse

54701

HSHS Sacred Heart Hospital, Eau Claire

Marshfield Clinic Cancer Center at Sacred Heart, Eau Claire

54868

Lakeview Medical Center-Marshfield Clinic, Rice Lake

Marshfield Medical Center-Rice Lake, Rice Lake

54904

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

54937

Aurora Health Center-Fond du Lac, Fond du Lac

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55422

North Memorial Medical Health Center, Robbinsdale

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55454

Health Partners Inc, Minneapolis

55805

Essentia Health Cancer Center, Duluth

Saint Luke's Hospital of Duluth, Duluth

55905

Mayo Clinic in Rochester, Rochester

56201

Rice Memorial Hospital, Willmar

56303

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud

56601

Sanford Joe Lueken Cancer Center, Bemidji

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

57105

Avera Cancer Institute, Sioux Falls

57401

Avera Cancer Institute-Aberdeen, Aberdeen

57701

Rapid City Regional Hospital, Rapid City

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

58201

Altru Cancer Center, Grand Forks

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

59715

Bozeman Health Deaconess Hospital, Bozeman

60026

NorthShore University HealthSystem-Glenbrook Hospital, Glenview

60035

NorthShore University HealthSystem-Highland Park Hospital, Highland Park

60068

Advocate Lutheran General Hospital, Park Ridge

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60201

NorthShore University HealthSystem-Evanston Hospital, Evanston

60540

Edward Hospital/Cancer Center, Naperville

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60585

Edward Hospital/Cancer Center?Plainfield, Plainfield

60611

Northwestern University, Chicago

60612

Rush University Medical Center, Chicago

61615

Illinois CancerCare-Peoria, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61701

OSF Saint Joseph Medical Center, Bloomington

61801

Carle Cancer Center, Urbana

62401

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Central Illinois Hematology Oncology Center, Springfield

Southern Illinois University School of Medicine, Springfield

62781

Springfield Memorial Hospital, Springfield

63017

Saint Luke's Hospital, Chesterfield

63110

Washington University School of Medicine, St Louis

63131

Missouri Baptist Medical Center, St Louis

63141

Mercy Hospital Saint Louis, St Louis

63703

Mercy Cancer Center - Cape Girardeau, Cape Girardeau

64057

Centerpoint Medical Center LLC, Independence

64086

Saint Luke's East - Lee's Summit, Lee's Summit

64111

Saint Luke's Hospital of Kansas City, Kansas City

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66044

Lawrence Memorial Hospital, Lawrence

66209

Menorah Medical Center, Overland Park

66701

Cancer Center of Kansas - Fort Scott, Fort Scott

66720

Cancer Center of Kansas - Chanute, Chanute

67042

Cancer Center of Kansas - El Dorado, El Dorado

67068

Cancer Center of Kansas-Kingman, Kingman

67114

Cancer Center of Kansas - Newton, Newton

67124

Cancer Center of Kansas - Pratt, Pratt

67152

Cancer Center of Kansas - Wellington, Wellington

67156

Cancer Center of Kansas - Winfield, Winfield

67208

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Ascension Via Christi Hospitals Wichita, Wichita

