Mechanistic Approach to Preventing Atrophy and Restoring Function in Older Adults

PHASE2CompletedINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

December 31, 2014

Primary Completion Date

February 29, 2020

Study Completion Date

February 29, 2020

Conditions
Muscle AtrophyQuality of Life
Interventions
DRUG

Essential Amino Acids (EAA)

Twice daily ingestion of 20 or 23 grams of EAA for 7 days leading up to surgery and continuing for 6 weeks after surgery \[surgery = primary total knee arthroplasty\]

DRUG

Placebo (Alanine)

Twice daily ingestion of 20 or 23 grams Placebo (alanine) for 7 days leading up to surgery and continuing for 6 weeks after surgery \[surgery = primary total knee arthroplasty\]

Trial Locations (2)

97401

Slocum Center for Orthopedics and Sports Medicine, Eugene

97401-1240

University of Oregon, Eugene

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Slocum Center for Orthopedics and Sports Medicine

OTHER

collaborator

Slocum Research & Education Foundation

OTHER

collaborator

Oregon Research Institute

OTHER

collaborator

Oregon Health and Science University

OTHER

collaborator

University of Arkansas

OTHER

collaborator

National Institute on Aging (NIA)

NIH

lead

University of Oregon

OTHER