421
Participants
Start Date
August 4, 2014
Primary Completion Date
April 15, 2016
Study Completion Date
December 15, 2023
Chemotherapy
Randomization to either Osimertinib or platinum-based doublet-chemotherapy on Day 1 of every 21d cycle in a 2:1 (Osimertinib:platinum-based doublet-chemotherapy) ratio
Cross-over to Osimertinib
"Once subjects on the platinum-based doublet chemotherapy arm are determined to have objective radiological progression according to RECIST 1.1 by the investigator and confirmed by independent central imaging review, they will be given the opportunity to begin treatment with Osimertinib 80mg, once daily. These subjects may continue treatment with Osimertinib even after disease progression, as long as they are continuing to show clinical benefit, as judged by the investigator.~Subjects who stop platinum-based doublet chemotherapy for reasons other than objective disease progression according to RECIST 1.1 will not be eligible to cross-over to Osimertinib."
Research Site, Taipei
Research Site, Hsinchu
Research Site, Taoyuan District
Research Site, Changhua
Research Site, Tainan City
Research Site, Budapest
Research Site, Darlinghurst
Research Site, Kogarah
Research Site, Heidelberg
Research Site, Woolloongabba
Research Site, Nedlands
Research Site, Seoul
Research Site, Taipei
Research Site, New York
Research Site, Orbassano
Research Site, Goyang-si
Research Site, Seongnam-si
Research Site, Marseille
Research Site, Suwon
Research Site, Milan
Research Site, Chevy Chase
Research Site, Dijon
Research Site, Incheon
Research Site, Oldenburg
Research Site, Madrid
Research Site, Madrid
Research Site, Cheongju-si
Research Site, Málaga
Research Site, Charleston
Research Site, Atlanta
Research Site, Toulouse
Research Site, Gainesville
Research Site, Orlando
Research Site, Pembroke Pines
Research Site, Taichung
Research Site, Taichung
Research Site, Seville
Research Site, Ulsan
Research Site, Essen
Research Site, Indianapolis
Research Site, Meldola
Research Site, Busan
Research Site, Zaragoza
Research Site, México
Research Site, Milwaukee
Research Site, Lille
Research Site, Park Ridge
Research Site, Frankfurt
Research Site, Clermont-Ferrand
Research Site, Strasbourg
Research Site, Oaxaca City
Research Site, Marrero
Research Site, Gerlingen
Research Site, Paris
Research Site, Houston
Research Site, Kaohsiung City
Research Site, Kaohsiung City
Research Site, Avellino
Research Site, Kaohsiung City
Research Site, Anaheim
Research Site, Orange
Research Site, Regensburg
Research Site, Villejuif
Research Site, Santa Rosa
Research Site, Würzburg
Research Site, Tacoma
Research Site, Lacey
Research Site, Beijing
Research Site, Beijing
Research Site, Moscow
Research Site, Changchun
Research Site, Harbin
Research Site, Saint Petersburg
Research Site, Saint Petersburg
Research Site, Saint Petersburg
Research Site, Shanghai
Research Site, Tianjin
Research Site, Hangzhou
Research Site, Nanchang
Research Site, Fuzhou
Research Site, Chongqing
Research Site, Chongqing
Research Site, Zhengzhou
Research Site, Guangzhou
Research Site, Guangzhou
Research Site, Yekaterinburg
Research Site, Omsk
Research Site, Ürümqi
Research Site, Norwalk
Research Site, Lebanon
Research Site, Brick
Research Site, Hershey
Research Site, Edmonton
Research Site, Vancouver
Research Site, Halifax
Research Site, Ottawa
Research Site, Toronto
Research Site, Montreal
Research Site, Shanghai
Research Site, Hong Kong
Research Site, Shatin
Research Site, Roma
Research Site, Akashi-shi
Research Site, Bunkyō City
Research Site, Fukuoka
Research Site, Hirakata-shi
Research Site, Kanazawa
Research Site, Kitaadachi-gun
Research Site, Kobe
Research Site, Kurashiki-shi
Research Site, Kyoto
Research Site, Matsuyama
Research Site, Nagoya
Research Site, Natori-shi
Research Site, Niigata
Research Site, Okayama
Research Site, Osaka
Research Site, Osaka
Research Site, Sakaishi
Research Site, Sayama
Research Site, Shinjuku-ku
Research Site, Sunto-gun
Research Site, Takatsuki-shi
Research Site, Wakayama
Research Site, Yokohama
Research Site, Yokohama
Research Site, Yokohama
Research Site, Amsterdam
Research Site, Amsterdam
Research Site, Groningen
Research Site, Jinju
Research Site, Seoul
Research Site, Seoul
Research Site, Seoul
Research Site, Seoul
Research Site, Madrid
Research Site, Gothenburg
Research Site, Lund
Research Site, Stockholm
Research Site, Aberdeen
Research Site, Bristol
Research Site, Edinburgh
Research Site, Glasgow
Research Site, Huddersfield
Research Site, London
Research Site, London
Research Site, Manchester
Research Site, Newcastle upon Tyne
Research Site, Nottingham
Research Site, Wolverhampton
Lead Sponsor
AstraZeneca
INDUSTRY