Cancer Center of Kansas - Wichita, Wichita

67301

Cancer Center of Kansas-Independence, Independence

67357

Cancer Center of Kansas - Parsons, Parsons

67401

Cancer Center of Kansas - Salina, Salina

67460

Cancer Center of Kansas - McPherson, McPherson

67801

Cancer Center of Kansas - Dodge City, Dodge City

67905

Cancer Center of Kansas-Liberal, Liberal

68114

Nebraska Methodist Hospital, Omaha

68122

Alegent Health Immanuel Medical Center, Omaha

68124

Alegent Health Bergan Mercy Medical Center, Omaha

Nebraska Cancer Specialists - Omaha, Omaha

68131

Creighton University Medical Center, Omaha

68198

University of Nebraska Medical Center, Omaha

68701

Faith Regional Health Services Carson Cancer Center, Norfolk

68803

Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island

68847

CHI Health Good Samaritan, Kearney

70121

Ochsner Medical Center Jefferson, New Orleans

70809

Mary Bird Perkins Cancer Center, Baton Rouge

70810

The NeuroMedical Center-Clinic, Baton Rouge

72205

University of Arkansas for Medical Sciences, Little Rock

73104

University of Oklahoma Health Sciences Center, Oklahoma City

74146

Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

77030

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

Ben Taub General Hospital, Houston

M D Anderson Cancer Center, Houston

Memorial Hermann Texas Medical Center, Houston

78234

Brooke Army Medical Center, Fort Sam Houston

80026

Kaiser Permanente-Rock Creek, Lafayette

80045

UCHealth University of Colorado Hospital, Aurora

80113

Swedish Medical Center, Englewood

80120

Rocky Mountain Cancer Centers-Littleton, Littleton

80122

AdventHealth Littleton, Littleton

80124

Kaiser Permanente-Lone Tree, Lone Tree

80205

Kaiser Permanente-Franklin, Denver

80303

Boulder Community Foothills Hospital, Boulder

80304

Rocky Mountain Cancer Centers-Boulder, Boulder

80401

Intermountain Health Lutheran Hospital, Wheat Ridge

80501

Rocky Mountain Cancer Centers-Longmont, Longmont

80524

Poudre Valley Hospital, Fort Collins

80539

Banner McKee Medical Center, Loveland

80631

Banner North Colorado Medical Center, Greeley

80907

Penrose-Saint Francis Healthcare, Colorado Springs

Rocky Mountain Cancer Centers-Penrose, Colorado Springs

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

85259

Mayo Clinic in Arizona, Scottsdale

85719

Banner University Medical Center - Tucson, Tucson

89502

Renown Regional Medical Center, Reno

90027

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90033

Los Angeles General Medical Center, Los Angeles

USC / Norris Comprehensive Cancer Center, Los Angeles

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

92093

UC San Diego Moores Cancer Center, La Jolla

92663

USC Norris Oncology/Hematology-Newport Beach, Newport Beach

92835

Saint Jude Medical Center, Fullerton

92868

Saint Joseph Hospital - Orange, Orange

93720

Fresno Cancer Center, Fresno

Kaiser Permanente-Fresno, Fresno

94010

Mills-Peninsula Medical Center, Burlingame

94063

Kaiser Permanente-Redwood City, Redwood City

94080

Kaiser Permanente Cancer Treatment Center, South San Francisco

Kaiser Permanente-South San Francisco, South San Francisco

94115

Kaiser Permanente-San Francisco, San Francisco

94143

UCSF Medical Center-Parnassus, San Francisco

94520

John Muir Medical Center-Concord, Concord

94531

Kaiser Permanente-Deer Valley Medical Center, Antioch

94538

Kaiser Permanente-Fremont, Fremont

94577

Kaiser Permanente San Leandro, San Leandro

94589

Kaiser Permanente-Vallejo, Vallejo

94596

Kaiser Permanente-Walnut Creek, Walnut Creek

94598

John Muir Medical Center-Walnut Creek, Walnut Creek

94611

Kaiser Permanente Oakland-Broadway, Oakland

Kaiser Permanente-Oakland, Oakland

94801

Kaiser Permanente-Richmond, Richmond

94903

Kaiser Permanente-San Rafael, San Rafael

94928

Rohnert Park Cancer Center, Rohnert Park

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95065

Palo Alto Medical Foundation-Santa Cruz, Santa Cruz

95119

Kaiser Permanente-Santa Teresa-San Jose, San Jose

95210

Kaiser Permanente-Stockton, Stockton

95356

Kaiser Permanente-Modesto, Modesto

95403

Kaiser Permanente-Santa Rosa, Santa Rosa

95661

Kaiser Permanente-Roseville, Roseville

Sutter Roseville Medical Center, Roseville

95670

Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova

95678

The Permanente Medical Group-Roseville Radiation Oncology, Roseville

95687

Northbay Cancer Center, Vacaville

95688

Kaiser Permanente Medical Center-Vacaville, Vacaville

95816

Sutter Medical Center Sacramento, Sacramento

95817

University of California Davis Comprehensive Cancer Center, Sacramento

95823

Kaiser Permanente-South Sacramento, Sacramento

South Sacramento Cancer Center, Sacramento

95825

Kaiser Permanente Sacramento Medical Center, Sacramento

96813

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

Queen's Cancer Cenrer - POB I, Honolulu

Queen's Medical Center, Honolulu

Straub Clinic and Hospital, Honolulu

96817

Hawaii Cancer Care Inc-Liliha, Honolulu

Queen's Cancer Center - Kuakini, Honolulu

97210

Legacy Good Samaritan Hospital and Medical Center, Portland

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97227

Kaiser Permanente Northwest, Portland

98001

MultiCare Auburn Medical Center, Auburn

98101

Virginia Mason Medical Center, Seattle

98166

Highline Medical Center-Main Campus, Burien

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

98335

MultiCare Gig Harbor Medical Park, Gig Harbor

98368

Jefferson Healthcare, Port Townsend

98372

MultiCare Good Samaritan Hospital, Puyallup

98405

Franciscan Research Center-Northwest Medical Plaza, Tacoma

MultiCare Tacoma General Hospital, Tacoma

Northwest Medical Specialties PLLC, Tacoma

98664

PeaceHealth Southwest Medical Center, Vancouver

99508

Katmai Oncology Group, Anchorage

Providence Alaska Medical Center, Anchorage

06102

Hartford Hospital, Hartford

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06451

Midstate Medical Center, Meriden

06050

The Hospital of Central Connecticut, New Britain

06520

Yale University, New Haven

32224-9980

Mayo Clinic in Florida, Jacksonville

04401

Eastern Maine Medical Center, Bangor

04412

Lafayette Family Cancer Center-EMMC, Brewer

04086

New England Cancer Specialists - Topsham, Topsham

04092

New England Cancer Specialists, Westbrook

02114

Massachusetts General Hospital Cancer Center, Boston

02215

Dana-Farber Cancer Institute, Boston

01420

Simonds-Sinon Regional Cancer Center, Fitchburg

01854

Lowell General Hospital, Lowell

01655

UMass Memorial Medical Center - University Campus, Worcester

03301

New Hampshire Oncology Hematology PA-Concord, Concord

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

03103

Solinsky Center for Cancer Care, Manchester

03802

Portsmouth Regional Hospital, Portsmouth

08818

John F Kennedy Medical Center, Edison

07601

Hackensack University Medical Center, Hackensack

07039

Saint Barnabas Medical Center, Livingston

08903

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick

Rutgers Cancer Institute of New Jersey, New Brunswick

07652

The Valley Hospital - Luckow Pavilion, Paramus

07450

Valley Health System Ridgewood Campus, Ridgewood

07902

Overlook Hospital, Summit

07675

Valley Health System-Hematology/Oncology, Westwood

02903

Rhode Island Hospital, Providence

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

05405

University of Vermont and State Agricultural College, Burlington

54235-1495

Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay

00927

Fundacion De Investigacion de Diego, San Juan

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT02152982 - Temozolomide With or Without Veliparib in Treating Patients With Newly Diagnosed Glioblastoma Multiforme | Biotech Hunter | Biotech Hunter